J. Iulek
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View article: The antiviral BDGR-49 provides protection from lethal, neurotropic Venezuelan equine encephalitis virus intranasal infection in mice
The antiviral BDGR-49 provides protection from lethal, neurotropic Venezuelan equine encephalitis virus intranasal infection in mice Open
Venezuelan, western, and eastern equine encephalitis virus (VEEV, WEEV, and EEEV) cause a febrile illness that may result in fatal neurological disease in humans and equines. Human infections are typically from mosquito bites, although cas…
View article: CHEMOTYPE VERBOCCIDENTAFURAN IN Baccharis punctulata (Asteraceae): FURANIC SESQUITERPENES CORRELATION AND MOLECULAR DOCKING INTO THE BENZODIAZEPINE RECEPTOR
CHEMOTYPE VERBOCCIDENTAFURAN IN Baccharis punctulata (Asteraceae): FURANIC SESQUITERPENES CORRELATION AND MOLECULAR DOCKING INTO THE BENZODIAZEPINE RECEPTOR Open
The compound verboccidentafuran (1) was identified from the essential oil of the leaves of Baccharis punctulata DC. (Asteraceae) specimens for the first time in Brazil. The variation of this compound found in male and female specimens may …
View article: MAW point mutation impairs H. Seropedicae RecA ATP hydrolysis and DNA repair without inducing large conformational changes in its structure
MAW point mutation impairs H. Seropedicae RecA ATP hydrolysis and DNA repair without inducing large conformational changes in its structure Open
RecA is a multifunctional protein that plays a central role in DNA repair in bacteria. The structural Make ATP Work motif (MAW) is proposed to control the ATPase activity of RecA. In the present work, we report the biochemical activity and…
View article: Use of Protein Thin Film Organized by External Electric Field as a Template for Protein Crystallization
Use of Protein Thin Film Organized by External Electric Field as a Template for Protein Crystallization Open
The well-known difficulty to obtain high-quality protein crystals has motivated researchers to come up with new methods or modifications of established crystallization methods to stimulate the growth of good diffracting crystals. In the pr…
View article: Conformational variability of the stationary phase survival protein E from <i>Xylella fastidiosa</i> revealed by X-ray crystallography, small-angle X-ray scattering studies, and normal mode analysis
Conformational variability of the stationary phase survival protein E from <i>Xylella fastidiosa</i> revealed by X-ray crystallography, small-angle X-ray scattering studies, and normal mode analysis Open
Xylella fastidiosa is a xylem-limited bacterium that infects a wide variety of plants. Stationary phase survival protein E is classified as a nucleotidase, which is expressed when bacterial cells are in the stationary growth phase and subj…
View article: Structural and Functional Studies of H. seropedicae RecA Protein – Insights into the Polymerization of RecA Protein as Nucleoprotein Filament
Structural and Functional Studies of H. seropedicae RecA Protein – Insights into the Polymerization of RecA Protein as Nucleoprotein Filament Open
The bacterial RecA protein plays a role in the complex system of DNA damage repair. Here, we report the functional and structural characterization of the Herbaspirillum seropedicae RecA protein (HsRecA). HsRecA protein is more efficient at…
View article: Evaluation of the Activity of the Essential Oil from an Ornamental Flower against Aedes aegypti: Electrophysiology, Molecular Dynamics and Behavioral Assays
Evaluation of the Activity of the Essential Oil from an Ornamental Flower against Aedes aegypti: Electrophysiology, Molecular Dynamics and Behavioral Assays Open
Dengue fever has spread worldwide and affects millions of people every year in tropical and subtropical regions of Africa, Asia, Europe and America. Since there is no effective vaccine against the dengue virus, prevention of disease transm…
View article: Crystallization and X Ray Diffraction Data Analyses of the Enzyme Urocanate Hydratase from<i>Trypanosoma cruzi</i>
Crystallization and X Ray Diffraction Data Analyses of the Enzyme Urocanate Hydratase from<i>Trypanosoma cruzi</i> Open
Cristalização e Análises dos Dados de
View article: Crystallization and Crystallographic Analyses of Triosephosphate Isomerase from Naegleria gruberi
Crystallization and Crystallographic Analyses of Triosephosphate Isomerase from Naegleria gruberi Open
Cristalização e Análises Cristalográficas da Triose Fosfato Isomerase de Naegleria gruberiResumo: A enzima Triose fosfato isomerase de Naegleria gruberi (NgTIM) participa da via glicolítica, na qual atua na conversão de dihidroxiacetona fo…
View article: Isolation, Bioactivity and Structural Studies of 6-acetyl-7-hydroxy-2,2-dimethylchoromene from Calea hispida
Isolation, Bioactivity and Structural Studies of 6-acetyl-7-hydroxy-2,2-dimethylchoromene from Calea hispida Open
Isolamento, Bioatividade e Estudos Estruturais do 6-acetil-7-hidroxi-2,2dimetilcromeno de Calea hispidaResumo: Os voláteis obtidos de folhas de Calea hispida foram analisados por GC-MS-FID e apresentaram (E)-erolidol, β-u e e o, espatule o…