Arnold van de Laar
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View article: Higher plasma dicarbonyl levels are associated with liver fibrosis in obese individuals
Higher plasma dicarbonyl levels are associated with liver fibrosis in obese individuals Open
Introduction Methylglyoxal (MGO) is a very reactive compound that modifies proteins, forming advanced glycation end products (AGEs) and activating inflammatory pathways. Elevated MGO levels have been linked to various diseases, including t…
View article: Quantifying malabsorption after Roux-en-Y gastric bypass and sleeve gastrectomy using near infrared spectroscopy
Quantifying malabsorption after Roux-en-Y gastric bypass and sleeve gastrectomy using near infrared spectroscopy Open
Background: Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are common bariatric procedures that lead to substantial and sustained weight loss. RYGB includes both a restrictive and malabsorptive component due to anatomical rero…
View article: New Insights into Ruling Out Internal Herniations After Laparoscopic Gastric Bypass on the Abdominal CT Scan: The OPERATE study
New Insights into Ruling Out Internal Herniations After Laparoscopic Gastric Bypass on the Abdominal CT Scan: The OPERATE study Open
Background Internal herniation (IH) is a potentially life-threatening complication after gastric bypass. Accurate diagnosis of IH remains challenging. This study aims to validate the Eindhoven2020 (EHV20) scoring system for ruling out IH a…
View article: Alterations in bile acid kinetics after bariatric surgery in patients with obesity with or without type 2 diabetes
Alterations in bile acid kinetics after bariatric surgery in patients with obesity with or without type 2 diabetes Open
Novo Nordisk Fonden, Leducq Foundation, Swedish Heart-Lung Foundation, Knut and Alice Wallenberg Foundation, the ALF-agreement, ZonMw.
View article: Tissue-specific inflammation and insulin sensitivity in subjects with obesity
Tissue-specific inflammation and insulin sensitivity in subjects with obesity Open
Obesity is associated with low-grade inflammation and insulin resistance (IR). The contribution of adipose tissue (AT) and hepatic inflammation to IR remains unclear. We conducted a study across three cohorts to investigate this relationsh…
View article: The burden of abdominal pain after bariatric surgery in terms of diagnostic testing: the OPERATE study
The burden of abdominal pain after bariatric surgery in terms of diagnostic testing: the OPERATE study Open
The diagnostic burden in patients with abdominal pain following BS is high. The most frequently performed diagnostic test is an abdominal CT scan, yielding the highest number of diagnoses in these patients.
View article: The effects of laparoscopic Roux-en-Y gastric bypass and one-anastomosis gastric bypass on glycemic control and remission of type 2 diabetes mellitus: study protocol for a multi-center randomized controlled trial (the DIABAR-trial)
The effects of laparoscopic Roux-en-Y gastric bypass and one-anastomosis gastric bypass on glycemic control and remission of type 2 diabetes mellitus: study protocol for a multi-center randomized controlled trial (the DIABAR-trial) Open
Background Metabolic surgery induces rapid remission of type 2 diabetes mellitus (T2DM). There is a paucity of high level evidence comparing the efficacy of the laparoscopic Roux-en-Y gastric bypass (RYGB) and the laparoscopic one-anastomo…
View article: Gut-derived bacterial flagellin induces beta-cell inflammation and dysfunction
Gut-derived bacterial flagellin induces beta-cell inflammation and dysfunction Open
Hyperglycemia and type 2 diabetes (T2D) are caused by failure of pancreatic beta cells. The role of the gut microbiota in T2D has been studied, but causal links remain enigmatic. Obese individuals with or without T2D were included from two…
View article: Hyperinsulinemia is highly associated with markers of hepatocytic senescence in two independent cohorts
Hyperinsulinemia is highly associated with markers of hepatocytic senescence in two independent cohorts Open
Cellular senescence is an essentially irreversible growth arrest that occurs in response to various cellular stressors and may contribute to development of type 2 diabetes and Non-Alcoholic Fatty Liver Disease (NAFLD). Here, we investig…
View article: Hyperinsulinemia Is Highly Associated With Markers of Hepatocytic Senescence in Two Independent Cohorts
Hyperinsulinemia Is Highly Associated With Markers of Hepatocytic Senescence in Two Independent Cohorts Open
Cellular senescence is an essentially irreversible growth arrest that occurs in response to various cellular stressors and may contribute to development of type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD). In this arti…
View article: Hyperinsulinemia is highly associated with markers of hepatocytic senescence in two independent cohorts
Hyperinsulinemia is highly associated with markers of hepatocytic senescence in two independent cohorts Open
Cellular senescence is an essentially irreversible growth arrest that occurs in response to various cellular stressors and may contribute to development of type 2 diabetes and Non-Alcoholic Fatty Liver Disease (NAFLD). Here, we investig…
View article: Systems analysis of metabolic responses to a mixed meal test in an obese cohort reveals links between tissue metabolism and the gut microbiota
Systems analysis of metabolic responses to a mixed meal test in an obese cohort reveals links between tissue metabolism and the gut microbiota Open
Individuals with prediabetes and type 2 diabetes mellitus (T2DM) have poor ability to adapt to diet-triggered perturbations. We investigated global metabolic responses to a mixed meal test (MMT) in morbidly obese individuals with different…
View article: Compensatory intestinal antibody response against pro-inflammatory microbiota after bariatric surgery
Compensatory intestinal antibody response against pro-inflammatory microbiota after bariatric surgery Open
Obesity and type 2 diabetes (T2D) are growing burdens for individuals and the health-care system. Bariatric surgery is an efficient, but drastic treatment to reduce body weight, normalize glucose values, and reduce low-grade inflammation. …
View article: Gut-derived bacterial flagellin induces beta-cell inflammation and dysfunction
Gut-derived bacterial flagellin induces beta-cell inflammation and dysfunction Open
Objective Hyperglycemia and type 2 diabetes (T2D) are caused by failure of pancreatic beta cells. The role of the gut microbiota in T2D has been studied but causal links remain enigmatic. Design Obese individuals with or without T2D were i…
View article: Fecal microbiota transplantation does not alter bacterial translocation and visceral adipose tissue inflammation in individuals with obesity
Fecal microbiota transplantation does not alter bacterial translocation and visceral adipose tissue inflammation in individuals with obesity Open
Aims Visceral adipose tissue inflammation is a fundamental mechanism of insulin resistance in obesity and type 2 diabetes. Translocation of intestinal bacteria has been suggested as a driving factor for the inflammation. However, although …
View article: Psychological functioning and well‐being before and after bariatric surgery; what is the benefit of being self‐compassionate?
Psychological functioning and well‐being before and after bariatric surgery; what is the benefit of being self‐compassionate? Open
Objective To investigate whether patients’ psychological well‐being (depression, quality of life, body image satisfaction) and functioning (self‐efficacy for eating and exercising behaviours and food cravings) improve 12 months after baria…
View article: A systems biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort Study
A systems biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort Study Open
Introduction Prevalence of obesity and associated diseases, including type 2 diabetes mellitus, dyslipidaemia and non‐alcoholic fatty liver disease (NAFLD), are increasing. Underlying mechanisms, especially in humans, are unclear. Bariatri…
View article: Issue Information
Issue Information Open
Long non-coding RNA LINC00337 induces autophagy and chemoresistance to cisplatin
View article: RBP4 increases lipolysis in human adipocytes and is associated with increased lipolysis and hepatic insulin resistance in obese women
RBP4 increases lipolysis in human adipocytes and is associated with increased lipolysis and hepatic insulin resistance in obese women Open
Retinol‐binding protein‐4 (RBP4) is elevated in serum and adipose tissue (AT) in obesity‐induced insulin resistance and correlates inversely with insulin‐stimulated glucose disposal. But its role in insulin‐mediated suppression of lipolysi…
View article: Risk Factors for Cholecystectomy After Laparoscopic Roux-En-Y Gastric Bypass
Risk Factors for Cholecystectomy After Laparoscopic Roux-En-Y Gastric Bypass Open
Background Patients who have undergone bariatric surgery are at risk for subsequent cholecystectomy. We aimed to identify risk factors for cholecystectomy after laparoscopic Roux-en-Y gastric bypass (LRYGB). Methods We conducted a retrospe…
View article: Randomized clinical trial of an enhanced recovery after surgery programme<i>versus</i>conventional care in laparoscopic Roux‐en‐Y gastric bypass surgery
Randomized clinical trial of an enhanced recovery after surgery programme<i>versus</i>conventional care in laparoscopic Roux‐en‐Y gastric bypass surgery Open
Patients under ERAS care recovered faster after LRYGB surgery than those receiving conventional care, with no increase in readmission and postoperative morbidity rates. Registration number: NTR3853 (http://www.trialregister.nl/).
View article: Randomized clinical trial of intracutaneously<i>versus</i>transcutaneously sutured ileostomy to prevent stoma-related complications (ISI trial)
Randomized clinical trial of intracutaneously<i>versus</i>transcutaneously sutured ileostomy to prevent stoma-related complications (ISI trial) Open
Background Ileostomy construction is a common procedure but can be associated with morbidity. The stoma is commonly secured to the skin using transcutaneous sutures. It is hypothesized that intracutaneous sutures result in a tighter adhere…
View article: A novel fully covered double-bump stent for staple line leaks after bariatric surgery: a retrospective analysis
A novel fully covered double-bump stent for staple line leaks after bariatric surgery: a retrospective analysis Open
The success rate and the migration rate of the Beta stent seem comparable to other stents in this retrospective study. Despite the novel double-bump structure of the stent, the migration rate does not seem to be decreased.