Jay Nath
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View article: Current Evidence and Future Perspectives to Implement Continuous and End-Ischemic Use of Normothermic and Oxygenated Hypothermic Machine Perfusion in Clinical Practice
Current Evidence and Future Perspectives to Implement Continuous and End-Ischemic Use of Normothermic and Oxygenated Hypothermic Machine Perfusion in Clinical Practice Open
The use of high-risk renal grafts for transplantation requires the optimization of pretransplant assessment and preservation reconditioning strategies to decrease the organ discard rate and to improve short- and long-term clinical outcomes…
View article: Kidney Transplantation From Deceased Donors With Vaccine-induced Immune Thrombocytopenia and Thrombosis: An Updated Analysis of the UK Experience
Kidney Transplantation From Deceased Donors With Vaccine-induced Immune Thrombocytopenia and Thrombosis: An Updated Analysis of the UK Experience Open
Background. The emergence and attendant mortality of vaccine-induced immune thrombocytopenia and thrombosis (VITT) as a consequence of vaccination against severe acute respiratory syndrome coronavirus 2 have resulted in some patients with …
View article: Simply Adding Oxygen during Hypothermic Machine Perfusion to Combat the Negative Effects of Ischemia-Reperfusion Injury: Fundamentals and Current Evidence for Kidneys
Simply Adding Oxygen during Hypothermic Machine Perfusion to Combat the Negative Effects of Ischemia-Reperfusion Injury: Fundamentals and Current Evidence for Kidneys Open
The use of high-risk renal grafts for transplantation requires optimization of pretransplant preservation and assessment strategies to improve clinical outcomes as well as to decrease organ discard rate. With oxygenation proposed as a resu…
View article: P1651HLA CW12 IN KIDNEY TRANSPLANT RECIPIENTS IS A NOVEL RISK FACTOR FOR THE DEVELOPMENT OF POST-TRANSPLANTATION DIABETES: A SINGLE-CENTRE RETROSPECTIVE STUDY
P1651HLA CW12 IN KIDNEY TRANSPLANT RECIPIENTS IS A NOVEL RISK FACTOR FOR THE DEVELOPMENT OF POST-TRANSPLANTATION DIABETES: A SINGLE-CENTRE RETROSPECTIVE STUDY Open
Background and Aims Counselling kidney transplant candidates for their personalised risk of developing post-transplantation diabetes mellitus (PTDM) requires an understanding of risk factors. While some risk factors are well defined (e.g. …
View article: ShearFAST: a user-friendly<i>in vitro</i>toolset for high throughput, inexpensive fluid shear stress experiments
ShearFAST: a user-friendly<i>in vitro</i>toolset for high throughput, inexpensive fluid shear stress experiments Open
Fluid shear stress is a key modulator of cellular physiology in vitro and in vivo , but its effects are under-investigated due to requirements for complicated induction methods. Herein we report the validation of ShearFAST; a smartphone ap…
View article: Late Breaking Poster
Late Breaking Poster Open
Introduction and Aim: It is a genetic and metabolic disease characterized by accumulation of metabolic wastes in lysozomes as a result of muopolysaccharides that have been destroyed in the body.In this study, care of the child with mucopol…
View article: A simple ex vivo model of human renal allograft preservation using the gonadal vein
A simple ex vivo model of human renal allograft preservation using the gonadal vein Open
Introduction Hypothermic machine perfusion, an organ preservation modality, involves flow of chilled preservation fluid through an allograft’s vasculature. This study describes a simple, reproducible, human model that allows for interrogat…
View article: Recipient Outcomes From Nondirected Live Kidney Donors: A UK-based Cohort Study
Recipient Outcomes From Nondirected Live Kidney Donors: A UK-based Cohort Study Open
Background Increasing numbers of patients with end-stage renal failure are receiving kidneys from nondirected kidney donors (NKDs), also known as altruistic donors. Transplant outcomes for recipients of such kidneys are largely inferred fr…
View article: Repatriation of Patients to Referral Centers and Outcomes After Kidney Transplantation: A Single-center Analysis From the United Kingdom
Repatriation of Patients to Referral Centers and Outcomes After Kidney Transplantation: A Single-center Analysis From the United Kingdom Open
Background The aim of this study was to compare posttransplant outcomes of kidney allograft recipients between those followed up at transplant centers and those that were repatriated back to referral renal units. Methods We analyzed data f…
View article: The Influence of Donor to Recipient Size Matching on Kidney Transplant Outcomes
The Influence of Donor to Recipient Size Matching on Kidney Transplant Outcomes Open
Background Nephron endowment in renal transplantation is infrequently considered, but may have important implications for post kidney transplantation outcomes. In this population-cohort study, we analyzed the deceased-donor kidney transpla…
View article: The impact of donor body mass index on outcomes after deceased kidney transplantation - a national population-cohort study
The impact of donor body mass index on outcomes after deceased kidney transplantation - a national population-cohort study Open
The aim of this study was to determine the effect of donor body mass index (BMI) on deceased donor kidney transplant outcomes. Data were collected from the UK Transplant Registry for all deceased donor kidney transplant recipients between …
View article: Ethnicity matching and outcomes after kidney transplantation in the United Kingdom
Ethnicity matching and outcomes after kidney transplantation in the United Kingdom Open
Our data confirm inferior outcomes associated with non-white kidney donors for kidney transplant recipients of any ethnicity in a risk-adjusted model for the United Kingdom population. However, contrary to non-renal transplant literature, …
View article: Mortality risk after cancer diagnosis in kidney transplant recipients: the limitations of analyzing hospital administration data alone
Mortality risk after cancer diagnosis in kidney transplant recipients: the limitations of analyzing hospital administration data alone Open
Administrative data are frequently used for epidemiological studies but its usefulness to analyze cancer epidemiology after kidney transplantation is unclear. In this retrospective population‐based cohort study, we identified every adult k…
View article: The clinical benefits and metabolic mechanisms of ex vivo machine perfusion of kidneys prior to transplantation
The clinical benefits and metabolic mechanisms of ex vivo machine perfusion of kidneys prior to transplantation Open
Hypothermic machine perfusion (HMP) is well established in the practice of renal transplantation and is associated with improved short and long-term outcomes for selected organs. Despite the advantages of this therapy during the period pri…
View article: Outcomes of donation after circulatory death kidneys undergoing hypothermic machine perfusion following static cold storage: A UK population-based cohort study
Outcomes of donation after circulatory death kidneys undergoing hypothermic machine perfusion following static cold storage: A UK population-based cohort study Open
Evidence is currently lacking regarding the outcomes of kidneys undergoing hypothermic machine perfusion (HMP) in patients in the United Kingdom. Using the National Health Service Blood and Transplant database, the authors compared outcome…
View article: MP831ANALYSIS OF A NATIONAL DATASET: SINGLE KIDNEY TRANSPLANT OUTCOMES IN PAEDIATRIC DONORS TO ADULT RECIPIENTS
MP831ANALYSIS OF A NATIONAL DATASET: SINGLE KIDNEY TRANSPLANT OUTCOMES IN PAEDIATRIC DONORS TO ADULT RECIPIENTS Open
with hypertension (p=0.87)).There was no difference in ET-1 levels in children with hypertension and normal BP (4.12 (0.91; 5.28) vs. 2.09 (1.54; 11.05), p=0.67).Children with decreased EDVR had significantly higher thickness of posterior …
View article: Do outcomes after kidney transplantation differ for black patients in England versus New York State? A comparative, population-cohort analysis
Do outcomes after kidney transplantation differ for black patients in England versus New York State? A comparative, population-cohort analysis Open
Objectives Inferior outcomes for black kidney transplant recipients in the USA may not be generalisable elsewhere. In this population cohort analysis, we compared outcomes for black kidney transplant patients in England versus New York Sta…
View article: Cancer‐related outcomes in kidney allograft recipients in England versus New York State: a comparative population‐cohort analysis between 2003 and 2013
Cancer‐related outcomes in kidney allograft recipients in England versus New York State: a comparative population‐cohort analysis between 2003 and 2013 Open
It is unclear whether cancer‐related epidemiology after kidney transplantation is translatable between countries. In this population‐cohort study, we compared cancer incidence and all‐cause mortality after extracting data for every kidney‐…
View article: 13C glucose labelling studies using 2D NMR are a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
13C glucose labelling studies using 2D NMR are a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys Open
This study conclusively demonstrates that de novo metabolism occurs during HMP and highlights active metabolic pathways in this hypothermic, hypoxic environment. Whilst the majority of the (13)C-enriched glucose is metabolised into glycoly…
View article: Effect of cold ischaemia time on outcome after living donor renal transplantation
Effect of cold ischaemia time on outcome after living donor renal transplantation Open
Background The aim of the present study was to determine the effects of cold ischaemia time (CIT) on living donor kidney transplant recipients in a large national data set. Methods Data from the National Health Service Blood and Transplant…