Bobbie‐Jo Webb‐Robertson
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View article: Islet-intrinsic sex differences in inflammatory signaling contribute to autoimmune diabetes susceptibility
Islet-intrinsic sex differences in inflammatory signaling contribute to autoimmune diabetes susceptibility Open
Whereas most autoimmune diseases exhibit female predominance, type 1 diabetes (T1D) occurs more frequently in males after puberty, suggesting a role for sex hormones in disease modification. Because islet β cells actively shape local immun…
View article: Genetic mapping of complement system proteins for islet autoimmunity in children with high risk of T1D
Genetic mapping of complement system proteins for islet autoimmunity in children with high risk of T1D Open
Recent studies have reported the involvement of complement system proteins in the initiation and progression of islet autoimmunity (IA) in the study of Type 1 diabetes (T1D). However, the genetic factors of complement system proteins at th…
View article: Challenges and Opportunities in State‐of‐the‐Art Proteomics Analysis for Biomarker Development From Plasma Extracellular Vesicles
Challenges and Opportunities in State‐of‐the‐Art Proteomics Analysis for Biomarker Development From Plasma Extracellular Vesicles Open
Extracellular vesicles (EVs) are membrane‐bound particles secreted by cells, playing crucial roles in intercellular communication. The composition of EVs can undergo changes in response to stress and disease conditions, making them excelle…
View article: Assessing the Impact of Measurement Precision on Metabolite Identification Probability in Multidimensional Mass Spectrometry-Based, Reference-Free Metabolomics
Assessing the Impact of Measurement Precision on Metabolite Identification Probability in Multidimensional Mass Spectrometry-Based, Reference-Free Metabolomics Open
Identification of compounds with minimal ambiguity remains a central challenge in mass spectrometry-based metabolomics. Conventional compound identification relies on comparing analytical signatures (e.g., mass-to-charge ratio, collision c…
View article: Low Peripheral Blood Counts and Elevated Proinflammatory Cytokines Signal a Poor CD19 Chimeric Antigen Receptor T-cell Response in Acute Lymphoblastic Leukemia
Low Peripheral Blood Counts and Elevated Proinflammatory Cytokines Signal a Poor CD19 Chimeric Antigen Receptor T-cell Response in Acute Lymphoblastic Leukemia Open
CD19 chimeric antigen receptor T-cell (CAR-T) therapy has significantly improved outcomes for patients with relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL). However, approximately 20% of patients fail to achieve a compl…
View article: The oleaginous yeast Rhodosporidium toruloides engineered for biomass hydrolysate-derived (E)-α-bisabolene production
The oleaginous yeast Rhodosporidium toruloides engineered for biomass hydrolysate-derived (E)-α-bisabolene production Open
The oleaginous yeast Rhodosporidiumtoruloides has been exploited for many bioproducts, including several terpenes, owing to its oleaginous nature and biomass inhibitor tolerance. Here, we built upon previous (E)-α-bisabolene work by iterat…
View article: RNA Splicing Events in Circulation Distinguish Individuals With and Without New-onset Type 1 Diabetes
RNA Splicing Events in Circulation Distinguish Individuals With and Without New-onset Type 1 Diabetes Open
Context Alterations in RNA splicing may influence protein isoform diversity that contributes to or reflects the pathophysiology of certain diseases. Whereas specific RNA splicing events in pancreatic islets have been investigated in models…
View article: Supplementary Video S1 from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets
Supplementary Video S1 from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets Open
Example of P-MartCancer workflow on example dataset demonstrating nearly all of P-MartCancer functionality.
View article: Data from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets
Data from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets Open
P-MartCancer is an interactive web-based software environment that enables statistical analyses of peptide or protein data, quantitated from mass spectrometry–based global proteomics experiments, without requiring in-depth knowledge of sta…
View article: Supplementary Video S1 from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets
Supplementary Video S1 from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets Open
Example of P-MartCancer workflow on example dataset demonstrating nearly all of P-MartCancer functionality.
View article: Data from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets
Data from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets Open
P-MartCancer is an interactive web-based software environment that enables statistical analyses of peptide or protein data, quantitated from mass spectrometry–based global proteomics experiments, without requiring in-depth knowledge of sta…
View article: Supplementary Video S1 from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets
Supplementary Video S1 from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets Open
Example of P-MartCancer workflow on example dataset demonstrating nearly all of P-MartCancer functionality.
View article: Supplementary Video S1 from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets
Supplementary Video S1 from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets Open
Example of P-MartCancer workflow on example dataset demonstrating nearly all of P-MartCancer functionality.
View article: Data from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets
Data from P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets Open
P-MartCancer is an interactive web-based software environment that enables statistical analyses of peptide or protein data, quantitated from mass spectrometry–based global proteomics experiments, without requiring in-depth knowledge of sta…
View article: Inhibition of the eukaryotic initiation factor-2α kinase PERK decreases risk of autoimmune diabetes in mice
Inhibition of the eukaryotic initiation factor-2α kinase PERK decreases risk of autoimmune diabetes in mice Open
Preventing the onset of autoimmune type 1 diabetes (T1D) is feasible through pharmacological interventions that target molecular stress-responsive mechanisms. Cellular stresses, such as nutrient deficiency, viral infection, or unfolded pro…
View article: Proteogenomic characterization of difficult-to-treat breast cancer with tumor cells enriched through laser microdissection
Proteogenomic characterization of difficult-to-treat breast cancer with tumor cells enriched through laser microdissection Open
Background Breast cancer (BC) is the most commonly diagnosed cancer and the leading cause of cancer death among women globally. Despite advances, there is considerable variation in clinical outcomes for patients with non-luminal A tumors, …
View article: Associations between SARS-CoV-2 Infection or COVID-19 Vaccination and Human Milk Composition: A Multi-Omics Approach
Associations between SARS-CoV-2 Infection or COVID-19 Vaccination and Human Milk Composition: A Multi-Omics Approach Open
The risk of contracting SARS-CoV-2 via human milk-feeding is virtually non-existent. Adverse effects of COVID-19 vaccination for lactating individuals are not different from the general population, and no evidence has been found that their…
View article: Mapping Microhabitats: Metabolome Informed Proteome Imaging of Lignocellulose Decomposition by a Naturally Evolved Microbial Consortium
Mapping Microhabitats: Metabolome Informed Proteome Imaging of Lignocellulose Decomposition by a Naturally Evolved Microbial Consortium Open
The annotated protein database was curated to annotate MS/MS data in the manuscript titled 'Mapping Microhabitats: Metabolome Informed Proteome Imaging of Lignocellulose Decomposition by a Naturally Evolved Microbial Consortium'.