Jost B. Jonas
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View article: Safety of íntravitreal panitumumab combined with intravitreal ranibizumab in rabbits
Safety of íntravitreal panitumumab combined with intravitreal ranibizumab in rabbits Open
Purpose To examine the safety of intravitreally applied epidermal growth factor (EGF) receptor antibody panitumumab combined with intravitreally injected vascular endothelial growth factor (VEGF) antibody ranibizumab in rabbits. Methods Th…
View article: Changes of the Optic Nerve Head and Macula in High Myopia in a 10-Year Follow-Up: The Beijing Eye Study
Changes of the Optic Nerve Head and Macula in High Myopia in a 10-Year Follow-Up: The Beijing Eye Study Open
Over the 10-year follow-up, >75% of highly myopic eyes showed progressive myopic changes of the optic nerve head and macula.
View article: Artificial intelligence-driven metabolomics of retinal nerve fibre layer to profile risks of mortality and cardiometabolic diseases
Artificial intelligence-driven metabolomics of retinal nerve fibre layer to profile risks of mortality and cardiometabolic diseases Open
Retinal nerve fibre layer (RNFL) is a non-invasive structural biomarker of cardiometabolic health, yet its biological underpinnings remain unknown. Here, we integrate advanced retinal optical biopsy and artificial intelligence (AI) algorit…
View article: Refractive Error Centile Curves for Asian and Western Children and Adolescents: An Individual Level Meta-Analysis
Refractive Error Centile Curves for Asian and Western Children and Adolescents: An Individual Level Meta-Analysis Open
Population-based centile analysis offers the prospect of estimating the risk of myopia development in individuals and monitoring the treatment efficacy of myopia control interventions. This meta-analysis shows the need for age-, sex-, and …
View article: Glaucomatous, Glaucoma-Like, and Non-Glaucomatous Optic Neuropathy in High Myopia: The Two-Continent Study
Glaucomatous, Glaucoma-Like, and Non-Glaucomatous Optic Neuropathy in High Myopia: The Two-Continent Study Open
Highly myopic eyes had considerable prevalences of NGON and GLON/GON, usually higher than 20% and 10%, respectively. The single IOP reading was ≤21 millimeters of mercury (mm Hg) in ≥70% of the eyes with GLON/GON. NGON (associated with lar…
View article: Topical Application of Everolimus Attenuates Lens-Induced Myopia Through mTORC1 Suppression
Topical Application of Everolimus Attenuates Lens-Induced Myopia Through mTORC1 Suppression Open
This novel ophthalmic formulation effectively delivered everolimus to the posterior segment and inhibited myopia progression, supporting its clinical potential for myopia control.
View article: Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries
Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries Open
Summary Background Polygenic risk scores (PRSs) improve type 2 diabetes (T2D) prediction beyond clinical risk factors but perform poorly in non-European populations, where T2D burden is often higher, undermining their global clinical utili…
View article: Estimates on the Number of People Blind or Visually Impaired due to Diabetic Retinopathy in Southern Urals
Estimates on the Number of People Blind or Visually Impaired due to Diabetic Retinopathy in Southern Urals Open
Purpose. To determine the prevalence of blindness and visual impairment due to diabetic retinopathy in the studied region. Material and methods. In the period from 2015 to 2017, a cross-sectional population-based clinical study «Ural Eye a…
View article: Artificial Intelligence‐Based Detection of Central Retinal Artery Occlusion Within 4.5 Hours on Standard Fundus Photographs
Artificial Intelligence‐Based Detection of Central Retinal Artery Occlusion Within 4.5 Hours on Standard Fundus Photographs Open
Background Prompt diagnosis of acute central retinal artery occlusion (CRAO) is crucial for therapeutic management and stroke prevention. However, most stroke centers lack onsite ophthalmic expertise before considering fibrinolytic treatme…
View article: Peripapillary Hyperreflective Ovoid Mass-Like Structures: Prevalence and Associations in the Adult Population of the Beijing Eye Study
Peripapillary Hyperreflective Ovoid Mass-Like Structures: Prevalence and Associations in the Adult Population of the Beijing Eye Study Open
PHOMS are relatively rare in the general adult and elderly population and mainly associated with a small optic disc. They are not related to a decrease in visual function or peripapillary retinal nerve fiber layer thickness, and they do no…
View article: Longitudinal evaluation of Bruch's membrane opening-minimum rim width in Chinese children: The Hong Kong Children Eye Study
Longitudinal evaluation of Bruch's membrane opening-minimum rim width in Chinese children: The Hong Kong Children Eye Study Open
Global and sectoral BMO-MRW increased over 3 years among school children aged 6-8 years, affected by larger axial elongation, larger BMO area enlargement, more marked RNFL thickening, and decrease in optic disc area.
View article: Prevalence of Myopia and Axial Length Distribution in China: The Wuhu Children and Adolescents Eye Study
Prevalence of Myopia and Axial Length Distribution in China: The Wuhu Children and Adolescents Eye Study Open
Compared with previous studies, the present investigation suggests a further rise in the prevalence of myopia, particularly high myopia, in the younger generations in China.
View article: Relationship of Choroidal Thickness With Age-Related Macular Degeneration in Asians: An Asian Eye Epidemiology Consortium Meta-Analysis
Relationship of Choroidal Thickness With Age-Related Macular Degeneration in Asians: An Asian Eye Epidemiology Consortium Meta-Analysis Open
In a large Asian cohort, AMD is associated with a thicker choroid in early AMD, iAMD, and nAMD, but not in GA. Studying the CT will help to better characterize Asian AMD phenotypes, which may show differences compared with AMD phenotypes i…
View article: The real-world effectiveness of defocus incorporated multiple segments and highly aspherical lenslets on myopia control: a longitudinal study from the French myopia cohort
The real-world effectiveness of defocus incorporated multiple segments and highly aspherical lenslets on myopia control: a longitudinal study from the French myopia cohort Open
Aims To evaluate the efficacy of myopia control by spectacle lenses in a real-world study. Methods This is a longitudinal, retrospective, comparative, observational, real-world study of the French Myopia Cohort. Records of prescriptions fo…
View article: Myopia and high myopia trends in Chinese children and adolescents over 25 years: a nationwide study with projections to 2050
Myopia and high myopia trends in Chinese children and adolescents over 25 years: a nationwide study with projections to 2050 Open
National Natural Science Foundation of China (#82271086; #82388101; #72495123).
View article: Epidermal growth factor receptor antibody and axial elongation in experimental myopia
Epidermal growth factor receptor antibody and axial elongation in experimental myopia Open
Purpose To evaluate the effect of intraocularly applied epidermal growth factor receptor (EGFR) antibody panitumumab on axial elongation. Methods This is a preclinical, safety, and efficacy experimental study. Guinea pigs aged 2–3 weeks we…
View article: Aqueous humour concentrations of <scp>HB</scp> ‐ <scp>EGF</scp> , <scp>EGF</scp> and <scp>VEGF</scp> ‐A and axial length in humans
Aqueous humour concentrations of <span>HB</span> ‐ <span>EGF</span> , <span>EGF</span> and <span>VEGF</span> ‐A and axial length in humans Open
Purpose To investigate relationships between the intraocular concentrations of heparin‐binding epidermal growth factor (HB‐EGF), epidermal growth factor (EGF) and vascular endothelial growth factor A (VEGF‐A) in dependence on axial length …
View article: Macular ridges: Prevalence and associated factors—The Beijing Eye Study
Macular ridges: Prevalence and associated factors—The Beijing Eye Study Open
Purpose To explore the prevalence and associated factors of macular ridges in a population‐based study sample. Methods From the participants of the population‐based Beijing Eye Study ( n = 3468), we included all eyes with an axial length o…