Kenneth J. Ryan
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View article: IL-27 signaling limits the diversity of antigen-specific T cells and interferes with protection induced by BCG vaccination
IL-27 signaling limits the diversity of antigen-specific T cells and interferes with protection induced by BCG vaccination Open
Tuberculosis (TB) is the leading cause of death due to a pathogen. The live-attenuated BCG vaccine is the only approved vaccine to prevent TB, but it fails to confer long-term protection. We hypothesize that the immunosuppressive cytokine …
View article: Transitioning from night to day transplants: changing the transplant culture for optimisation through a province-wide quality improvement initiative
Transitioning from night to day transplants: changing the transplant culture for optimisation through a province-wide quality improvement initiative Open
Background Organ transplants, some of the most complex operations, have historically been performed overnight due to logistical challenges in healthcare systems. Overnight transplants contribute to transplant team burnout and can compromis…
View article: IL-27 alters inflammatory cytokine expression and limits protective immunity against Mycobacterium tuberculosis in a neonatal BCG vaccination model
IL-27 alters inflammatory cytokine expression and limits protective immunity against Mycobacterium tuberculosis in a neonatal BCG vaccination model Open
Background Efforts to control tuberculosis (TB), caused by the pathogen Mycobacterium tuberculosis (Mtb), have been hampered by the immense variability in protection from BCG vaccination. While BCG protects young children from some forms o…
View article: Sequential Bayesian assurance tests for degradation data
Sequential Bayesian assurance tests for degradation data Open
Measuring degradation of items in a reliability context may be all that is feasible. There may simply be neither enough time nor resources to produce a sufficient number of item failures to characterize the underlying time-until-failure di…
View article: Legendre pairs of lengths<i>ℓ</i>≡ 0 (mod 5)
Legendre pairs of lengths<i>ℓ</i>≡ 0 (mod 5) Open
By assuming a type of balance for length ℓ=87 \ell =87 and nontrivial subgroups of multiplier groups of Legendre pairs (LPs) for length ℓ=85 \ell =85 , we find LPs of these lengths. We then study the power spectral density (PSD) values of …
View article: Analysis of overlapping count data
Analysis of overlapping count data Open
Counts of a specific characteristic were obtained within regions defined on an object that was manufactured in a proprietary setting. The count regions were altered during production and resulted in misaligned or overlapping count data. A …
View article: Working with Dynamic Earthquake Rupture Models: A Practical Guide
Working with Dynamic Earthquake Rupture Models: A Practical Guide Open
Dynamic rupture models are physics-based simulations that couple fracture mechanics to wave propagation and are used to explain specific earthquake observations or to generate a suite of predictions to understand the influence of frictiona…
View article: Analysis of overlapping count data
Analysis of overlapping count data Open
Counts of a specific characteristic were obtained within regions defined on an object that was manufactured in a proprietary setting. The count regions were altered during production and resulted in misaligned or overlapping count data. A …
View article: Analysis of Repeatability and Reproducibility Studies With Ordinal Measurements
Analysis of Repeatability and Reproducibility Studies With Ordinal Measurements Open
A Bayesian inferential approach with a noninformative prior is introduced to analyze ordinal repeatability and reproducibility (R&R) data using the De Mast–Van Wieringen model. This approach is extended with a weakly informative prior and …
View article: On Data Integration Problems With Manifolds
On Data Integration Problems With Manifolds Open
This article focuses on data integration problems where the predictor variables for some response variable partition into known subsets. This type of data is often referred to as multi-view data, and each subset of the predictors is called…
View article: On Data Integration Problems With Manifolds
On Data Integration Problems With Manifolds Open
This article focuses on data integration problems where the predictor variables for some response variable partition into known subsets. This type of data is often referred to as multi-view data, and each subset of the predictors is called…
View article: On Data Integration Problems with Manifolds
On Data Integration Problems with Manifolds Open
This paper focuses on data integration problems where the predictor variables for some response variable partition into known subsets. This type of data is often referred to as multi-view data, and each subset of the predictors is called a…
View article: Analysis of Repeatability and Reproducibility Studies With Ordinal Measurements
Analysis of Repeatability and Reproducibility Studies With Ordinal Measurements Open
A Bayesian inferential approach with a noninformative prior is introduced to analyze ordinal repeatability and reproducibility (R&R) data using the De Mast–Van Wieringen model. This approach is extended with a weakly informative prior and …
View article: Integer Programming for Classifying Orthogonal Arrays
Integer Programming for Classifying Orthogonal Arrays Open
Classifying orthogonal arrays is a well known important class of problems that asks for finding all non-isomorphic, non-negative integer solutions to a class of systems of constraints. Solved instances are scarce. We develop two new method…
View article: Integer Programming for Enumerating Orthogonal Arrays
Integer Programming for Enumerating Orthogonal Arrays Open
Statistical design of experiments is widely used in scientific and industrial investigations. An optimum orthogonal array can extract as much information as possible at a fixed cost. Finding (optimum) orthogonal arrays is an open (yet fund…