Jasmin Sidhu
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View article: Pre-existing and early cellular immune factors correlate with functionally complete protection against primary controlled human SARS-CoV-2 infection
Pre-existing and early cellular immune factors correlate with functionally complete protection against primary controlled human SARS-CoV-2 infection Open
Identifying host factors that mediate protection against newly-emergent viruses is needed for improved pandemic preparedness. Here, we analysed pre- and early post-exposure immune factors associated with resisting SARS-CoV-2 infection afte…
View article: MON-213 Preliminary Patient Demographics And Baseline Characteristics From A Phase 3 Study (sunrize) Of Ersodetug For Hypoglycemia Due To Congenital Hyperinsulinism: Trial In Progress
MON-213 Preliminary Patient Demographics And Baseline Characteristics From A Phase 3 Study (sunrize) Of Ersodetug For Hypoglycemia Due To Congenital Hyperinsulinism: Trial In Progress Open
Disclosure: G. Saha: Employee and shareholder of Rezolute Inc. E. O'Boyle: Employee and shareholder of Rezolute Inc. L. Lugos: Employee and shareholder of Rezolute Inc. J.K. Sidhu: Employee and shareholder of Rezolute Inc. D.E. Hood: Emplo…
View article: Mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge in seronegative adults
Mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge in seronegative adults Open
Human infection challenge permits in-depth, early, and pre-symptomatic characterization of the immune response, enabling the identification of factors that are important for viral clearance. Here, we performed intranasal inoculation of 34 …
View article: Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19
Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19 Open
Background While inflammatory and immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in peripheral blood are extensively described, responses at the upper respiratory mucosal site of initial infectio…
View article: Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease after COVID-19 hospitalisation
Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease after COVID-19 hospitalisation Open
One in ten SARS-CoV-2 infections result in prolonged symptoms termed long COVID, yet disease phenotypes and mechanisms are poorly understood. We studied the blood proteome of 719 previously hospitalised adults with long COVID grouped by sy…
View article: Mucosal and Systemic Immune Correlates of Viral Control following SARS-CoV-2 Infection Challenge in Seronegative Adults
Mucosal and Systemic Immune Correlates of Viral Control following SARS-CoV-2 Infection Challenge in Seronegative Adults Open
Human infection challenge permits characterisation of the associated immune response in unparalleled depth, enabling evaluation of early pre-symptomatic immune changes and the dynamic immune factors important for viral clearance. Here, 34 …
View article: Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease
Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease Open
One in ten SARS-CoV-2 infections result in prolonged symptoms termed ‘long COVID’, yet disease phenotypes and mechanisms are poorly understood. We studied the blood proteome of 719 adults, grouped by long COVID symptoms. Elevated markers o…
View article: Supplementary tables from Serum Molecular Signatures of Weight Change during Early Breast Cancer Chemotherapy
Supplementary tables from Serum Molecular Signatures of Weight Change during Early Breast Cancer Chemotherapy Open
Supplementary tables
View article: Data from Serum Molecular Signatures of Weight Change during Early Breast Cancer Chemotherapy
Data from Serum Molecular Signatures of Weight Change during Early Breast Cancer Chemotherapy Open
Purpose: Weight gain in women receiving chemotherapy for breast cancer is associated with a higher risk of recurrence but its mechanisms are poorly understood.Experimental Design: To investigate this, we assessed the metabolic, cytokine, a…
View article: Supplementary tables from Serum Molecular Signatures of Weight Change during Early Breast Cancer Chemotherapy
Supplementary tables from Serum Molecular Signatures of Weight Change during Early Breast Cancer Chemotherapy Open
Supplementary tables
View article: Data from Serum Molecular Signatures of Weight Change during Early Breast Cancer Chemotherapy
Data from Serum Molecular Signatures of Weight Change during Early Breast Cancer Chemotherapy Open
Purpose: Weight gain in women receiving chemotherapy for breast cancer is associated with a higher risk of recurrence but its mechanisms are poorly understood.Experimental Design: To investigate this, we assessed the metabolic, cytokine, a…
View article: Wearable physiologic monitoring in healthcare simulation
Wearable physiologic monitoring in healthcare simulation Open
The ability to non-invasively monitor physiological changes in healthcare providers in simulation settings is important as it can provide insights into the hidden internal states of individuals. Physiologic monitoring has been used success…
View article: Decorin–induced, preeclampsia-associated microRNA-512-3p restrains extravillous trophoblast functions by targeting USF2/PPP3R1 axis
Decorin–induced, preeclampsia-associated microRNA-512-3p restrains extravillous trophoblast functions by targeting USF2/PPP3R1 axis Open
Decorin (DCN) is a leucine-rich proteoglycan produced by chorionic villus mesenchymal cells anddecidual cells during human pregnancy. Studies from our laboratory demonstrated that decidua-derived DCN restrains multiple trophoblast function…
View article: Nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination
Nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination Open
Summary Background Most studies of immunity to SARS-CoV-2 focus on circulating antibody, giving limited insights into mucosal defences that prevent viral replication and onward transmission. We studied nasal and plasma antibody responses o…
View article: A frameshift variant in specificity protein 1 triggers superactivation of Sp1-mediated transcription in familial bone marrow failure
A frameshift variant in specificity protein 1 triggers superactivation of Sp1-mediated transcription in familial bone marrow failure Open
Significance Bone marrow failure (BMF) syndromes are inherited life-threatening conditions characterized by low blood cell production and predisposition to cancer. In this study we report a germ line frameshift variant in the Sp1 transcrip…
View article: Genome instability is a consequence of transcription deficiency in patients with bone marrow failure harboring biallelic <i>ERCC6L2</i> variants
Genome instability is a consequence of transcription deficiency in patients with bone marrow failure harboring biallelic <i>ERCC6L2</i> variants Open
Significance Bone marrow failure (BMF) is an inherited life-threatening condition characterized by defective hematopoiesis, developmental abnormalities, and predisposition to cancer. BMF caused by ERCC6L2 mutations is considered to be a ge…
View article: Expanding the phenotypic and genetic spectrum of radioulnar synostosis associated hematological disease
Expanding the phenotypic and genetic spectrum of radioulnar synostosis associated hematological disease Open
Congenital radioulnar synostosis (RUS) is a rare developmental abnormality involving fusion of the bones of the forearms (radius and ulna) preventing normal supination of the affected forearm and has been recognized in orthopaedic literatu…
View article: In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells
In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells Open
Recent experimental data showed that the PI3K pathway contributes to resistance to temozolomide (TMZ) in paediatric glioblastoma and that this effect is reversed by combination treatment of TMZ with a PI3K inhibitor. Our aim is to assess w…
View article: Pediatric and adult glioblastoma radiosensitization induced by PI3K/mTOR inhibition causes early metabolic alterations detected by nuclear magnetic resonance spectroscopy
Pediatric and adult glioblastoma radiosensitization induced by PI3K/mTOR inhibition causes early metabolic alterations detected by nuclear magnetic resonance spectroscopy Open
Poor outcome for patients with glioblastomas is often associated with radioresistance. PI3K/mTOR pathway deregulation has been correlated with radioresistance; therefore, PI3K/mTOR inhibition could render tumors radiosensitive. In this stu…
View article: combinationPI-103+TMZ_N Al-Saffar.xlsx
combinationPI-103+TMZ_N Al-Saffar.xlsx Open
Summary of molecular and NMR-detected metabolic changes following treatment with the PI3K/mTOR inhibitor PI-103 or TMZ as single agents and in combination in the paediatric cell lines KNS42 and SF188.
View article: Metabonomic analysis of ovarian tumour cyst fluid by proton nuclear magnetic resonance spectroscopy
Metabonomic analysis of ovarian tumour cyst fluid by proton nuclear magnetic resonance spectroscopy Open
The majority of ovarian tumours are of the epithelial type, which can be sub classified as benign, borderline or malignant. Epithelial tumours usually have cystic spaces filled with cyst fluid, the metabolic profile of which reflects the m…