Kar Keung Cheng
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View article: Electrocardiogram abnormalities and cardiovascular risk prediction in older Chinese: the Guangzhou Biobank Cohort Study
Electrocardiogram abnormalities and cardiovascular risk prediction in older Chinese: the Guangzhou Biobank Cohort Study Open
Background Evidence on the associations of multiple minor ECG abnormalities (EA) with cardiovascular disease (CVD) and mortality in older populations is limited, particularly whether a weighted EA score better predicts CVD risk than a sing…
View article: Associations of multimorbidity with mortality, hospital stay, and hospitalization costs in Chinese surgical patients: a retrospective cohort study
Associations of multimorbidity with mortality, hospital stay, and hospitalization costs in Chinese surgical patients: a retrospective cohort study Open
Multimorbidity was linked to a 2 to 7-fold increase in mortality, 1-2 extra hospital days, and $1,510-2,771 higher costs compared with patients having one or no morbidities. This large-scale annual study in China underscores the need for e…
View article: A noninvasive model for chronic kidney disease screening and common pathological type identification from retinal images
A noninvasive model for chronic kidney disease screening and common pathological type identification from retinal images Open
Chronic kidney disease (CKD) is a global health challenge, but invasive renal biopsies, the gold standard for diagnosis and prognosis, are often clinically constrained. To address this, we developed the kidney intelligent diagnosis system …
View article: Systematic analysis of associations between obesity and memory decline
Systematic analysis of associations between obesity and memory decline Open
Despite the development of numerous obesity indicators, the optimal measure associated with memory remains to be elucidated. We examined and compared these associations whilst also exploring potential interactions with education. We analys…
View article: Chest x‐ray aortic size and risk of death and cardiovascular disease in older Chinese: Guangzhou biobank cohort study
Chest x‐ray aortic size and risk of death and cardiovascular disease in older Chinese: Guangzhou biobank cohort study Open
Background Chest radiograph can independently predict adverse outcomes in outpatients. We examined the associations of aortic knob width (AKW), ascending aortic length (AAL), and ascending aortic width (AAW) from chest x‐ray with death and…
View article: Association between sarcopenic obesity, obesity, sarcopenia and quality of life in middle-aged and older Chinese: the Guangzhou Biobank Cohort Study
Association between sarcopenic obesity, obesity, sarcopenia and quality of life in middle-aged and older Chinese: the Guangzhou Biobank Cohort Study Open
Purpose Sarcopenic obesity (SO) is increasing globally, especially in aging populations. This study aims to analyze whether SO is more strongly associated with poorer quality of life (QoL) than obesity or sarcopenia alone. Methods SO was d…
View article: Trajectories of lipid profile with cognitive function: 12-year follow-up of Guangzhou Biobank cohort study
Trajectories of lipid profile with cognitive function: 12-year follow-up of Guangzhou Biobank cohort study Open
Studies on the trajectories of lipid profile with cognitive decline are scarce and inconsistent. We examined this association and explored potential effect modification. Lipid profiles including high-density lipoprotein cholesterol (HDL-C)…
View article: The efficacy and safety of thymosin α1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial
The efficacy and safety of thymosin α1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial Open
Objective To evaluate whether the immunomodulatory drug thymosin α1 reduces mortality in adults with sepsis. Design Multicentre, double blinded, placebo controlled phase 3 trial. Setting 22 centres in China, September 2016 to December 2020…
View article: COPD burden and healthcare management across four middle-income countries within the Breathe Well research programme: a descriptive study
COPD burden and healthcare management across four middle-income countries within the Breathe Well research programme: a descriptive study Open
Background Chronic obstructive pulmonary disease is one of the world’s leading causes of morbidity and mortality, with many low- and middle-income countries still experiencing an increase. Effective management requires a strong primary hea…
View article: Optimal QT Correction Formula for Older Chinese: Guangzhou Biobank Cohort Study
Optimal QT Correction Formula for Older Chinese: Guangzhou Biobank Cohort Study Open
Introduction: To identify the optimal QT correction formula for generating corrected QT (QTc) and cutoffs for prolonged QTc, and examine the associations with mortality and cardiovascular disease (CVD) in older Chinese. Methods: A prospect…
View article: Longitudinal Association of Changes in Metabolic Syndrome with Cognitive Function: 12-Year Follow-up of the Guangzhou Biobank Cohort Study
Longitudinal Association of Changes in Metabolic Syndrome with Cognitive Function: 12-Year Follow-up of the Guangzhou Biobank Cohort Study Open
Background: The association of changes in metabolic syndrome (MetS) with cognitive function remains unclear. We explored this association using prospective and Mendelian randomization (MR) studies.Methods: MetS components including high-de…
View article: Development and application of a rapid research prioritisation process for identifying health research priorities in low- and middle-income countries: the RAPID-RP stakeholder analysis
Development and application of a rapid research prioritisation process for identifying health research priorities in low- and middle-income countries: the RAPID-RP stakeholder analysis Open
Background Health research should be locally prioritised by key stakeholders to ensure the best use of available resources, maximum likelihood of research leading to uptake into policy and practice and relevance to the needs of the potenti…
View article: Association of oral health with all-cause and cause-specific mortality in older Chinese adults: A 14-year follow-up of the Guangzhou Biobank Cohort study
Association of oral health with all-cause and cause-specific mortality in older Chinese adults: A 14-year follow-up of the Guangzhou Biobank Cohort study Open
Both less frequent toothbrushing and a greater number of missing teeth were associated with higher risks of all-cause, CVD, stroke, and respiratory disease mortality, showing dose-response patterns, but not with IHD and cancer mortality. M…
View article: Quality of asynchronous webchats vs in-person consultations for postpartum depression in China: a cross-sectional, mixed methods study using standardized patients
Quality of asynchronous webchats vs in-person consultations for postpartum depression in China: a cross-sectional, mixed methods study using standardized patients Open
China Medical Board, National Natural Science Foundation of China, and Swiss Agency for Development and Cooperation Global Cooperation Department.
View article: Association of adverse childhood experiences with anemia in older Chinese: Guangzhou Biobank Cohort Study
Association of adverse childhood experiences with anemia in older Chinese: Guangzhou Biobank Cohort Study Open
To examine the association of adverse childhood experiences (ACEs) with anemia among older people. 24,116 participants aged 50 years or above were recruited. Multivariable linear and logistic regression was used to assess the associations …
View article: Childhood socio-economic disadvantages versus adverse care experiences: Mediation and moderation impacts on late-life depressive symptoms
Childhood socio-economic disadvantages versus adverse care experiences: Mediation and moderation impacts on late-life depressive symptoms Open
Background Whether material deprivation-related childhood socio-economic disadvantages (CSD) and care-related adverse childhood experiences (ACE) have different impacts on depressive symptoms in middle-aged and older people is unclear. Met…