Jamal Khalife
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View article: Characterization of GEXP15 as a Potential Regulator of Protein Phosphatase 1 in Plasmodium falciparum
Characterization of GEXP15 as a Potential Regulator of Protein Phosphatase 1 in Plasmodium falciparum Open
The Protein Phosphatase type 1 catalytic subunit (PP1c) (PF3D7_1414400) operates in combination with various regulatory proteins to specifically direct and control its phosphatase activity. However, there is little information about this p…
View article: Characterization of the<i>Plasmodium berghei</i>regulatory AAA-ATPase subunit Rpt3 as an activator of Protein Phosphatase 1: direct and indirect evidence
Characterization of the<i>Plasmodium berghei</i>regulatory AAA-ATPase subunit Rpt3 as an activator of Protein Phosphatase 1: direct and indirect evidence Open
The 26S proteasome is the main proteolytic machine involved in protein degradation, thus contributing to homeostasis or stress response of eukaryotic cells. This macromolecular complex, consisting of a 20S core particle assembled with one …
View article: Characterization of GEXP15 as a potential regulator of Protein Phosphatase 1 and partner of ribosomal complex in<i>Plasmodium falciparum</i>
Characterization of GEXP15 as a potential regulator of Protein Phosphatase 1 and partner of ribosomal complex in<i>Plasmodium falciparum</i> Open
The Protein Phosphatase type 1 catalytic subunit (PP1c) (PF3D7_1414400) operates in combination with various regulatory proteins to specifically direct and control its phosphatase activity. However, little is known about this phosphatase a…
View article: Dactylosporolides: Glycosylated Macrolides from <i>Dactylosporangium fulvum</i>
Dactylosporolides: Glycosylated Macrolides from <i>Dactylosporangium fulvum</i> Open
A series of novel macrolides were discovered from the culture supernatant of the rare soil actinobacteria Dactylosporangium fulvum and named dactylosporolides A-C. The structure and absolute configuration of these dactylosporolides …
View article: <i>Plasmodium berghei</i> leucine-rich repeat protein 1 downregulates protein phosphatase 1 activity and is required for efficient oocyst development
<i>Plasmodium berghei</i> leucine-rich repeat protein 1 downregulates protein phosphatase 1 activity and is required for efficient oocyst development Open
Protein phosphatase 1 (PP1) is a key enzyme for Plasmodium development. However, the detailed mechanisms underlying its regulation remain to be deciphered. Here, we report the functional characterization of the Plasmodium berghei leucine-r…
View article: Deciphering the Role of Protein Phosphatases in Apicomplexa: The Future of Innovative Therapeutics?
Deciphering the Role of Protein Phosphatases in Apicomplexa: The Future of Innovative Therapeutics? Open
Parasites belonging to the Apicomplexa phylum still represent a major public health and world-wide socioeconomic burden that is greatly amplified by the spread of resistances against known therapeutic drugs. Therefore, it is essential to p…
View article: Mapping PP1c and Its Inhibitor 2 Interactomes Reveals Conserved and Specific Networks in Asexual and Sexual Stages of Plasmodium
Mapping PP1c and Its Inhibitor 2 Interactomes Reveals Conserved and Specific Networks in Asexual and Sexual Stages of Plasmodium Open
Malaria parasites require multiple phosphorylation and dephosphorylation steps to drive signaling pathways for proper differentiation and transformation. Several protein phosphatases, including protein phosphatase 1 (PP1), one of the main …
View article: Supplementary Tables from <i>Plasmodium berghei</i> leucine-rich repeat protein 1 downregulates protein phosphatase 1 activity and is required for efficient oocyst development
Supplementary Tables from <i>Plasmodium berghei</i> leucine-rich repeat protein 1 downregulates protein phosphatase 1 activity and is required for efficient oocyst development Open
Protein phosphatase 1 (PP1) is a key enzyme for Plasmodium development. However, the detailed mechanisms underlying its regulation remain to be deciphered. Here, we report the functional characterization of the Plasmodium berghei…
View article: Supplementary Tables from <i>Plasmodium berghei</i> leucine-rich repeat protein 1 downregulates protein phosphatase 1 activity and is required for efficient oocyst development
Supplementary Tables from <i>Plasmodium berghei</i> leucine-rich repeat protein 1 downregulates protein phosphatase 1 activity and is required for efficient oocyst development Open
Protein phosphatase 1 (PP1) is a key enzyme for Plasmodium development. However, the detailed mechanisms underlying its regulation remain to be deciphered. Here, we report the functional characterization of the Plasmodium berghei…
View article: The UPR sensor IRE1α promotes dendritic cell responses to control <i>Toxoplasma gondii</i> infection
The UPR sensor IRE1α promotes dendritic cell responses to control <i>Toxoplasma gondii</i> infection Open
View article: Rab11A regulates dense granule transport and secretion during Toxoplasma gondii invasion of host cells and parasite replication
Rab11A regulates dense granule transport and secretion during Toxoplasma gondii invasion of host cells and parasite replication Open
Toxoplasma gondii possesses an armada of secreted virulent factors that enable parasite invasion and survival into host cells. These factors are contained in specific secretory organelles, the rhoptries, micronemes and dense granules that …
View article: 200225surveillancemaismon8102018commentairescshcb
200225surveillancemaismon8102018commentairescshcb Open
View article: Essential role of GEXP15, a specific Protein Phosphatase type 1 partner, in Plasmodium berghei in asexual erythrocytic proliferation and transmission
Essential role of GEXP15, a specific Protein Phosphatase type 1 partner, in Plasmodium berghei in asexual erythrocytic proliferation and transmission Open
The essential and distinct functions of Protein Phosphatase type 1 (PP1) catalytic subunit in eukaryotes are exclusively achieved through its interaction with a myriad of regulatory partners. In this work, we report the molecular and funct…
View article: Plasmodium pseudo-Tyrosine Kinase-like binds PP1 and SERA5 and is exported to host erythrocytes
Plasmodium pseudo-Tyrosine Kinase-like binds PP1 and SERA5 and is exported to host erythrocytes Open
Pseudokinases play key roles in many biological processes but they are poorly understood compared to active kinases. Eight putative pseudokinases have been predicted in Plasmodium species. We selected the unique pseudokinase belonging to t…
View article: 190524aviscssojagmb151
190524aviscssojagmb151 Open
View article: 190301aviscshcbmaisrx-015
190301aviscshcbmaisrx-015 Open
View article: Avis en réponse à la saisine de l’ANSM. Paris le 20 décembre 2019
Avis en réponse à la saisine de l’ANSM. Paris le 20 décembre 2019 Open
L'ANSM a récemment initié une réflexion en vue de la modification des modalités de qualification et de suivi des organismes et produits entrant dans la catégorie des micro-organismes et toxines, appelés MOT, devant nécessiter une déclarati…
View article: Avis en réponse à la saisine HCB - dossier EFSA-GMO-NL-2018-153. Paris, le 24 mai 2019
Avis en réponse à la saisine HCB - dossier EFSA-GMO-NL-2018-153. Paris, le 24 mai 2019 Open
View article: Characterization of a Protein Phosphatase Type-1 and a Kinase Anchoring Protein in Plasmodium falciparum
Characterization of a Protein Phosphatase Type-1 and a Kinase Anchoring Protein in Plasmodium falciparum Open
With its multiple regulatory partners, the conserved Protein Phosphatase type-1 (PP1) plays a central role in many functions of the biology of eukaryotic cells, including Plasmodium falciparum. Here, we characterized a protein named…
View article: Identification of novel quinazoline derivatives as potent antiplasmodial agents
Identification of novel quinazoline derivatives as potent antiplasmodial agents Open
View article: Peptides derived from <em>Plasmodium falciparum</em> leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro [Corrigendum]
Peptides derived from <em>Plasmodium falciparum</em> leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro [Corrigendum] Open
[This corrects the article on p. 85 in vol. 12.].
View article: Peptides derived from Plasmodium falciparum leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro
Peptides derived from Plasmodium falciparum leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro Open
Christine Pierrot,1 Xiguang Zhang,2 Gigliola Zhangi,2 Aline Fréville,1 Angelita Rebollo,2 Jamal Khalife1 1Center for Infection and Immunity of Lille, U1019 – UMR 8204, Institut Pasteur de Lille, Université d…
View article: Peptides derived from <em>Plasmodium falciparum</em> leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro
Peptides derived from <em>Plasmodium falciparum</em> leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro Open
The biogenesis of protein phosphatase 1 (PP1) holoenzyme in eukaryotes requires diverse regulatory subunit proteins (RSPs) that bind to the highly conserved PP1 catalytic subunit (PP1c) and direct its spatiotemporal activity as well as its…
View article: Effect of blood type on anti-α-Gal immunity and the incidence of infectious diseases
Effect of blood type on anti-α-Gal immunity and the incidence of infectious diseases Open
The identification of factors affecting the susceptibility to infectious diseases is essential toward reducing their burden on the human population. The ABO blood type correlates with susceptibility to malaria and other infectious diseases…
View article: HCB_ Avis sur les risques environnementaux et sanitaires liés à la mise sur le marche de pétunias génétiquement modifiés non-autorisés
HCB_ Avis sur les risques environnementaux et sanitaires liés à la mise sur le marche de pétunias génétiquement modifiés non-autorisés Open
View article: Avis sur les nouvelles techniques d’obtention de plantes (New plant breeding techniques-NPBT)
Avis sur les nouvelles techniques d’obtention de plantes (New plant breeding techniques-NPBT) Open
Commanditaire : Ministère de l'Agriculture, de l'Agroalimentaire et de la Forêt (France) ;Type de commande : Commande avec contrat/convention/lettre de saisine ;Type de commanditaire ou d'auteur de la saisine : Ministères, parlements et le…
View article: Antiplasmodial Activity Is an Ancient and Conserved Feature of Tick Defensins
Antiplasmodial Activity Is an Ancient and Conserved Feature of Tick Defensins Open
Ancestral sequence reconstruction has been widely used to test evolution-based hypotheses. The genome of the European tick vector, Ixodes ricinus, encodes for defensin peptides with diverse antimicrobial activities against distantly…
View article: Identification of Plasmodium falciparum Translation Initiation eIF2β Subunit: Direct Interaction with Protein Phosphatase Type 1
Identification of Plasmodium falciparum Translation Initiation eIF2β Subunit: Direct Interaction with Protein Phosphatase Type 1 Open
Protein phosphatase 1 (PP1c) is one of the main phosphatases whose function is shaped by many regulators to confer a specific location and a selective function for this enzyme. Here, we report that eukaryotic initiation factor 2β of Plasmo…
View article: Phosphatases are Emerging as Novel Druggable Targets in <i>Plasmodium</i>
Phosphatases are Emerging as Novel Druggable Targets in <i>Plasmodium</i> Open
View article: Analysis of the interactome of the Ser/Thr Protein Phosphatase type 1 in Plasmodium falciparum
Analysis of the interactome of the Ser/Thr Protein Phosphatase type 1 in Plasmodium falciparum Open
To the best of our knowledge, this is the first study on PfPP1 interactome. The data reports several conserved PP1 interacting proteins as well as a high number of specific interactors to PfPP1. Their analysis indicates a high diversity of…