Javed Khan
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View article: Pro-osteogenic effects of green Rooibos (Aspalathus linearis) against different dietary backgrounds in male Wistar rats
Pro-osteogenic effects of green Rooibos (Aspalathus linearis) against different dietary backgrounds in male Wistar rats Open
Previous in vitro studies have demonstrated direct effects of Rooibos (Aspalathus linearis) on bone cell populations, notably osteoblasts and osteoclasts, but in vivo evidence of Rooibos effects on bone remain scant. Here, we compared the …
View article: Oncolytic Maraba Virus MG1 Mediates Direct and Natural Killer Cell-Dependent Lysis of Ewing Sarcoma
Oncolytic Maraba Virus MG1 Mediates Direct and Natural Killer Cell-Dependent Lysis of Ewing Sarcoma Open
Background: Ewing sarcoma (EWS) is a rare cancer of the bone and soft tissue, most prevalent in children and young adults. The treatment of EWS has progressed relatively little in over 30 years. Survival rates for patients, particularly th…
View article: Frequency of prostate cancer in patients with abnormal prostate-specific antigen (4–10 ng/mL) and normal digital rectal examination of prostate
Frequency of prostate cancer in patients with abnormal prostate-specific antigen (4–10 ng/mL) and normal digital rectal examination of prostate Open
Objective: To determine the frequency of prostate cancer (PCa) in patients with normal digital rectal examination (DRE) and prostate-specific antigen (PSA) levels of 4–10 ng/mL. Material and Methods: This cross-sectional study was conducte…
View article: Exploration of contemporary modernization in UWSNs in the context of localization including opportunities for future research in machine learning and deep learning
Exploration of contemporary modernization in UWSNs in the context of localization including opportunities for future research in machine learning and deep learning Open
The exchange of information in Wireless Sensor Networks (WSNs) across different environments, whether they are above the ground, underground, underwater, or in space has advanced significantly over time. Among these advancements, precise l…
View article: Improving Individualized Rhabdomyosarcoma Prognosis Predictions Using Somatic Molecular Biomarkers
Improving Individualized Rhabdomyosarcoma Prognosis Predictions Using Somatic Molecular Biomarkers Open
PURPOSE Molecular markers increasingly influence risk-stratified treatment selection for pediatric rhabdomyosarcoma (RMS). This study aims to integrate molecular and clinical data to produce individualized prognosis predictions that can fu…
View article: MACROPHAGE ACTIVATION SYNDROME (MAS) SECONDARY TO MYCOBACTERIUM BOVIS CYSTITIS FOLLOWING INTRAVESICAL INSTILLATION OF BACILLUS CALMETTE-GUERIN (BCG) VACCINE: A CASE REPORT WITH REVIEW OF LITERATURE
MACROPHAGE ACTIVATION SYNDROME (MAS) SECONDARY TO MYCOBACTERIUM BOVIS CYSTITIS FOLLOWING INTRAVESICAL INSTILLATION OF BACILLUS CALMETTE-GUERIN (BCG) VACCINE: A CASE REPORT WITH REVIEW OF LITERATURE Open
Background: Intravesical Bacillus Calmette-Guerin (BCG) vaccine instillation is widely used for the treatment of superficial bladder cancer. While mild non-infectious problems have mostly been reported with intravesical BCG instillation, s…
View article: The Symphony of Consumer Partnering and Clinical Governance: An Organizational Review Using the RE‐AIM Framework
The Symphony of Consumer Partnering and Clinical Governance: An Organizational Review Using the RE‐AIM Framework Open
Introduction Partnering with Consumers in healthcare systems is now widely accepted and mandated in many countries. Despite this acceptance, there is minimal information regarding the best practice of how to successfully establish systems …
View article: Improving Individualized Rhabdomyosarcoma Prognosis Predictions Using Somatic Molecular Biomarkers
Improving Individualized Rhabdomyosarcoma Prognosis Predictions Using Somatic Molecular Biomarkers Open
Purpose Molecular markers, such as FOXO1 fusion genes and TP53 and MYOD1 mutations, increasingly influence risk-stratified treatment selection for pediatric rhabdomyosarcoma (RMS). This study aims to integrate molecular and clinical data t…
View article: Germline Genetic Testing and Survival Outcomes Among Children With Rhabdomyosarcoma
Germline Genetic Testing and Survival Outcomes Among Children With Rhabdomyosarcoma Open
Importance Determining the impact of germline cancer-predisposition variants (CPVs) on outcomes could inform novel approaches to testing and treating children with rhabdomyosarcoma. Objective To assess whether CPVs are associated with outc…
View article: CAR-T cell expansion platforms yield distinct T cell differentiation states
CAR-T cell expansion platforms yield distinct T cell differentiation states Open
With investigators looking to expand engineered T cell therapies such as CAR-T to new tumor targets and patient populations, a variety of cell manufacturing platforms have been developed to scale manufacturing capacity using closed and/or …
View article: Enabling Zero Trust Security in IoMT Edge Network
Enabling Zero Trust Security in IoMT Edge Network Open
Internet of Medical Things (IoMT) deals with a patient-data-rich segment, which makes security and privacy a severe concern for patients. Therefore, access control is a significant aspect of ensuring trust in the IoMT. However, deploying e…
View article: Neopetrotaurines A–C, Isoquinoline Alkaloids with an Unprecedented Taurine Bridge from the Sponge <i>Neopetrosia</i> sp
Neopetrotaurines A–C, Isoquinoline Alkaloids with an Unprecedented Taurine Bridge from the Sponge <i>Neopetrosia</i> sp Open
Neopetrotaurines A-C (1-3), unusual alkaloids possessing two isoquinoline-derived moieties that are linked via a unique taurine bridge, were isolated from a Neopetrosia sp. marine sponge. These new compounds have proton-deficient structura…
View article: Efficacy and Safety of Intraoperative Methylene Blue Dye for Sentinel Lymph Node Detection in Breast Cancer Surgery
Efficacy and Safety of Intraoperative Methylene Blue Dye for Sentinel Lymph Node Detection in Breast Cancer Surgery Open
Background: Sentinel lymph node biopsy (SLNB) is the gold standard for axillary staging in early breast cancer. Although dual-agent mapping with radioisotopes and blue dye yields the highest detection rates, many centers lack access to nuc…
View article: Stability and Functional Outcome of ACL Reconstruction Using Semitendinosus Autograft: A Prospective Study of 20 Patients
Stability and Functional Outcome of ACL Reconstruction Using Semitendinosus Autograft: A Prospective Study of 20 Patients Open
Background: Anterior cruciate ligament (ACL) reconstruction is one of the most frequently performed procedures in young, active patients. Graft selection remains debated, with hamstring autografts increasingly preferred due to reduced dono…
View article: Comparative Analysis of Zinc Levels in Patients with Chronic Leg Ulcers and Healthy Individuals: A Cross-Sectional Study
Comparative Analysis of Zinc Levels in Patients with Chronic Leg Ulcers and Healthy Individuals: A Cross-Sectional Study Open
Background: Zinc is an essential trace element critical to immune function and wound healing. Chronic leg ulcers are persistent wounds that affect millions of individuals globally. Zinc deficiency has been implicated in the pathophysiology…
View article: Efficacy of Antibiotic Prophlaxis in Preventing Surgical Site Infections: A Review of Current Practices and Emerging Alternatives in General and Plastic Surgery
Efficacy of Antibiotic Prophlaxis in Preventing Surgical Site Infections: A Review of Current Practices and Emerging Alternatives in General and Plastic Surgery Open
Background: Effective preventive measures are necessary to reduce the incidence of surgical site infections (SSIs), which continue to be a leading cause of postoperative morbidity. Objective: This study aimed to evaluate the efficacy of an…
View article: FIGURE 1 from Piperacetazine Directly Binds to the PAX3::FOXO1 Fusion Protein and Inhibits Its Transcriptional Activity
FIGURE 1 from Piperacetazine Directly Binds to the PAX3::FOXO1 Fusion Protein and Inhibits Its Transcriptional Activity Open
Purification of recombinant PAX3::FOXO1 protein from bacteria. A, PAX3::FOXO1 protein is expressed in E. coli. The most prominent bands following induction with isopropyl-beta-D-thiogalactopyranoside (IPTG) appeared just above the 100 kDa …
View article: Supplementary Figure 4 from Piperacetazine Directly Binds to the PAX3::FOXO1 Fusion Protein and Inhibits Its Transcriptional Activity
Supplementary Figure 4 from Piperacetazine Directly Binds to the PAX3::FOXO1 Fusion Protein and Inhibits Its Transcriptional Activity Open
Reduction of PAX3::FOXO1 protein expression does not alter proliferation rates of FP-RMS cell lines but reduces anchorage-independent growth.
View article: Supplementary Figure 3 from Piperacetazine Directly Binds to the PAX3::FOXO1 Fusion Protein and Inhibits Its Transcriptional Activity
Supplementary Figure 3 from Piperacetazine Directly Binds to the PAX3::FOXO1 Fusion Protein and Inhibits Its Transcriptional Activity Open
Piperacetazine IC50 values across various cell lines.
View article: FIGURE 4 from Piperacetazine Directly Binds to the PAX3::FOXO1 Fusion Protein and Inhibits Its Transcriptional Activity
FIGURE 4 from Piperacetazine Directly Binds to the PAX3::FOXO1 Fusion Protein and Inhibits Its Transcriptional Activity Open
Piperacetazine alters the expression of PAX3::FOXO1 target genes. A, Protein expression of PAX3::FOXO1 target genes was evaluated by Western blot analysis in RH30 cells treated with 10 µmol/L piperacetazine for 6 days. B, RNA-seq was perfo…
View article: Supplementary Tables 1, 2, and 3 from Piperacetazine Directly Binds to the PAX3::FOXO1 Fusion Protein and Inhibits Its Transcriptional Activity
Supplementary Tables 1, 2, and 3 from Piperacetazine Directly Binds to the PAX3::FOXO1 Fusion Protein and Inhibits Its Transcriptional Activity Open
Supplementary Tables 1, 2, and 3