Fenella J. Kirkham
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View article: Longitudinal Analysis of Sleep-disordered Breathing and Cognitive Outcomes in Children Living with Sickle Cell Anaemia
Longitudinal Analysis of Sleep-disordered Breathing and Cognitive Outcomes in Children Living with Sickle Cell Anaemia Open
Objectives: Sleep-disordered breathing (SDB) and cognitive challenges are commonly observed in children living with sickle cell anaemia (SCA). This study investigated the longitudinal change in polysomnographic outcomes and the association…
View article: Psychosocial impact of leg ulcers on the quality of life of adults living with sickle cell disease in Ghana
Psychosocial impact of leg ulcers on the quality of life of adults living with sickle cell disease in Ghana Open
BackgroundSickle cell disease-related persistent chronic manifestations, such as leg ulcers, continue to raise clinical and psychosocial concerns. The Quality of Life (QoL) issues have not been adequately defined in sickle cell disease (SC…
View article: Identifying strokes in Nigerian children with sickle cell disease as part of clinical trials: training curriculum for healthcare professionals in low-income settings
Identifying strokes in Nigerian children with sickle cell disease as part of clinical trials: training curriculum for healthcare professionals in low-income settings Open
Introduction Nigeria has the highest proportion of children with sickle cell anemia (SCA) globally; without transcranial Doppler screening and ongoing treatment (regular blood transfusions or hydroxyurea therapy), 10% will have a stroke in…
View article: Prevalence of Antiplatelet and Anticoagulation Therapy in Children with Sickle Cell Anemia and Stroke.
Prevalence of Antiplatelet and Anticoagulation Therapy in Children with Sickle Cell Anemia and Stroke. Open
Sickle cell anemia (SCA) is a hemoglobinopathy resulting in both overt and silent strokes in the pediatric population. Multiple mechanisms including anemia, hypercoagulability, secondary moyamoya syndrome, paradoxical embolism, and platele…
View article: Sleep Behaviour in Sickle Cell Disease: A Systematic Review and Meta-Analysis
Sleep Behaviour in Sickle Cell Disease: A Systematic Review and Meta-Analysis Open
Background/Objectives: There is a high prevalence of sleep behaviour disorders, as well as sleep disordered breathing (SDB), in individuals living with sickle cell disease (SCD). SDB has been systematically reviewed; therefore, this system…
View article: Decline in Processing Speed Tells Only Half the Story: Developmental Delay in Children Living with Sickle Cell Disease
Decline in Processing Speed Tells Only Half the Story: Developmental Delay in Children Living with Sickle Cell Disease Open
Children with sickle cell disease (SCD) may experience cognitive difficulties, including slowed processing speed. Thus, we investigated if processing speed changes over time. From 1992–2001, 103 participants with SCD aged 3–16 years (n ≤ 8…
View article: Diagnosis and Management of Cerebral Venous Thrombosis: A Scientific Statement From the American Heart Association
Diagnosis and Management of Cerebral Venous Thrombosis: A Scientific Statement From the American Heart Association Open
Cerebral venous thrombosis accounts for 0.5% to 3% of all strokes. The most vulnerable populations include young individuals, women of reproductive age, and patients with a prothrombotic state. The clinical presentation of cerebral venous …
View article: Implementing early rehabilitation and mobilisation for children in UK paediatric intensive care units: the PERMIT feasibility study
Implementing early rehabilitation and mobilisation for children in UK paediatric intensive care units: the PERMIT feasibility study Open
Background Early rehabilitation and mobilisation encompass patient-tailored interventions, delivered within intensive care, but there are few studies in children and young people within paediatric intensive care units. Objectives To explor…
View article: Executive Function and Processing Speed in Children Living with Sickle Cell Anemia
Executive Function and Processing Speed in Children Living with Sickle Cell Anemia Open
Executive function and processing speed difficulties are observed in children living with sickle cell anemia (SCA). The influence of processing speed on executive function is not well understood. We recruited 59 children living with SCA an…
View article: Brain Volumes and Cognition in Patients with Sickle Cell Anaemia: A Systematic Review and Meta-Analysis
Brain Volumes and Cognition in Patients with Sickle Cell Anaemia: A Systematic Review and Meta-Analysis Open
Cognitive decline is a major problem in paediatric and adult patients with sickle cell anaemia (SCA) and affects the quality of life. Multiple studies investigating the association between quantitative and qualitative neuroimaging findings…
View article: Mind the gap: trajectory of cognitive development in young individuals with sickle cell disease: a cross-sectional study
Mind the gap: trajectory of cognitive development in young individuals with sickle cell disease: a cross-sectional study Open
Study objectives Compared to typically developing children and young adults (CYA-TD), those living with Sickle Cell Disease (CYA-SCD) experience more cognitive difficulties, particularly with executive function. Few studies have examined t…
View article: Tele-neuropsychological Assessment of Children and Young People: A Systematic Review
Tele-neuropsychological Assessment of Children and Young People: A Systematic Review Open
The coronavirus pandemic identified a clinical need for pediatric tele-neuropsychology (TeleNP) assessment. However, due to limited research, clinicians have had little information to develop, adapt, or select reliable pediatric assessment…
View article: Neuroimaging and Cognitive Function in Sickle Cell Disease: A Systematic Review
Neuroimaging and Cognitive Function in Sickle Cell Disease: A Systematic Review Open
Sickle cell disease (SCD) is the most common inherited single-gene disease. Complications include chronic anaemia, reduced oxygen-carrying capability, and cerebral vasculopathy, resulting in silent cerebral infarction, stroke, and cognitiv…
View article: Effects of regional brain volumes on cognition in sickle cell anemia: A developmental perspective
Effects of regional brain volumes on cognition in sickle cell anemia: A developmental perspective Open
Background and objectives Cognitive difficulties in people with sickle cell anemia (SCA) are related to lower processing speed index (PSI) and working memory index (WMI). However, risk factors are poorly understood so preventative strategi…
View article: Editorial: Cerebral oxygen supply and demand in sickle cell disease: Evidence of local ischemia despite global hyperemia
Editorial: Cerebral oxygen supply and demand in sickle cell disease: Evidence of local ischemia despite global hyperemia Open
Sickle cell disease (SCD) is a collection of hemoglobinopathies that affects millions worldwide. 20 People with SCD are at high risk for neurocognitive complications, including stroke, silent cerebral 21 infarction, and slow processing spe…
View article: Brain volume in Tanzanian children with sickle cell anaemia: A neuroimaging study
Brain volume in Tanzanian children with sickle cell anaemia: A neuroimaging study Open
Summary Brain injury is a common complication of sickle cell anaemia (SCA). White matter (WM) and cortical and subcortical grey matter (GM), structures may have reduced volume in patients with SCA. This study focuses on whether silent cere…
View article: Quantitative susceptibility mapping (QSM) and R2* of silent cerebral infarcts in sickle cell anemia
Quantitative susceptibility mapping (QSM) and R2* of silent cerebral infarcts in sickle cell anemia Open
Silent cerebral infarction (SCI) is the most commonly reported radiological abnormality in patients with sickle cell anemia (SCA) and is associated with future clinical stroke risk. To date, there have been few histological and quantitativ…
View article: A Comparison of MRI Quantitative Susceptibility Mapping and TRUST-Based Measures of Brain Venous Oxygen Saturation in Sickle Cell Anaemia
A Comparison of MRI Quantitative Susceptibility Mapping and TRUST-Based Measures of Brain Venous Oxygen Saturation in Sickle Cell Anaemia Open
In recent years, interest has grown in the potential for magnetic resonance imaging (MRI) measures of venous oxygen saturation (Y v ) to improve neurological risk prediction. T 2 -relaxation-under-spin-tagging (TRUST) is an MRI technique w…
View article: A case‐control and seven‐year longitudinal neurocognitive study of adults with sickle cell disease in Ghana
A case‐control and seven‐year longitudinal neurocognitive study of adults with sickle cell disease in Ghana Open
Summary Ageing in sickle cell disease (SCD) is associated with a myriad of end‐organ complications, including cerebrovascular damage and cognitive impairment (CI). Although CI is very common in SCD, little is known about cognitive function…
View article: Quantification of Silent Cerebral Infarction on High-Resolution FLAIR and Cognition in Sickle Cell Anemia
Quantification of Silent Cerebral Infarction on High-Resolution FLAIR and Cognition in Sickle Cell Anemia Open
Research in sickle cell anemia (SCA) has used, with limited race-matched control data, binary categorization of patients according to the presence or absence of silent cerebral infarction (SCI). SCI have primarily been identified using low…
View article: Considerations for Selecting Cognitive Endpoints and Psychological Patient-Reported Outcomes for Clinical Trials in Pediatric Patients With Sickle Cell Disease
Considerations for Selecting Cognitive Endpoints and Psychological Patient-Reported Outcomes for Clinical Trials in Pediatric Patients With Sickle Cell Disease Open
Pediatric patients with sickle cell disease (SCD) experience a range of medical complications that result in significant morbidity and mortality. Recent advances in prophylactic and curative treatment approaches have highlighted the need f…
View article: Early mobilisation and rehabilitation in the PICU: a UK survey
Early mobilisation and rehabilitation in the PICU: a UK survey Open
Objective To understand the context and professional perspectives of delivering early rehabilitation and mobilisation (ERM) within UK paediatric intensive care units (PICUs). Design A web-based survey administered from May 2019 to August 2…
View article: Individual Watershed Areas in Sickle Cell Anemia: An Arterial Spin Labeling Study
Individual Watershed Areas in Sickle Cell Anemia: An Arterial Spin Labeling Study Open
Previous studies have pointed to a role for regional cerebral hemodynamic stress in neurological complications in patients with sickle cell anemia (SCA), with watershed regions identified as particularly at risk of ischemic tissue injury. …
View article: Venous cerebral blood flow quantification and cognition in patients with sickle cell anemia
Venous cerebral blood flow quantification and cognition in patients with sickle cell anemia Open
Prior studies have described high venous signal qualitatively using arterial spin labelling (ASL) in patients with sickle cell anemia (SCA), consistent with arteriovenous shunting. We aimed to quantify the effect and explored cross-section…
View article: Long-term therapeutic effect of eslicarbazepine acetate in children: An open-label extension of a cognition study in children aged 6–16 years
Long-term therapeutic effect of eslicarbazepine acetate in children: An open-label extension of a cognition study in children aged 6–16 years Open
The majority of patients remained on ESL during the 2-year OLE, and treatment efficacy was maintained. Adverse events were consistent with the known safety profile of ESL, and no new safety signals were identified.
View article: S130: PROCESSING SPEED DECLINES OVER TIME IN 4--25-YEAR-OLDS WITH SICKLE CELL DISEASE
S130: PROCESSING SPEED DECLINES OVER TIME IN 4--25-YEAR-OLDS WITH SICKLE CELL DISEASE Open
Background: Alongside physiological symptoms, young people with sickle cell disease (SCD) may also experience cognitive difficulties, including poorer processing speed. Processing speed develops rapidly from birth to around mid-childhood, …