Shihao Chen
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View article: The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding
The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding Open
MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken. By precisely modulating the expression of key immune genes, miRNAs coordinate both innate and ada…
View article: Disulfiram Prevents Blood-Brain Barrier Disruption in Epileptic Mice by Inhibiting Astrocyte Pyroptosis to Improve Seizure Activity
Disulfiram Prevents Blood-Brain Barrier Disruption in Epileptic Mice by Inhibiting Astrocyte Pyroptosis to Improve Seizure Activity Open
View article: A novel mechanism by which c-MYC is aberrantly activated by epigenetic silencing of its antisense lncRNA in colon cancer
A novel mechanism by which c-MYC is aberrantly activated by epigenetic silencing of its antisense lncRNA in colon cancer Open
Background Proto-oncogenes are abnormally activated in nearly all types of tumors. However, the epigenetic mechanism of proto-oncogene activation has not yet been well elucidated. Methods The present study involved the construction of a do…
View article: Accuracy of a novel ultrasound biomicroscope for measuring corneal epithelial thickness and agreement with an SD-OCT based device
Accuracy of a novel ultrasound biomicroscope for measuring corneal epithelial thickness and agreement with an SD-OCT based device Open
The Insight 100 provides good repeatability and reproducibility for ET measurements in normal and post-T-PRK eyes. CET can be used interchangeably between Insight 100 and RTVue-XR, however, it is not recommended for other positions.
View article: The 1st Solution for 7th LSVOS RVOS Track: SaSaSa2VA
The 1st Solution for 7th LSVOS RVOS Track: SaSaSa2VA Open
Referring video object segmentation (RVOS) requires segmenting and tracking objects in videos conditioned on natural-language expressions, demanding fine-grained understanding of both appearance and motion. Building on Sa2VA, which couples…
View article: Transcriptomic analysis identifies key genes associated with nutrient deprivation responses in infectious bursal disease virus infection
Transcriptomic analysis identifies key genes associated with nutrient deprivation responses in infectious bursal disease virus infection Open
View article: Development and validation of the VAE-NT index: a novel biomechanical parameter for distinguishing subclinical corneal abnormalities
Development and validation of the VAE-NT index: a novel biomechanical parameter for distinguishing subclinical corneal abnormalities Open
Purpose The aim of this study is to develop an index for distinguishing between very asymmetric ectasia with normal topography (VAE-NT) eyes and normal eyes, with good performance in validity, reliability, and predictive values. Methods In…
View article: Beyond Appearance: Geometric Cues for Robust Video Instance Segmentation
Beyond Appearance: Geometric Cues for Robust Video Instance Segmentation Open
Video Instance Segmentation (VIS) fundamentally struggles with pervasive challenges including object occlusions, motion blur, and appearance variations during temporal association. To overcome these limitations, this work introduces geomet…
View article: VectorLLM: Human-like Extraction of Structured Building Contours vis Multimodal LLMs
VectorLLM: Human-like Extraction of Structured Building Contours vis Multimodal LLMs Open
Automatically extracting vectorized building contours from remote sensing imagery is crucial for urban planning, population estimation, and disaster assessment. Current state-of-the-art methods rely on complex multi-stage pipelines involvi…
View article: Machine learning-driven prediction of immune checkpoint inhibitor responses against cholangiocarcinoma: a bile biopsy perspective
Machine learning-driven prediction of immune checkpoint inhibitor responses against cholangiocarcinoma: a bile biopsy perspective Open
Background The treatment of cholangiocarcinoma (CCA) continues to face numerous clinical challenges, including the prediction of sensitivity to immunotherapy and the development of preoperative diagnostic models. Methods In this study, we …
View article: Application of the Brillouin Optical Scanning System in the Regional Corneal Biomechanical Evaluation of Keratoconus and Its Correlation with Corvis ST Parameters
Application of the Brillouin Optical Scanning System in the Regional Corneal Biomechanical Evaluation of Keratoconus and Its Correlation with Corvis ST Parameters Open
(1) Background: The early diagnosis of keratoconus is critical for prognosis. Traditional methods like ORA and Corvis ST measure overall corneal biomechanics but lack regional specificity and are affected by intraocular pressure. In contra…
View article: Historical and projected extreme climate changes in the upper Yellow River Basin, China
Historical and projected extreme climate changes in the upper Yellow River Basin, China Open
View article: Anterior Cervical V‐Shaped Osteotomy and Fusion (<scp>ACVF</scp>) for Retro‐Corporeal Decompression Bypassing Anterior Corpus Vertebra: A Technical Note
Anterior Cervical V‐Shaped Osteotomy and Fusion (<span>ACVF</span>) for Retro‐Corporeal Decompression Bypassing Anterior Corpus Vertebra: A Technical Note Open
Objective Anterior cervical discectomy and fusion (ACDF) is a trans‐intervertebral space procedure with limited ability to treat compression at the back of the vertebral body. Anterior cervical corpectomy and fusion (ACCF) can be applied i…
View article: Early diagnosis of keratoconus using corneal biomechanics and OCT derived technologies
Early diagnosis of keratoconus using corneal biomechanics and OCT derived technologies Open
View article: Comparison of Two Types of Silicone Hydrogel Bandage Contact Lenses Used as Bandage Contact Lenses After Transepithelial Photorefractive Keratectomy - Randomized, Double-Blind, Contralateral Eye Study
Comparison of Two Types of Silicone Hydrogel Bandage Contact Lenses Used as Bandage Contact Lenses After Transepithelial Photorefractive Keratectomy - Randomized, Double-Blind, Contralateral Eye Study Open
Purpose: To compare the clinical outcomes of Lotrafilcon A and Balafilcon A silicone hydrogel contact lenses used as therapeutic bandage contact lenses (BCL) following transepithelial photorefractive keratectomy (TPRK). Materials and Metho…
View article: Pixel-SAIL: Single Transformer For Pixel-Grounded Understanding
Pixel-SAIL: Single Transformer For Pixel-Grounded Understanding Open
Multimodal Large Language Models (MLLMs) achieve remarkable performance for fine-grained pixel-level understanding tasks. However, all the works rely heavily on extra components, such as vision encoder (CLIP), segmentation experts, leading…
View article: CSSinger: End-to-End Chunkwise Streaming Singing Voice Synthesis System Based on Conditional Variational Autoencoder
CSSinger: End-to-End Chunkwise Streaming Singing Voice Synthesis System Based on Conditional Variational Autoencoder Open
Singing Voice Synthesis (SVS) aims to generate singing voices of high fidelity and expressiveness. Conventional SVS systems usually utilize an acoustic model to transform a music score into acoustic features, followed by a vocoder to recon…
View article: Iron deficiency specifically activated anthocyanin accumulation in out pericarp of red-fleshed kiwifruit (Actinidia chinensis)
Iron deficiency specifically activated anthocyanin accumulation in out pericarp of red-fleshed kiwifruit (Actinidia chinensis) Open
View article: Effects of a perioperative support program on reducing psychological distress for family caregivers of patients with early-stage lung cancer: a pilot randomised controlled trial
Effects of a perioperative support program on reducing psychological distress for family caregivers of patients with early-stage lung cancer: a pilot randomised controlled trial Open
View article: Are They the Same? Exploring Visual Correspondence Shortcomings of Multimodal LLMs
Are They the Same? Exploring Visual Correspondence Shortcomings of Multimodal LLMs Open
Recent advancements in multimodal large language models (MLLM) have shown a strong ability in visual perception, reasoning abilities, and vision-language understanding. However, the visual matching ability of MLLMs is rarely studied, despi…
View article: Whole-genome sequencing identifies novel loci for keratoconus and facilitates risk stratification in a Han Chinese population
Whole-genome sequencing identifies novel loci for keratoconus and facilitates risk stratification in a Han Chinese population Open
Background Keratoconus (KC) is a prevalent corneal condition with a modest genetic basis. Recent studies have reported significant genetic associations in multi-ethnic cohorts. However, the situation in the Chinese population remains unkno…
View article: Subclinical parents assist in the detection of genetic variants in keratoconus by trio-based whole-exome sequencing.
Subclinical parents assist in the detection of genetic variants in keratoconus by trio-based whole-exome sequencing. Open
We found that the candidate variants identified in clinically diagnosed patients and their subclinical parents may cause keratoconus through an autosomal dominant inheritance pattern, with different variable expressivity. This study indicat…
View article: Endogenous retroviruses activate MARCO-mediated macrophage inflammatory response to restrain oncogenic retroviral infection
Endogenous retroviruses activate MARCO-mediated macrophage inflammatory response to restrain oncogenic retroviral infection Open
View article: Endogenous Retroviruses Activate Marco-Mediated Macrophage Inflammatory Response to Restrain Retroviral Infection
Endogenous Retroviruses Activate Marco-Mediated Macrophage Inflammatory Response to Restrain Retroviral Infection Open
View article: Comparison of Changes In Triglyceride-Glucose-Related Indices for Predicting the Risk of Stroke
Comparison of Changes In Triglyceride-Glucose-Related Indices for Predicting the Risk of Stroke Open
View article: Gamma-Band Binaural Beats Neuromodulation Enhances P300 Classification in an Auditory Brain-Computer Interface Paradigm
Gamma-Band Binaural Beats Neuromodulation Enhances P300 Classification in an Auditory Brain-Computer Interface Paradigm Open
While established neuromodulation techniques like transcranial magnetic stimulation and transcranial direct current stimulation have shown potential for enhancing brain-computer interface (BCI) performance, their clinical adoption faces ch…
View article: Bioinspired Flexible Piezoresistive Sensor With Cross-Gradient Architecture for High-Performance Tactile Sensing
Bioinspired Flexible Piezoresistive Sensor With Cross-Gradient Architecture for High-Performance Tactile Sensing Open
View article: Study on Mechanical Properties and Application of Magnesium Phosphate Modified Cement
Study on Mechanical Properties and Application of Magnesium Phosphate Modified Cement Open
In today's environment, the use of magnesium phosphate cement is more and more extensive, but it still faces problems such as fast setting and brittleness. This paper aims to solve the problem and improve the fire resistance of magnesium p…
View article: CSSinger: End-to-End Chunkwise Streaming Singing Voice Synthesis System Based on Conditional Variational Autoencoder
CSSinger: End-to-End Chunkwise Streaming Singing Voice Synthesis System Based on Conditional Variational Autoencoder Open
Singing Voice Synthesis (SVS) {aims} to generate singing voices {of high} fidelity and expressiveness. {Conventional SVS systems usually utilize} an acoustic model to transform a music score into acoustic features, {followed by a vocoder t…
View article: Antibacterial Properties of PCL@45s5 Composite Biomaterial Scaffolds Based on Additive Manufacturing
Antibacterial Properties of PCL@45s5 Composite Biomaterial Scaffolds Based on Additive Manufacturing Open
This study focuses on the development of polymer–bioglass composite bone scaffolds for the treatment of bone defects. PCL particles and 45s5 bioglass powder were employed as raw materials to fabricate PCL/45s5 composite wires with mass fra…