John R. Lake
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View article: Long‐Term Outcomes of Patients Who Receive a Liver Transplant for Hepatitis B With Limited Use of Hepatitis B Immunoglobulin
Long‐Term Outcomes of Patients Who Receive a Liver Transplant for Hepatitis B With Limited Use of Hepatitis B Immunoglobulin Open
Chronic hepatitis B virus (HBV) infection is a leading cause of cirrhosis and hepatocellular carcinoma (HCC). Post‐transplant HBV reinfection represents an important post‐liver transplantation (LT) complication, which can result in death o…
View article: Similarities and Differences Between Allogeneic Hematopoietic Cell and Organ Transplantation and What We Can Learn From Each Other to Guide Global Health Strategy
Similarities and Differences Between Allogeneic Hematopoietic Cell and Organ Transplantation and What We Can Learn From Each Other to Guide Global Health Strategy Open
Background Allogeneic hematopoietic cell transplantation (HCT) and solid organ transplantation (SOT) have evolved into successful, curative treatments for many severe congenital and acquired diseases. Both use medical products of human ori…
View article: Manufacturing and Functional Characterization of Bioengineered Liver Grafts for Extracorporeal Liver Assistance in Acute Liver Failure
Manufacturing and Functional Characterization of Bioengineered Liver Grafts for Extracorporeal Liver Assistance in Acute Liver Failure Open
Acute Liver Failure (ALF) is a life-threatening illness characterized by the rapid onset of abnormal liver biochemistries, coagulopathy, and the development of hepatic encephalopathy. Extracorporeal bioengineered liver (BEL) grafts could o…
View article: Protocolized screening and detection of occult alcohol use before and after liver transplant: Lessons learned from a quality improvement initiative
Protocolized screening and detection of occult alcohol use before and after liver transplant: Lessons learned from a quality improvement initiative Open
When screening for ETOH use in pre- and post-LT patients, protocol adherence is higher using PEth compared to EtG. While protocolized biomarker screening can detect recurrent ETOH use in this population, engagement of patients into chemica…
View article: Lower survival and higher rates of cirrhosis in patients with ROUX-EN-Y gastric bypass hospitalised with alcohol-associated hepatitis
Lower survival and higher rates of cirrhosis in patients with ROUX-EN-Y gastric bypass hospitalised with alcohol-associated hepatitis Open
Objective The incidence of alcohol-associated liver disease (ALD) is increasing, and weight loss surgery is more common due to the obesity epidemic. Roux-en-Y gastric bypass (RYGB) is associated with alcohol use disorder and ALD; however, …
View article: Impact of Donor Liver Macrovesicular Steatosis on Deceased Donor Yield and Posttransplant Outcome
Impact of Donor Liver Macrovesicular Steatosis on Deceased Donor Yield and Posttransplant Outcome Open
Background. The Scientific Registry of Transplant Recipients (SRTR) had not traditionally considered biopsy results in risk-adjustment models, yet biopsy results may influence outcomes and thus decisions regarding organ acceptance. Methods…
View article: Outcomes of patients with acute liver failure listed for liver transplantation: A multicenter prospective cohort analysis
Outcomes of patients with acute liver failure listed for liver transplantation: A multicenter prospective cohort analysis Open
Liver transplantation (LT) is a life‐saving treatment for patients with acute liver failure (ALF). Currently, there are few detailed data regarding long‐term outcomes after LT for ALF. We combined prospective data from the Acute Liver Fail…
View article: CAQ Corner: Immune‐mediated complications
CAQ Corner: Immune‐mediated complications Open
John R. Lake, MD Mary Thomson, MD The immune system's ability to distinguish "self" from "nonself" is key to our defense against infections and malignancy. Alloantigen recognition occurs when a transplant recipient's immune system recogniz…
View article: Acute cellular rejection in liver transplantation recipients following vaccination against coronavirus disease 2019: A case series
Acute cellular rejection in liver transplantation recipients following vaccination against coronavirus disease 2019: A case series Open
To the editor, Vaccination of liver transplantation (LT) recipients is vital to prevent transmissible infections and serious illness in a vulnerable population. The massive toll taken by the coronavirus disease 2019 (COVID‐19) pandemic has…
View article: Ledipasvir and Sofosbuvir Plus Ribavirin for Treatment of HCV Infection in Patients With Advanced Liver Disease
Ledipasvir and Sofosbuvir Plus Ribavirin for Treatment of HCV Infection in Patients With Advanced Liver Disease Open
BACKGROUND & AIMS: There are no effective and safe treatments for chronic hepatitis C virus (HCV) infection of patients who have advanced liver disease. METHODS: In this phase 2, open-label study, we assessed treatment with the NS5A inhibi…
View article: Protein-losing Enteropathy Due to Inferior Vena Cava Stenosis in a Liver Transplant Recipient
Protein-losing Enteropathy Due to Inferior Vena Cava Stenosis in a Liver Transplant Recipient Open
INTRODUCTION Inferior vena cava (IVC) stenosis is an uncommon complication of liver transplantation (LT) and is seen in <3% of all LTs. We describe a novel presentation of IVC stenosis in a liver transplant recipient resulting in protein-l…
View article: The Impact of Biologics for the Management of Inflammatory Bowel Disease on Liver Enzymes
The Impact of Biologics for the Management of Inflammatory Bowel Disease on Liver Enzymes Open
Watch a video presentation of this article Over the past two decades, biologic therapies have revolutionized the care for people with inflammatory bowel disease (IBD), but each therapy comes with risks, including the possibility of liver i…
View article: Bariatric Surgery is Associated With Decreased Progression of Nonalcoholic Fatty Liver Disease to Cirrhosis
Bariatric Surgery is Associated With Decreased Progression of Nonalcoholic Fatty Liver Disease to Cirrhosis Open
Objective: This study sought to compare trends in the development of cirrhosis between patients with NAFLD who underwent bariatric surgery and a well-matched group of nonsurgical controls. Summary of Background Data: Patients with NAFLD wh…
View article: Supplementary Material for: Recurrence of Hepatocellular Carcinoma in Hepatitis C Virus (HCV) Liver Transplant Recipients Treated with Pretransplant Direct-Acting Antiviral (DAA) Therapy
Supplementary Material for: Recurrence of Hepatocellular Carcinoma in Hepatitis C Virus (HCV) Liver Transplant Recipients Treated with Pretransplant Direct-Acting Antiviral (DAA) Therapy Open
Background: Direct-acting antivirals (DAAs) have revolutionized the treatment of hepatitis C virus (HCV). The impact of DAAs on recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) remains uncertain. Objective: We …
View article: OPTN/SRTR 2018 Annual Data Report: Hepatitis C
OPTN/SRTR 2018 Annual Data Report: Hepatitis C Open
Direct acting antivirals (DAAs) have fundamentally changed the treatment of hepatitis C virus (HCV) infection and reduced the discard rate of HCV-infected organs by offering a treatment option with a high likelihood of cure posttransplant.…
View article: Recurrence of Hepatocellular Carcinoma in Hepatitis C Virus (HCV) Liver Transplant Recipients Treated with Pretransplant Direct-Acting Antiviral (DAA) Therapy
Recurrence of Hepatocellular Carcinoma in Hepatitis C Virus (HCV) Liver Transplant Recipients Treated with Pretransplant Direct-Acting Antiviral (DAA) Therapy Open
Background: Direct-acting antivirals (DAAs) have revolutionized the treatment of hepatitis C virus (HCV). The impact of DAAs on recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) remains uncertain. Objective: We …
View article: Meeting Report: The Dallas Consensus Conference on Liver Transplantation for Alcohol Associated Hepatitis
Meeting Report: The Dallas Consensus Conference on Liver Transplantation for Alcohol Associated Hepatitis Open
Liver transplantation (LT) for alcohol associated hepatitis (AH) remains controversial. We convened a consensus conference to examine various aspects of LT for AH. The goal was not to unequivocally endorse LT for AH; instead, it was to pro…
View article: OPTN/SRTR 2017 Annual Data Report: Liver
OPTN/SRTR 2017 Annual Data Report: Liver Open
Data on adult liver transplants performed in the US in 2017 are notable for (1) continued growth in numbers of new waitlist registrants (11,514) and of transplants performed (8,082); (2) continued increase in the transplant rate (51.5 per …
View article: CON: Anticoagulation for Portal Vein Thrombosis in Advanced Cirrhosis
CON: Anticoagulation for Portal Vein Thrombosis in Advanced Cirrhosis Open
Watch a video presentation of this article Watch the interview with the author A recent systematic review and meta-analysis by Loffredo et al.1 examined the available literature regarding the differential effect of anticoagulation for PVT …
View article: OPTN/SRTR 2016 Annual Data Report: Liver
OPTN/SRTR 2016 Annual Data Report: Liver Open
Data on adult liver transplants performed in the US in 2016 are no-table for (1) the largest total number of transplants performed (7841); (2) the shortest median waiting time in recent history (11.3 months); (3) continued reduction in wai…
View article: Death With Low MELD Scores and Possible Implications for Organ Allocation
Death With Low MELD Scores and Possible Implications for Organ Allocation Open
An insight into profiles of patients dying with low MELD scores triggers consideration of how organs could be allocated to this disadvantaged patient cohort. See the article from Atiemo et al on page 2410. An insight into profiles of patie…