Andrew J. Lees
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View article: Charcot redux
Charcot redux Open
Jean-Martin Charcot was born in Paris on 29 November 1825. To mark the bicentenary of his birth, the International Society for the History of the Neurosciences held a meeting in July 2025 at the Brain Institute in Paris. AJ Lees discusses …
View article: Reduced striatal dopamine transmission as a transdiagnostic substrate of psychomotor retardation
Reduced striatal dopamine transmission as a transdiagnostic substrate of psychomotor retardation Open
Psychomotor retardation, defined as generalized slowing of movement and speech, is a feature of several neurological and psychiatric disorders. In this review, we discuss the hypothesis that reduced striatal dopaminergic transmission is a …
View article: Commissioning of the cryogenic system of the HL-LHC Inner Triplet String test bench
Commissioning of the cryogenic system of the HL-LHC Inner Triplet String test bench Open
For the High Luminosity LHC (HL-LHC) project, the final focusing Inner Triplet (IT) superconducting magnets of the LHC will be replaced by a new 60 m-long set of higher performance Nb 3 Sn magnets that will operate at 1.9 K in pressurised …
View article: Handwriting patterns in Isolated Rapid Eye Movement Sleep Behaviour Disorder
Handwriting patterns in Isolated Rapid Eye Movement Sleep Behaviour Disorder Open
Background Handwriting changes, such as micrographia, are recognised as an early manifestation of Parkinson’s disease (PD). Whilst isolated rapid eye movement sleep behaviour disorder (iRBD) is strongly associated with future PD diagnosis,…
View article: Мiryachit: A Culture‐Specific Startle Syndrome in the Saami People
Мiryachit: A Culture‐Specific Startle Syndrome in the Saami People Open
Background Miryachit is perhaps the most complex and least understood of the culture‐specific startle syndromes that include latah and the jumping Frenchmen of Maine. Objectives We carried out a field study to evaluate startle‐induced paro…
View article: Voluntary and involuntary motor behaviours in the varieties of religious experience
Voluntary and involuntary motor behaviours in the varieties of religious experience Open
Religion is a widespread feature of human life. Religions typically include both distinctive varieties of experience and also a set of foundational beliefs. An additional, but often overlooked, part of many religions is their expression th…
View article: Multimodal neuroimaging and plasma biomarker evidence of white matter macrostructure loss in Parkinson's dementia
Multimodal neuroimaging and plasma biomarker evidence of white matter macrostructure loss in Parkinson's dementia Open
Background Parkinson’s (PD) is common and debilitating with over half of patients progressing to postural instability, dementia or death within 10 years. However, onset and rate of progression is highly variable, reflecting heterogeneity i…
View article: Multimodal neuroimaging and plasma biomarker evidence of white matter macrostructure loss in Parkinson’s dementia
Multimodal neuroimaging and plasma biomarker evidence of white matter macrostructure loss in Parkinson’s dementia Open
Background Parkinson’s (PD) is common and debilitating with over half of patients progressing to postural instability, dementia or death within 10 years. However, onset and rate of progression is highly variable, reflecting heterogeneity i…
View article: The East London Parkinson’s Disease Project – A case-control study in a diverse population
The East London Parkinson’s Disease Project – A case-control study in a diverse population Open
Background There is a relative dearth of research on patients with Parkinson’s disease (PD) from under-represented ethnic groups in the United Kingdom. Objectives The East London Parkinson Disease project seeks to understand the clinical m…
View article: The Dopamine Dancer: The Value of Holistic Autotherapy in Parkinson's Disease
The Dopamine Dancer: The Value of Holistic Autotherapy in Parkinson's Disease Open
In 2013 one of us (Andrew J. Lees) described 2 women who "recovered" from Parkinson's disease after several years of slowly worsening symptoms. Both were able to slowly discontinue levodopa (l-DOPA) without relapse and remained asymptomati…
View article: Small Particles, Big Potential: Polymeric Nanoparticles for Drug Delivery in Parkinson's Disease
Small Particles, Big Potential: Polymeric Nanoparticles for Drug Delivery in Parkinson's Disease Open
Despite the availability of a number of efficacious treatments for Parkinson's disease, their limitations and drawbacks, particularly related to low brain bioavailability and associated side effects, emphasize the need for alternative and …
View article: Copper rings, blue moons and sunflower cataracts
Copper rings, blue moons and sunflower cataracts Open
When (Samuel Alexander) Kinnier Wilson described a new fatal disease that involved the liver and the lenticular nucleus of the brain in 1912[1] he was unable to recommend any treatment. In 1948 John Cumings demonstrated copper accumulation…
View article: The Motor Dysfunction Seen in Isolated <scp>REM</scp> Sleep Behavior Disorder
The Motor Dysfunction Seen in Isolated <span>REM</span> Sleep Behavior Disorder Open
Background Isolated Rapid Eye Movement (REM) sleep Behavior Disorder (iRBD) requires quantitative tools to detect incipient Parkinson's disease (PD). Methods A motor battery was designed and compared with the Movement Disorder Society‐Unif…
View article: Are we entering the ‘<i>Tau</i>-lemaic’ era of Parkinson’s disease?
Are we entering the ‘<i>Tau</i>-lemaic’ era of Parkinson’s disease? Open
This scientific commentary refers to ‘Nigrostriatal tau pathology in parkinsonism and Parkinson’s disease’ by Chu et al. (https://doi.org/10.1093/brain/awad388).
View article: Corticobasal degeneration: An update
Corticobasal degeneration: An update Open
Corticobasal degeneration (CBD) is one of the primary tauopathies with a disease onset in the 5th to 7th decade. CBD is a progressive condition of unknown aetiology, which is characterised neuropathologically by neuronal loss, astrogliosis…
View article: Encephalitis lethargica: clinical features and aetiology
Encephalitis lethargica: clinical features and aetiology Open
Encephalitis lethargica, an epidemic neurological illness, typically involved a severe sleep disorder and progressive parkinsonism. A century later, our understanding relies on seminal descriptions, more recent historical research and the …
View article: Neuroimaging and plasma evidence of early white matter loss in Parkinson’s disease with poor outcomes
Neuroimaging and plasma evidence of early white matter loss in Parkinson’s disease with poor outcomes Open
Parkinson’s disease is a common and debilitating neurodegenerative disorder, with over half of patients progressing to postural instability, dementia or death within 10 years of diagnosis. However, the onset and rate of progression to poor…
View article: Neuroimaging and plasma marker evidence for white matter macrostructure loss in Parkinson’s disease
Neuroimaging and plasma marker evidence for white matter macrostructure loss in Parkinson’s disease Open
Parkinson’s disease (PD) is the second commonest neurodegenerative disorder and over half of patients progress to postural instability, dementia or death within 10 years of diagnosis. However, onset and rate of progression to poor outcomes…
View article: Practical use of apomorphine infusion in Parkinson’s disease: lessons from the TOLEDO study and clinical experience
Practical use of apomorphine infusion in Parkinson’s disease: lessons from the TOLEDO study and clinical experience Open
Subcutaneous apomorphine infusion is a device-aided therapy for Parkinson’s disease that can be considered when motor fluctuations become persistent and are no longer adequately controlled by oral/transdermal medication. Apomorphine infusi…
View article: Issue Information
Issue Information Open
Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have f…
View article: Issue Information
Issue Information Open
Movement Disorders Clinical Practice-is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/…
View article: Life event
Life event Open
Journal Article Life event Get access A J Lees A J Lees The National Hospital, Queen Square, London, WC1N 3BG, UK E-mail: [email protected] https://orcid.org/0000-0002-2476-4385 Search for other works by this author on: Oxford Academic…
View article: The Emergence and Progression of Motor Dysfunction in Individuals at Risk of Parkinson's Disease
The Emergence and Progression of Motor Dysfunction in Individuals at Risk of Parkinson's Disease Open
Background PREDICT‐PD is a United Kingdom population‐based study aiming to stratify individuals for future Parkinson's disease (PD) using a risk algorithm. Methods A randomly selected, representative sample of participants in PREDICT‐PD we…
View article: The motor anomalies seen in isolated REM sleep behavior disorder
The motor anomalies seen in isolated REM sleep behavior disorder Open
Background Isolated REM sleep behavior disorder (iRBD) is known to be an early feature in some PD patients. Quantitative tools are needed to detect early motor anomalies in iRBD. Methods A motor battery was used to compare iRBD patients wi…