J. Timothy Lightfoot
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View article: “It All Rolls Downstream: Upstream Control of Physical Activity Regulation”
“It All Rolls Downstream: Upstream Control of Physical Activity Regulation” Open
Physical activity is regulated by a variety of genetic molecules. However, the pathways through which those molecules work to regulate activity is largely unknown. The purpose of this study was to gather the known genetic molecules that ar…
View article: Sibling Resemblance in Physical Activity Levels: The Peruvian Sibling Study on Growth and Health
Sibling Resemblance in Physical Activity Levels: The Peruvian Sibling Study on Growth and Health Open
Physical activity is associated with a host of positive health outcomes and is shaped by both genetic and environmental factors. We aim to: (1) estimate sibling resemblance in two physical activity phenotypes [total number of steps∙day−1 a…
View article: Physical Activity Impacts of an Activity-Friendly Community: A Natural Experiment Study Protocol
Physical Activity Impacts of an Activity-Friendly Community: A Natural Experiment Study Protocol Open
Background Stakeholders from multiple sectors are increasingly aware of the critical need for identifying sustainable interventions that promote healthy lifestyle behaviors. Activity-friendly communities (AFCs) have been known to provide o…
View article: Correction: Protein fractional synthesis rates within tissues of high- and low-active mice
Correction: Protein fractional synthesis rates within tissues of high- and low-active mice Open
[This corrects the article DOI: 10.1371/journal.pone.0242926.].
View article: Epistatic interactions of genes influence within-individual variation of physical activity traits in mice
Epistatic interactions of genes influence within-individual variation of physical activity traits in mice Open
A number of quantitative trait loci (QTLs) recently have been discovered that affect various activity traits in mice, but their collective impact does not appear to explain the consistently moderate to high heritabilities for these traits.…
View article: Protein fractional synthesis rates within tissues of high- and low-active mice
Protein fractional synthesis rates within tissues of high- and low-active mice Open
With the rise in physical inactivity and its related diseases, it is necessary to understand the mechanisms involved in physical activity regulation. Biological factors regulating physical activity are studied to establish a possible targe…
View article: Quantitative trait loci for physical activity traits in mice
Quantitative trait loci for physical activity traits in mice Open
The genomic locations and identities of the genes that regulate voluntary physical activity are presently unknown. The purpose of this study was to search for quantitative trait loci (QTL) that are linked with daily mouse running wheel dis…
View article: An Epistatic Genetic Basis for Physical Activity Traits in Mice
An Epistatic Genetic Basis for Physical Activity Traits in Mice Open
We recently identified several (4–8) quantitative trait loci (QTL) for 3 physical activity traits (daily distance, duration, and speed voluntarily run) in an F2 population of mice derived from an original intercross of 2 strains that exhib…
View article: Mitochondrial DNA lesions and copy number are strain dependent in endurance‐trained mice
Mitochondrial DNA lesions and copy number are strain dependent in endurance‐trained mice Open
In this pilot work, we selected two inbred strains that respond well to endurance training (ET) (FVB/NJ, and SJL/J strains), and two strains that respond poorly (BALB/cByJ and NZW/LacJ), to determine the effect of a standardized ET treadmi…
View article: A High Fat/High Sugar Diet Alters the Gastrointestinal Metabolome in a Sex Dependent Manner
A High Fat/High Sugar Diet Alters the Gastrointestinal Metabolome in a Sex Dependent Manner Open
The gut metabolome offers insight for identifying the source of diet related pathology. As such, the purpose of this study was to characterize alterations of the gut metabolome in female and male C57BL/6J mice randomly assigned to a standa…
View article: Activated whole-body arginine pathway in high-active mice
Activated whole-body arginine pathway in high-active mice Open
Our previous studies suggest that physical activity (PA) levels are potentially regulated by endogenous metabolic mechanisms such as the vasodilatory roles of nitric oxide (NO) production via the precursor arginine (ARG) and ARG-related pa…
View article: Association between Mitochondrial DNA Sequence Variants and V˙O2 max Trainability
Association between Mitochondrial DNA Sequence Variants and V˙O2 max Trainability Open
Purpose We designed the study to determine whether mitochondrial DNA (mtDNA) haplogroup, sequence, and heteroplasmy differed between individuals previously characterized as low (LR) or high responders (HR) as defined by their maximal oxyge…
View article: Postnatal wheel running mitigates endocrine disruption of mammary gland development in mice
Postnatal wheel running mitigates endocrine disruption of mammary gland development in mice Open
We investigated if access to a running wheel after in utero exposure to benzyl butyl phthalate (BBP) ameliorates the toxicological effects of BBP exposure. Our purpose was to determine if post-birth exercise after prenatal BBP exposure cou…
View article: Genetic variation in the pleiotropic association between physical activity and body weight in mice
Genetic variation in the pleiotropic association between physical activity and body weight in mice Open
Background A sedentary lifestyle is often assumed to lead to increases in body weight and potentially obesity and related diseases but in fact little is known about the genetic association between physical activity and body weight. We test…
View article: Genetic variation for body weight change in mice in response to physical exercise
Genetic variation for body weight change in mice in response to physical exercise Open
Background Physical activity is beneficial in reducing the weight gain and associated health problems often experienced by individuals as they age, but the association of weight change with physical activity remains complex. We tested for …
View article: Alleles associated with physical activity levels are estimated to be older than anatomically modern humans
Alleles associated with physical activity levels are estimated to be older than anatomically modern humans Open
The purpose of this study was to determine the estimated mutation age and conservation of single-nucleotide polymorphisms (SNPs) associated with physical activity (PA) in humans. All human SNPs found to be significantly associated with PA …
View article: Evaluating unmet needs in patients undergoing surgery for colorectal cancer: a patient reported outcome measures study
Evaluating unmet needs in patients undergoing surgery for colorectal cancer: a patient reported outcome measures study Open
Aim Patient reported outcome measures ( PROM s) are self‐reported measures of patients’ health status or health‐related quality of life at a single point in time. We aimed to evaluate the use of a colorectal PROM and conducted a focus grou…
View article: Biological/Genetic Regulation of Physical Activity Level
Biological/Genetic Regulation of Physical Activity Level Open
Future research on physical activity regulation should incorporate genetics and other biological determinants of physical activity instead of a sole reliance on social and other environmental determinants.
View article: High Fat High Sugar Diet Reduces Voluntary Wheel Running in Mice Independent of Sex Hormone Involvement
High Fat High Sugar Diet Reduces Voluntary Wheel Running in Mice Independent of Sex Hormone Involvement Open
Introduction: Indirect results in humans suggest that chronic overfeeding decreases physical activity with few suggestions regarding what mechanism(s) may link overfeeding and decreased activity. The primary sex hormones are known regulato…
View article: Environmental Endocrine Disruptor Affects Voluntary Physical Activity in Mice
Environmental Endocrine Disruptor Affects Voluntary Physical Activity in Mice Open
Maternal endocrine disruption altered hormone response, but not body composition in either sex of offspring, with a corresponding decreased activity throughout early adulthood in all offspring. These results suggest that exposure to common…
View article: Differential miRNA expression in inherently high- and low-active inbred mice
Differential miRNA expression in inherently high- and low-active inbred mice Open
Despite established health benefits of regular exercise, the majority of Americans do not meet the recommended levels of physical activity. While it is known that voluntary activity levels are largely heritable, the genetic mechanisms that…
View article: Comparison of Neurocognitive Testing and the Measurement of Marinobufagenin in Mild Traumatic Brain Injury: A Preliminary Report
Comparison of Neurocognitive Testing and the Measurement of Marinobufagenin in Mild Traumatic Brain Injury: A Preliminary Report Open
The evaluation of concussed athletes, including testing to determine if and when they may return to play, has become an important task of athletic trainers and team physicians. Currently, concussion protocols are in place, which depend lar…