J. Lynn Fink
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View article: Tumour‐informed workflow to use ctDNA as a biomarker for risk of recurrence in head and neck cancer patients post‐treatment
Tumour‐informed workflow to use ctDNA as a biomarker for risk of recurrence in head and neck cancer patients post‐treatment Open
Circulating tumour DNA (ctDNA) is a promising minimally invasive biomarker for monitoring treatment response in cancer patients. In this study, we developed a tumour‐informed workflow to enhance the detection of recurrence in head and neck…
View article: Tumour informed workflow to use ctDNA as a biomarker for risk of recurrence in head and neck cancer patients post-treatment
Tumour informed workflow to use ctDNA as a biomarker for risk of recurrence in head and neck cancer patients post-treatment Open
View article: Cytokine mRNA Delivery and Local Immunomodulation in the Placenta using Lipid Nanoparticles
Cytokine mRNA Delivery and Local Immunomodulation in the Placenta using Lipid Nanoparticles Open
During pregnancy, the maternal immune system adapts to balance tolerance of the semi-allogenic fetus while protecting the fetus from pathogens. Dysregulated immune activity at the maternal-fetal interface contributes to pregnancy complicat…
View article: A high throughput, functional screen of human Body Mass Index GWAS loci using tissue-specific RNAi Drosophila melanogaster crosses
A high throughput, functional screen of human Body Mass Index GWAS loci using tissue-specific RNAi Drosophila melanogaster crosses Open
Human GWAS of obesity have been successful in identifying loci associated with adiposity, but for the most part, these are non-coding SNPs whose function, or even whose gene of action, is unknown. To help identify the genes on which these …
View article: Inherited BRCA1 and RNF43 pathogenic variants in a familial colorectal cancer type X family
Inherited BRCA1 and RNF43 pathogenic variants in a familial colorectal cancer type X family Open
Genetic susceptibility to familial colorectal cancer (CRC), including for individuals classified as Familial Colorectal Cancer Type X (FCCTX), remains poorly understood. We describe a multi-generation CRC-affected family segregating pathog…
View article: 4MO Homologous recombination (HR) status of platinum-responsive advanced triple-negative breast cancers (aTNBC) treated with olaparib as maintenance therapy
4MO Homologous recombination (HR) status of platinum-responsive advanced triple-negative breast cancers (aTNBC) treated with olaparib as maintenance therapy Open
HR deficiency (HRD) may be exploited through use of DNA-damaging chemotherapy and/or PARP inhibitors (PARPi). The current biomarker to infer HRD in breast cancer (BC) is a germline pathogenic variant (PV) in BRCA1/2 (gBRCAm). This biomarke…
View article: Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing Open
Correction to: Nature Genetics, published online 05 February 2020. In the published version of this paper, the members of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium were listed in the Supplementary Information; however, th…
View article: Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition Open
Correction to: Nature Genetics, published online 05 February 2020. In the published version of this paper, the members of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium were listed in the Supplementary Information; however, th…
View article: Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer Open
View article: Minimizing Sample Failure Rates for Challenging Clinical Tumor Samples
Minimizing Sample Failure Rates for Challenging Clinical Tumor Samples Open
View article: Genome‐wide exploration reveals distinctive northern and southern variants of <i>Clonorchis sinensis</i> in the Far East
Genome‐wide exploration reveals distinctive northern and southern variants of <i>Clonorchis sinensis</i> in the Far East Open
Clonorchis sinensis is a carcinogenic liver fluke that causes clonorchiasis—a neglected tropical disease (NTD) affecting ~35 million people worldwide. No vaccine is available, and chemotherapy relies on one anthelmintic, praziquantel. This…
View article: Author Correction: Integrative pathway enrichment analysis of multivariate omics data
Author Correction: Integrative pathway enrichment analysis of multivariate omics data Open
View article: Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer
Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer Open
View article: Author Correction: Combined burden and functional impact tests for cancer driver discovery using DriverPower
Author Correction: Combined burden and functional impact tests for cancer driver discovery using DriverPower Open
View article: Author Correction: Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis
Author Correction: Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis Open
View article: Author Correction: Pathway and network analysis of more than 2500 whole cancer genomes
Author Correction: Pathway and network analysis of more than 2500 whole cancer genomes Open
View article: 076 Subtype specific analyses reveal infiltrative basal cell carcinoma are highly interactive with their environment
076 Subtype specific analyses reveal infiltrative basal cell carcinoma are highly interactive with their environment Open
View article: EBV-associated primary CNS lymphoma occurring after immunosuppression is a distinct immunobiological entity
EBV-associated primary CNS lymphoma occurring after immunosuppression is a distinct immunobiological entity Open
Primary central nervous system lymphoma (PCNSL) is confined to the brain, eyes, and cerebrospinal fluid without evidence of systemic spread. Rarely, PCNSL occurs in the context of immunosuppression (eg, posttransplant lymphoproliferative d…
View article: Marked mitochondrial genetic variation in individuals and populations of the carcinogenic liver fluke Clonorchis sinensis
Marked mitochondrial genetic variation in individuals and populations of the carcinogenic liver fluke Clonorchis sinensis Open
Clonorchiasis is a neglected tropical disease caused by the Chinese liver fluke, Clonorchis sinensis, and is often associated with a malignant form of bile duct cancer (cholangiocarcinoma). Although some aspects of the epidemiology of clon…
View article: Regional Variation in Epidermal Susceptibility to UV-Induced Carcinogenesis Reflects Proliferative Activity of Epidermal Progenitors
Regional Variation in Epidermal Susceptibility to UV-Induced Carcinogenesis Reflects Proliferative Activity of Epidermal Progenitors Open
View article: Comparative performance of the BGI and Illumina sequencing technology for single-cell RNA-sequencing
Comparative performance of the BGI and Illumina sequencing technology for single-cell RNA-sequencing Open
The libraries generated by high-throughput single cell RNA-sequencing (scRNA-seq) platforms such as the Chromium from 10× Genomics require considerable amounts of sequencing, typically due to the large number of cells. The ability to use t…
View article: Publisher Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
Publisher Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing Open
View article: Integrative pathway enrichment analysis of multivariate omics data
Integrative pathway enrichment analysis of multivariate omics data Open
View article: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing Open
View article: Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis
Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis Open
Long non-coding RNAs (lncRNAs) are a growing focus of cancer genomics studies, creating the need for a resource of lncRNAs with validated cancer roles. Furthermore, it remains debated whether mutated lncRNAs can drive tumorigenesis, and wh…
View article: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer Open
Chromatin is folded into successive layers to organize linear DNA. Genes within the same topologically associating domains (TADs) demonstrate similar expression and histone-modification profiles, and boundaries separating different domains…
View article: Pathway and network analysis of more than 2500 whole cancer genomes
Pathway and network analysis of more than 2500 whole cancer genomes Open
View article: Genomic footprints of activated telomere maintenance mechanisms in cancer
Genomic footprints of activated telomere maintenance mechanisms in cancer Open
View article: Combined burden and functional impact tests for cancer driver discovery using DriverPower
Combined burden and functional impact tests for cancer driver discovery using DriverPower Open
View article: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition Open