Denis Malvy
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View article: Safety and tolerability of Favipiravir compared to Ribavirin for the treatment of Lassa fever: A randomized controlled open-label phase II clinical trial
Safety and tolerability of Favipiravir compared to Ribavirin for the treatment of Lassa fever: A randomized controlled open-label phase II clinical trial Open
Introduction The Lassa virus (LV) causes Lassa fever (LF), a severe re-emerging disease. It affects several West African nations, with Nigeria having the greatest case burden. Currently, only supportive care and ribavirin are available for…
View article: Optimizing Health Across Humans, Animals, Plants, and Ecosystems: How Long Before Benefits Turn Harmful—and Harm Becomes Healing?
Optimizing Health Across Humans, Animals, Plants, and Ecosystems: How Long Before Benefits Turn Harmful—and Harm Becomes Healing? Open
The One Health framework endorsed by the quadripartite (World Health Organization, World Organisation for Animal Health, Food and Agriculture Organization, and United Nations Environment Program) is defined, in part, as an “integrated, uni…
View article: Optimiser conjointement la santé des humains, des animaux, des plantes et des écosystèmes : comment concilier bénéfices et inconvénients ?
Optimiser conjointement la santé des humains, des animaux, des plantes et des écosystèmes : comment concilier bénéfices et inconvénients ? Open
Le cadre One Health, approuvé conjointement par l’Organisation mondiale de la Santé, l’Organisation mondiale de la Santé animale, l’Organisation des Nations Unies pour l’alimentation et l’agriculture, et le Programme des Nations unies pour…
View article: Epidemiology of travel-associated dengue from 2007 to 2022: A GeoSentinel analysis
Epidemiology of travel-associated dengue from 2007 to 2022: A GeoSentinel analysis Open
Background Dengue is a leading cause of febrile illness among international travellers. We aimed to describe the epidemiology and clinical characteristics of imported dengue in returning travellers evaluated at GeoSentinel sites from 2007 …
View article: La mission du COVARS : comment anticiper les risques sanitaires dans une vision « Une seule Santé » de l’exposome
La mission du COVARS : comment anticiper les risques sanitaires dans une vision « Une seule Santé » de l’exposome Open
International audience
View article: Implémentation d’un réseau territorialisé « One Health » de recherche opérationnelle suite à l’émergence des arbovirus West Nile et Usutu en Nouvelle Aquitaine en 2022
Implémentation d’un réseau territorialisé « One Health » de recherche opérationnelle suite à l’émergence des arbovirus West Nile et Usutu en Nouvelle Aquitaine en 2022 Open
International audience
View article: Impaired balance between neutrophil extracellular trap formation and degradation by DNases in COVID-19 disease
Impaired balance between neutrophil extracellular trap formation and degradation by DNases in COVID-19 disease Open
View article: Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial
Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial Open
View article: Intestinal protozoa in returning travellers: a GeoSentinel analysis from 2007 to 2019
Intestinal protozoa in returning travellers: a GeoSentinel analysis from 2007 to 2019 Open
Background Prolonged diarrhoea is common amongst returning travellers and is often caused by intestinal protozoa. However, the epidemiology of travel-associated illness caused by protozoal pathogens is not well described. Methods We analys…
View article: Safety of Baricitinib in Vaccinated Patients with Severe and Critical COVID-19. Sub Study of the Randomised Bari-SolidAct Trial
Safety of Baricitinib in Vaccinated Patients with Severe and Critical COVID-19. Sub Study of the Randomised Bari-SolidAct Trial Open
View article: PA-424 The INTEGRATE study: an adaptive platform trial for the development of new interventions to combat Lassa Fever in West Africa
PA-424 The INTEGRATE study: an adaptive platform trial for the development of new interventions to combat Lassa Fever in West Africa Open
Background Lassa fever (LF) is a viral haemorrhagic fever responsible of 5000 deaths per year in West Africa, with in-hospital mortality at 12%. Ribavirin is the only treatment available with worrying toxicity, questionable efficacy and lo…
View article: OA-652 Safety and tolerability of favipiravir for the treatment of Lassa fever: a randomized controlled open label phase II clinical trial
OA-652 Safety and tolerability of favipiravir for the treatment of Lassa fever: a randomized controlled open label phase II clinical trial Open
Background Lassa fever (LF) is a severe re-emerging infectious disease caused by the Lassa virus (LV). LF is a priority disease on the World Health Organization's R&D blueprint and affects a large number of countries in West Africa, with N…
View article: One Health approach at the heart of the French Committee for monitoring and anticipating health risks
One Health approach at the heart of the French Committee for monitoring and anticipating health risks Open
View article: Scientific advisory councils in the COVID-19 response
Scientific advisory councils in the COVID-19 response Open
View article: PB0602 Plasma NET Markers Kinetics in COVID-19 Patients Receiving Immunomodulatory Treatments
PB0602 Plasma NET Markers Kinetics in COVID-19 Patients Receiving Immunomodulatory Treatments Open
View article: OC 55.1 Balance between Neutrophil Extracellular Trap Formation and DNase Activity in COVID-19 Patients
OC 55.1 Balance between Neutrophil Extracellular Trap Formation and DNase Activity in COVID-19 Patients Open
View article: Outcomes of targeted treatment in immunocompromised patients with asymptomatic or mild COVID-19: a retrospective study
Outcomes of targeted treatment in immunocompromised patients with asymptomatic or mild COVID-19: a retrospective study Open
View article: Self-application of aminoglycoside-based creams to treat cutaneous leishmaniasis in travelers
Self-application of aminoglycoside-based creams to treat cutaneous leishmaniasis in travelers Open
Background In endemic foci, the use of an aquaphilic cream containing paromomycin with/without gentamicin to treat cutaneous leishmaniasis (CL) is safe, painless and cures 78–82% of patients with New and Old World CL. Self-application in t…
View article: One year of SARS-CoV-2 circulation in the Nouvelle-Aquitaine region, February 2021–2022, France
One year of SARS-CoV-2 circulation in the Nouvelle-Aquitaine region, February 2021–2022, France Open
Background Since 2021, 3 variants of concern (VOC) have spread to France, causing successive epidemic waves. Objectives To describe the features of Alpha, Delta and Omicron VOC circulation in the Nouvelle-Aquitaine region, France, between …
View article: Acceptability and feasibility of home and hospital follow-up in Burkina Faso and Guinea: A mixed-method study among patients of the COVID-19 Coverage-Africa clinical trial
Acceptability and feasibility of home and hospital follow-up in Burkina Faso and Guinea: A mixed-method study among patients of the COVID-19 Coverage-Africa clinical trial Open
Patient experiences and perspectives on trial participation and follow-up may influence their compliance with research procedures or negatively impact their well-being. We aimed to explore the acceptability and feasibility of home-based an…
View article: Can haematological changes constitute a surrogate diagnostic parameter to detect schistosomiasis in migrants and travellers? - A retrospective analysis
Can haematological changes constitute a surrogate diagnostic parameter to detect schistosomiasis in migrants and travellers? - A retrospective analysis Open
Active egg-producing Schistosoma infections are associated with haematological alterations in returned travellers and migrants. However, these differences are discrete and seem to vary among disease stage and Schistosoma spec…
View article: Neutrophil Activation and Immune Thrombosis Profiles Persist in Convalescent COVID-19
Neutrophil Activation and Immune Thrombosis Profiles Persist in Convalescent COVID-19 Open
Purpose Following a severe COVID-19 infection, a proportion of individuals develop prolonged symptoms. We investigated the immunological dysfunction that underlies the persistence of symptoms months after the resolution of acute COVID-19. …
View article: Tobacco, alcohol, cannabis, and illicit drug use and their association with CD4/CD8 cell count ratio in people with controlled HIV: a cross-sectional study (ANRS CO3 AQUIVIH-NA-QuAliV)
Tobacco, alcohol, cannabis, and illicit drug use and their association with CD4/CD8 cell count ratio in people with controlled HIV: a cross-sectional study (ANRS CO3 AQUIVIH-NA-QuAliV) Open
View article: Implementing an outpatient clinical trial on COVID-19 treatment in an emergency epidemic context: a mixed methods study among operational and research stakeholders within the Coverage trial, Bordeaux (France)
Implementing an outpatient clinical trial on COVID-19 treatment in an emergency epidemic context: a mixed methods study among operational and research stakeholders within the Coverage trial, Bordeaux (France) Open
View article: Perceptions of COVID-19 among communities of Conakry (Guinea): a qualitative study exploring the context of the ANRS COV33 Coverage-Africa therapeutic trial
Perceptions of COVID-19 among communities of Conakry (Guinea): a qualitative study exploring the context of the ANRS COV33 Coverage-Africa therapeutic trial Open
Objectives To explore communities’ perceptions about COVID-19 in the context of the ANRS COV33 Coverage-Africa clinical trial evaluating the efficacy of treatments in preventing clinical worsening of COVID-19. Design Descriptive qualitativ…
View article: The number of cases, mortality and treatments of viral hemorrhagic fevers: A systematic review
The number of cases, mortality and treatments of viral hemorrhagic fevers: A systematic review Open
Background Viral hemorrhagic fevers (VHFs) are a group of diseases, which can be endemo-epidemic in some areas of the world. Most of them are characterized by outbreaks, which occur irregularly and are hard to predict. Innovative medical c…
View article: After 2 years of the COVID-19 pandemic, translating One Health into action is urgent
After 2 years of the COVID-19 pandemic, translating One Health into action is urgent Open
View article: Development of the PREDS score to predict in-hospital mortality of patients with Ebola virus disease under advanced supportive care: Results from the EVISTA cohort in the Democratic Republic of the Congo
Development of the PREDS score to predict in-hospital mortality of patients with Ebola virus disease under advanced supportive care: Results from the EVISTA cohort in the Democratic Republic of the Congo Open
View article: Epidemiological and clinical characteristics of patients with monkeypox in the GeoSentinel Network: a cross-sectional study
Epidemiological and clinical characteristics of patients with monkeypox in the GeoSentinel Network: a cross-sectional study Open
View article: Oropharyngeal and intestinal concentrations of opportunistic pathogens are independently associated with death of SARS-CoV-2 critically ill adults
Oropharyngeal and intestinal concentrations of opportunistic pathogens are independently associated with death of SARS-CoV-2 critically ill adults Open