María J. Redondo
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View article: <b>A Novel Approach for Assessing Outcomes of Type 1 Diabetes Prevention Trials Over a Fixed Time Interval</b>
<b>A Novel Approach for Assessing Outcomes of Type 1 Diabetes Prevention Trials Over a Fixed Time Interval</b> Open
We evaluated whether a binary metabolic endpoint for change (∆) from baseline to 1-year post-randomization could be useful in type 1 diabetes (T1D) prevention trials. Using 2hr-OGTT data from the abatacept prevention trial and similar part…
View article: <b>A Novel Approach for Assessing Outcomes of Type 1 Diabetes Prevention Trials Over a Fixed Time Interval</b>
<b>A Novel Approach for Assessing Outcomes of Type 1 Diabetes Prevention Trials Over a Fixed Time Interval</b> Open
We evaluated whether a binary metabolic endpoint for change (∆) from baseline to 1-year post-randomization could be useful in type 1 diabetes (T1D) prevention trials. Using 2hr-OGTT data from the abatacept prevention trial and similar part…
View article: The Heterogeneity of Type 1 Diabetes: Implications for Pathogenesis, Prevention, and Treatment—2024 <i>Diabetes</i>, <i>Diabetes Care</i>, and <i>Diabetologia</i> Expert Forum
The Heterogeneity of Type 1 Diabetes: Implications for Pathogenesis, Prevention, and Treatment—2024 <i>Diabetes</i>, <i>Diabetes Care</i>, and <i>Diabetologia</i> Expert Forum Open
This article summarizes the current understanding of the heterogeneity of type 1 diabetes from a June 2024 international Expert Forum organized by the editors of Diabetes, Diabetes Care, and Diabetologia. The Forum reviewed key factors con…
View article: The heterogeneity of type 1 diabetes: implications for pathogenesis, prevention, and treatment—2024 Diabetes, Diabetes Care, and Diabetologia Expert Forum
The heterogeneity of type 1 diabetes: implications for pathogenesis, prevention, and treatment—2024 Diabetes, Diabetes Care, and Diabetologia Expert Forum Open
This article summarises the current understanding of the heterogeneity of type 1 diabetes from a June 2024 international Expert Forum organised by the editors of Diabetes, Diabetes Care, and Diabetologia. The Forum reviewed key factors con…
View article: The Heterogeneity of Type 1 Diabetes: Implications for Pathogenesis, Prevention, and Treatment—2024 <i>Diabetes</i>, <i>Diabetes Care</i>, and <i>Diabetologia</i> Expert Forum
The Heterogeneity of Type 1 Diabetes: Implications for Pathogenesis, Prevention, and Treatment—2024 <i>Diabetes</i>, <i>Diabetes Care</i>, and <i>Diabetologia</i> Expert Forum Open
This article summarizes the current understanding of the heterogeneity of type 1 diabetes from a June 2024 international Expert Forum organized by the editors of Diabetes, Diabetes Care, and Diabetologia. The Forum reviewed key factors con…
View article: Contrasting Adult vs. Pediatric populations in a cohort of at risk relatives: The TrialNet Pathway to Prevention Study
Contrasting Adult vs. Pediatric populations in a cohort of at risk relatives: The TrialNet Pathway to Prevention Study Open
ObjectiveAdults represent over half of incident type 1 diabetes, yet research on disease progression predominantly focuses on at-risk children. We aimed to compare autoantibody screening outcomes and type 1 diabetes progression in adults v…
View article: Contrasting Adult vs. Pediatric populations in a cohort of at risk relatives: The TrialNet Pathway to Prevention Study
Contrasting Adult vs. Pediatric populations in a cohort of at risk relatives: The TrialNet Pathway to Prevention Study Open
ObjectiveAdults represent over half of incident type 1 diabetes, yet research on disease progression predominantly focuses on at-risk children. We aimed to compare autoantibody screening outcomes and type 1 diabetes progression in adults v…
View article: Development and recalibration of a multivariable type 1 diabetes prediction model for type 1 diabetes across multiple screening studies
Development and recalibration of a multivariable type 1 diabetes prediction model for type 1 diabetes across multiple screening studies Open
View article: The impact of ancestry on performance of type 1 diabetes genetic risk scores: high discrimination performance is maintained in African ancestry populations, but population specific thresholds may improve risk prediction
The impact of ancestry on performance of type 1 diabetes genetic risk scores: high discrimination performance is maintained in African ancestry populations, but population specific thresholds may improve risk prediction Open
OBJECTIVE Genetic risk scores (GRSs) for type 1 diabetes (T1D) may assist T1D classification and prediction but are often developed from European populations. To improve health outcomes, it is important to understand the performance and ut…
View article: Type 1 diabetes prediction in autoantibody-positive individuals: performance, time and money matter
Type 1 diabetes prediction in autoantibody-positive individuals: performance, time and money matter Open
View article: Enhancing Recruitment Rate and Heterogeneity in the TrialNet Pathway to Prevention Study: Insights from a Single Center Experience
Enhancing Recruitment Rate and Heterogeneity in the TrialNet Pathway to Prevention Study: Insights from a Single Center Experience Open
Studies to predict and prevent type 1 diabetes (T1D) are limited by small numbers and lack of participation from all affected populations. We compared TrialNet Pathway to Prevention recruitments at one pediatric center 12 months before (Ju…
View article: The Disposition Index in Autoantibody-Positive Individuals at Risk for Type 1 Diabetes
The Disposition Index in Autoantibody-Positive Individuals at Risk for Type 1 Diabetes Open
Since little is known about the disposition index (DI) in autoantibody-positive individuals, we have assessed whether DI has a similar association between insulin secretion and sensitivity to the association observed in other populations. …
View article: <b>The Disposition Index in Autoantibody-Positive Individuals at Risk for Type 1 Diabetes</b>
<b>The Disposition Index in Autoantibody-Positive Individuals at Risk for Type 1 Diabetes</b> Open
Since little is known about the disposition index (DI) in autoantibody-positive individuals, we have assessed whether DI has a similar association between insulin secretion and resistance to the association observed in other populations. I…
View article: IA-2A positivity increases risk of progression within and across established stages of type 1 diabetes
IA-2A positivity increases risk of progression within and across established stages of type 1 diabetes Open
View article: A type 1 diabetes prediction model has utility across multiple screening settings with recalibration
A type 1 diabetes prediction model has utility across multiple screening settings with recalibration Open
Background Accurate type 1 diabetes prediction is important to facilitate screening for pre-clinical type 1 diabetes to enable potential early disease-modifying interventions and to reduce the risk of severe presentation with diabetic keto…
View article: Fit24+, a Digital Diabetes Prevention Program for Hispanic Adolescents: Protocol for a Feasibility Pilot Study
Fit24+, a Digital Diabetes Prevention Program for Hispanic Adolescents: Protocol for a Feasibility Pilot Study Open
View article: Characteristics of autoantibody-positive individuals without high-risk HLA-DR4-DQ8 or HLA-DR3-DQ2 haplotypes
Characteristics of autoantibody-positive individuals without high-risk HLA-DR4-DQ8 or HLA-DR3-DQ2 haplotypes Open
View article: Metabolic, genetic and immunological features of relatives of type 1 diabetes patients with elevated insulin resistance
Metabolic, genetic and immunological features of relatives of type 1 diabetes patients with elevated insulin resistance Open
View article: MODY Calculator and Clinical Features Routinely Used to Distinguish MODY From Type 2 Diabetes in Adults Perform Poorly for Youth Clinically Diagnosed With Type 2 Diabetes
MODY Calculator and Clinical Features Routinely Used to Distinguish MODY From Type 2 Diabetes in Adults Perform Poorly for Youth Clinically Diagnosed With Type 2 Diabetes Open
View article: Identification of atypical pediatric diabetes mellitus cases using electronic medical records
Identification of atypical pediatric diabetes mellitus cases using electronic medical records Open
Introduction There are no established methods to identify children with atypical diabetes for further study. We aimed to develop strategies to systematically ascertain cases of atypical pediatric diabetes using electronic medical records (…
View article: Identification of type 1 diabetes risk phenotypes using an outcome-guided clustering analysis
Identification of type 1 diabetes risk phenotypes using an outcome-guided clustering analysis Open
View article: Diabetic ketoacidosis in youth with diabetes mellitus during the COVID-19 pandemic
Diabetic ketoacidosis in youth with diabetes mellitus during the COVID-19 pandemic Open
Objectives We sought to determine if the early months of the coronavirus disease 2019 (COVID-19) pandemic influenced pediatric diabetic ketoacidosis (DKA) hospitalization characteristics. Methods This is a cross-sectional study of youth wi…
View article: A global initiative to deliver precision health in diabetes
A global initiative to deliver precision health in diabetes Open
View article: Genetic Associations With C-peptide Levels Before Type 1 Diabetes Diagnosis in At-risk Relatives
Genetic Associations With C-peptide Levels Before Type 1 Diabetes Diagnosis in At-risk Relatives Open
Objective We sought to determine whether the type 1 diabetes genetic risk score-2 (T1D-GRS2) and single nucleotide polymorphisms are associated with C-peptide preservation before type 1 diabetes diagnosis. Methods We conducted a retrospect…
View article: Inaccurate diagnosis of diabetes type in youth: prevalence, characteristics, and implications
Inaccurate diagnosis of diabetes type in youth: prevalence, characteristics, and implications Open
Classifying diabetes at diagnosis is crucial for disease management but increasingly difficult due to overlaps in characteristics between the commonly encountered diabetes types. We evaluated the prevalence and characteristics of youth wit…
View article: Early Metabolic Endpoints Identify Persistent Treatment Efficacy in Recent-Onset Type 1 Diabetes Immunotherapy Trials
Early Metabolic Endpoints Identify Persistent Treatment Efficacy in Recent-Onset Type 1 Diabetes Immunotherapy Trials Open
Objective: Mixed meal tolerance test stimulated area under the curve (AUC) C-peptide at 12 to 24 months represents the primary endpoint for nearly all intervention trials seeking to preserve beta cell function in recent-onset type 1 diabet…
View article: Early Metabolic Endpoints Identify Persistent Treatment Efficacy in Recent-Onset Type 1 Diabetes Immunotherapy Trials
Early Metabolic Endpoints Identify Persistent Treatment Efficacy in Recent-Onset Type 1 Diabetes Immunotherapy Trials Open
OBJECTIVE Mixed-meal tolerance test–stimulated area under the curve (AUC) C-peptide at 12–24 months represents the primary end point for nearly all intervention trials seeking to preserve β-cell function in recent-onset type 1 diabetes. We…
View article: Early Metabolic Endpoints Identify Persistent Treatment Efficacy in Recent-Onset Type 1 Diabetes Immunotherapy Trials
Early Metabolic Endpoints Identify Persistent Treatment Efficacy in Recent-Onset Type 1 Diabetes Immunotherapy Trials Open
Objective: Mixed meal tolerance test stimulated area under the curve (AUC) C-peptide at 12 to 24 months represents the primary endpoint for nearly all intervention trials seeking to preserve beta cell function in recent-onset type 1 diabet…
View article: Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review
Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review Open
View article: Reply to ‘Slowly progressive insulin dependent diabetes mellitus in type 1 diabetes endotype 2’
Reply to ‘Slowly progressive insulin dependent diabetes mellitus in type 1 diabetes endotype 2’ Open