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View article: Fetal Bradycardia Prompting the Diagnosis and Management of Parental Long QT Syndrome
Fetal Bradycardia Prompting the Diagnosis and Management of Parental Long QT Syndrome Open
BACKGROUND: Long QT syndrome (LQTS) is primarily an inherited condition associated with the risk of sudden cardiac death. Due to variable phenotypic expression, a prolonged QT interval on a 12-lead ECG is not always present. LQTS may prese…
View article: Outcome of Tetralogy of Fallot Through Initial Palliation and Surgical Repair
Outcome of Tetralogy of Fallot Through Initial Palliation and Surgical Repair Open
Tetralogy of Fallot (ToF) is the most common cyanotic congenital heart disease, frequently diagnosed prenatally. To enhance understanding, we reviewed 18 years of our institutional outcomes for patients with classic ToF. There were 410 pat…
View article: Clinical Role of the Noninvasive Abdominal Fetal ECG in the Detection and Monitoring of Fetal Tachycardia
Clinical Role of the Noninvasive Abdominal Fetal ECG in the Detection and Monitoring of Fetal Tachycardia Open
BACKGROUND: Fetal tachycardias can cause adverse fetal outcomes including ventricular dysfunction, hydrops, and fetal demise. Postnatally, ECG is the gold standard, but, in fetal practice, echocardiography is used most frequently to diagno…
View article: Characterizing fetoplacental response to acute maternal hyperoxygenation in suspected coarctation of aorta using fetal cardiac <scp>MRI</scp>
Characterizing fetoplacental response to acute maternal hyperoxygenation in suspected coarctation of aorta using fetal cardiac <span>MRI</span> Open
Objective To characterize the fetoplacental response to acute maternal hyperoxygenation (AMH) in fetuses with suspected coarctation of the aorta (CoA) using fetal cardiac magnetic resonance imaging (MRI). Methods Pregnant women carrying a …
View article: Long-Term Outcome Following Prenatal Diagnosis of Transposition of the Great Arteries
Long-Term Outcome Following Prenatal Diagnosis of Transposition of the Great Arteries Open
Outcomes following the arterial switch operation (ASO) are well documented. Survival and long-term morbidity for fetuses diagnosed with dextro-transposition of the great arteries (d-TGA) are less reported. We aimed to document survival, re…
View article: Myocardial Deformation and Its Relation to Ventricular Shape, Preload, and Afterload in Fetuses with Suspected Coarctation of the Aorta
Myocardial Deformation and Its Relation to Ventricular Shape, Preload, and Afterload in Fetuses with Suspected Coarctation of the Aorta Open
Detailed characterization of myocardial deformation, ventricular shape, outflow tract size, inflow Doppler patterns, cerebroplacental circulation, and cardiac output of fetuses with suspected coarctation of the aorta (COA) and a control gr…
View article: Contemporary Outcome following intervention for Tetralogy of Fallot
Contemporary Outcome following intervention for Tetralogy of Fallot Open
Tetralogy of Fallot (ToF) is the most common cyanotic congenital heart disease, frequently diagnosed prenatally which enables parental education on the postnatal course. To enhance understanding, we reviewed 18 years of our institutional o…
View article: An exploratory analysis on diastolic function in the intensive compared with less intensive blood pressure control to prevent adverse cardiac remodelling in children with chronic kidney disease (HOT-KID): a parallel-group, open-label, multicentre, randomised, controlled trial
An exploratory analysis on diastolic function in the intensive compared with less intensive blood pressure control to prevent adverse cardiac remodelling in children with chronic kidney disease (HOT-KID): a parallel-group, open-label, multicentre, randomised, controlled trial Open
British Heart Foundation (PG/11/90/28,994); The authors MDS, PJC acknowledge financial support from the Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre and Clinical Resear…
View article: Cortical scaling of the neonatal brain in typical and altered development
Cortical scaling of the neonatal brain in typical and altered development Open
Theoretically derived scaling laws capture the nonlinear relationships between rapidly expanding brain volume and cortical gyrification across mammalian species and in adult humans. However, the preservation of these laws has not been comp…
View article: Video Clip Extraction From Fetal Ultrasound Scans Using Artificial Intelligence to Allow Remote Second Expert Review for Congenital Heart Disease
Video Clip Extraction From Fetal Ultrasound Scans Using Artificial Intelligence to Allow Remote Second Expert Review for Congenital Heart Disease Open
Objective To use artificial intelligence (AI) to automatically extract video clips of the fetal heart from a stream of ultrasound video, and to assess the performance of these when used for remote second review. Methods Using a dataset fro…
View article: Acute Maternal Hyperoxygenation to Predict Hypoxia and Need for Emergency Intervention in Fetuses With Transposition of the Great Arteries: A Pilot Study
Acute Maternal Hyperoxygenation to Predict Hypoxia and Need for Emergency Intervention in Fetuses With Transposition of the Great Arteries: A Pilot Study Open
A PA PI change ≤15% to AMH was associated with postnatal hypoxia due to PPHN. Increase in right and combined cardiac output and reduced MCA resistance with AMH are seen in those who do not require e-BAS.
View article: Fetal magnetic resonance imaging diagnosis of pulmonary lymphangiectasia in hypoplastic left heart syndrome: Association with fetal echocardiography and postnatal outcome
Fetal magnetic resonance imaging diagnosis of pulmonary lymphangiectasia in hypoplastic left heart syndrome: Association with fetal echocardiography and postnatal outcome Open
Fetuses with HLHS may exhibit a spectrum of lung changes on fetal MRI related to pulmonary venous obstruction. Whilst technical factors may also play a role, a degree of caution is advisable when interpreting more subtle forms of PL in fet…
View article: Virtual Reality for Preprocedure Planning of Covered Stent Correction of Superior Sinus Venosus Atrial Septal Defects
Virtual Reality for Preprocedure Planning of Covered Stent Correction of Superior Sinus Venosus Atrial Septal Defects Open
BACKGROUND: Covered stent correction (CSC) of a superior sinus venosus atrial septal defect is an alternative to surgery in selected patients, but anatomic variation means that assessment for CSC requires a 3-dimensional anatomic understan…
View article: Fetal Speckle Tracking Echocardiography Measured Global Longitudinal Strain and Strain Rate in Congenital Heart Disease: A Systematic Review and Meta‐Analysis
Fetal Speckle Tracking Echocardiography Measured Global Longitudinal Strain and Strain Rate in Congenital Heart Disease: A Systematic Review and Meta‐Analysis Open
Fetal two‐dimensional speckle tracking echocardiography (2D‐STE) is a novel technique that provides information on fetal heart function by measuring global longitudinal strain (GLS) and global longitudinal strain rate (GLSR). These feature…
View article: The onset of coarctation of the aorta before birth: Mechanistic insights from fetal arch anatomy and haemodynamics
The onset of coarctation of the aorta before birth: Mechanistic insights from fetal arch anatomy and haemodynamics Open
Accurate prenatal diagnosis of coarctation of the aorta (CoA) is challenging due to high false positive rate burden and poorly understood aetiology. Despite associations with abnormal blood flow dynamics, fetal arch anatomy changes and alt…
View article: Cortical scaling of the neonatal brain in typical and altered development
Cortical scaling of the neonatal brain in typical and altered development Open
Theoretically derived scaling laws capture the non-linear relationships between rapidly expanding brain volume and cortical gyrification across mammalian species and in adult humans. However, the preservation of these laws has not been com…
View article: The Added Dimension in Pediatric Mitral Valve Repair
The Added Dimension in Pediatric Mitral Valve Repair Open
[Figure: see text]
View article: Artificial Intelligence to Assist in the Screening Fetal Anomaly Ultrasound Scan (PROMETHEUS): A Randomised Controlled Trial
Artificial Intelligence to Assist in the Screening Fetal Anomaly Ultrasound Scan (PROMETHEUS): A Randomised Controlled Trial Open
Background Artificial intelligence (AI) has shown potential in improving the performance of screening fetal anomaly ultrasound scans. We aimed to assess the effect of AI on fetal ultrasound scanning, in terms of diagnostic performance, bio…
View article: Attentional development is altered in toddlers with congenital heart disease
Attentional development is altered in toddlers with congenital heart disease Open
Background Congenital Heart Disease (CHD) is the most common congenital abnormality. Survival rates are over 90%, however infants with CHD remain at high risk of attention and executive function impairments. These abilities are difficult t…
View article: Aortic Dilatation in Children and Young People With ADPKD
Aortic Dilatation in Children and Young People With ADPKD Open
Our data suggests increased prevalence of aortic root and ascending aortic dilatation in CYP with ADPKD compared with controls. Further studies are needed to understand the pathogenesis and its contribution to the high cardiovascular morbi…
View article: Structural covariance networks in the fetal brain reveal altered neurodevelopment for specific subtypes of congenital heart disease
Structural covariance networks in the fetal brain reveal altered neurodevelopment for specific subtypes of congenital heart disease Open
Background Altered structural brain development has been identified in fetuses with Congenital Heart Disease (CHD), suggesting that the neurodevelopmental impairment observed later in life might originate in utero. There are many interacti…
View article: Interaction between clinicians and artificial intelligence to detect fetal atrioventricular septal defects on ultrasound: how can we optimize collaborative performance?
Interaction between clinicians and artificial intelligence to detect fetal atrioventricular septal defects on ultrasound: how can we optimize collaborative performance? Open
Objectives Artificial intelligence (AI) has shown promise in improving the performance of fetal ultrasound screening in detecting congenital heart disease (CHD). The effect of giving AI advice to human operators has not been studied in thi…
View article: Double aortic arch: a comparison of fetal cardiovascular magnetic resonance, postnatal computed tomography and surgical findings
Double aortic arch: a comparison of fetal cardiovascular magnetic resonance, postnatal computed tomography and surgical findings Open
Fetal CMR provides novel insights into perinatal evolution of DAA. The smaller LAA can develop coarctation or atresia related to postnatal constriction of the arterial duct, making diagnosis of DAA challenging with contrast-enhanced CT/CMR…
View article: Executive Function in Preschool Children with Congenital Heart Disease and Controls: The Role of a Cognitively Stimulating Home Environment
Executive Function in Preschool Children with Congenital Heart Disease and Controls: The Role of a Cognitively Stimulating Home Environment Open
Supporting parents to provide a cognitively stimulating home environment may improve EF in children with CHD. The home and parenting environment should be considered when designing intervention studies aimed at improving EF in this patient…
View article: Individualized cortical gyrification in neonates with congenital heart disease
Individualized cortical gyrification in neonates with congenital heart disease Open
Congenital heart disease is associated with impaired early brain development and adverse neurodevelopmental outcomes. This study investigated how individualized measures of preoperative cortical gyrification index differ in 142 infants wit…