Radha Mahendran
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An IoT enabled computational model and application development for monitoring cardiovascular risks Open
Technological advancement in the rise of the Internet of Things (IoT) and computational modelling and application development has revolutionized medical care. Monitoring cardiovascular risks is faster, easier, and more accurate than ever. …
Study of morphology and orchid mycorrhizal associations in Malaxis rheedei Open
The mycorrhizal association in orchids is a striking example of mutualism, where the orchid and the associated mycorrhizal fungi exchange essential nutrients and support each other’s growth and reproduction. The present study focused on a …
In Silico Interaction Studies of Salacinol with Inhibitors of IAP Proteins Open
Salacia reticulata is an important medicinal plant, that is widely distributed in some parts of the sub-continent of India.Salacinol, a biologically active component found in the plant, has been shown through numerous pharmaceutical studie…
An Overview on Advanced Genetic Disease Diagnosis and Prediction Techniques Using Genome Data Open
A genetic disorder in individuals is caused by the inheritance of two alleles from the parents.This review focuses on various techniques that are used to diagnose or predict the possibility of a genetic disorder in patients.The conventiona…
Developing a Next-generation Multitudinous Epitope-based Vaccine Against Biotinidase Deficiency; An Immunoinformatics-based Approach Open
Biotinidase deficiency is a rare genetic disorder brought out by BTD (Biotinidase gene) mutations.Genetic disorders are not curable but there are drugs available for suppressing Biotinidase deficiency.To overcome this problem a vaccine tha…
In Silico Screening of SNP's in Prion Protein and Comparative Studies between Phytochemical Compounds that inhibit Prion Protein Causing Neuro-degenerative Diseases Open
The misfolded PrP (prion protein) aggregates and deposits in the brain as a sign of neurodegenerative diseases, which are very lethal.The prion-like prionoids lead to a variety of neurodegenerative diseases in humans as well as in animals.…
Characteristic Features and Signalling Cascade of Novel Zoonotic Coronavirus Open
The outbreak of coronavirus disease 2019 (COVID-19) due to its highly virulent nature has created a health crisis worldwide. It has attracted biologists’ attention to understand the morphology, host-pathogen interaction and signalling casc…
A detailed investigation in determining Alzheimer’s disease and its risk factor using different classification techniques Open
The prevalence of genetic disorders has recently crept surprisingly high. Neurodegenerative complications, specifically, pose physical and mental stress to parents and caretakers. These complications may be witnessed in the case of dementi…
<i>In silico</i> approach to inhibit Synthetic HIV-TAT activity using Phytoconstituents of <i>Moringa oleifera</i> leaves extract Open
TAT (Trans-activator-Transcription Protein), a viral protein is encoded by the TAT gene in HIV-1-which is a lethal subtype of HIV (Human immunodeficiency Virus). It is vital for the transcription of the viral genome. Previous studies show …
“In Silico Metabolic Pathway Analysis and Docking Analysis of Treponema Pallidum Subs. Pallidum Nichols for Potential Drug Targets” Open
Objective: Syphilis is a sexually transmitted infection caused by the spirochaete, Treponema pallidum subspecies pallidum nichols. In this study, a comparative metabolic pathway analysis and molecular docking was performed to identify puta…
“Molecular Modeling and Identification of Inhibitors against Human Mitochondrial Thymidine Kinase 2” Open
Objective:Mitochondrial disorders linked to Thymidine Kinase 2 (TK2) deficiency is associated to long term treatment with antiviral nucleoside analogues such as AZT (AZidoThymidine). The accumulation of AZT-TP (AZidoThymidine-TriPhosphate)…
Computational Screening of the Phytocompounds from the Plant <i>Ballota nigra Linn</i> against the Human Papillomavirus (HPV) E6 Open
Cancer is major cause of death rate in world wide. Cervical cancer is the second most common type of cancer in women, where the cancer develops at lower part of the uterus. Literature studies clearly depicts that the mainstream of the huma…
Identification and Analysis of Natural Compounds as Fungal Inhibitors from <i>Ocimum sanctum</i> using <i>in silico</i> Virtual Screening and Molecular Docking Open
In ancient days, fungal infections were curable; now due the environmental changes the available synthetic drug is not able to cure the diseases. The day to day practice of using traditional plants as a medicine has been increased to cure …
Virtual Screening and Analysis of Bioactive Compounds of <i>Momordica charantia</i> against Diabetes using Computational Approaches Open
Diabetes is one of the most serious metabolic disorders across the world which affects all age groups. World Health Organization (WHO) ranked the top diabetic countries in which India was ranked among the top three which diagnosed 62 milli…
Homology Modeling and <i>in silico</i> docking analysis of BDNF in the treatment of Alzheimer's disease Open
Alzheimer’s disease (AD) is a progressive, degenerative disorder that affects the brain’s nerve cells or neurons resulting in memory loss, thinking and behavorial changes. This neurodegenerative disorder affects the neurons of the brain by…
An <i>in silico</i> determination of Drug-Like Molecules from Plant Source to Treat Leprosy-A Neglected Tropical Infectious Disease of India Open
In developing countries, awareness towards controlling the infectious diseases with high mortality and morbidity among poor people is neglected. Leprosy otherwise known as Hansen’s disease, remains chronic from ancient times which is one a…
Lactobacillus fermentum on ammonia reduction and growth promotion of Macrobrachium rosenbergii post-larvae, and in vitro competitive exclusions of pathogenic bacteria Open
The effect of a probiotic bacterium, Lactobacillus fermentum on ammonia reduction and growth promotion of Macrobrachium rosenbergii post-larvae, and in vitro competitive exclusion of certain pathogenic bacteria, Shigella sonnei, Salmonella…
In vitro Antibacterial Activity of different crude leaves extracts of <i>Sterculia foetida</i> Linn Open
Sterculia foetida is a soft handsome woody tree with various pharmacological properties and they are most prevalently found in India, Thailand, Indonesia, Ghana, and Australia. The biochemically active compounds present in the plant posses…
Insights on Impact of Missense SNPs of Human USH2A associated with Usher Syndrome II Open
Usher syndrome, also known as Hallgren syndrome, is an extremely rare genetic disorder caused by a mutation in any one of at least 11 genes resulting in a combination of hearing loss and visual impairment. It is a leading cause of deaf bli…
Interaction Efficiency of Drugs towards the Novel Membranous Structure-Maurer's cleft for Malarial Disease Open
India, being a developing country, incidence of malarial infection prevail as a major socio-economic problem, though the infection is both treatable and preventable. There are nine anopheline vectors to transmit three specific Plasmodial s…
Computer-aided vaccine designing approach against fish pathogens Edwardsiella tarda and Flavobacterium columnare using bioinformatics softwares Open
Edwardsiella tarda and Flavobacterium columnare are two important intracellular pathogenic bacteria that cause the infectious diseases edwardsiellosis and columnaris in wild and cultured fish. Prediction of major histocompatibility complex…