Malik Peiris
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View article: Pathogenesis and Transmissibility of Middle East Respiratory Syndrome Coronaviruses of African Origin in Alpacas
Pathogenesis and Transmissibility of Middle East Respiratory Syndrome Coronaviruses of African Origin in Alpacas Open
The Middle East Respiratory Syndrome coronavirus (MERS-CoV) remains a highly significant threat to global public health. Dromedary camels are the zoonotic source of human infection. All cases of zoonotic Middle East Respiratory Syndrome (M…
View article: A Cross‐Sectional Virological and Sero‐Epidemiological Study of Exposures to Avian Influenza A(H5N1) and A(H9N2) Viruses in Live Bird Market Workers in Dhaka, Bangladesh
A Cross‐Sectional Virological and Sero‐Epidemiological Study of Exposures to Avian Influenza A(H5N1) and A(H9N2) Viruses in Live Bird Market Workers in Dhaka, Bangladesh Open
Background Avian influenza A viruses (AIVs) are endemic among poultry in Bangladesh sold at live bird markets (LBMs). We assessed virologic and serologic evidence of exposure to AIVs among LBM workers. Methods A cross‐sectional study recru…
View article: A Systematic Review of New, Enhanced Surveillance Systems and Methodologies for Zoonotic Influenza Viruses in Animals and Human–Animal Interface
A Systematic Review of New, Enhanced Surveillance Systems and Methodologies for Zoonotic Influenza Viruses in Animals and Human–Animal Interface Open
In 2009, the World Health Organization (WHO) developed a public health research agenda for influenza to guide researchers and outline directions and priority areas for research on influenza aiming at reducing the burden of seasonal epidemi…
View article: The hemagglutinin proteins of clades 1 and 2.3.4.4b H5N1 highly pathogenic avian influenza viruses exhibit comparable attachment patterns to avian and mammalian tissues
The hemagglutinin proteins of clades 1 and 2.3.4.4b H5N1 highly pathogenic avian influenza viruses exhibit comparable attachment patterns to avian and mammalian tissues Open
The global spread of the A/goose/Guangdong/1/96-lineage H5N1 highly pathogenic avian influenza (HPAI) viruses has been accompanied by an expanded host range and the establishment of sustained viral transmission among dairy cattle. To evalu…
View article: HLA-B*15:01-positive severe COVID-19 patients lack CD8 <sup>+</sup> T cell pools with highly expanded public clonotypes
HLA-B*15:01-positive severe COVID-19 patients lack CD8 <sup>+</sup> T cell pools with highly expanded public clonotypes Open
Understanding host factors driving asymptomatic versus severe disease outcomes is of key importance if we are to control emerging and re-emerging viral infections. HLA-B*15:01 has been associated with asymptomatic SARS-CoV-2 infection in n…
View article: Molecular Epidemiology of SARS-CoV-2 Detected from Different Areas of the Kandy District of Sri Lanka from November 2020–March 2022
Molecular Epidemiology of SARS-CoV-2 Detected from Different Areas of the Kandy District of Sri Lanka from November 2020–March 2022 Open
A comprehensive analysis of the molecular epidemiology of SARS-CoV-2 in the Kandy District of Sri Lanka from November 2020 to March 2022 was conducted to address the limited genomic surveillance data available across the country. The study…
View article: Influenza vaccine effectiveness against hospitalizations associated with influenza a in Hong Kong children aged 9 months to 17 years, 2024/25
Influenza vaccine effectiveness against hospitalizations associated with influenza a in Hong Kong children aged 9 months to 17 years, 2024/25 Open
Influenza began circulating in Hong Kong in mid-December 2024. As of 12 March 2025, 1279 children were enrolled in a prospective test negative study for influenza vaccine effectiveness (VE). Among 209 influenza-positive cases, 71 % had inf…
View article: Evaluation of pandemic potential of the genotype 4 (G4) swine influenza virus using ex vivo and in vitro cultures of the human respiratory tract
Evaluation of pandemic potential of the genotype 4 (G4) swine influenza virus using ex vivo and in vitro cultures of the human respiratory tract Open
Recent studies have reported a genotype 4 (G4) reassortant Eurasian avian-like (EA) H1N1 virus in swine, demonstrating a potential pandemic threat in humans. Here, we have compared the tropism, replication competence and pro-inflammatory c…
View article: Role and Contribution of Serological Surveillance in Animals and Exposed Humans to the Study of Zoonotic Influenza Disease Epidemiology: A Scoping Review
Role and Contribution of Serological Surveillance in Animals and Exposed Humans to the Study of Zoonotic Influenza Disease Epidemiology: A Scoping Review Open
Background: Zoonotic influenza viruses pose a significant and evolving public health threat. In response to the recent rise in H5N1 cross-species transmission, the World Health Organization (WHO) R&D Blueprint for Epidemics consultations h…
View article: A Framework for Measuring Population Immunity Against Influenza Using Individual Antibody Titers
A Framework for Measuring Population Immunity Against Influenza Using Individual Antibody Titers Open
Measuring population immunity is crucial for epidemic control and prevention of infectious diseases. While correlates of protection have been identified at the individual level for some pathogens, methods to translate these into population…
View article: Vision Based Navigation System for 8x8 Scaled Combat Vehicle
Vision Based Navigation System for 8x8 Scaled Combat Vehicle Open
Recent trends in the transportation and automotive industry have seen vehicles progress towards complete autonomous navigation methods. Many studies and investigations in this area involve implementing algorithms alongside simulated models…
View article: The impact of clade B lineage 5 MERS coronaviruses spike mutations from 2015 to 2023 on virus entry and replication competence
The impact of clade B lineage 5 MERS coronaviruses spike mutations from 2015 to 2023 on virus entry and replication competence Open
Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging coronavirus that can cause zoonotic disease in humans with lethal severe viral pneumonia. Dromedary camels are the source of zoonotic infection. As of June 2025, MERS-C…
View article: A single-dose intranasal immunization with a novel bat influenza A virus-vectored MERS vaccine provides effective protection against lethal MERS-CoV challenge
A single-dose intranasal immunization with a novel bat influenza A virus-vectored MERS vaccine provides effective protection against lethal MERS-CoV challenge Open
The threat to global health security posed by Middle East respiratory syndrome coronavirus (MERS-CoV) and emerging MERS-like coronaviruses highlights the need to develop safe and efficient vaccines. Viral vector vaccines have been shown to…
View article: Transmission Pathways of Zoonotic Influenza Viruses and Influencing Factors: A Systematic Review of Recent Findings
Transmission Pathways of Zoonotic Influenza Viruses and Influencing Factors: A Systematic Review of Recent Findings Open
Recent outbreaks of zoonotic influenza viruses underscored the need for a deeper understanding of transmission pathways and factors influencing spillover events. Understanding the combined effects of environmental conditions, host interact…
View article: The hemagglutinin proteins of clades 1 and 2.3.4.4b H5N1 highly pathogenic avian influenza viruses exhibit comparable attachment patterns to avian and mammalian tissues
The hemagglutinin proteins of clades 1 and 2.3.4.4b H5N1 highly pathogenic avian influenza viruses exhibit comparable attachment patterns to avian and mammalian tissues Open
The global spread of the A/goose/Guangdong/1/96-lineage H5N1 highly pathogenic avian influenza (HPAI) viruses is accompanied by an expanded host range and the establishment of sustained viral transmission among dairy cattle. To evaluate if…
View article: Clinical characteristics and severity of hand, foot, and mouth disease by virus serotype: A prospective hospital-based cohort study
Clinical characteristics and severity of hand, foot, and mouth disease by virus serotype: A prospective hospital-based cohort study Open
The circulating enteroviruses (EVs) serotypes in hand, foot and mouth disease (HFMD) inpatients remained unclear. This study aimed to investigate the serotype-specific associations between clinical characteristics and severity of HFMD inpa…
View article: Dynamic Interaction Between SARS-CoV-2 and Influenza A Virus Infection in Human Respiratory Tissues and Cells
Dynamic Interaction Between SARS-CoV-2 and Influenza A Virus Infection in Human Respiratory Tissues and Cells Open
With the concurrent circulations of SARS-CoV-2 omicron and influenza A viruses in the community, there is evidence showing co-infection with both viruses. However, disease severity may vary due to the complex immunity landscape of the pati…
View article: Pandemic Preparedness: Learning from COVID-19
Pandemic Preparedness: Learning from COVID-19 Open
No abstract available
View article: Viral diversity in bats based on Sri Lankan studies - A mini review
Viral diversity in bats based on Sri Lankan studies - A mini review Open
The emergence of the COVID-19 pandemic and the recent re-emergence of Nipah virus in India has further highlighted the need for identifying animal reservoirs of emerging viral infections, including coronaviruses. Bats have been recognised …
View article: Humoral and cellular immunogenicity of a fourth dose BNT162b2 in children with chronic kidney diseases
Humoral and cellular immunogenicity of a fourth dose BNT162b2 in children with chronic kidney diseases Open
Background Children with chronic kidney disease (CKD) are at risk of severe complications after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and are recommended to receive vaccine boosters. Although coronavirus di…
View article: Enhanced Influenza Vaccines Extend A(H3N2) Antibody Reactivity in Older Adults but Prior Vaccination Effects Persist
Enhanced Influenza Vaccines Extend A(H3N2) Antibody Reactivity in Older Adults but Prior Vaccination Effects Persist Open
Background Influenza vaccine effectiveness can be reduced in older adults and among repeatedly vaccinated groups. Results from year 1 of “PIVOT,” a randomized trial among adults aged ≥65 years in Hong Kong, showed that adjuvanted (Adj), hi…
View article: Bone and Joint Infections: A Retrospective Chart Review of the Medically Underserved Rio Grande Valley
Bone and Joint Infections: A Retrospective Chart Review of the Medically Underserved Rio Grande Valley Open
Background: The Rio Grande Valley (RGV) is a demographically unique region. The goal of this study was to expand the knowledge of orthopedics in the RGV and analyze disparities between individuals with osteomyelitis, septic arthritis, and …
View article: Surveillance of coronaviruses in wild aquatic birds in Hong Kong: expanded genetic diversity and discovery of novel subgenus in the <i>Deltacoronavirus</i>
Surveillance of coronaviruses in wild aquatic birds in Hong Kong: expanded genetic diversity and discovery of novel subgenus in the <i>Deltacoronavirus</i> Open
Migratory birds may carry emerging viruses over long distances. Regular surveillance and metagenomic analysis were employed to explore the diversity of avian coronaviruses at Hong Kong’s Mai Po Wetland. We tested a total of 3239 samples co…