Owen J. T. McCarty
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View article: Novel small molecule inhibitors of mitochondrial permeability transition pore (mPTP) block platelet procoagulant activity
Novel small molecule inhibitors of mitochondrial permeability transition pore (mPTP) block platelet procoagulant activity Open
Subpopulations of procoagulant platelets expose phosphatidylserine (PS) on their plasma membrane, providing a catalytic surface for thrombin generation and fibrin formation. Platelet PS exposure is critical for coagulation factor assembly …
View article: Inhibition of platelet kinase signaling and scaffolding activities with small molecule proteolysis-targeting chimeras (PROTACs)
Inhibition of platelet kinase signaling and scaffolding activities with small molecule proteolysis-targeting chimeras (PROTACs) Open
Tyrosine kinase inhibitors (TKIs) play an expanding role in treating cancers and other diseases, including thromboinflammatory and vascular conditions. However, many TKIs cause off-target or toxic effects in healthy cells of the blood and …
View article: CODAvision: best practices and a user-friendly interface for rapid, customizable segmentation of medical images
CODAvision: best practices and a user-friendly interface for rapid, customizable segmentation of medical images Open
Image-based machine learning tools have emerged as powerful resources for analyzing medical images, with deep learning-based semantic segmentation commonly utilized to enable spatial quantification of structures in images. However, customi…
View article: Effects of maternal edible THC consumption on offspring lung growth and function in a rhesus macaque model
Effects of maternal edible THC consumption on offspring lung growth and function in a rhesus macaque model Open
In a translational rhesus macaque model, chronic prenatal delta-9-tetrahydrocannabinol exposure resulted in decreased lung volumes in offspring measured at 6 mo of age. These decreases correlated with altered DNA methylation in the lung, i…
View article: A model of zymogen factor XII: insights into protease activation
A model of zymogen factor XII: insights into protease activation Open
In plasma, the zymogens factor XII (FXII) and prekallikrein reciprocally convert each other to the proteases FXIIa and plasma kallikrein (PKa). PKa cleaves high-molecular-weight kininogen (HK) to release bradykinin, which contributes to re…
View article: Characterization of the procoagulant phenotype of amniotic fluid across gestation in rhesus macaques and humans
Characterization of the procoagulant phenotype of amniotic fluid across gestation in rhesus macaques and humans Open
Overall, our findings reveal that the addition of AF to plasma enhances coagulation in a manner dependent on phospholipids as well as the presence of proteases and other proteins that directly regulate coagulation. We describe a correlatio…
View article: Coagulation factor XI regulates endothelial cell permeability and barrier function in vitro and in vivo
Coagulation factor XI regulates endothelial cell permeability and barrier function in vitro and in vivo Open
Loss of endothelial barrier function contributes to the pathophysiology of many inflammatory diseases. Coagulation factor XI (FXI) plays a regulatory role in inflammation. Although activation of FXI increases vascular permeability in vivo,…
View article: Effects of in utero delta-9-tetrahydrocannabinol (THC) exposure on fetal and infant musculoskeletal development in a preclinical nonhuman primate model
Effects of in utero delta-9-tetrahydrocannabinol (THC) exposure on fetal and infant musculoskeletal development in a preclinical nonhuman primate model Open
The endocannabinoid system (ECS) plays a major role in the maintenance of bodily homeostasis and adaptive response to external insults. It has been shown to regulate crucial physiological processes and behaviors, spanning nervous functions…
View article: The development, use, and challenges of electromechanical tissue stimulation systems
The development, use, and challenges of electromechanical tissue stimulation systems Open
Background Tissue stimulations greatly affect cell growth, phenotype, and function, and they play an important role in modeling tissue physiology. With the goal of understanding the cellular mechanisms underlying the response of tissues to…
View article: Contact Activation: Where Thrombosis and Hemostasis Meet on a Foreign Surface, Plus a Mini-editorial Compilation (“Part XVI”)
Contact Activation: Where Thrombosis and Hemostasis Meet on a Foreign Surface, Plus a Mini-editorial Compilation (“Part XVI”) Open
Welcome to the latest issue of Seminars in Thrombosis and Hemostasis (STH); this issue primarily devoted to highlighting the contact activation pathway of coagulation. Developed to provide an overview of the current body of knowledge aroun…
View article: Removal of Endothelial Surface-associated Von Villebrand Factor Suppresses Accelerate Datherosclerosis After Myocardial Infarction
Removal of Endothelial Surface-associated Von Villebrand Factor Suppresses Accelerate Datherosclerosis After Myocardial Infarction Open
Background Thromboinflammation involving platelet adhesion to endothelial surface-associated von Willebrand factor (VWF) has been implicated in the accelerated progression of non-culprit plaques after MI. The aim of this study was to use a…
View article: Comparison of bleeding and thrombotic outcomes in <scp>veno‐venous extracorporeal membrane oxygenation</scp>: Heparin versus bivalirudin
Comparison of bleeding and thrombotic outcomes in <span>veno‐venous extracorporeal membrane oxygenation</span>: Heparin versus bivalirudin Open
Objectives We aimed to evaluate thrombotic and hemorrhagic complications with heparin versus bivalirudin use in veno‐venous extracorporeal membrane oxygenation (V‐V ECMO). Methods We performed a retrospective cohort study of adult patients…
View article: Three-dimensional reconstruction of fetal rhesus macaque kidneys at single-cell resolution reveals complex inter-relation of structures
Three-dimensional reconstruction of fetal rhesus macaque kidneys at single-cell resolution reveals complex inter-relation of structures Open
Kidneys are among the most structurally complex organs in the body. Their architecture is critical to ensure proper function and is often impacted by diseases such as diabetes and hypertension. Understanding the spatial interplay between t…
View article: Activation of coagulation FXI promotes endothelial inflammation and amplifies platelet activation in a nonhuman primate model of hyperlipidemia
Activation of coagulation FXI promotes endothelial inflammation and amplifies platelet activation in a nonhuman primate model of hyperlipidemia Open
FXI activation promotes the proinflammatory phenotype of hyperlipidemia by priming platelet activation and inciting endothelial cell dysfunction.
View article: Cytoprotective E-WE thrombin reduces disease severity in a murine model of relapsing-remitting multiple sclerosis
Cytoprotective E-WE thrombin reduces disease severity in a murine model of relapsing-remitting multiple sclerosis Open
There are limited treatment options for mitigating acute relapsing attacks for patients with multiple sclerosis. We tested the hypothesis that harnessing the cytoprotective activity of the blood coagulation enzyme, thrombin, would provide …
View article: Biology of factor XI
Biology of factor XI Open
Unique among coagulation factors, the coagulation factor XI (FXI) arose through a duplication of the gene KLKB1, which encodes plasma prekallikrein. This evolutionary origin sets FXI apart structurally because it is a homodimer with 2 iden…
View article: The development, use, and challenges of electromechanical tissue stimulation systems
The development, use, and challenges of electromechanical tissue stimulation systems Open
Tissues including lung, heart, and bone in the body are subjected to biological, electrical, and mechanical stimulations. These stimulations greatly affect their growth, phenotype, and function, and play an important role in modeling tissu…