John D. Meeker
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View article: Hurricane María and Prenatal Maternal Mental Health: Variations in Stress, Social Support, and Depression Across Disaster Recovery Periods in Puerto Rico
Hurricane María and Prenatal Maternal Mental Health: Variations in Stress, Social Support, and Depression Across Disaster Recovery Periods in Puerto Rico Open
View article: Prenatal exposure to environmental phenolic compounds and their association with childhood atopic dermatitis, asthma, and allergic rhinitis in the ECHO cohort
Prenatal exposure to environmental phenolic compounds and their association with childhood atopic dermatitis, asthma, and allergic rhinitis in the ECHO cohort Open
Phenolic compounds may be harmful to the developing fetus, but many have not been studied in-depth for adverse childhood allergic and respiratory health effects. We hypothesized that higher levels of phenolic compounds in prenatal spot uri…
View article: Maternal bioactive lipids during pregnancy and early childhood neurodevelopment and behavior
Maternal bioactive lipids during pregnancy and early childhood neurodevelopment and behavior Open
Background Maternal immune activation, including inflammation and oxidative stress during pregnancy, has been linked to child neurodevelopmental problems (NDP) and emotional and behavioral problems (EBP). Polyunsaturated fatty acids (PUFAs…
View article: A Tutorial on Conducting Mediation Analysis with Exposure Mixtures
A Tutorial on Conducting Mediation Analysis with Exposure Mixtures Open
Causal mediation analysis is a powerful tool in environmental health research, allowing researchers to uncover the pathways through which exposures influence health outcomes. While traditional mediation methods have been widely applied to …
View article: Associations of Organophosphate Ester Flame Retardant Exposures during Pregnancy with Gestational Duration and Fetal Growth: The Environmental influences on Child Health Outcomes (ECHO) Program
Associations of Organophosphate Ester Flame Retardant Exposures during Pregnancy with Gestational Duration and Fetal Growth: The Environmental influences on Child Health Outcomes (ECHO) Program Open
BACKGROUND: Widespread exposure to organophosphate ester (OPE) flame retardants with potential reproductive toxicity raises concern regarding the impacts of gestational exposure on birth outcomes. Previous studies of prenatal OPE exposure …
View article: Prenatal exposure to phthalates and alternative plasticizers and emotional and behavioral outcomes in early childhood in the Environmental influences on Child Health outcomes (ECHO) cohort
Prenatal exposure to phthalates and alternative plasticizers and emotional and behavioral outcomes in early childhood in the Environmental influences on Child Health outcomes (ECHO) cohort Open
View article: Examining the association between gestational phenol exposure and infant non-nutritive suck in two Environmental influences on Child Health Outcomes cohorts
Examining the association between gestational phenol exposure and infant non-nutritive suck in two Environmental influences on Child Health Outcomes cohorts Open
Background: Non-nutritive suck (NNS) is a measure of neurofunction sensitive to environmental exposures in utero. This study aimed to evaluate the relationship between gestational phenol exposure and NNS patterning. Methods: Mother-infant …
View article: Statistical Methods for Chemical Mixtures: A Roadmap for Practitioners Using Simulation Studies and a Sample Data Analysis in the PROTECT Cohort
Statistical Methods for Chemical Mixtures: A Roadmap for Practitioners Using Simulation Studies and a Sample Data Analysis in the PROTECT Cohort Open
We develop an integrated R package "CompMix" that provides a platform for mixtures analysis where the practitioners can implement a pipeline that includes several approaches for mixtures analysis. Our study offers guidelines for selecting …
View article: Periods of susceptibility for associations between phthalate exposure and preterm birth: Results from a pooled analysis of 16 US cohorts
Periods of susceptibility for associations between phthalate exposure and preterm birth: Results from a pooled analysis of 16 US cohorts Open
The association of preterm birth with gestational biomarkers of DEHP exposure, but not other phthalate metabolites, differed by the timing of exposure. First and second trimester exposures demonstrated the greatest associations. Our study …
View article: Racial and Ethnic Disparities in Phthalate Exposure and Preterm Birth: A Pooled Study of Sixteen U.S. Cohorts
Racial and Ethnic Disparities in Phthalate Exposure and Preterm Birth: A Pooled Study of Sixteen U.S. Cohorts Open
BACKGROUND: Phthalate exposures are ubiquitous during pregnancy and may contribute to racial and ethnic disparities in preterm birth. OBJECTIVES: We investigated race and ethnicity in the relationship between biomarkers of phthalate exposu…
View article: Associations among PM<sub>2.5</sub>, corticotropin releasing hormone, estriol, and progesterone in pregnant persons in Puerto Rico
Associations among PM<sub>2.5</sub>, corticotropin releasing hormone, estriol, and progesterone in pregnant persons in Puerto Rico Open
Background. Exposure to PM 2.5 is associated with adverse birth outcomes and early development. Pregnancy is typically characterized by the production of several important hormones that impact aspects of maternal and fetal physiology, incl…
View article: Associations Between Ambient PM2.5 and Thyroid Hormones in Pregnant Persons in Puerto Rico
Associations Between Ambient PM2.5 and Thyroid Hormones in Pregnant Persons in Puerto Rico Open
Introduction: This study investigates associations between fine particulate air pollution (PM2.5) exposure and thyroid hormone levels during pregnancy in Puerto Rican individuals, a vulnerable population facing socioeconomic and environmen…
View article: Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort
Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort Open
Melamine, its analogues, and aromatic amines (AAs) were commonly detected in a previous study of pregnant women in the Environmental influences on Child Health Outcomes (ECHO) Cohort. While these chemicals have identified toxicities, littl…
View article: Prenatal exposure to environmental bisphenols over time and their association with childhood asthma, allergic rhinitis and atopic dermatitis in the ECHO consortium
Prenatal exposure to environmental bisphenols over time and their association with childhood asthma, allergic rhinitis and atopic dermatitis in the ECHO consortium Open
View article: Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and their influence on inflammatory biomarkers in pregnancy: Findings from the LIFECODES cohort
Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and their influence on inflammatory biomarkers in pregnancy: Findings from the LIFECODES cohort Open
The observed suppression of both regulatory (IL-10) and pro-inflammatory (TNF-α) cytokines suggests that PFAS may alter maternal inflammatory processes or immune functions during pregnancy. Further research is needed to understand the effe…
View article: Changes in exposure to environmental contaminants in the aftermath of Hurricane Maria among pregnant women in northern Puerto Rico
Changes in exposure to environmental contaminants in the aftermath of Hurricane Maria among pregnant women in northern Puerto Rico Open
Experiencing a hurricane during pregnancy is associated with increased risk of adverse birth outcomes and poor mental health. Pregnant people from marginalized communities are more susceptible to adverse effects, as they have fewer resourc…
View article: Exposure to organophosphate ester flame retardants and plasticizers and associations with preeclampsia and blood pressure in pregnancy
Exposure to organophosphate ester flame retardants and plasticizers and associations with preeclampsia and blood pressure in pregnancy Open
We observed null associations between OPE metabolites and preeclampsia, but some positive and some inverse associations with blood pressure in pregnancy. While our study was well-designed to assess associations with blood pressure, future …
View article: Association of Phenols, Parabens, and Their Mixture with Maternal Blood Pressure Measurements in the PROTECT Cohort
Association of Phenols, Parabens, and Their Mixture with Maternal Blood Pressure Measurements in the PROTECT Cohort Open
Our findings indicate that phenol and paraben exposure may collectively increase the risk of stage 1 or 2 hypertension during pregnancy, which has important implications for fetal and maternal health. https://doi.org/10.1289/EHP14008.
View article: Prenatal Exposure to Metals and Blood Pressure During Pregnancy in Puerto Rico
Prenatal Exposure to Metals and Blood Pressure During Pregnancy in Puerto Rico Open
View article: Associations of urinary polycyclic aromatic hydrocarbon (PAH) metabolites and their mixture with thyroid hormone concentration during pregnancy:A repeated measures study
Associations of urinary polycyclic aromatic hydrocarbon (PAH) metabolites and their mixture with thyroid hormone concentration during pregnancy:A repeated measures study Open
View article: Prenatal exposure to phenols and fetal growth across pregnancy
Prenatal exposure to phenols and fetal growth across pregnancy Open
View article: Prenatal exposure to metals and metalloids and child neurodevelopment outcomes in Puerto Rico
Prenatal exposure to metals and metalloids and child neurodevelopment outcomes in Puerto Rico Open
View article: Predictors of urinary glyphosate analytes among pregnant women in northern Puerto Rico
Predictors of urinary glyphosate analytes among pregnant women in northern Puerto Rico Open
View article: Associations among urinary polycyclic aromatic hydrocarbon biomarker concentrations and birth outcomes in LIFECODES
Associations among urinary polycyclic aromatic hydrocarbon biomarker concentrations and birth outcomes in LIFECODES Open
View article: Changes in prenatal urinary concentrations of triclocarban and triclosan following the US FDA ban in 2016: the ECHO cohorts
Changes in prenatal urinary concentrations of triclocarban and triclosan following the US FDA ban in 2016: the ECHO cohorts Open
View article: Prenatal Per- and Polyfluoroalkyl Substances (PFAS) and Oxidative Stress: Evidence from the LIFECODES Study
Prenatal Per- and Polyfluoroalkyl Substances (PFAS) and Oxidative Stress: Evidence from the LIFECODES Study Open
View article: Racial and ethnic disparities in prenatal environmental phenol and paraben exposures in the ECHO cohorts
Racial and ethnic disparities in prenatal environmental phenol and paraben exposures in the ECHO cohorts Open
View article: Prenatal exposure to environmental phenols and fetal growth across pregnancy in the LIFECODES fetal growth study
Prenatal exposure to environmental phenols and fetal growth across pregnancy in the LIFECODES fetal growth study Open
We observed associations between some biomarkers of phenol exposure and ultrasound measures of fetal growth, though associations at the time of delivery were attenuated. These findings are consistent with hypotheses that phenols have the p…
View article: Association of maternal fish consumption and ω-3 supplement use during pregnancy with child autism-related outcomes: results from a cohort consortium analysis
Association of maternal fish consumption and ω-3 supplement use during pregnancy with child autism-related outcomes: results from a cohort consortium analysis Open
These results extend previous work by suggesting that prenatal fish intake, but not ω-3 supplement use, may be associated with lower likelihood of both autism diagnosis and related traits. Given the low-fish intake in the United States gen…
View article: Organophosphate Ester Flame Retardants and Plasticizers in Relation to Fetal Growth in the LIFECODES Fetal Growth Study
Organophosphate Ester Flame Retardants and Plasticizers in Relation to Fetal Growth in the LIFECODES Fetal Growth Study Open
In a large prospective cohort, gestational OPE exposures were associated with larger fetal size during pregnancy, but associations at delivery were null. DPHP concentrations were associated with heightened risk of an SGA birth. These findi…