Stephen J. Meltzer
YOU?
Author Swipe
View article: Chromosome 20q gene signature associated with colorectal cancer progression
Chromosome 20q gene signature associated with colorectal cancer progression Open
Amplification of human chromosome 20q has been reported as the most frequently recurring genetic abnormality associated with large scale changes in mRNA and protein levels in sporadic colorectal carcinomas. While some studies have found 20…
View article: Spatiotemporal Study of a Risk-Stratification Epigenetic-Based Biomarker Assay in Patients With Barrett Esophagus
Spatiotemporal Study of a Risk-Stratification Epigenetic-Based Biomarker Assay in Patients With Barrett Esophagus Open
INTRODUCTION: Barrett esophagus (BE) is the strongest known risk factor for developing esophageal adenocarcinoma (EAC), the second-most lethal cancer in the United States. Esopredict is a novel validated methylation-based biomarker assay t…
View article: Neoplastic Progression Risk in Females With Barrett’s Esophagus: A Systematic Review and Meta-Analysis of Individual Patient Data
Neoplastic Progression Risk in Females With Barrett’s Esophagus: A Systematic Review and Meta-Analysis of Individual Patient Data Open
Although females had a lower neoplastic progression risk, sex differences were smaller than previously reported, and time to progression was similar for both sexes. Future research should focus on other factors than sex to identify low- an…
View article: Analytical Validation of Esopredict, an Epigenetic Prognostic Assay for Patients with Barrett’s Esophagus
Analytical Validation of Esopredict, an Epigenetic Prognostic Assay for Patients with Barrett’s Esophagus Open
EsopredictTM is a prognostic assay that risk-stratifies Barrett’s esophagus patients to predict future progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC). Established based on foundational studies at Johns Hopkins…
View article: Validation of an Epigenetic Prognostic Assay to Accurately Risk-Stratify Patients With Barrett Esophagus
Validation of an Epigenetic Prognostic Assay to Accurately Risk-Stratify Patients With Barrett Esophagus Open
INTRODUCTION: Esophageal adenocarcinoma (EAC) is the second-most lethal cancer in the United States, with Barrett esophagus (BE) being the strongest risk factor. Assessing the future risk of neoplastic progression in patients with BE is di…
View article: Cancer Methylation Biomarker Detection in an Automated, Portable, Multichannel Magnetofluidic Platform
Cancer Methylation Biomarker Detection in an Automated, Portable, Multichannel Magnetofluidic Platform Open
Early detection of cancer is critical to improving clinical outcomes, especially in territories with limited healthcare resources. DNA methylation biomarkers have shown promise in early cancer detection, but typical workflows require highl…
View article: Establishing mouse and human oral esophageal organoids to investigate the tumor immune response
Establishing mouse and human oral esophageal organoids to investigate the tumor immune response Open
Organoid culture systems are very powerful models that recapitulate in vivo organ development and disease pathogenesis, offering great promise in basic research, drug screening and precision medicine. However, the application of organoids …
View article: Data from Methylation Biomarker Panel Performance in EsophaCap Cytology Samples for Diagnosing Barrett's Esophagus: A Prospective Validation Study
Data from Methylation Biomarker Panel Performance in EsophaCap Cytology Samples for Diagnosing Barrett's Esophagus: A Prospective Validation Study Open
Purpose:Barrett's esophagus is the only known precursor of esophageal adenocarcinoma (EAC). Although endoscopy and biopsy are standard methods for Barrett's esophagus diagnosis, their high cost and risk limit their use as a screening modal…
View article: Supplementary Fig. 1 from EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers
Supplementary Fig. 1 from EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers Open
Coverage distribution of the gitBS performed on 300 plasma samples
View article: Supplementary Table 4 from Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles
Supplementary Table 4 from Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles Open
PDF file - 65K
View article: Supplementary Fig. 17 from EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers
Supplementary Fig. 17 from EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers Open
Pan-GI prediction accuracy using various number of DMRs identified from pan-GI vs. healthy plasma sample analysis
View article: Supplementary Fig. 1 from EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers
Supplementary Fig. 1 from EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers Open
Coverage distribution of the gitBS performed on 300 plasma samples
View article: Supplementary Figure S1 from <i>Reprimo</i> Methylation Is a Potential Biomarker of Barrett's-Associated Esophageal Neoplastic Progression
Supplementary Figure S1 from <i>Reprimo</i> Methylation Is a Potential Biomarker of Barrett's-Associated Esophageal Neoplastic Progression Open
Supplementary Figure S1 from Reprimo Methylation Is a Potential Biomarker of Barrett's-Associated Esophageal Neoplastic Progression
View article: Data from Evaluation of Salivary Exosomal Chimeric <i>GOLM1-NAA35</i> RNA as a Potential Biomarker in Esophageal Carcinoma
Data from Evaluation of Salivary Exosomal Chimeric <i>GOLM1-NAA35</i> RNA as a Potential Biomarker in Esophageal Carcinoma Open
Purpose:Transcriptionally induced chimeric RNAs are an important emerging area of research into molecular signatures for biomarker and therapeutic target development. Salivary exosomes represent a relatively unexplored, but convenient, and…
View article: Supplementary Table 5 from Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles
Supplementary Table 5 from Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles Open
PDF file - 14K
View article: Supplementary Fig. 9 from EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers
Supplementary Fig. 9 from EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers Open
Hierarchical clustering of PDAC and healthy plasma samples
View article: Raw data 3 from Evaluation of Salivary Exosomal Chimeric <i>GOLM1-NAA35</i> RNA as a Potential Biomarker in Esophageal Carcinoma
Raw data 3 from Evaluation of Salivary Exosomal Chimeric <i>GOLM1-NAA35</i> RNA as a Potential Biomarker in Esophageal Carcinoma Open
Raw data 3-Supplementary Zip including supplementary tables with the qRT-PCR data from the patient cohorts with the amplification profile data (validation cohort)
View article: Supplementary Fig. 11 from EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers
Supplementary Fig. 11 from EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers Open
CRC prediction accuracy using various number of DMRs identified from CRC vs. healthy plasma sample analysis
View article: Supplementary Fig. 3 from EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers
Supplementary Fig. 3 from EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers Open
Workflow of model training and test for GI cancer prediction. (a) Initial markers discovery was conducted with 1653 GI cancer and 287 normal tissues. Targeted bisulfite sequencing that covers the initial selected CpG sites was performed on…
View article: CCR Translation for This Article from Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles
CCR Translation for This Article from Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles Open
CCR Translation for This Article from Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles
View article: Supplementary Data from Methylation Biomarker Panel Performance in EsophaCap Cytology Samples for Diagnosing Barrett's Esophagus: A Prospective Validation Study
Supplementary Data from Methylation Biomarker Panel Performance in EsophaCap Cytology Samples for Diagnosing Barrett's Esophagus: A Prospective Validation Study Open
supplementary figures and tables
View article: Supplementary Table 2 from Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles
Supplementary Table 2 from Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles Open
PDF file - 54K
View article: Supplementary Table-S3 from EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers
Supplementary Table-S3 from EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers Open
Supplementary Table-S3
View article: Supplementary Table-S5 from EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers
Supplementary Table-S5 from EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers Open
Supplementary Table-S5
View article: Supplementary Table-S7 from EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers
Supplementary Table-S7 from EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers Open
Supplementary Table-S7
View article: Supplementary Figures 1-4 from Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles
Supplementary Figures 1-4 from Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles Open
PDF file - 980K
View article: Supplementary Table-S4 from EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers
Supplementary Table-S4 from EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers Open
Supplementary Table-S4