J. Milnes
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View article: Next generation microchannel plate detectors for high spatial and temporal resolution
Next generation microchannel plate detectors for high spatial and temporal resolution Open
Multi-anode Microchannel Plate (MCP) detectors provide unique performance, especially with regards to sub 30 ps timing resolution, signal-photon sensitivity, and modular design. Developments for High-Energy Physics applications such as the…
View article: Inferring fusion nuclear burnwidths with low gain photomultiplier impulse response functions
Inferring fusion nuclear burnwidths with low gain photomultiplier impulse response functions Open
When an inertial confinement fusion implosion is compressed, it maintains thermonuclear density and temperatures for a very short time scale, about 100 ps. The Gamma Reaction History diagnostic measures the time evolution of the fusion bur…
A reconfigurable Micro-channel plate “RSP” detector for wide-range application in charged particle detection Open
We have developed an MCP detector with reconfigurable read-out which is capable of recording the position and time information for single particle counting and alternatively of operating at high particle flux with optical read-out. This is…
View article: Utilising machine learning algorithms for high speed data processing of a single photon counting 256 channel PMT with a timing resolution of 60 ps
Utilising machine learning algorithms for high speed data processing of a single photon counting 256 channel PMT with a timing resolution of 60 ps Open
Development of a 256 Micro-Channel Plate Photo-Multiplier Tube (MCP-PMT) to further increase the spatial resolution while maintaining the temporal resolution of 60ps using charge sharing techniques would enable a novel commercial camera sy…
View article: Test-beam demonstration of a TORCH prototype module
Test-beam demonstration of a TORCH prototype module Open
The TORCH time-of-flight detector is designed to provide a 15 ps timing resolution for charged particles, resulting in π /K particle identification up to 10 GeV/c momentum over a 10 m flight path. Cherenkov photons, produced in a quartz pl…
View article: Performance of a prototype TORCH time-of-flight detector
Performance of a prototype TORCH time-of-flight detector Open
TORCH is a novel time-of-flight detector, designed to provide charged particle identification of pions, kaons and protons in the momentum range 2-20 GeV/c over a 9.5 m flight path. A detector module, comprising a 10mm thick quartz plate, p…
View article: Investigating machine learning solutions for a 256 channel TCSPC camera with sub-70 ps single photon timing per channel at data rates >10 Gbps
Investigating machine learning solutions for a 256 channel TCSPC camera with sub-70 ps single photon timing per channel at data rates >10 Gbps Open
The development of a Time Correlated Single Photon Counting (TCSPC) camera with 256 channels has enabled several applications where single photon sensitivity is crucial, such as LiDAR, Fluorescent Lifetime IMaging (FLIM) and quantum inform…
View article: A precision time of flight readout system for the TORCH prototype detector
A precision time of flight readout system for the TORCH prototype detector Open
The TORCH detector provides low-momentum particle identification, combining Time of Flight (TOF) and Cherenkov techniques to achieve charged particle pi/K/p separation between 2–20 GeV/c over a flight distance of 10 m. The measurement requ…
View article: Picosecond timing of charged particles using the TORCH detector
Picosecond timing of charged particles using the TORCH detector Open
TORCH is a large-area, high-precision time-of-flight (ToF) detector designed to provide charged-particle identification in the 2-20 GeV$/c$ momentum range. Prompt Cherenkov photons emitted by charged hadrons as they traverse a 10mm quartz …
View article: Test-beam performance of a TORCH prototype module
Test-beam performance of a TORCH prototype module Open
The TORCH time-of-flight detector is designed to provide a 15 ps timing resolution for charged particles, resulting in $K/\\pi$ $(p/K)$ particle identification up to momentum of about 10(15) GeV/$c$ over a 10 m flight distance. Cherenkov p…
The Acetylcholine-Activated Potassium Current Inhibitor XAF-1407 Terminates Persistent Atrial Fibrillation in Goats Open
Aims: The acetylcholine-activated inward rectifier potassium current (I KACh ) has been proposed as an atrial-selective target for the treatment of atrial fibrillation (AF). Using a novel selective I KACh inhibitor XAF-1407, the study inve…
View article: A benzopyran with antiarrhythmic activity is an inhibitor of Kir3.1-containing potassium channels
A benzopyran with antiarrhythmic activity is an inhibitor of Kir3.1-containing potassium channels Open
Atrial fibrillation (AF) is the most commonly diagnosed cardiac arrhythmia and is associated with increased morbidity and mortality. Currently approved AF antiarrhythmic drugs have limited efficacy and/or carry the risk of ventricular proa…
View article: Status of the TORCH time-of-flight detector
Status of the TORCH time-of-flight detector Open
TORCH is a novel time-of-flight detector, designed to provide $\\pi$/K particle identification up to 10$\\,\\text{GeV}/c$ momentum over a 10$\\,$m flight path. Based on the DIRC principle, Cherenkov photons are produced in a quartz plate o…
Effect of selective <i>I</i><sub>K,ACh</sub> inhibition by XAF‐1407 in an equine model of tachypacing‐induced persistent atrial fibrillation Open
Background and Purpose Inhibition of the G‐protein gated ACh‐activated inward rectifier potassium current, I K,ACh may be an effective atrial selective treatment strategy for atrial fibrillation (AF). Therefore, the anti‐arrhythmic and ele…
View article: Status of the TORCH Project
Status of the TORCH Project Open
The TORCH time-of-flight detector will provide particle identification between 2–10 GeV/c momentum over a flight distance of 10 m, and is designed for large-area coverage, up to 30 m2. A 15 ps time-of-flight resolution per incident particl…
View article: Multi-Anode Square Microchannel Plate Photomultiplier Tube
Multi-Anode Square Microchannel Plate Photomultiplier Tube Open
Photek has developed a high performance 4096-anode photomultiplier tube using microchannel plates as the gain medium. Additionally, the detector has been designed in a square format to maximise the active area and allow for easy tiling to …
Lightsheet fluorescence lifetime imaging microscopy with wide‐field time‐correlated single photon counting Open
We report on wide‐field time‐correlated single photon counting (TCSPC)‐based fluorescence lifetime imaging microscopy (FLIM) with lightsheet illumination. A pulsed diode laser is used for excitation, and a crossed delay line anode image in…
View article: The TORCH time-of-flight detector
The TORCH time-of-flight detector Open
The TORCH detector is a time-of-flight system that is being developed for use in particle physics experiments with the aim of providing particle identification, over a wide area, in the momentum range 2 to 10 GeV/c. The detector exploits p…
View article: Genetic variation in <i>GNB5</i> causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (<i>I</i>K,ACh)
Genetic variation in <i>GNB5</i> causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (<i>I</i>K,ACh) Open
Mutations in GNB5, encoding the G-protein β5 subunit (Gβ5), have recently been linked to a multisystem disorder that includes severe bradycardia. Here, we investigated the mechanism underlying bradycardia caused by the recessive p.S81L Gβ5…
View article: Status of the TORCH time-of-flight project
Status of the TORCH time-of-flight project Open
TORCH is a time-of-flight detector, designed to provide charged pi/K particle identification up to a momentum of 10 GeV/c for a 10 m flight path. To achieve this level of performance, a time resolution of 15 ps per incident particle is req…