Explanipedia

Circulating extracellular vesicle-miRNAs as epigenetic mediators of metabolic, inflammatory, and neurological pathways in pediatric obesity. Open

Mangesh Dattu Hade, Eduardo Reátegui, J. Nicholas Brenton, Setty M. Magaña · 2025

Pediatric obesity represents a significant global health concern, associated with increased risk of early-onset metabolic disorders, chronic inflammation, and neurodevelopmental complications. Understanding the epigenetic mechanisms underl…

Extracellular vesicle miRNA signatures in pediatric onset-multiple sclerosis and obesity-driven immune and metabolic dysregulation Open

Mangesh Dattu Hade, Eduardo Reátegui, J. Nicholas Brenton, Setty M. Magaña · 2025

Background Multiple sclerosis (MS) is a chronic, demyelinating autoimmune syndrome of the central nervous system (CNS). The cause of MS remains unknown; however, a dysregulated metabolome appears to play a contributing role. Up to 10% of a…

Time to treatment in pediatric patients with repeated episodes of status epilepticus Open

Jennifer V. Gettings, Iván Sánchez Fernández, Anne E. Anderson, J. Nicholas Brenton, Afra Can , et al. · 2025

Time to treatment with benzodiazepine and non-benzodiazepine ASM in patients with repeated episodes of status epilepticus does not improve for a second episode of status epilepticus, suggesting additional opportunities for intervention and…

Symptom-triggered testing detects early stage and low volume resectable advanced stage ovarian cancer Open

Fong Lien Kwong, Caroline Kristunas, Clare Davenport, Jonathan J Deeks, Susan Mallett , et al. · 2024

Our results demonstrate that one in four women identified with high grade serous ovarian cancer through the fast-track pathway following symptom-triggered testing was diagnosed with early-stage disease. Symptom-triggered testing may help i…

Association of nutritional intake with clinical and imaging activity in pediatric multiple sclerosis Open

Sonam D Mohan, Skyler Peterson, J. Nicholas Brenton, Suzan L. Carmichael, Akash Virupakshaiah , et al. · 2024

Background: Understanding nutrition’s role in multiple sclerosis (MS) can guide recommendations and intervention-based studies. Objective: Evaluate the association between nutrition and pediatric-onset MS outcomes. Methods: Prospective lon…

The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex Open

Naila Makhani, Christine Lebrun‐Frénay, Aksel Sıva, Veronika Shabanova, Evangeline Wassmer , et al. · 2024

Time to Treatment in Pediatric Patients with Repeated Episodes of Status Epilepticus Open

Jennifer V. Gettings, Iván Sánchez Fernández, Anne E. Anderson, J. Nicholas Brenton, Afra Can , et al. · 2024

Objective To compare pediatric patients who presented with repeated status epilepticus episodes to patients with a single episode of status epilepticus and identify distinguishing clinical factors. Methods Retrospective analysis of a multi…

Safety and Efficacy of Fingolimod and Ocrelizumab in Pediatric Patients with Multiple Sclerosis Open

Benton Spirek, J. Nicholas Brenton · 2024

Multiple Sclerosis and Family Planning Open

Erin Kelly, Casey Engel, Rylan Pearsall, J. Nicholas Brenton, Riley Bove , et al. · 2023

Over the past few decades, women with MS have received a wide range of evolving guidance surrounding family planning, pregnancy, and postpartum care. Survey data suggest improvements in MS/pregnancy counseling and medical management in rec…

Progression risk stratification with six-minute walk gait speed trajectory in multiple sclerosis Open

Myla Goldman, Shanshan Chen, Robert W. Motl, Rylan Pearsall, Unsong Oh , et al. · 2023

Background Multiple Sclerosis (MS) disease progression has notable heterogeneity among patients and over time. There is no available single method to predict the risk of progression, which represents a significant and unmet need in MS. Met…

Interim guidelines for the assessment and treatment of pain in children with multiple sclerosis Open

Catherine Stratton, Areti Vassilopoulos, J. Nicholas Brenton, Kirsten Potter, Wendy Vargas , et al. · 2023

Introduction Pain in multiple sclerosis (MS) is common, but literature on pain in children with MS remains scarce. Pain has physical, psychological, and social implications in MS, and both comprehensive assessment and interdisciplinary man…

Pediatric Neurology Trainee Award Open

J. Nicholas Brenton, Lauren A. Beslow, Audrey C. Brumback, Jay Desai, Francis J. DiMario , et al. · 2023

Ketogenic diet in relapsing multiple sclerosis: Patient perceptions, post-trial diet adherence & outcomes Open

Emma Wetmore, Diana Lehner‐Gulotta, Brian Florenzo, Brenda Banwell, Anna Bergqvist , et al. · 2023

Early Clinical Variables Associated With Refractory Convulsive Status Epilepticus in Children Open

Katrina Peariso, Ravindra Arya, Tracy A. Glauser, Nicholas S. Abend, Cristina Barcia Aguilar , et al. · 2023

This study provides Class II evidence that patient and clinical factors may predict RSE in children with convulsive seizures.

MRI Features and Their Association With Outcomes in Children With Anti-NMDA Receptor Encephalitis Open

Grace Gombolay, J. Nicholas Brenton, Jennifer H. Yang, Coral M. Stredny, Ryan Kammeyer , et al. · 2023

Abnormal frontal and occipital lesions on MRI may associate with 1-year mRS in pNMDARE. MRI of the brain may be a helpful prognostication tool that should be examined in future studies.

Environmental Influences on Risk and Disease Course in Pediatric Multiple Sclerosis Open

Darina Dinov, J. Nicholas Brenton · 2023

Serum neurofilament light chain in relapsing multiple sclerosis patients on a ketogenic diet Open

Unsong Oh, Emma Woolbright, Diana Lehner‐Gulotta, Rachael Coleman, Mark R. Conaway , et al. · 2023

Socioeconomic, Clinical, and Laboratory Parameters Differentiating Pediatric Patients With MOG Antibody–Associated Disease and Multiple Sclerosis Open

Brian Florenzo, J. Nicholas Brenton · 2023

Studies indicate differences in the clinical phenotypes and neuroimaging of children with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) compared to multiple sclerosis; however, there are limited data assessing the…

Six-Minute Walk as a Measure of Walking Capacity and Endurance in Patients With Pediatric-Onset Multiple Sclerosis Open

J. Nicholas Brenton, Brian Florenzo, Hitoshi Koshiya, Seulgi Min, Emma Woolbright , et al. · 2022

This study provides Class III evidence that, compared with healthy controls, patients with POMS walk shorter distances on the 6MW test, are less able to accelerate to peak speed at the end of the test, and are less physically active.

Pediatric Acquired Demyelinating Disorders Open

J. Nicholas Brenton · 2022

Although many of the demyelinating disorders presented in this article can affect children and adults across the age spectrum, the clinical and radiologic phenotypes, treatment considerations, and long-term prognoses are often distinct in …

Pediatric Neurology Trainee Award Open

J. Nicholas Brenton, Audrey C. Brumback, Jay Desai, John R. Mytinger, Morris H. Scantlebury · 2022

Phase II study of ketogenic diets in relapsing multiple sclerosis: safety, tolerability and potential clinical benefits Open

J. Nicholas Brenton, Diana Lehner‐Gulotta, Emma Woolbright, Brenda Banwell, Anna Bergqvist , et al. · 2022

Background Dietary changes impact human physiology and immune function and have potential as therapeutic strategies. Objective Assess the tolerability of a ketogenic diet (KD) in patients with relapsing multiple sclerosis (MS) and define t…

Body size perceptions & diet modification in youth with multiple sclerosis Open

Emma Woolbright, Hitoshi Koshiya, J. Nicholas Brenton · 2021

Benzodiazepine administration patterns before escalation to second‐line medications in pediatric refractory convulsive status epilepticus Open

Theodore Sheehan, Marta Amengual‐Gual, Alejandra Vasquez, Nicholas S. Abend, Anne E. Anderson , et al. · 2021

Objective This study was undertaken to evaluate benzodiazepine (BZD) administration patterns before transitioning to non‐BZD antiseizure medication (ASM) in pediatric patients with refractory convulsive status epilepticus (rSE). Methods Th…

Factors associated with long‐term outcomes in pediatric refractory status epilepticus Open

Marina Gaínza‐Lein, Cristina Barcia Aguilar, Juan Piantino, Kevin Chapman, Iván Sánchez Fernández , et al. · 2021

Objective This study was undertaken to describe long‐term clinical and developmental outcomes in pediatric refractory status epilepticus (RSE) and identify factors associated with new neurological deficits after RSE. Methods We performed r…

Clinical presentation of new onset refractory status epilepticus in children (the pSERG cohort) Open

Claudine Sculier, Cristina Barcia Aguilar, Nicolas Gaspard, Marina Gaínza‐Lein, Iván Sánchez Fernández , et al. · 2021

Objective We aimed to characterize the clinical profile and outcomes of new onset refractory status epilepticus (NORSE) in children, and investigated the relationship between fever onset and status epilepticus (SE). Methods Patients with r…

First-line medication dosing in pediatric refractory status epilepticus Open

Alejandra Vasquez, Marina Gaínza‐Lein, Nicholas S. Abend, Marta Amengual‐Gual, Anne E. Anderson , et al. · 2020

This study provides Class III evidence that patients with RSE who present with male sex, older age, no prior diagnosis of epilepsy, and delayed BZD treatment are more likely to receive low total BZD doses. This study provides Class III evi…

Association of guideline publication and delays to treatment in pediatric status epilepticus Open

Iván Sánchez Fernández, Nicholas S. Abend, Marta Amengual‐Gual, Anne E. Anderson, Ravindra Arya , et al. · 2020

Publication of evidence on delays in time to treatment was not associated with improvements in time to treatment of rSE, although it was associated with an increase in the proportion of patients who received at least 1 BZD before hospital …

Trainee Award Announcement Open

Yasmin Khakoo, J. Nicholas Brenton, John R. Mytinger, James J. Reese, Morris H. Scantlebury · 2020

Multiple Sclerosis in Children: Current and Emerging Concepts Open

J. Nicholas Brenton, Ryan Kammeyer, Lauren Gluck, Teri Schreiner, Naila Makhani · 2020

Multiple sclerosis is being increasingly recognized and diagnosed in children. In the past several years, advances have been made in diagnosing multiple sclerosis in children, identifying new genetic and environmental risk factors, delinea…

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