Jens Overgaard
YOU?
Author Swipe
View article: Failure pattern and salvage in head and neck cancer of unknown primary: A national study by DAHANCA
Failure pattern and salvage in head and neck cancer of unknown primary: A national study by DAHANCA Open
The study findings support a personalized treatment strategy guided by HPV status and highlight the importance of including salvage outcomes in treatment efficacy analyses.
View article: Late dysphagia after changes in high-dose clinical tumour volume margin for head and neck cancer patients
Late dysphagia after changes in high-dose clinical tumour volume margin for head and neck cancer patients Open
Background and purpose: One of the factors influencing disease control and toxicity risk after radiotherapy is selection of treatment volume margin. This study evaluates whether different gross tumour volume (GTV) to high-dose clinical tar…
View article: Eliminating the high-risk CTV1 margin in DAHANCA oropharyngeal radiotherapy: Dosimetric impact on dysphagia and organ-at-risk doses
Eliminating the high-risk CTV1 margin in DAHANCA oropharyngeal radiotherapy: Dosimetric impact on dysphagia and organ-at-risk doses Open
Background and purpose: Radiotherapy for head and neck cancer must balance tumour control with late toxicities such as dysphagia and xerostomia. Recent retrospective studies suggest that the margin from the gross tumour volume (GTV) to the…
View article: Dual-tracer autoradiographic analysis of glucose metabolism and hypoxia in orthotopic and PDX tumor models
Dual-tracer autoradiographic analysis of glucose metabolism and hypoxia in orthotopic and PDX tumor models Open
Background and purpose: Quantification/mapping of tumor hypoxia may guide pretreatment decision-making in radiation oncology. Hypoxia-selective positron emission tomography (PET) tracers, like 18F-fluoroazomycin arabinoside (FAZA), allow a…
View article: Hypoxia-induced radioresistance in squamous cell carcinoma of the anus treated with radiotherapy − a validating study
Hypoxia-induced radioresistance in squamous cell carcinoma of the anus treated with radiotherapy − a validating study Open
The expression of the 15 hypoxia-related genes and classification of tumors as more or less hypoxic based on pre-treatment tumor tissue were prognostic for LRF in a large SCCA dataset. This underlines the importance of hypoxia in SCCA and …
View article: Mutational profile of oropharyngeal squamous cell carcinoma in relation to HPV, tobacco smoking and prognosis with validation in the DAHANCA 19 randomized trial
Mutational profile of oropharyngeal squamous cell carcinoma in relation to HPV, tobacco smoking and prognosis with validation in the DAHANCA 19 randomized trial Open
Background and purpose: This study investigated prognostic biomarkers in oropharyngeal squamous cell carcinoma (OPSCC), with a focus on tumors related to human papillomavirus (HPV) infection and potential molecular effects of tobacco smoki…
View article: Subsite variation of HPV-related p16-expression in oropharynx cancer: Incidence and prognostic impact in a population-based DAHANCA cohort 1986–2020
Subsite variation of HPV-related p16-expression in oropharynx cancer: Incidence and prognostic impact in a population-based DAHANCA cohort 1986–2020 Open
p16-expression are implemented in the TNM8 classification of oropharyngeal cancer (OPSCC). Based on a nationwide cohort, we provide a detailed description of subsite variation in the age-standardised incidence-rates of OPSCC alongside an e…
View article: The <scp>DAHANCA</scp> 27 Phase <scp>II</scp> Study: Transoral Laser Microsurgery for <scp>T1aN0M0</scp> Glottic Squamous Cell Carcinoma, a Comparison to Accelerated Radiotherapy
The <span>DAHANCA</span> 27 Phase <span>II</span> Study: Transoral Laser Microsurgery for <span>T1aN0M0</span> Glottic Squamous Cell Carcinoma, a Comparison to Accelerated Radiotherapy Open
Introduction Endoscopic surgery of T1a glottic squamous cell carcinoma (SCC) is believed to have advantages compared to radiotherapy (RT), including short duration, cost‐effectiveness, repeatability, and RT reserved for second tumors/failu…
View article: A systematic review and proportional meta-analysis of image-based pattern of loco-regional failure analyses outcomes in head and neck squamous cell carcinoma
A systematic review and proportional meta-analysis of image-based pattern of loco-regional failure analyses outcomes in head and neck squamous cell carcinoma Open
Most loco-regional failures for patients treated with primary RT for HNSCC are related to the high-dose volume. Therefore, a focus on biomarkers predicting individual tumor radiosensitivity is warranted to enable individualized treatment i…
View article: The clinical utility of circulating human papillomavirus across squamous cell carcinomas
The clinical utility of circulating human papillomavirus across squamous cell carcinomas Open
Background and purpose: The similarities in biology, treatment regimens and outcome between the different human papillomavirus (HPV) associated squamous cell carcinomas (SCCs) allow for extrapolation of results generated from one SC tumor …
View article: ESHO 2–85. Hyperthermia as an adjuvant to radiation therapy in the treatment of advanced neck nodes: A randomized multicenter study by the European Society for Hyperthermic Oncology
ESHO 2–85. Hyperthermia as an adjuvant to radiation therapy in the treatment of advanced neck nodes: A randomized multicenter study by the European Society for Hyperthermic Oncology Open
Background and purpose: European Society for Hyperthermic Oncology (ESHO) 2–85 is a multicenter randomized trial investigating hyperthermia (HT) as an adjuvant to radiotherapy (RT) in treatment of locally advanced neck nodes. The trial nev…
View article: Internal mammary node irradiation in 4541 node-positive breast cancer patients treated with newer systemic therapies and 3D-based radiotherapy (DBCG IMN2): a prospective, nationwide, population-based cohort study
Internal mammary node irradiation in 4541 node-positive breast cancer patients treated with newer systemic therapies and 3D-based radiotherapy (DBCG IMN2): a prospective, nationwide, population-based cohort study Open
This work was supported by the Danish Cancer Society and Department of Clinical Medicine, Aarhus University, Denmark.
View article: The Rationale for Combining Hypofractionated Radiation and Hyperthermia
The Rationale for Combining Hypofractionated Radiation and Hyperthermia Open
The conventional radiation treatment of cancer patients has typically involved a large number of daily treatments with relatively low doses of radiation. However, improved technology has now resulted in the increased use of fewer radiation…
View article: Quality assurance of internal mammary node irradiation in the DBCG IMN2 study
Quality assurance of internal mammary node irradiation in the DBCG IMN2 study Open
For IMN_ESTRO_IC1-3, we found a significantly higher IMN dose coverage in right-sided than in left-sided patients supporting treatment according to study guidelines in the DBCG IMN2 study.
View article: Epidemiology and treatment outcome of nasopharyngeal carcinoma in a low-incidence population – a DAHANCA analysis in Denmark 2000–2018
Epidemiology and treatment outcome of nasopharyngeal carcinoma in a low-incidence population – a DAHANCA analysis in Denmark 2000–2018 Open
Introduction: Nasopharyngeal carcinoma (NPC) is a rare disease and most studies have therefore been conducted in endemic areas. The aim of this study was to describe epidemiology and treatment outcomes of NPC in a population-based, non-end…
View article: Lars R Holsti (1926–2023), Big name in Finnish and Nordic oncology
Lars R Holsti (1926–2023), Big name in Finnish and Nordic oncology Open
Holsti's childhood in Haapajärvi was cut short by the sudden death of his father.The family had to move to Helsinki.He entered the medical faculty in 1948.Specialization in cancer treatment was a matter of course for him.In the early years…
View article: Essential data variables for a minimum dataset for head and neck cancer trials and clinical research: HNCIG consensus recommendations and database
Essential data variables for a minimum dataset for head and neck cancer trials and clinical research: HNCIG consensus recommendations and database Open
The Head and Neck Cancer International Group (HNCIG) has undertaken an international modified Delphi process to reach consensus on the essential data variables to be included in a minimum database for HNC research. Endorsed by 19 research …
View article: High-dose loco-regional pattern of failure after primary radiotherapy in p16 positive and negative head and neck squamous cell carcinoma – A DAHANCA 19 study
High-dose loco-regional pattern of failure after primary radiotherapy in p16 positive and negative head and neck squamous cell carcinoma – A DAHANCA 19 study Open
Radioresistance is the primary cause of failure after RT for HNSCC irrespective of HPV/p16 status. Thus, focus on predictors for the response to RT is warranted to identify patients with higher risk of high-dose failure that might benefit …
View article: Separating distant recurrences from second primaries in head and neck squamous cell carcinomas – A <scp>DAHANCA</scp> group analysis on paired tumor samples
Separating distant recurrences from second primaries in head and neck squamous cell carcinomas – A <span>DAHANCA</span> group analysis on paired tumor samples Open
Background In head and neck squamous cell carcinomas (HNSCC), there is no clinically available method to separate distant metastases (DMs) from SCC secondary primary tumors. The study aimed to assess the genetic relationship in paired tumo…