J. Philip Miller
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View article: (334) Association Between Hand Dominance and Curve Laterality in Peyronie’s Disease: A Retrospective Analysis Patients Treated With Xiaflex
(334) Association Between Hand Dominance and Curve Laterality in Peyronie’s Disease: A Retrospective Analysis Patients Treated With Xiaflex Open
Introduction Peyronie’s disease (PD) commonly presents with penile curvature, with potential influences from hand dominance on curve laterality. Objective This study investigates the relationship between hand dominance and curve laterality…
View article: Associations between prenatal inflammation and dimensions of depressive symptoms across the perinatal period
Associations between prenatal inflammation and dimensions of depressive symptoms across the perinatal period Open
Findings provide additional evidence for the role of IL-6 and TNF-α in perinatal depressive symptoms. Anhedonia symptoms and third-trimester inflammation may be particularly important. Future work focusing on dimensions of depressive sympt…
View article: Evaluating and Optimizing Just-in-Time Adaptive Interventions in a Digital Mental Health Intervention (Wysa for Chronic Pain) for Middle-Aged and Older Adults With Chronic Pain: Protocol for a Series of Randomized Trials
Evaluating and Optimizing Just-in-Time Adaptive Interventions in a Digital Mental Health Intervention (Wysa for Chronic Pain) for Middle-Aged and Older Adults With Chronic Pain: Protocol for a Series of Randomized Trials Open
Background On a population level, digital mental health interventions effectively reduce depression and anxiety symptoms. However, middle-aged and older adults with chronic pain and coexisting depression or anxiety have not been adequately…
View article: OmniCellAgent: Towards AI Co-Scientists for Scientific Discovery in Precision Medicine
OmniCellAgent: Towards AI Co-Scientists for Scientific Discovery in Precision Medicine Open
The convergence of large language models (LLMs), AI agents, and large-scale omic datasets—such as single-cell omics, marks the arrival of a critical inflection point in biomedical research, via autonomous data mining and novel hypothesis g…
View article: Development of a mouse model for <i>Klebsiella pneumoniae</i> -associated neonatal sepsis
Development of a mouse model for <i>Klebsiella pneumoniae</i> -associated neonatal sepsis Open
Klebsiella pneumoniae is a major cause of neonatal sepsis in low- to middle-income countries. With the proportion of multidrug-resistant K. pneumoniae strains increasing globally and the lack of novel antibiotics in the pipeline, vaccinati…
View article: High‐Frequency, At‐Home Monitoring of Drug Safety and Tolerability in Clinical Trials: Results From Studies of Fluvoxamine for <scp>COVID</scp>‐19 Treatment
High‐Frequency, At‐Home Monitoring of Drug Safety and Tolerability in Clinical Trials: Results From Studies of Fluvoxamine for <span>COVID</span>‐19 Treatment Open
Clinical trials are increasingly using remote monitoring techniques at the patient's home. We conducted a secondary analysis of remote safety and tolerability monitoring from two fully‐remote clinical trials that tested fluvoxamine for the…
View article: Moderators of antidepressant augmentation versus switch in the OPTIMUM randomised controlled trial
Moderators of antidepressant augmentation versus switch in the OPTIMUM randomised controlled trial Open
Background Older adults with treatment-resistant depression (TRD) benefit more from treatment augmentation than switching. It is useful to identify moderators that influence these treatment strategies for personalised medicine. Aims Our ob…
View article: IL-1β/IRAK4 Axis Promotes Ovarian Tumor Development at the Mesothelium Injury Sites
IL-1β/IRAK4 Axis Promotes Ovarian Tumor Development at the Mesothelium Injury Sites Open
Epithelial ovarian cancer (EOC) cells seed at mesothelial inflammation or injury sites. Lack of animal models recapitulating tumor cells seeding at inflamed sites in EOC hinders mechanistic studies and therapy developments. Here, we develo…
View article: Neural Network for Correlated Survival Outcomes Using Frailty Model
Neural Network for Correlated Survival Outcomes Using Frailty Model Open
Extensive literature has been proposed for the analysis of correlated survival data. Subjects within a cluster share some common characteristics, e.g., genetic and environmental factors, so their time-to-event outcomes are correlated. The …
View article: How thermally stable are vanadium cathode Li-ion cells?
How thermally stable are vanadium cathode Li-ion cells? Open
Vanadium-based cathodes (ζ-V 2 O 5 , ε-VOPO 4 ) showed high capacity for enabling multi-electron transfer, with thermal stability comparable to that of LFP.
View article: BioMedGraphica: An All-in-One Platform for Joint Textual Biomedical Prior Knowledge and Numeric Graph Generation
BioMedGraphica: An All-in-One Platform for Joint Textual Biomedical Prior Knowledge and Numeric Graph Generation Open
Multi-omic data analysis is essential for scientific discovery in precision medicine. However, translating statistical results of omic data analysis into novel scientific hypothesis remains a significant challenge. Human experts must manua…
View article: Visual Field Progression in the Ocular Hypertension Treatment Study
Visual Field Progression in the Ocular Hypertension Treatment Study Open
Some participants in OHTS had rapid rates of VF loss in one or both eyes despite being followed in a clinical study. This emphasizes that ocular hypertensive patients require careful follow-up, especially those at high risk of developing P…
View article: Multicenter Clinical Performance Evaluation of the NeuMoDx CT/NG Assay 2.0
Multicenter Clinical Performance Evaluation of the NeuMoDx CT/NG Assay 2.0 Open
Background Given the continued increases in rates of both Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infection, additional diagnostic assays may be useful in increasing access to testing for these sexually transmitted infect…
View article: Prenatal social disadvantage is associated with alterations in functional networks at birth
Prenatal social disadvantage is associated with alterations in functional networks at birth Open
Childhood exposure to social disadvantage is a major risk factor for psychiatric disorders and poor developmental, educational, and occupational outcomes, presumably because adverse exposures alter the neurodevelopmental processes that con…
View article: Klebsiella pneumoniae Lipopolysaccharide as a Vaccine Target and the Role of Antibodies in Protection from Disease
Klebsiella pneumoniae Lipopolysaccharide as a Vaccine Target and the Role of Antibodies in Protection from Disease Open
Klebsiella pneumoniae is well recognized as a serious cause of infection in healthcare-associated settings and immunocompromised individuals; however, accumulating evidence from resource-limited nations documents an alarming rise in commun…
View article: The Cognitive Profile of Older Adults With Treatment-Resistant Depression: An Analysis of the OPTIMUM Randomized Controlled Trial
The Cognitive Profile of Older Adults With Treatment-Resistant Depression: An Analysis of the OPTIMUM Randomized Controlled Trial Open
Participants with TR-LLD presented with broad cognitive deficits relative to healthy norms. Given poorer outcomes following standard pharmacotherapy associated with impaired set shifting, future research needs to identify alternative treat…
View article: Poor Sleep is Common in Treatment-Resistant Late-life Depression and Associated With Poorer Antidepressant Response: Findings From the OPTIMUM Clinical Trial
Poor Sleep is Common in Treatment-Resistant Late-life Depression and Associated With Poorer Antidepressant Response: Findings From the OPTIMUM Clinical Trial Open
Insufficient sleep is common in TRLLD and it is associated with poorer treatment response to antidepressants.
View article: Health Care Provider Clustering Using Fusion Penalty in Quasi‐Likelihood
Health Care Provider Clustering Using Fusion Penalty in Quasi‐Likelihood Open
There has been growing research interest in developing methodology to evaluate the health care providers' performance with respect to a patient outcome. Random and fixed effects models are traditionally used for such a purpose. We propose …
View article: Associations between prenatal adversity and neonatal white matter microstructure on language outcomes at age 2 years
Associations between prenatal adversity and neonatal white matter microstructure on language outcomes at age 2 years Open
Background Early life adversity is associated with microstructural alterations in white matter regions that subserve language. However, the mediating and moderating pathways between adversities experienced in utero and key neonatal white m…
View article: Relationship between Patient Health Questionnaire (PHQ-9) and Montgomery-Asberg Depression Rating Scale (MADRS) total scores in older adults with major depressive disorder: An analysis of the OPTIMUM clinical trial
Relationship between Patient Health Questionnaire (PHQ-9) and Montgomery-Asberg Depression Rating Scale (MADRS) total scores in older adults with major depressive disorder: An analysis of the OPTIMUM clinical trial Open
Our conversion tables relating PHQ-9 and MADRS scores can be used to compare treatment outcomes using aggregate data in studies that only used one of these scales.
View article: Long-term outcomes of peripheral blood stem cell unrelated donors mobilized with filgrastim
Long-term outcomes of peripheral blood stem cell unrelated donors mobilized with filgrastim Open
Allogeneic hematopoietic cell transplantation is a life-saving procedure used to treat a variety of devastating diseases. It requires hematopoietic stem cells collected via filgrastim-mobilized peripheral blood stem cells (PBSCs) or bone m…
View article: Perioperative mental health intervention for depression and anxiety symptoms in older adults study protocol: design and methods for three linked randomised controlled trials
Perioperative mental health intervention for depression and anxiety symptoms in older adults study protocol: design and methods for three linked randomised controlled trials Open
Introduction Preoperative anxiety and depression symptoms among older surgical patients are associated with poor postoperative outcomes, yet evidence-based interventions for anxiety and depression have not been applied within this setting.…
View article: Forchlorfenuron-Induced Mitochondrial Respiration Inhibition and Metabolic Shifts in Endometrial Cancer
Forchlorfenuron-Induced Mitochondrial Respiration Inhibition and Metabolic Shifts in Endometrial Cancer Open
Forchlorfenuron (FCF) is a widely used plant cytokinin that enhances fruit quality and size in agriculture. It also serves as a crucial pharmacological tool for the inhibition of septins. However, the precise target of FCF has not yet been…
View article: Maternal prenatal social disadvantage and neonatal functional connectivity: Associations with psychopathology symptoms at age 12 months.
Maternal prenatal social disadvantage and neonatal functional connectivity: Associations with psychopathology symptoms at age 12 months. Open
Recent research has reported effects of socioeconomic status on neurobehavioral development as early as infancy, including positive associations between income and brain structure, functional connectivity, and behavior later in childhood (…
View article: Prenatal exposure to maternal disadvantage-related inflammatory biomarkers: associations with neonatal white matter microstructure
Prenatal exposure to maternal disadvantage-related inflammatory biomarkers: associations with neonatal white matter microstructure Open
Prenatal exposure to heightened maternal inflammation has been associated with adverse neurodevelopmental outcomes, including atypical brain maturation and psychiatric illness. In mothers experiencing socioeconomic disadvantage, immune act…
View article: Precision Medicine: Interaction Survival Tree for Recurrent Event Data
Precision Medicine: Interaction Survival Tree for Recurrent Event Data Open
In randomized controlled trials, individual subjects experiencing recurrent events may display heterogeneous treatment effects. That is, certain subjects might experience beneficial effects, while others might observe negligible improvemen…
View article: Deep learning models to predict primary open‐angle glaucoma
Deep learning models to predict primary open‐angle glaucoma Open
Summary Glaucoma is a major cause of blindness and vision impairment worldwide, and visual field (VF) tests are essential for monitoring the conversion of glaucoma. While previous studies have primarily focused on using VF data at a single…