Philip Wenzel
YOU?
Author Swipe
View article: Warfarin reduces circulating white blood cell count: Post-hoc analysis of two randomized trials
Warfarin reduces circulating white blood cell count: Post-hoc analysis of two randomized trials Open
Warfarin is a widely used vitamin K antagonist (VKA) with known pleiotropic effects beyond anticoagulation. Preclinical and case-control evidence suggests that warfarin may affect hematopoiesis, but longitudinal human evidence is lacking. …
View article: Echocardiographic Changes With Mavacamten in Nonobstructive Hypertrophic Cardiomyopathy
Echocardiographic Changes With Mavacamten in Nonobstructive Hypertrophic Cardiomyopathy Open
View article: Side-by-Side Comparison of Culture Media Uncovers Phenotypic and Functional Differences in Primary Mouse Aortic Mural Cells
Side-by-Side Comparison of Culture Media Uncovers Phenotypic and Functional Differences in Primary Mouse Aortic Mural Cells Open
(1) Background: Vascular mural cells reside in the media and outer layers of the vessel wall. Their ability to proliferate and migrate or to change phenotype in response to external cues is a central feature of the vascular response to inj…
View article: CD40-TRAF6 inhibition suppresses cardiovascular inflammation, oxidative stress and functional complications in a mouse model of arterial hypertension
CD40-TRAF6 inhibition suppresses cardiovascular inflammation, oxidative stress and functional complications in a mouse model of arterial hypertension Open
Cardiovascular disease is the leading cause of disease burden and death worldwide and is fueled by vascular inflammation. CD40L-CD40-TRAF signaling is involved in the progression of atherosclerosis and drives the development of coronary he…
View article: Antagonizing IL-17A reduces vascular inflammation and oxidative stress formation but not vascular dysfunction induced by one week of Angiotensin II treatment
Antagonizing IL-17A reduces vascular inflammation and oxidative stress formation but not vascular dysfunction induced by one week of Angiotensin II treatment Open
View article: Decipher-HFpEF (DZHK 12): normalization of T1 and T2 maps using travelling volunteers
Decipher-HFpEF (DZHK 12): normalization of T1 and T2 maps using travelling volunteers Open
View article: Antagonizing IL-17A reduces vascular inflammation and oxidative stress formation but not vascular dysfunction induced by one week of Angiotensin II treatment
Antagonizing IL-17A reduces vascular inflammation and oxidative stress formation but not vascular dysfunction induced by one week of Angiotensin II treatment Open
View article: Erratum to ‘Illustrated State-of-the-Art Capsules of the ISTH 2024 Congress’ [Research and Practice in Thrombosis and Haemostasis Volume 8, Issue 4, May 2024, 102432]
Erratum to ‘Illustrated State-of-the-Art Capsules of the ISTH 2024 Congress’ [Research and Practice in Thrombosis and Haemostasis Volume 8, Issue 4, May 2024, 102432] Open
View article: Erratum to ‘Illustrated State-of-the-Art Capsules of the ISTH 2024 Congress’ [Research and Practice in Thrombosis and Haemostasis Volume 8, Issue 4, May 2024, 102432]
Erratum to ‘Illustrated State-of-the-Art Capsules of the ISTH 2024 Congress’ [Research and Practice in Thrombosis and Haemostasis Volume 8, Issue 4, May 2024, 102432] Open
Erratum to "Illustrated State-of-the-Art Capsules of the ISTH 2024 Congress"
View article: Myeloid cell-derived interleukin-6 induces vascular dysfunction and vascular and systemic inflammation
Myeloid cell-derived interleukin-6 induces vascular dysfunction and vascular and systemic inflammation Open
Aims The cytokine interleukin-6 (IL-6) plays a central role in the inflammation cascade as well as cardiovascular disease progression. Since myeloid cells are a primary source of IL-6 formation, we aimed to generate a mouse model to study …
View article: Atherosclerosis is an inflammatory disease: treat it as such!
Atherosclerosis is an inflammatory disease: treat it as such! Open
View article: Illustrated State-of-the-Art Capsules of the ISTH 2024 Congress
Illustrated State-of-the-Art Capsules of the ISTH 2024 Congress Open
Here, we present a series of illustrated capsules from the State of the Art (SOA) speakers at the 2024 International Society on Thrombosis and Haemostasis Congress in Bangkok, Thailand. This year's Congress marks the first time that the In…
View article: Vascular dysfunction and arterial hypertension in experimental celiac disease are mediated by gut-derived inflammation and oxidative stress
Vascular dysfunction and arterial hypertension in experimental celiac disease are mediated by gut-derived inflammation and oxidative stress Open
Our study sheds light in the heightened cardiovascular risk associated with active CeD, revealing a gut-to-cardiovascular inflammatory axis potentially mediated by immune cell infiltration and IL-17A. These findings augment our understandi…
View article: Protected high risk percutaneous coronary intervention—Impella 5.0 as a single-access technique: a case report
Protected high risk percutaneous coronary intervention—Impella 5.0 as a single-access technique: a case report Open
Background Patients requiring coronary intervention after acute myocardial infarction, with decompensated heart failure and multiple co-morbidities, present a challenging clinical scenario. Addressing such high-risk cases has been a marked…
View article: Etiologies and predictors of mortality in an all-comer population of patients with non-ischemic heart failure
Etiologies and predictors of mortality in an all-comer population of patients with non-ischemic heart failure Open
Background Despite progress in diagnosis and therapy of heart failure (HF), etiology and risk stratification remain elusive in many patients. Methods The My Biopsy HF Study (German clinical trials register number: DRKS22178) is a retrospec…
View article: Health position paper and redox perspectives - Disease burden by transportation noise
Health position paper and redox perspectives - Disease burden by transportation noise Open
View article: A nationwide trend analysis on the usage of endomyocardial biopsy
A nationwide trend analysis on the usage of endomyocardial biopsy Open
Background Endomyocardial biopsy (EMB) is a safe procedure performed in diagnostic work‐up of cardiac disease. Hypothesis Data regarding temporal trends of total numbers, characteristics, in‐hospital outcomes, and complications of patients…
View article: Inflammation in endomyocardial biopsies correlates with improved cardiac recovery and correlates inversely with mortality in patients with non-ischemic heart failure with reduced ejection fraction
Inflammation in endomyocardial biopsies correlates with improved cardiac recovery and correlates inversely with mortality in patients with non-ischemic heart failure with reduced ejection fraction Open
Background Heart failure (HF) is a major cause of morbidity, mortality and healthcare costs worldwide. Although the overall mortality is high, individual outcomes show a large variability, reflecting our incomplete comprehension of the com…
View article: MyD88 in myeloid cells promotes angiotensin II-induced vascular inflammation and is associated with all-cause mortality and incident heart failure in humans with arterial hypertension
MyD88 in myeloid cells promotes angiotensin II-induced vascular inflammation and is associated with all-cause mortality and incident heart failure in humans with arterial hypertension Open
Background Angiotensin II (AngII) causes hypertension and promotes vascular accumulation of inflammatory cells. We aimed to determine how myeloid factor of differentiation 88 (MyD88) contributes to vascular dysfunction and arterial hyperte…
View article: CRIP1: Role in the pathogenesis of hypertension by regulating interactions with cytoskeletal proteins
CRIP1: Role in the pathogenesis of hypertension by regulating interactions with cytoskeletal proteins Open
Background Hypertension is a complex polygenic disease and the underlying molecular mechanisms remain unknown. In an interdisciplinary approach, we identified cysteine-rich protein 1 (CRIP1) in human monocytes as being strongly associated …
View article: OC 70.5 Coagulation Factor XI Contributes to the Infarct Size and Inflammationin Myocardial Ischemia/Reperfusion Injury
OC 70.5 Coagulation Factor XI Contributes to the Infarct Size and Inflammationin Myocardial Ischemia/Reperfusion Injury Open
View article: Evaluation of right-ventricular function by two-dimensional echocardiography and two-dimensional speckle-tracking echocardiography in patients with successful RCA CTO recanalization
Evaluation of right-ventricular function by two-dimensional echocardiography and two-dimensional speckle-tracking echocardiography in patients with successful RCA CTO recanalization Open
View article: Cardiac MRI Findings in Patients Clinically Referred for Evaluation of Post-Acute Sequelae of SARS-CoV-2 Infection
Cardiac MRI Findings in Patients Clinically Referred for Evaluation of Post-Acute Sequelae of SARS-CoV-2 Infection Open
Persistent or recurrent cardiovascular symptoms have been identified as one of the hallmarks of long-COVID or post-acute sequelae of SARS-CoV-2 infection (PASC). The purpose of this study was to determine the prevalence and extent of cardi…
View article: Reactive oxygen species produced by myeloid cells in psoriasis as a potential biofactor contributing to the development of vascular inflammation
Reactive oxygen species produced by myeloid cells in psoriasis as a potential biofactor contributing to the development of vascular inflammation Open
Psoriasis is an immune‐mediated inflammatory skin disease driven by interleukin‐17A (IL‐17A) and associated with cardiovascular dysfunction. We used a severe psoriasis mouse model of keratinocyte IL‐17A overexpression (K14‐IL‐17A ind/+ , I…
View article: Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis
Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis Open
The Fourth Maastricht Consensus Conference on Thrombosis included the following themes. Theme 1: The “coagulome” as a critical driver of cardiovascular disease. Blood coagulation proteins also play divergent roles in biology and pathophysi…
View article: Evaluation of right atrial function by two-dimensional echocardiography and strain imaging in patients with RCA CTO recanalization
Evaluation of right atrial function by two-dimensional echocardiography and strain imaging in patients with RCA CTO recanalization Open
Objectives The right heart is mainly supplied with blood by the right coronary artery (RCA). The impact of RCA chronic total occlusion (CTO) on the function of the right heart [right atrium (RA) and ventricle (RV)] and whether successful r…
View article: Cardiac MRI-based right-to-left ventricular blood pool T2 relaxation times ratio correlates with exercise capacity in patients with chronic heart failure
Cardiac MRI-based right-to-left ventricular blood pool T2 relaxation times ratio correlates with exercise capacity in patients with chronic heart failure Open
The proposed RV/LV T2 ratio, obtained by two simple measurements on a routinely acquired four-chamber T2 map, was superior to established parameters of cardiac function to predict exercise capacity and the presence of post-exercise dyspnea…
View article: Aircraft noise exposure induces pro-inflammatory vascular conditioning and amplifies vascular dysfunction and impairment of cardiac function after myocardial infarction
Aircraft noise exposure induces pro-inflammatory vascular conditioning and amplifies vascular dysfunction and impairment of cardiac function after myocardial infarction Open
Aims Traffic noise may play an important role in the development and deterioration of ischaemic heart disease. Thus, we sought to determine the mechanisms of cardiovascular dysfunction and inflammation induced by aircraft noise in a mouse …
View article: Targeting myeloid cell coagulation signaling blocks MAP kinase/TGF-β1–driven fibrotic remodeling in ischemic heart failure
Targeting myeloid cell coagulation signaling blocks MAP kinase/TGF-β1–driven fibrotic remodeling in ischemic heart failure Open
Despite major advances in acute interventions for myocardial infarction (MI), adverse cardiac remodeling and excess fibrosis after MI causing ischemic heart failure (IHF) remain a leading cause of death worldwide. Here we identify a profib…
View article: Arginase-1 Deletion in Erythrocytes Promotes Vascular Calcification via Enhanced GSNOR (S-Nitrosoglutathione Reductase) Expression and NO Signaling in Smooth Muscle Cells
Arginase-1 Deletion in Erythrocytes Promotes Vascular Calcification via Enhanced GSNOR (S-Nitrosoglutathione Reductase) Expression and NO Signaling in Smooth Muscle Cells Open
Background: Erythrocytes (red blood cells) participate in the control of vascular NO bioavailability. The purpose of this study was to determine whether and how genetic deletion of ARG1 (arginase-1) affects vascular smooth muscle cell NO s…