John Wright
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View article: A genes and health recall study of intrahepatic cholestasis of pregnancy and cholestatic liver disease
A genes and health recall study of intrahepatic cholestasis of pregnancy and cholestatic liver disease Open
Background Cholestatic liver disease disproportionately affects South Asians, yet they remain underrepresented in genomic studies. This recall study aimed to recall volunteers from a British South Asian genetic cohort that were considered …
View article: BiB: Age of Wonder data release
BiB: Age of Wonder data release Open
Born in Bradford (BiB): Age of Wonder is a seven-year research programme documenting the experiences of adolescents growing up in a large, multi-ethnic city in the UK. It is an extension of the Born in Bradford birth cohort study (Wright …
View article: Cell type-specific methylome-wide association studies of childhood ADHD symptoms
Cell type-specific methylome-wide association studies of childhood ADHD symptoms Open
Studying DNA methylation (DNAm) can provide insights into gene-regulatory mechanisms underlying attention-deficit/hyperactivity disorder (ADHD). While most DNAm studies were performed in bulk tissue, this study used statistical deconvoluti…
View article: Antenatal Corticosteroids and Infectious Diseases Throughout Childhood
Antenatal Corticosteroids and Infectious Diseases Throughout Childhood Open
Importance International guidelines recommend the use of antenatal corticosteroids (ACS) in pregnancies at risk of imminent preterm birth before 34 weeks’ gestation. However, whether ACS leads to long-term risk of infection from childhood …
View article: Undiagnosed G6PD Deficiency in Black and Asian Individuals Is Prevalent and Contributes to Health Inequalities in Type 2 Diabetes Diagnosis and Complications
Undiagnosed G6PD Deficiency in Black and Asian Individuals Is Prevalent and Contributes to Health Inequalities in Type 2 Diabetes Diagnosis and Complications Open
OBJECTIVE Glucose-6-phosphate dehydrogenase (G6PD) deficiency presents silently and is not routinely screened. It is associated with markedly lower HbA1c for the prevailing glucose levels. Since HbA1c is internationally recommended to diag…
View article: Born and Bred in (BaBi): an efficient, place-based birth e-cohort network
Born and Bred in (BaBi): an efficient, place-based birth e-cohort network Open
Background Routine datasets are increasingly used in research to learn more about health and care systems over time. This paper describes the protocol for a novel, multi-site, life course e-cohort embedded in standard clinical practice: Th…
View article: Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity
Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity Open
Genes and Health (G&H) is a biomedical study of adult British-Pakistani and -Bangladeshi research volunteers enriched for autozygosity. We performed whole exome sequencing in 44,028 G&H participants, establishing the largest publicly avail…
View article: A good move for health?: Analyzing urban exposure trajectories of residential relocation and mental health in populations in Bradford
A good move for health?: Analyzing urban exposure trajectories of residential relocation and mental health in populations in Bradford Open
Residential relocation can be leveraged as a natural experiment. This study examined the changes in environmental exposures due to residential relocation in two samples of within-city movers in Bradford (UK); 2089 residents (66% women, mea…
View article: The emergence of common health conditions across the life course: evidence from the Born in Bradford family cohort
The emergence of common health conditions across the life course: evidence from the Born in Bradford family cohort Open
Background Born in Bradford (BiB) is a family cohort study with linked routine health records. We calculated the rates of common health conditions and explored differences between White European and South Asian participants. Methods 21 hea…
View article: Understanding Social Inequalities in Childhood Asthma: Quantifying the Mediating Role of Modifiable Early-Life Risk Factors in Seven European Birth Cohorts
Understanding Social Inequalities in Childhood Asthma: Quantifying the Mediating Role of Modifiable Early-Life Risk Factors in Seven European Birth Cohorts Open
There was a consistent tendency for children from disadvantaged SECs to be at greater risk of asthma in the European cohorts examined. Our results suggest that early-life risk factors partially mediate these disparities and, therefore, tha…
View article: Trajectory of Early Life Adiposity Among South Asian Children
Trajectory of Early Life Adiposity Among South Asian Children Open
Importance Measures of childhood adiposity merit investigation, particularly in individuals of South Asian descent. Objective To investigate prenatal and childhood factors associated with the trajectory of adiposity in South Asian children…
View article: The association between prenatal and early-life antibiotic use and obesity at 4-5 years in the Born in Bradford birth cohort
The association between prenatal and early-life antibiotic use and obesity at 4-5 years in the Born in Bradford birth cohort Open
Introduction The prevalence of childhood obesity has quadrupled globally over the last 30 years highlighting the urgency for robust research on modifiable risk factors. This study investigates the association between prenatal and early-lif…
View article: Can inflammatory bowel disease be treated with diet?
Can inflammatory bowel disease be treated with diet? Open
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View article: Early-life Exposome and Health-related Immune Signatures in Childhood
Early-life Exposome and Health-related Immune Signatures in Childhood Open
Background Early-life environmental exposures are suspected to modify important immune processes related to child health. Yet, no study has investigated immunotoxicity in relation to the exposome and multiple health domains simultaneously.…
View article: UK Longitudinal Linkage Collaboration (UK LLC): The National Trusted Research Environment for Longitudinal Research
UK Longitudinal Linkage Collaboration (UK LLC): The National Trusted Research Environment for Longitudinal Research Open
IntroductionThe UK Longitudinal Linkage Collaboration (UK LLC) is the national Trusted Research Environment (TRE) for the UK's longitudinal research community, supporting the UK's unparalleled collection of Longitudinal Population Studies …
View article: Conducting longitudinal cohort research in secondary schools: Insights from the Born in Bradford Age of Wonder study
Conducting longitudinal cohort research in secondary schools: Insights from the Born in Bradford Age of Wonder study Open
Background Adolescence is a critical period of development which paves the way for longer term health trajectories and lifestyles. Understanding the variety of factors which influence adolescent health is crucial to developing intervention…
View article: Multi-omics architecture of childhood obesity and metabolic dysfunction uncovers biological pathways and prenatal determinants
Multi-omics architecture of childhood obesity and metabolic dysfunction uncovers biological pathways and prenatal determinants Open
Childhood obesity poses a significant public health challenge, yet the molecular intricacies underlying its pathobiology remain elusive. Leveraging extensive multi-omics profiling (methylome, miRNome, transcriptome, proteins and metabolite…
View article: Optical properties of unoxidized and oxidized titanium nitride thin films
Optical properties of unoxidized and oxidized titanium nitride thin films Open
This study reports a pulsed laser deposition-assisted synthesis of highly metallic titanium nitride (TiN) and a series of semiconducting titanium oxynitride (TiN x O y ) compounds in thin film form with tunable plasmonic properties by care…
View article: Association of exposure to second-hand smoke during childhood with blood DNA methylation
Association of exposure to second-hand smoke during childhood with blood DNA methylation Open
Our findings highlight the potential biological effects of SHS on blood DNAm. These findings support further research on epigenetic factors mediating deleterious effects of SHS on child health and call for public health policies aimed at r…