José Rodrigo Pauli
YOU?
Author Swipe
View article: Supplementation with GPR120 (Ffar4) ligand omega-3 does not improve survival in murine sepsis models
Supplementation with GPR120 (Ffar4) ligand omega-3 does not improve survival in murine sepsis models Open
This study uncovers worsening in survival in mice models pretreated with omega-3 supplementation. We demonstrated decreased Ffar4 receptor expression in macrophages and adipocytes when challenged with acute and chronic sepsis models in vit…
View article: Time‐restricted feeding combined with exercise improves hepatic and glycaemic metabolism in obese mice: A sex‐dependent study
Time‐restricted feeding combined with exercise improves hepatic and glycaemic metabolism in obese mice: A sex‐dependent study Open
Erratic feeding patterns, such as those experienced by shift workers, can exacerbate obesity and metabolic‐associated fatty liver disease (MAFLD). Both nutritional factors and sexual dimorphism influence the progression of MAFLD. Time‐rest…
View article: NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity
NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity Open
Brown adipose tissue (BAT) is a highly specialized thermogenic tissue and plays a critical role in controlling energy expenditure and metabolic homeostasis. BAT dysfunction is associated with body weight gain and metabolic disorders in mic…
View article: Notch1 Signalling Is Downregulated by Aerobic Exercise, Leading to Improvement of Hepatic Metabolism in Obese Mice
Notch1 Signalling Is Downregulated by Aerobic Exercise, Leading to Improvement of Hepatic Metabolism in Obese Mice Open
Background and Aims Notch1 protein plays a significant role in hepatic metabolism, as evidenced by its correlation with insulin resistance in the livers of obese individuals, making it an intriguing research target. Therefore, this study a…
View article: Author Correction: Hypothalamic S1P/S1PR1 axis controls energy homeostasis
Author Correction: Hypothalamic S1P/S1PR1 axis controls energy homeostasis Open
Correction to: Nature Communicationshttps://doi.org/10.1038/ncomms5859, published online 25 September 2014 In the original version of this Article, the Western blot images of Tubulin from the arcuate nucleus and hindbrain and the blots of …
View article: Short‐term exercise counteracts accelerated ageing impacts on physical performance and liver health in mice
Short‐term exercise counteracts accelerated ageing impacts on physical performance and liver health in mice Open
Senescence impairs liver physiology, mitochondrial function and circadian regulation, resulting in systemic metabolic dysregulation. Given the limited research on the effects of combined exercise on an ageing liver, this study aimed to eva…
View article: Physical exercise elicits UPRmt in the skeletal muscle: The role of c-Jun N-terminal kinase
Physical exercise elicits UPRmt in the skeletal muscle: The role of c-Jun N-terminal kinase Open
Our findings provide new insights into how exercise triggers mitostress signals toward the oxidative capacity in the skeletal muscle.
View article: Time-restricted feeding combined with resistance exercise prevents obesity and improves lipid metabolism in the liver of mice fed a high-fat diet
Time-restricted feeding combined with resistance exercise prevents obesity and improves lipid metabolism in the liver of mice fed a high-fat diet Open
Whether time-restricted feeding (TRF) combined with resistance exercise training (RT) may be more efficient compared with these interventions alone is still unclear. We show that when combined with RT, TRF provided additional benefits, bei…
View article: Time-Restricted Feeding and Weight Loss in Obesity: A Mini Review on the Impacts on Skeletal Muscle Mass
Time-Restricted Feeding and Weight Loss in Obesity: A Mini Review on the Impacts on Skeletal Muscle Mass Open
Across the globe, obesity is a significant concern for public health, a disease characterized by excessive accumulation of body fat, with a negative impact on health. Time-restricted feeding (TRF), in which food accessibility is restricted…
View article: An obesogenic diet mitigates brown adipose tissue‐induced thermogenesis, shifting the metabolism towards triacylglycerol synthesis and favouring obesity development
An obesogenic diet mitigates brown adipose tissue‐induced thermogenesis, shifting the metabolism towards triacylglycerol synthesis and favouring obesity development Open
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
View article: Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice
Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice Open
These results demonstrate that lower PKCθ/PKCε activity and sn-1,2-DAG content, especially in the PM compartment, can explain the preserved muscle insulin sensitivity in RC-EXE mice.
View article: Mirabegron and Physical Exercise Is a Potential Strategical for BAT Activation in Obesity
Mirabegron and Physical Exercise Is a Potential Strategical for BAT Activation in Obesity Open
(1) Background: Obesity is a global epidemic issue that has increased greatly in recent decades. Although interventions such as nutritional approaches and the practice of physical exercise are potential therapies to combat obesity, in some…
View article: IL-6 deletion decreased REV-ERBα protein and influenced autophagy and mitochondrial markers in the skeletal muscle after acute exercise
IL-6 deletion decreased REV-ERBα protein and influenced autophagy and mitochondrial markers in the skeletal muscle after acute exercise Open
Interleukin 6 (IL-6) acts as a pro and anti-inflammatory cytokine, has an intense correlation with exercise intensity, and activates various pathways such as autophagy and mitochondrial unfolded protein response. Also, IL-6 is interconnect…
View article: Liraglutide and Exercise: A Possible Treatment for Obesity?
Liraglutide and Exercise: A Possible Treatment for Obesity? Open
(1) Background: Obesity has become an important public health problem worldwide, and its characterization as a chronic disease reflects the impact of a complex and multifactorial condition. The treatment for obesity is based on lifestyle i…
View article: Evidence for a neuromuscular circuit involving hypothalamic interleukin-6 in the control of skeletal muscle metabolism
Evidence for a neuromuscular circuit involving hypothalamic interleukin-6 in the control of skeletal muscle metabolism Open
Hypothalamic interleukin-6 (IL6) exerts a broad metabolic control. Here, we demonstrated that IL6 activates the ERK1/2 pathway in the ventromedial hypothalamus (VMH), stimulating AMPK/ACC signaling and fatty acid oxidation in mouse skeleta…
View article: Strength training alters the tissue fatty acids profile and slightly improves the thermogenic pathway in the adipose tissue of obese mice
Strength training alters the tissue fatty acids profile and slightly improves the thermogenic pathway in the adipose tissue of obese mice Open
Obesity is a disease characterized by the exacerbated increase of adipose tissue. A possible way to decrease the harmful effects of excessive adipose tissue is to increase the thermogenesis process, to the greater energy expenditure genera…
View article: Using Intermittent Fasting as a Non-pharmacological Strategy to Alleviate Obesity-Induced Hypothalamic Molecular Pathway Disruption
Using Intermittent Fasting as a Non-pharmacological Strategy to Alleviate Obesity-Induced Hypothalamic Molecular Pathway Disruption Open
Intermittent fasting (IF) is a popular intervention used to fight overweight/obesity. This condition is accompanied by hypothalamic inflammation, limiting the proper signaling of molecular pathways, with consequent dysregulation of food in…
View article: Evidence for a neuromuscular circuit involving hypothalamic Interleukin-6 signaling in the control of skeletal muscle metabolism
Evidence for a neuromuscular circuit involving hypothalamic Interleukin-6 signaling in the control of skeletal muscle metabolism Open
Hypothalamic interleukin-6 (IL6) exerts a broad metabolic control, including energy expenditure1, food consumption2, glucose homeostasis2, etc. Here we demonstrated that Interleukin-6 (IL6) activates the ERK1/2 pathway in the ventromedial …
View article: Exercise Counterbalances Rho/ROCK2 Signaling Impairment in the Skeletal Muscle and Ameliorates Insulin Sensitivity in Obese Mice
Exercise Counterbalances Rho/ROCK2 Signaling Impairment in the Skeletal Muscle and Ameliorates Insulin Sensitivity in Obese Mice Open
Physical exercise is considered a fundamental strategy in improving insulin sensitivity and glucose uptake in skeletal muscle. However, the molecular mechanisms underlying this regulation, primarily on skeletal muscle glucose uptake, are n…
View article: Short-Term Strength Exercise Reduces Hepatic Insulin Resistance in Obese Mice by Reducing PTP1B Content, Regardless of Changes in Body Weight
Short-Term Strength Exercise Reduces Hepatic Insulin Resistance in Obese Mice by Reducing PTP1B Content, Regardless of Changes in Body Weight Open
Obesity is closely related to insulin resistance and type 2 diabetes genesis. The liver is a key organ to glucose homeostasis since insulin resistance in this organ increases hepatic glucose production (HGP) and fasting hyperglycemia. The …