Explanipedia

Alcohol use disorder and use of rhythm control therapies in patients with atrial fibrillation: A nationwide cohort study Open

Miika Vanhanen, Jussi Jaakkola, Juhani Airaksinen, Olli Halminen, Jukka Putaala , et al. · 2025

AUD is independently associated with markedly lower use of rhythm control therapies in AF patients. These disparities are most pronounced among socioeconomically disadvantaged individuals, highlighting the need for targeted interventions t…

Association of Subgingival Microbiota Composition With Risk, Severity, and Outcome of Cryptogenic Ischemic Stroke in Young Adults Open

Muhammed Manzoor, Svetislav Zarić, Anbo Dong, Jaakko Leskelä, Milla Pietiäinen , et al. · 2025

Background Oral and gut dysbiosis has been linked to stroke pathogenesis and its prognosis. However, the relationship between the subgingival microbiota and cryptogenic ischemic stroke (CIS) remains unclear. We compared the subgingival mic…

Psychiatric disorders after traumatic intracranial hemorrhage: the HEAD Helsinki study Open

Janne Kinnunen, Jukka Putaala, Ivan Marinković, Jarno Satopää, Mika Niemelä , et al. · 2025

s Background The extent of psychiatric disorders after head injury is not well recognized. We assessed the prevalence and treatment of psychiatric disorders after traumatic intracranial hemorrhage (tICH) in a 10-year follow-up. Methods An …

Oral Microbial Determinants of Saliva and Serum Lipopolysaccharide Activity Open

Muhammed Manzoor, Jukka Putaala, Svetislav Zarić, Jaakko Leskelä, Airong Dong , et al. · 2025

Lipopolysaccharide (LPS) is a virulence factor of gram-negative bacteria, and endotoxemia or translocation of LPS in serum plays a significant role in oral and systemic pathologies. The contribution of the oral microbiome composition to sa…

Cost Differences Between Oral Anticoagulation Therapies in Patients with Atrial Fibrillation in Finland Open

Ossi Lehtonen, Olli Halminen, Juhani Airaksinen, Jari Haukka, Jukka Putaala , et al. · 2025

EUPAS29845.

Seizures after decompressive surgery for cerebral venous thrombosis Open

Mayte Sánchez van Kammen, Sanjith Aaron, Jorge M. Ferreira, Patrícia Canhão, Adriana Bastos Conforto , et al. · 2025

Introduction The incidence and outcomes of seizures among patients with severe cerebral venous thrombosis treated with decompressive surgery are unknown as are potential predictors of seizures in these patients. Patients and methods We rep…

Venous thromboembolisms and stroke risk in patients with atrial fibrillation: a nationwide cohort study Open

Eero Jalli, Jussi Jaakkola, Ville L. Langén, Juhani Airaksinen, Olli Halminen , et al. · 2025

Medicine Physics Engineering

Aims Little is known about the association of venous thromboembolisms (VTEs) on the risk of ischaemic stroke (IS) in patients with atrial fibrillation (AF). Nevertheless, both pulmonary embolism (PE) and deep venous thromboembolism (DVT) a…

Heart Failure and Stroke Risk in Atrial Fibrillation: Temporal Trends From a Nationwide Cohort Study Open

Eero Jalli, Ville L. Langén, Jussi Jaakkola, Juhani Airaksinen, Olli Halminen , et al. · 2025

Medicine Engineering

Background Heart failure (HF) is a well‐recognized risk factor for ischemic stroke (IS) in patients with atrial fibrillation (AF). Advancements in medical research have significantly improved the detection and management of both AF and HF.…

Anti-beta2-glycoprotein I IgG antibodies are associated with early-onset cryptogenic ischemic stroke Open

Nina Jaakonmäki, Tuukka Helin, Tímea Szántó, Marialuisa Zedde, Tomi Sarkanen , et al. · 2025

Medicine Engineering

Background: Previously undetected antiphospholipid antibodies (aPLs) potentially provide explanations for early-onset cryptogenic ischemic stroke (CIS). Prior association studies conducted over a decade ago were inconclusive and not focuse…

CEREBRAL MICROBLEEDS ARE ASSOCIATED WITH DEFICITS IN COGNITIVE PROCESSING SPEED AND EXECUTIVE FUNCTIONS IN MIDDLE-AGED ADULTS WITH TYPE 1 DIABETES Open

Iiris Kyläheiko, Aleksi Tarkkonen, Linda Kuusela, Juha Martola, Teemu Paajanen , et al. · 2025

Psychology Medicine

Background Adults with type 1 diabetes (T1D) have an increased risk of developing cerebral small vessel disease (cSVD)-related brain changes already in midlife, yet their significance for cognitive functions remains poorly understood. We i…

Factors associated with oral anticoagulant non-use at first ischemic stroke in atrial fibrillation: A nationwide study Open

Marko Vilpponen, Aapo L. Aro, Olli Halminen, Paula Tiili, Miika Linna , et al. · 2025

Medicine Engineering

Background: Limited data exist on characteristics and patterns associated with patients with atrial fibrillation (AF) who encounter first-ever ischemic stroke (IS) while not on oral anticoagulation (OAC) therapy. Methods: From a nationwide…

Hemorrhagic Stroke in Atrial Fibrillation: Trends in Incidence, Case Fatality, and Prior Oral Anticoagulation Open

Paula Tiili, Mika Lehto, Olli Halminen, Jari Haukka, Ossi Lehtonen , et al. · 2025

Medicine Physics Engineering

Background Despite increased atrial fibrillation (AF) and oral anticoagulation (OAC) use among patients with intracerebral hemorrhage, trends in hemorrhagic stroke (HS) incidence in AF remain unclear. We examined recent epidemiological tre…

Quality of anticoagulation and outcomes after mechanical aortic valve replacement in patients with atrial fibrillation: a nationwide cohort study Open

Joonas Lehto, Rikhard Björn, Olli Halminen, Miika Linna, Jari Haukka , et al. · 2025

Medicine Engineering Physics

Aims Mechanical aortic valve replacement (AVR) remains the primary treatment for younger patients with severe aortic valve disease. However, limited information is available regarding the quality of the required lifelong vitamin K antagoni…

Timing of starting anticoagulation following decompressive surgery for cerebral vein and sinus thrombosis: An observational study Open

Mariana Costa Taveira, Sanjith Aaron, Jorge Ferreira, Jonathan M. Coutinho, Patrícia Canhão , et al. · 2025

Medicine

Background: Anticoagulation is the mainstay acute therapy for cerebral venous thrombosis (CVT). Decompressive surgery is required in a small minority of patients with large parenchymal lesions and impending herniation, which requires a tem…

Reduced dose direct oral anticoagulants and time-in-therapeutic-range defined warfarin in new-onset atrial fibrillation: a report from the nationwide FinACAF study Open

Alex Luojus, Mika Lehto, Olli Halminen, Ossi Lehtonen, Mikko Niemi , et al. · 2025

Medicine Engineering

Aims Direct oral anticoagulants (DOACs) at reduced dosage regimens are the first choice of ischaemic stroke (IS) prevention for patients with atrial fibrillation (AF) and elevated bleeding risk or renal insufficiency. We compared the outco…

Burden of Modifiable Risk Factors in Young-Onset Cryptogenic Ischemic Stroke by High-Risk Patent Foramen Ovale Open

Jukka Putaala, Nicolas Martinez‐Majander, Michelle Leppert, Lauri Tulkki, Jani Pirinen , et al. · 2025

Medicine Engineering

BACKGROUND: The incidence of young-onset ischemic stroke is rising, driven by cryptogenic ischemic stroke (CIS) and patients without vascular risk factors. This study examines the burden and associations of modifiable traditional, nontradi…

Oral microbiome dysbiosis in cryptogenic ischemic stroke patients with high-risk patent foramen ovale Open

Muhammed Manzoor, Jaakko Leskelä, Milla Pietiäinen, Nicolas Martinez‐Majander, Eija Könönen , et al. · 2025

Medicine Biology Engineering

Patent foramen ovale (PFO) is the most common congenital heart abnormality of foetal origin and has been associated with cryptogenic ischemic stroke (CIS) through several mechanisms, with most theories supporting paradoxical embolism. Othe…

Progression of Cerebral Small Vessel Disease Among Neurologically Asymptomatic Middle-Aged Individuals With Type 1 Diabetes Open

Aleksi Tarkkonen, Iiris Kyläheiko, Jussi Inkeri, Marika I. Eriksson, Lena M. Thorn , et al. · 2025

Medicine

OBJECTIVE To investigate the potential progression rate of cerebral small vessel disease (CSVD) in brain MRI among neurologically asymptomatic middle-aged individuals with type 1 diabetes. RESEARCH DESIGN AND METHODS A total of 172 individ…

Association Between Self-Perceived Stress and Cryptogenic Ischemic Stroke in Young Adults Open

Shakar Kutal, Lauri Tulkki, Tomi Sarkanen, Petra Redfors, Katarina Jood , et al. · 2025

Medicine Psychology Philosophy

Clinical trial registration number: NCT01934725.

Age at type 1 diabetes onset does not influence attained brain volume Open

Tor-björn Claesson, Stefan Mutter, Jukka Putaala, Eero Salli, Daniel Gordin , et al. · 2025

Medicine

Introduction Type 1 diabetes is suspected to hamper brain growth, implying that people with earlier diabetes onset would, on average, achieve lower maximal brain volume. We set out to test this hypothesis. Methods Examining brain MRI scans…

Alcohol use disorder and initiation of oral anticoagulant therapy in patients with atrial fibrillation: A nationwide cohort study Open

Miika Vanhanen, Jussi Jaakkola, Juhani Airaksinen, Olli Halminen, Jukka Putaala , et al. · 2025

Medicine Chemistry

AUDs are associated with a significantly lower rate of OAC initiation even after accounting for comorbidities that influence OAC initiation.

Statin therapy in ischemic stroke patients with atrial fibrillation: Efficacy and safety outcomes Open

Michele Marvardi, Maurizio Paciaroni, Valeria Caso, Michele Marvardi, Mario Ferrante , et al. · 2025

Medicine Engineering

Introduction: The efficacy and safety of statins for secondary prevention in patients who have experienced a cardioembolic stroke are not well-defined. However, previous observational data reported hyperlipidemia as a risk factor for both …

Multimodality Cardiac Imaging in Ischemic Stroke: Insights into the Heart-Brain Interaction Open

Gard M. S. Myrmel, Ulrike Waje‐Andreassen, Jani Pirinen, Juha Sinisalo, Vesa Järvinen , et al. · 2025

Medicine Engineering

Background: Approximately 7.6 million individuals experience a new ischemic stroke each year, and roughly 25% of all ischemic strokes are cardiogenic in origin, carrying a high risk of recurrence, death, and disability. To prevent future i…

Jukka Putaala YOU? Author Swipe