Explanipedia

Domain mapping of disease mutations reveals pathogenic SORL1 variants in Alzheimer’s disease Open

Matthijs W. J. de Waal, Giulia Monti, Christa de Geus, Shahzad Ahmad, Philippe Amouyel , et al. · 2025

‘A Completely Different Person’: Embodied Dialectics and Biographical Disruption After Stroke Open

Sophie Rowland‐Coomber, Eleanor Stevens, Christopher McKevitt, Nicholas J Williamson, Iman Muzafar , et al. · 2025

Stroke is a leading cause of complex disability, with many survivors experiencing mobility, cognitive and/or speech and language impairment. This paper explores the relationship between biographical disruption and body studies through expe…

Estimating annual deaths from stroke in adults under 70 years of age in Freetown Sierra Leone: A comparative analysis of a hospital-based stroke register and a population-based verbal autopsy study Open

Daniel Youkee, Marina Soley‐Bori, Gibrilla F. Deen, Prabhat Jha, Anteneh Assalif , et al. · 2025

Background: In Sub-Saharan Africa (SSA), most stroke epidemiological data comes from hospital-based registers, which are prone to selection bias, and data may be unrepresentative of stroke burden at the population level. The degree of inco…

Long‐Term Course of Depression After Stroke and Risk Factors for Symptoms With Poor Progression: A Population‐Based Study Open

Lu Liu, Iain Marshall, Ajay Bhalla, Xianqi Li, Salma Ayis , et al. · 2025

Background Data on the long‐term poststroke depression trajectories and their determinants are limited. This study aims to estimate the 5‐year course of poststroke depression and identify risk factors for recurrent and persistent depressio…

Modeling common Alzheimer’s disease with high and low polygenic risk in human iPSC: A large-scale research resource Open

Emily Maguire, Jincy Winston, Simon R. Ellwood, Rachel O’Donoghue, Bethany Shaw , et al. · 2025

Decide less, communicate more: On the construct validity of end-to-end fact-checking in medicine Open

Sebastian Joseph, Iain Marshall, Junyi Jessy Li · 2025

Technological progress has led to concrete advancements in tasks that were regarded as challenging, such as automatic fact-checking. Interest in adopting these systems for public health and medicine has grown due to the high-stakes nature …

Long-term outcomes of depression up to 10-years after stroke in the South London Stroke Register: a population-based study Open

Lu Liu, Iain Marshall, Xianqi Li, Ajay Bhalla, Lidan Liu , et al. · 2025

National Institute for Health and Care Research (NIHR202339).

Caught in the Web of Words: Do LLMs Fall for Spin in Medical Literature? Open

Hye Sun Yun, Karen Y C Zhang, Ramez Kouzy, Iain Marshall, Junyi Jessy Li , et al. · 2025

Medical research faces well-documented challenges in translating novel treatments into clinical practice. Publishing incentives encourage researchers to present "positive" findings, even when empirical results are equivocal. Consequently, …

Trends in Ethnic Disparities in Stroke Care and Long-Term Outcomes Open

Eva Emmett, Matthew O’Connell, Ruonan Pei, Abdel Douiri, David Wyatt , et al. · 2025

Importance Reducing the burden of stroke is a public health priority. While higher stroke incidence among ethnic minority populations (defined in the context of this study as individuals who are not White) is well established, reports on e…

Socioeconomic Status and Stroke: A Review of the Latest Evidence on Inequalities and Their Drivers Open

Camila Pantoja‐Ruiz, Rufus Akinyemi, Diego Lucumí, Daniel Youkee, Eva Emmett , et al. · 2024

The latest research on socioeconomic status (SES) and stroke continues to demonstrate that individuals with low SES are at a higher risk of stroke, receive lower-quality care, and experience poorer outcomes. Despite growing evidence on the…

Thirty years of the South London Stroke Register Open

Eva Emmett, Fara Hamidi, Hatem A Wafa, J Coumbe, Abdel Douiri , et al. · 2024

Since the beginning of the South London Stroke Register (SLSR) in 1995, stroke care has undergone major transformations and the SLSR adapted alongside. Recruitment strategies changed in line with patient pathways, and data collections were…

Extremely rare CNVs contributing to Alzheimer disease risk: a case-control association analysis of exome sequencing data from 22,319 individuals Open

Olivier Quenez, Catherine Schramm, Kévin Cassinari, Aude Nicolas, J H M Groeneveld , et al. · 2024

Rare coding single nucleotide variants (SNV) and short insertions or deletions (indels) contribute to Alzheimer disease (AD) genetic risk, from pathogenic variants in autosomal dominant genes to risk factors with diverse effects. In contra…

The FAIR database: facilitating access to public health research literature Open

Zhixue Zhao, James Thomas, Gregory Kell, Claire Stansfield, Mark Clowes , et al. · 2024

Objectives In public health, access to research literature is critical to informing decision-making and to identify knowledge gaps. However, identifying relevant research is not a straightforward task since public health interventions are …

RealMedQA: A pilot biomedical question answering dataset containing realistic clinical questions Open

Gregory Kell, Angus Roberts, Serge Umansky, Yuti Khare, Najma Ahmed , et al. · 2024

Clinical question answering systems have the potential to provide clinicians with relevant and timely answers to their questions. Nonetheless, despite the advances that have been made, adoption of these systems in clinical settings has bee…

A scoping review of stroke registers in Sub-Saharan Africa Open

Daniel Youkee, Mamadu Baldeh, Anthony Rudd, Marina Soley‐Bori, Charles Wolfe , et al. · 2024

Background: Stroke registers are recommended as a key priority by the Lancet Neurology World Stroke Organization Commission for Stroke, 2023, and the African Stroke Leaders’ Summit, 2022. Aims: This scoping review aims to map where stroke …

A systematic review of the incidence and outcomes of ICD-11 defined stroke Open

Holli Groff, Sariha Yousfani, Camila Pantoja‐Ruiz, Abdel Douiri, Ajay Bhalla , et al. · 2024

The impact of the ICD-11 change in stroke definition on incidence and outcomes may have been overestimated by individual studies. Community-based stroke services with access to DWI MRI are likely to accurately diagnose greater numbers of p…

Automatically Extracting Numerical Results from Randomized Controlled Trials with Large Language Models Open

Hye Sun Yun, David Pogrebitskiy, Iain Marshall, Byron Wallace · 2024

Meta-analyses statistically aggregate the findings of different randomized controlled trials (RCTs) to assess treatment effectiveness. Because this yields robust estimates of treatment effectiveness, results from meta-analyses are consider…

Quality of life and quality-adjusted life years after stroke in Sierra Leone Open

Daniel Youkee, Gibrilla F. Deen, Catherine Sackley, D R Lisk, Iain Marshall , et al. · 2024

Background: Stroke is a leading cause of mortality and negatively affects health-related quality of life (HRQoL). HRQoL after stroke is understudied in Africa and there are no reports of quality-adjusted life years after stroke (QALYs) in …

The feasibility, repeatability, validity and responsiveness of the EQ-5D-3L in Krio for patients with stroke in Sierra Leone Open

Daniel Youkee, Sahr Pessima, Catherine Sackley, Marina Soley‐Bori, Gibrilla F. Deen , et al. · 2024

Natural history of depression up to 18 years after stroke: a population-based South London Stroke Register study Open

Lu Liu, Iain Marshall, Ruonan Pei, Ajay Bhalla, Charles Wolfe , et al. · 2024

National Institute for Health and Care Research (NIHR202339).

Question answering systems for health professionals at the point of care—a systematic review Open

Gregory Kell, Angus Roberts, Serge Umansky, Linglong Qian, Davide Ferrari , et al. · 2024

Objectives Question answering (QA) systems have the potential to improve the quality of clinical care by providing health professionals with the latest and most relevant evidence. However, QA systems have not been widely adopted. This syst…

Burden of intracerebral haemorrhage in Europe: forecasting incidence and mortality between 2019 and 2050 Open

Hatem A Wafa, Iain Marshall, Charles Wolfe, Wanqing Xie, Catherine O. Johnson , et al. · 2024

Question answering systems for health professionals at the point of care -- a systematic review Open

Gregory Kell, Angus Roberts, Serge Umansky, Linglong Qian, Davide Ferrari , et al. · 2024

Objective: Question answering (QA) systems have the potential to improve the quality of clinical care by providing health professionals with the latest and most relevant evidence. However, QA systems have not been widely adopted. This syst…

Patient-Oriented Unsupervised Learning to Unlock Patterns of Multimorbidity Associated with Stroke using Primary Care Electronic Health Records Open

Marc Delord, Xiaohui Sun, Annastazia Learoyd, Vasa Ćurčin, Iain Marshall , et al. · 2024

Background: Identifying and characterising the longitudinal patterns of multimorbidity associated with stroke is needed to better understand patients' needs and inform new models of care. Methods: We used an unsupervised patient-oriented c…

Do Multi-Document Summarization Models <i>Synthesize</i>? Open

Jay DeYoung, Stephanie C. Martinez, Iain Marshall, Byron Wallace · 2024

Multi-document summarization entails producing concise synopses of collections of inputs. For some applications, the synopsis should accurately synthesize inputs with respect to a key aspect, e.g., a synopsis of film reviews written about …

A Systematic Review of the Incidence and Outcomes of ICD-11 Defined Stroke Open

Holli Groff, Sariha Yousfani, Camila Pantoja‐Ruiz, Abdel Douiri, Ajay Bhalla , et al. · 2024

Trajectories of depressive symptoms 10 years after stroke and associated risk factors: a prospective cohort study Open

Lu Liu, Xianqi Li, Iain Marshall, Ajay Bhalla, Yanzhong Wang , et al. · 2023

National Institute for Health and Care Research (NIHR).

Trialstreamer database (CSV) Open

Iain Marshall, Byron Wallace · 2023

We provide up-to-date data indexed by Trialstreamer in CSV format.

Trialstreamer database (CSV) Open

Iain Marshall, Byron Wallace · 2023

We provide up-to-date data indexed by Trialstreamer in CSV format.

Trialstreamer database (CSV) Open

Iain Marshall, Byron Wallace · 2023

We provide up-to-date data indexed by Trialstreamer in CSV format.

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