José Viña
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View article: The Length of Lactation and Model of Weaning Modulate Key Regulatory Nodes of Murine Mammary Gland Involution
The Length of Lactation and Model of Weaning Modulate Key Regulatory Nodes of Murine Mammary Gland Involution Open
Reduced lactation after forced weaning induces a tumor-promoting environment in the mammary gland, triggering key regulatory nodes common to both post-lactation involution and breast cancer, including calpains and miRs. We investigated how…
View article: Impact of Sarcopenic Diabetes on Outcomes and Mortality in Older Adults Hospitalized for Hip Fracture: A Nested Case–Control Study Within a Real-World Evidence Cohort
Impact of Sarcopenic Diabetes on Outcomes and Mortality in Older Adults Hospitalized for Hip Fracture: A Nested Case–Control Study Within a Real-World Evidence Cohort Open
Background: This study addresses the prevalence and outcomes of sarcopenic diabetes among older adults hospitalized for hip fractures, highlighting its association with nutritional status, frailty, in-hospital outcomes, and mortality. With…
View article: Pomegranate Extract Modulates Oxidative Stress by Reducing Basal ROS Levels and Protecting White Blood Cells from Induced Oxidative Damage in Aging Mice
Pomegranate Extract Modulates Oxidative Stress by Reducing Basal ROS Levels and Protecting White Blood Cells from Induced Oxidative Damage in Aging Mice Open
Aging is associated with increased oxidative stress, which contributes to cellular dysfunction and age-related diseases. Pomegranate extract (PE), rich in antioxidant polyphenols, may help mitigate oxidative damage. This study evaluated wh…
View article: Association Between Lycopene and Metabolic Disease Risk and Mortality: Systematic Review and Meta-Analysis
Association Between Lycopene and Metabolic Disease Risk and Mortality: Systematic Review and Meta-Analysis Open
Background: Lycopene, a dietary carotenoid with antioxidant properties, protects against sun-induced skin damage, prostatic conditions such as chronic prostatitis, and cancer; however, its role in metabolic disorders, including metabolic s…
View article: Bcl-xL overexpression in T cells preserves muscle mitochondrial structure and function and prevents frailty in old mice
Bcl-xL overexpression in T cells preserves muscle mitochondrial structure and function and prevents frailty in old mice Open
Our previous transcriptomic analysis revealed an up-regulation of the antiapoptotic protein B cell lymphoma-extra large (Bcl-xL) in centenarians relative to octogenarians or younger cohorts. In this study, we used Bcl-xL–overexpressing mic…
View article: Phenotypic upregulation of hexocylceramides and ether‐linked phosphocholines as markers of human extreme longevity
Phenotypic upregulation of hexocylceramides and ether‐linked phosphocholines as markers of human extreme longevity Open
Centenarians and their relatives possess a notable survival advantage, with higher longevity and reduced susceptibility to major age‐related diseases. To date, characteristic omics profiles of centenarians have been described, demonstratin…
View article: Diet and exercise in frailty and sarcopenia. Molecular aspects
Diet and exercise in frailty and sarcopenia. Molecular aspects Open
Function declines throughout life although phenotypical manifestations in terms of frailty or disability are only seen in the later periods of our life. The causes underlying lifelong function decline are the aging process "per se", chroni…
View article: Free radicals in Alzheimer's disease: From pathophysiology to clinical trial results
Free radicals in Alzheimer's disease: From pathophysiology to clinical trial results Open
In this review, we examine the role of oxidative stress in the pathophysiology of Alzheimer's Disease (AD). Amyloid-beta (Aβ) induces damage not only extracellularly but also within the intracellular environment. Mitochondria, a principal …
View article: Influence of Polypharmacy on Post-surgical Mortality in Elderly Adults With Hip Fracture
Influence of Polypharmacy on Post-surgical Mortality in Elderly Adults With Hip Fracture Open
Purpose: Polypharmacy is a common problem in surgical patients with hip fractures. Their influence on the mortality is what we pretend to study, aiming to inform management strategies and reduce mortality risks. Methods: A retrospective st…
View article: Involvement of Aryl Hydrocarbon Receptor in Longevity and Healthspan: Insights from Humans, Mice, and C. elegans
Involvement of Aryl Hydrocarbon Receptor in Longevity and Healthspan: Insights from Humans, Mice, and C. elegans Open
In previous studies, using transcriptomic analysis, we observed higher levels of aryl hydrocarbon receptor (AHR) gene expression in the peripheral blood cells of centenarians compared to octogenarians. This suggests the potential significa…
View article: Unlocking the biochemical secrets of longevity: balancing healthspan and lifespan
Unlocking the biochemical secrets of longevity: balancing healthspan and lifespan Open
In an era of rising global life expectancies, research focuses on enhancing the quality of extended years. This review examines the link between mitochondrial function and aging, highlighting the importance of healthspan alongside lifespan…
View article: Glucose 6 phosphate dehydrogenase overexpression rescues the loss of cognition in the double transgenic APP/PS1 mouse model of Alzheimer’s disease
Glucose 6 phosphate dehydrogenase overexpression rescues the loss of cognition in the double transgenic APP/PS1 mouse model of Alzheimer’s disease Open
Mice models of Alzheimer's disease (APP/PS1) typically experience cognitive decline with age. G6PD overexpressing mice (G6PD-Tg) exhibit better protection from age-associated functional decline including improvements in metabolic and muscl…
View article: Physical Interventions Restore Physical Frailty and the Expression of CXCL-10 and IL-1β Inflammatory Biomarkers in Old Individuals and Mice
Physical Interventions Restore Physical Frailty and the Expression of CXCL-10 and IL-1β Inflammatory Biomarkers in Old Individuals and Mice Open
Background: Frailty is a geriatric syndrome associated with negative health outcomes that represents a dynamic condition with a potential of reversibility after physical exercise interventions. Typically, inflammatory and senescence marker…
View article: Randomised controlled trial combining vitamin E-functionalised chocolate with physical exercise to reduce the risk of protein–energy malnutrition in predementia aged people: study protocol for Choko-Age
Randomised controlled trial combining vitamin E-functionalised chocolate with physical exercise to reduce the risk of protein–energy malnutrition in predementia aged people: study protocol for Choko-Age Open
Objective Protein–energy malnutrition and the subsequent muscle wasting (sarcopenia) are common ageing complications. It is knowing to be also associated with dementia. Our programme will test the cytoprotective functions of vitamin E comb…
View article: Pharmacological and genetic increases in liver NADPH levels ameliorate NASH progression in female mice
Pharmacological and genetic increases in liver NADPH levels ameliorate NASH progression in female mice Open
Non-alcoholic steatohepatitis (NASH) is one of the fastest growing liver diseases worldwide, and oxidative stress is one of NASH main key drivers. Nicotinamide adenine dinucleotide phosphate (NADPH) is the ultimate donor of reductive power…
View article: Pomegranate Extract Administration Reverses Loss of Motor Coordination and Prevents Oxidative Stress in Cerebellum of Aging Mice
Pomegranate Extract Administration Reverses Loss of Motor Coordination and Prevents Oxidative Stress in Cerebellum of Aging Mice Open
The cerebellum is responsible for complex motor functions, like maintaining balance and stance, coordination of voluntary movements, motor learning, and cognitive tasks. During aging, most of these functions deteriorate, which results in f…
View article: Plasma acylcarnitines and gut‐derived aromatic amino acids as sex‐specific hub metabolites of the human aging metabolome
Plasma acylcarnitines and gut‐derived aromatic amino acids as sex‐specific hub metabolites of the human aging metabolome Open
Aging biology entails a cell/tissue deregulated metabolism that affects all levels of biological organization. Therefore, the application of “omic” techniques that are closer to phenotype, such as metabolomics, to the study of the aging pr…
View article: Glucose 6-P Dehydrogenase Overexpression Improves Aging-Induced Endothelial Dysfunction in Aorta from Mice: Role of Arginase II
Glucose 6-P Dehydrogenase Overexpression Improves Aging-Induced Endothelial Dysfunction in Aorta from Mice: Role of Arginase II Open
The increase of vascular arginase activity during aging causes endothelial dysfunction. This enzyme competes with the endothelial nitric oxide synthase (eNOS) for L-arginine substrate. Our hypothesis is that glucose 6-P dehydrogenase (G6PD…
View article: Is Frailty Diagnosis Important in Patients with COPD? A Narrative Review of the Literature
Is Frailty Diagnosis Important in Patients with COPD? A Narrative Review of the Literature Open
Frailty is prevalent in older adults and is related to a worsening functionality, quality of life, and health outcomes. Though there is an increasing interest in this field, the relationship between frailty and worsening COPD outcomes rema…
View article: Effect of Familial Longevity on Frailty and Sarcopenia: A Case–Control Study
Effect of Familial Longevity on Frailty and Sarcopenia: A Case–Control Study Open
Familial longevity confers advantages in terms of health, functionality, and longevity. We sought to assess potential differences in frailty and sarcopenia in older adults according to a parental history of extraordinary longevity. A total…
View article: Real-Life Outcomes of a Multicomponent Exercise Intervention in Community-Dwelling Frail Older Adults and Its Association with Nutritional-Related Factors
Real-Life Outcomes of a Multicomponent Exercise Intervention in Community-Dwelling Frail Older Adults and Its Association with Nutritional-Related Factors Open
Most of the studies on physical exercise in older adults have been conducted through randomized clinical trials performed under tight experimental conditions. Data regarding Real-Life physical exercise intervention programs in older adults…
View article: Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice
Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice Open
Aging is associated with an increased risk of frailty, disability, and mortality. Strategies to delay the degenerative changes associated with aging and frailty are particularly interesting. We treated old animals with small extracellular …
View article: Glucose 6-P Dehydrogenase—An Antioxidant Enzyme with Regulatory Functions in Skeletal Muscle during Exercise
Glucose 6-P Dehydrogenase—An Antioxidant Enzyme with Regulatory Functions in Skeletal Muscle during Exercise Open
Hypomorphic Glucose 6-P dehydrogenase (G6PD) alleles, which cause G6PD deficiency, affect around one in twenty people worldwide. The high incidence of G6PD deficiency may reflect an evolutionary adaptation to the widespread prevalence of m…