Bruno Robert
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View article: How air pollution with PM25 affect the pulmonary immune system to favor infections ? 9233
How air pollution with PM25 affect the pulmonary immune system to favor infections ? 9233 Open
Description Air pollution represents a major risk to public health, affecting millions of people around the world. Among its many harmful impacts, the increased susceptibility to respiratory infections is particularly concerning. Fine part…
View article: Generation Using Phage-Display of pH-Dependent Antibodies Against the Tumor-Associated Antigen AXL
Generation Using Phage-Display of pH-Dependent Antibodies Against the Tumor-Associated Antigen AXL Open
Background/Objectives: Tumor-associated antigens are not tumor-specific antigens but proteins that are overexpressed by tumor cells and also weakly expressed at the surface of healthy tissues. Therefore, some side effects are observed when…
View article: The Arming of Natural Killer Cells With Fc‐Engineered Monoclonal Antibodies Confers Specificity Against Tumor B Cells
The Arming of Natural Killer Cells With Fc‐Engineered Monoclonal Antibodies Confers Specificity Against Tumor B Cells Open
International audience
View article: Residential Satisfaction, Health Status and Satisfaction-With-Life Among Students in the Near-Campus Housing Environment of Samaru-Zaria, Nigeria
Residential Satisfaction, Health Status and Satisfaction-With-Life Among Students in the Near-Campus Housing Environment of Samaru-Zaria, Nigeria Open
Housing adequacy, measured using residential satisfaction ratings of housing environment attributes, was analysed for relationships with health status and satisfaction with life (SwL) among students living off-campus within the near-campus…
View article: Generation of non-genetically modified, CAR-like, NK cells
Generation of non-genetically modified, CAR-like, NK cells Open
Background Natural killer (NK) cell therapy is considered an attractive and safe strategy for anticancer therapy. Nevertheless, when autologous or allogenic NK cells are used alone, the clinical benefit has been disappointing. This is part…
View article: The arming of NK cells with Fc-engineered rituximab confers them specificity against CD20-expressing cells
The arming of NK cells with Fc-engineered rituximab confers them specificity against CD20-expressing cells Open
Clinical effects of IgG1 monoclonal antibodies (mAb) relies on various mechanisms, including antibody dependent cell-mediated cytotoxicity (ADCC), which requires natural killer (NK) cells as the main immune effectors. These cells are emerg…
View article: Fc-engineered monoclonal antibodies to reduce off-target liver uptake
Fc-engineered monoclonal antibodies to reduce off-target liver uptake Open
Background Radiolabeled-antibodies usually display non-specific liver accumulation that may impair image analysis and antibody biodistribution. Here, we investigated whether Fc silencing influenced antibody biodistribution. We compared rec…
View article: 10th antibody industrial symposium: new developments in antibody and adoptive cell therapies
10th antibody industrial symposium: new developments in antibody and adoptive cell therapies Open
The annual "Antibody Industrial Symposium", co-organized by LabEx MAbImprove and MabDesign, held its 10th anniversary edition in Montpellier, France, on June 28-29, 2022. The meeting focused on new results and concepts in antibody engineer…
View article: Supplementary Figure 1 from Single-Domain Antibody–Based and Linker-Free Bispecific Antibodies Targeting FcγRIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells
Supplementary Figure 1 from Single-Domain Antibody–Based and Linker-Free Bispecific Antibodies Targeting FcγRIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells Open
PDF file - 60K, Lack of competition between bsFab and human IgG for FcγRIIIa binding.
View article: Supplementary Methods from Single-Domain Antibody–Based and Linker-Free Bispecific Antibodies Targeting FcγRIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells
Supplementary Methods from Single-Domain Antibody–Based and Linker-Free Bispecific Antibodies Targeting FcγRIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells Open
PDF file - 120K
View article: Supplementary Methods from Single-Domain Antibody–Based and Linker-Free Bispecific Antibodies Targeting FcγRIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells
Supplementary Methods from Single-Domain Antibody–Based and Linker-Free Bispecific Antibodies Targeting FcγRIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells Open
PDF file - 120K
View article: Data from Single-Domain Antibody–Based and Linker-Free Bispecific Antibodies Targeting FcγRIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells
Data from Single-Domain Antibody–Based and Linker-Free Bispecific Antibodies Targeting FcγRIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells Open
Antibody-dependent cell-mediated cytotoxicity, one of the most prominent modes of action of antitumor antibodies, suffers from important limitations due to the need for optimal interactions with Fcγ receptors. In this work, we report the d…
View article: Supplementary Figure 1 from Single-Domain Antibody–Based and Linker-Free Bispecific Antibodies Targeting FcγRIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells
Supplementary Figure 1 from Single-Domain Antibody–Based and Linker-Free Bispecific Antibodies Targeting FcγRIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells Open
PDF file - 60K, Lack of competition between bsFab and human IgG for FcγRIIIa binding.
View article: Supplementary Figure Legend from Single-Domain Antibody–Based and Linker-Free Bispecific Antibodies Targeting FcγRIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells
Supplementary Figure Legend from Single-Domain Antibody–Based and Linker-Free Bispecific Antibodies Targeting FcγRIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells Open
PDF file - 70K
View article: Data from Single-Domain Antibody–Based and Linker-Free Bispecific Antibodies Targeting FcγRIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells
Data from Single-Domain Antibody–Based and Linker-Free Bispecific Antibodies Targeting FcγRIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells Open
Antibody-dependent cell-mediated cytotoxicity, one of the most prominent modes of action of antitumor antibodies, suffers from important limitations due to the need for optimal interactions with Fcγ receptors. In this work, we report the d…
View article: Supplementary Figure Legend from Single-Domain Antibody–Based and Linker-Free Bispecific Antibodies Targeting FcγRIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells
Supplementary Figure Legend from Single-Domain Antibody–Based and Linker-Free Bispecific Antibodies Targeting FcγRIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells Open
PDF file - 70K
View article: Supplementary Table S1 from Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis
Supplementary Table S1 from Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis Open
Suppl.Table 1: Analysis of the cellular localization, pathways and gene expression modification of the 100 genes most correlated with AXL expression in 254 basal-like breast cancers.
View article: Data from Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis
Data from Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis Open
Purpose: AXL receptor tyrosine kinase has been described as a relevant molecular marker and a key player in invasiveness, especially in triple-negative breast cancer (TNBC).Experimental Design: We evaluate the antitumor effic…
View article: Supplementary Table S1 from Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis
Supplementary Table S1 from Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis Open
Suppl.Table 1: Analysis of the cellular localization, pathways and gene expression modification of the 100 genes most correlated with AXL expression in 254 basal-like breast cancers.
View article: Data from Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis
Data from Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis Open
Purpose: AXL receptor tyrosine kinase has been described as a relevant molecular marker and a key player in invasiveness, especially in triple-negative breast cancer (TNBC).Experimental Design: We evaluate the antitumor effic…
View article: Supplementary Figure S1-S6 from Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis
Supplementary Figure S1-S6 from Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis Open
Supplementary Figure 1. AXL, MER and TYRO-3 expression in Triple Negative Breast Cancer (TNBC) cell lines and PDXs by Western blot analysis. Supplementary Figure 2. AXL mRNA expression in a large dataset of breast cancer tumors. Supplement…
View article: Supplementary Figure S1-S6 from Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis
Supplementary Figure S1-S6 from Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis Open
Supplementary Figure 1. AXL, MER and TYRO-3 expression in Triple Negative Breast Cancer (TNBC) cell lines and PDXs by Western blot analysis. Supplementary Figure 2. AXL mRNA expression in a large dataset of breast cancer tumors. Supplement…
View article: Supplementary Table 2 from Quantitative Phosphoproteomics Reveals a Cluster of Tyrosine Kinases That Mediates Src Invasive Activity in Advanced Colon Carcinoma Cells
Supplementary Table 2 from Quantitative Phosphoproteomics Reveals a Cluster of Tyrosine Kinases That Mediates Src Invasive Activity in Advanced Colon Carcinoma Cells Open
Supplementary Table 2 from Quantitative Phosphoproteomics Reveals a Cluster of Tyrosine Kinases That Mediates Src Invasive Activity in Advanced Colon Carcinoma Cells
View article: Supplementary Figure 1 from Quantitative Phosphoproteomics Reveals a Cluster of Tyrosine Kinases That Mediates Src Invasive Activity in Advanced Colon Carcinoma Cells
Supplementary Figure 1 from Quantitative Phosphoproteomics Reveals a Cluster of Tyrosine Kinases That Mediates Src Invasive Activity in Advanced Colon Carcinoma Cells Open
Supplementary Figure 1 from Quantitative Phosphoproteomics Reveals a Cluster of Tyrosine Kinases That Mediates Src Invasive Activity in Advanced Colon Carcinoma Cells
View article: Supplementary Table 1 from Quantitative Phosphoproteomics Reveals a Cluster of Tyrosine Kinases That Mediates Src Invasive Activity in Advanced Colon Carcinoma Cells
Supplementary Table 1 from Quantitative Phosphoproteomics Reveals a Cluster of Tyrosine Kinases That Mediates Src Invasive Activity in Advanced Colon Carcinoma Cells Open
Supplementary Table 1 from Quantitative Phosphoproteomics Reveals a Cluster of Tyrosine Kinases That Mediates Src Invasive Activity in Advanced Colon Carcinoma Cells
View article: Activation of neuronal FLT3 promotes exaggerated sensorial and emotional pain-related behaviors facilitating the transition from acute to chronic pain
Activation of neuronal FLT3 promotes exaggerated sensorial and emotional pain-related behaviors facilitating the transition from acute to chronic pain Open
View article: Targeting the splicing isoforms of spleen tyrosine kinase affects the viability of colorectal cancer cells
Targeting the splicing isoforms of spleen tyrosine kinase affects the viability of colorectal cancer cells Open
Spleen tyrosine kinase (Syk) expression have been both positively and negatively associated with tumorigenesis. Our goal was to evaluate the contribution of Syk and its two splice variants, full length Syk (L) and short isoform Syk (S), in…
View article: Oncogenic Signalling of PEAK2 Pseudokinase in Colon Cancer
Oncogenic Signalling of PEAK2 Pseudokinase in Colon Cancer Open
The PEAK family pseudokinases are essential components of tyrosine kinase (TK) pathways that regulate cell growth and adhesion; however, their role in human cancer remains unclear. Here, we report an oncogenic activity of the pseudokinase …
View article: Strategies for selective functionalization of amorphous chalcogenide rib waveguides
Strategies for selective functionalization of amorphous chalcogenide rib waveguides Open
View article: Upregulated flotillins and sphingosine kinase 2 derail AXL vesicular traffic to promote epithelial-mesenchymal transition
Upregulated flotillins and sphingosine kinase 2 derail AXL vesicular traffic to promote epithelial-mesenchymal transition Open
Altered endocytosis and vesicular trafficking are major players during tumorigenesis. Flotillin overexpression, a feature observed in many invasive tumors and identified as a marker of poor prognosis, induces a deregulated endocytic and tr…