Jaime Soto
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View article: Use of a novel lag screw by technique approach for repair of a severe lumbar fracture associated with ankylosing spondylitis: A technical case report
Use of a novel lag screw by technique approach for repair of a severe lumbar fracture associated with ankylosing spondylitis: A technical case report Open
Background: The lag screw is a common technique and device used in orthopedic surgery for compressing simple fractures. Here, a lag screw was used to treat a traumatic L5-S1 fracture in a 53-year-old patient with ankylosing spondylitis (AS…
View article: Cutaneous leishmaniasis treatment and therapeutic outcomes in special populations: A collaborative retrospective study
Cutaneous leishmaniasis treatment and therapeutic outcomes in special populations: A collaborative retrospective study Open
Background Treatment guidance for children and older adult patients affected by cutaneous leishmaniasis (CL) is unclear due to limited representation of these groups in clinical trials. Methods We conducted a collaborative retrospective st…
View article: Treatment of Bolivian Leishmania braziliensis Cutaneous and Mucosal Leishmaniasis
Treatment of Bolivian Leishmania braziliensis Cutaneous and Mucosal Leishmaniasis Open
Although infection with Leishmania braziliensis is perhaps the key reason to treat New World cutaneous leishmaniasis (CL) and mucosal leishmaniasis (ML), the total literature contains relatively few reported cases. With the aim of suppleme…
View article: Tamoxifen reduces inflammatory infiltration of neutrophils in the airways
Tamoxifen reduces inflammatory infiltration of neutrophils in the airways Open
Tamoxifen is a drug of choice for treatment of breast cancer but it has also been reported to bear anti-inflammatory activity. Previously, we have observed that tamoxifen treatment successfully reduced inflammation in horses affected by eq…
View article: Mass Drug Administration of Triclabendazole for Fasciola Hepatica in Bolivia
Mass Drug Administration of Triclabendazole for Fasciola Hepatica in Bolivia Open
Human infection with Fasciola hepatica leads to obstruction of the common bile duct by adult worms and disease characterized by biliary colic, epigastric pain, and nausea. Recommended treatment is a single dose of triclabendazole (TCBZ) (1…
View article: Miltefosine Combined with Intralesional Pentamidine for Leishmania braziliensis Cutaneous Leishmaniasis in Bolivia
Miltefosine Combined with Intralesional Pentamidine for Leishmania braziliensis Cutaneous Leishmaniasis in Bolivia Open
Bolivian cutaneous leishmaniasis due to Leishmania braziliensis was treated with the combination of miltefosine (150 mg/day for 28 days) plus intralesional pentamidine (120 μg/mm 2 lesion area on days 1, 3, and 5). Ninety-two per cent of 5…
View article: Topical 15% Paromomycin-Aquaphilic for Bolivian <i>Leishmania braziliensis</i> Cutaneous Leishmaniasis: A Randomized, Placebo-controlled Trial
Topical 15% Paromomycin-Aquaphilic for Bolivian <i>Leishmania braziliensis</i> Cutaneous Leishmaniasis: A Randomized, Placebo-controlled Trial Open
NCT03096457.
View article: Harmonized clinical trial methodologies for localized cutaneous leishmaniasis and potential for extensive network with capacities for clinical evaluation
Harmonized clinical trial methodologies for localized cutaneous leishmaniasis and potential for extensive network with capacities for clinical evaluation Open
The consensus reached allows standardization of future clinical research across OWCL and NWCL sites. We encourage CL researchers to adopt and adapt as required the proposed parameters and outcomes in their future trials and provide feedbac…
View article: Intralesional Pentamidine: A Novel Therapy for Single Lesions of Bolivian Cutaneous Leishmaniasis
Intralesional Pentamidine: A Novel Therapy for Single Lesions of Bolivian Cutaneous Leishmaniasis Open
A novel therapy, intralesional (IL) pentamidine, was compared to intralesional therapy with antimony (ILSb), a World Health Organization–recommended therapy, for single Bolivian Leishmania braziliensis lesions. In Study 1, 90 patients were…