Steven J. Jacobsen
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View article: A population-based epidemiological study of hip fractures among the elderly of the United States.
A population-based epidemiological study of hip fractures among the elderly of the United States. Open
A population-based epidemiological study of hip fractures among the elderly of the United States.
View article: A systematic study of the effects of volatile species on the structure and physical properties of amorphous SiO2
A systematic study of the effects of volatile species on the structure and physical properties of amorphous SiO2 Open
View article: Volatile retention and incorporation during pebble accretion: a combined shock and spectroscopy study
Volatile retention and incorporation during pebble accretion: a combined shock and spectroscopy study Open
View article: Research data warehouse: using electronic health records to conduct population-based observational studies.
Research data warehouse: using electronic health records to conduct population-based observational studies. Open
Although the RDW is unique to KPSC, its methodologies and experience may provide useful insights for researchers of other healthcare systems worldwide in the era of big data analysis.
View article: Structural Analysis of Non-native Peptide-Based Catalysts Using 2D NMR-Guided MD Simulations
Structural Analysis of Non-native Peptide-Based Catalysts Using 2D NMR-Guided MD Simulations Open
Proteins and enzymes generally achieve their functions by creating well-defined 3D architectures that pre-organize reactive functionalities. Mimicking this approach to supramolecular pre-organization is leading to the development of highly…
View article: Post-licensure safety study of new-onset immune-mediated diseases, herpes zoster, and anaphylaxis in adult recipients of HepB-CpG vaccine versus HepB-alum vaccine
Post-licensure safety study of new-onset immune-mediated diseases, herpes zoster, and anaphylaxis in adult recipients of HepB-CpG vaccine versus HepB-alum vaccine Open
This large post-licensure study did not identify evidence of safety concerns for HepB-CpG compared to HepB-alum for immune-mediated diseases, HZ, or anaphylaxis.
View article: Supplementary Tables 1-2, Figures 1-5 from 6-Thioguanine Reactivates Epigenetically Silenced Genes in Acute Lymphoblastic Leukemia Cells by Facilitating Proteasome-mediated Degradation of DNMT1
Supplementary Tables 1-2, Figures 1-5 from 6-Thioguanine Reactivates Epigenetically Silenced Genes in Acute Lymphoblastic Leukemia Cells by Facilitating Proteasome-mediated Degradation of DNMT1 Open
PDF file - 322K
View article: Data from 6-Thioguanine Reactivates Epigenetically Silenced Genes in Acute Lymphoblastic Leukemia Cells by Facilitating Proteasome-mediated Degradation of DNMT1
Data from 6-Thioguanine Reactivates Epigenetically Silenced Genes in Acute Lymphoblastic Leukemia Cells by Facilitating Proteasome-mediated Degradation of DNMT1 Open
Thiopurines including 6-thioguanine (SG), 6-mercaptopurine, and azathioprine are effective anticancer agents with remarkable success in clinical practice, especially in effective treatment of acute lymphoblastic leukemia (ALL). …
View article: Data from 6-Thioguanine Reactivates Epigenetically Silenced Genes in Acute Lymphoblastic Leukemia Cells by Facilitating Proteasome-mediated Degradation of DNMT1
Data from 6-Thioguanine Reactivates Epigenetically Silenced Genes in Acute Lymphoblastic Leukemia Cells by Facilitating Proteasome-mediated Degradation of DNMT1 Open
Thiopurines including 6-thioguanine (SG), 6-mercaptopurine, and azathioprine are effective anticancer agents with remarkable success in clinical practice, especially in effective treatment of acute lymphoblastic leukemia (ALL). …
View article: Supplementary Tables 1-2, Figures 1-5 from 6-Thioguanine Reactivates Epigenetically Silenced Genes in Acute Lymphoblastic Leukemia Cells by Facilitating Proteasome-mediated Degradation of DNMT1
Supplementary Tables 1-2, Figures 1-5 from 6-Thioguanine Reactivates Epigenetically Silenced Genes in Acute Lymphoblastic Leukemia Cells by Facilitating Proteasome-mediated Degradation of DNMT1 Open
PDF file - 322K
View article: Blanching of two commercial Norwegian brown seaweeds - for reduction of iodine and other compounds of importance for food safety and quality
Blanching of two commercial Norwegian brown seaweeds - for reduction of iodine and other compounds of importance for food safety and quality Open
View article: Using shockless ramp compression to investigate melting in Earth’s mantle
Using shockless ramp compression to investigate melting in Earth’s mantle Open
View article: 115. Post-licensure Safety Study of New-onset Immune-mediated Diseases, Herpes Zoster, and Anaphylaxis in Adult Recipients of HepB-CPG Vaccine Versus HepB-alum Vaccine
115. Post-licensure Safety Study of New-onset Immune-mediated Diseases, Herpes Zoster, and Anaphylaxis in Adult Recipients of HepB-CPG Vaccine Versus HepB-alum Vaccine Open
Background HepB-CpG (Heplisav-B; Dynavax) is a licensed hepatitis B vaccine with a novel adjuvant that requires only 2 doses (0, 1 month) compared to a 3-dose (0, 1, 6 months) HepB-alum vaccine (Engerix-B; GlaxoSmithKline). Monitoring of s…
View article: Travelers and travel vaccines at six health care systems in the Vaccine Safety Datalink
Travelers and travel vaccines at six health care systems in the Vaccine Safety Datalink Open
View article: Shock Ramp of SiO2 melt.
Shock Ramp of SiO2 melt. Open
View article: Water in Silicates: A Combined Shock & Spectroscopy Study.
Water in Silicates: A Combined Shock & Spectroscopy Study. Open
View article: Shock and shock-ramp compression of iron-rich (Mg,Fe)O up to Earth?s core conditions.
Shock and shock-ramp compression of iron-rich (Mg,Fe)O up to Earth?s core conditions. Open
View article: Using Shockless Ramp Compression to Investigate Melting in the Earth?s Mantle.
Using Shockless Ramp Compression to Investigate Melting in the Earth?s Mantle. Open
View article: Risk for Shoulder Conditions After Vaccination: A Population-Based Study Using Real-World Data.
Risk for Shoulder Conditions After Vaccination: A Population-Based Study Using Real-World Data. Open
Centers for Disease Control and Prevention.
View article: Identifying Cases of Shoulder Injury Related to Vaccine Administration (SIRVA) in the United States: Development and Validation of a Natural Language Processing Method
Identifying Cases of Shoulder Injury Related to Vaccine Administration (SIRVA) in the United States: Development and Validation of a Natural Language Processing Method Open
Background Shoulder injury related to vaccine administration (SIRVA) accounts for more than half of all claims received by the National Vaccine Injury Compensation Program. However, due to the difficulty of finding SIRVA cases in large hea…
View article: Association Between 2-Dose vs 3-Dose Hepatitis B Vaccine and Acute Myocardial Infarction
Association Between 2-Dose vs 3-Dose Hepatitis B Vaccine and Acute Myocardial Infarction Open
In this cohort study, receipt of HepB-CpG vaccine compared with HepB-alum vaccine did not meet the statistical criterion for increased risk of acute myocardial infarction.
View article: Water in silicates: A combined shock and spectroscopy study.
Water in silicates: A combined shock and spectroscopy study. Open
View article: Shock and shock-ramp compression of iron-rich (Mg,Fe)O at Earth?s core conditions.
Shock and shock-ramp compression of iron-rich (Mg,Fe)O at Earth?s core conditions. Open
studies benefit greatly from isentropic, off‐Hugoniot experiments since they can cover pressure‐temperature (P‐T) conditions that are close to adiabatic profiles found in planetary interiors. We used this method to drive iron to P‐T condit…
View article: Shock-ramp compression of iron-rich (Mg,Fe)O: preliminary theory and application to Earth?s ultra-low velocity zones.
Shock-ramp compression of iron-rich (Mg,Fe)O: preliminary theory and application to Earth?s ultra-low velocity zones. Open
View article: Exploring Earth’s Deep Water Cycle using Sublithospheric Diamonds
Exploring Earth’s Deep Water Cycle using Sublithospheric Diamonds Open
Sublithospheric diamonds, which may form within the transition zone and lower mantle, are the very deepest direct samples of the Earth's interior.[e.g., 1, 2, 3].Diamond can protect mineral inclusions from reactions during ascent to the su…
View article: Causes of Death in End-Stage Kidney Disease: Comparison between the United States Renal Data System and a Large Integrated Health Care System
Causes of Death in End-Stage Kidney Disease: Comparison between the United States Renal Data System and a Large Integrated Health Care System Open
Introduction: Using a large diverse population of incident end-stage kidney disease (ESKD) patients from an integrated health system, we sought to evaluate the concordance of causes of death (CODs) between the underlying COD from the Unite…
View article: Variation in SARS-CoV-2 molecular test sensitivity by specimen types in a large sample of emergency department patients
Variation in SARS-CoV-2 molecular test sensitivity by specimen types in a large sample of emergency department patients Open
This study provides robust evidence that patient-collected saliva and anterior nares are sensitive for SARS-CoV-2 molecular testing in emergency department settings, particularly among adults ages ≥40 years and those with multiple symptoms…
View article: Considerations for estimating real-world outcomes and value in vaccination: A case study with adult hepatitis B virus vaccination
Considerations for estimating real-world outcomes and value in vaccination: A case study with adult hepatitis B virus vaccination Open
Metrics estimating vaccine real-world effectiveness and value may guide informed decisions in vaccine selection. For example, using eVPR and CPP, HepB-CpG represents a more effective, value-advantaged approach than HepB-Alum toward reducin…
View article: Disparities in Outpatient and Telehealth Visits During the COVID-19 Pandemic in a Large Integrated Health Care Organization: Retrospective Cohort Study
Disparities in Outpatient and Telehealth Visits During the COVID-19 Pandemic in a Large Integrated Health Care Organization: Retrospective Cohort Study Open
Background Dramatic decreases in outpatient visits and sudden increases in telehealth visits were observed during the COVID-19 pandemic, but it was unclear whether these changes differed by patient demographics and socioeconomic status. Ob…
View article: Can silicate melts in the Earth?s upper mantle be seismically detected? A shockless-compression study on Thor.
Can silicate melts in the Earth?s upper mantle be seismically detected? A shockless-compression study on Thor. Open