J. R. Leite
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View article: Peptides from Animal Venoms: A Promising Frontier in Diabetes Therapy via Multi-Target Mechanisms
Peptides from Animal Venoms: A Promising Frontier in Diabetes Therapy via Multi-Target Mechanisms Open
Background/Objectives: Bioactive peptides derived from animal venoms, toxins, and secretions demonstrate considerable pharmacological potential for use in the management of diabetes mellitus—a highly prevalent metabolic disorder of substan…
View article: The Temporal Aspect of Bodily Experiences of Emotions: Where do You Feel The First Sensation?
The Temporal Aspect of Bodily Experiences of Emotions: Where do You Feel The First Sensation? Open
Recently, body maps have increasingly been used to identify patterns in respect of the location of the physical sensations elicited by emotions. However, in addition to understanding how emotions are topographically manifest in the body, i…
View article: Functional studies and molecular dynamics reveal BPP-BrachyNH2-induced relaxation in male rat small mesenteric arteries via binding to argininosuccinate synthase
Functional studies and molecular dynamics reveal BPP-BrachyNH2-induced relaxation in male rat small mesenteric arteries via binding to argininosuccinate synthase Open
View article: Enhancing Antimicrobial Peptides from Frog Skin: A Rational Approach
Enhancing Antimicrobial Peptides from Frog Skin: A Rational Approach Open
Antimicrobial resistance is a global health threat, which has been worsened by the slow development of new antibiotics. The rational design of natural-derived antimicrobial peptides (AMPs) offers a promising alternative for enhancing the e…
View article: Antioxidant Activity and Cytotoxicity of Baru Nut Oil (Dipteryx alata Vogel) Nanoemulsion in Human Cells
Antioxidant Activity and Cytotoxicity of Baru Nut Oil (Dipteryx alata Vogel) Nanoemulsion in Human Cells Open
Baru nut oil (Dipteryx alata Vogel) is a lipidic extract from a species endemic to the Cerrado biome, renowned for its antioxidant potential. This study aimed to develop a nanoemulsion containing baru nut oil (BNON) using lecithin and poly…
View article: Eco-Friendly Agrotech Approach of Citrate-Coated Silver Nanoparticles: Antimicrobial and Effective Control of Meloidogyne Incognita Nematodes
Eco-Friendly Agrotech Approach of Citrate-Coated Silver Nanoparticles: Antimicrobial and Effective Control of Meloidogyne Incognita Nematodes Open
View article: Extraction and Identification of Flavonoids from the Leaves of Pilocarpus microphyllus: Focus on Antioxidant Activity and Neuroprotective Profile
Extraction and Identification of Flavonoids from the Leaves of Pilocarpus microphyllus: Focus on Antioxidant Activity and Neuroprotective Profile Open
This work is based on research aiming to extract and identify flavonoids from jaborandi (Pilocarpus microphyllus) leaves and investigate their antioxidant and acute antinociceptive capacity. Characterization of the constituents of the ethy…
View article: INTRAGENIC ANTIMICROBIAL PEPTIDE HS02 INCREASES THE EXPRESSION OF COMPONENTS INVOLVED IN PYROPTOSIS AND EXERTS ANTINEOPLASTIC EFFECTS IN HUMAN LEUKEMIA CELL LINES
INTRAGENIC ANTIMICROBIAL PEPTIDE HS02 INCREASES THE EXPRESSION OF COMPONENTS INVOLVED IN PYROPTOSIS AND EXERTS ANTINEOPLASTIC EFFECTS IN HUMAN LEUKEMIA CELL LINES Open
The anticancer potential of some antimicrobial peptides has been reported. Hs02 is a recently characterized Intragenic Antimicrobial Peptide (IAP), which was able to exhibit potent antimicrobial and anti-inflammatory action. In this study,…
View article: Synergic Effect of the Antimicrobial Peptide ToAP2 and Fluconazole on Candida albicans Biofilms
Synergic Effect of the Antimicrobial Peptide ToAP2 and Fluconazole on Candida albicans Biofilms Open
Candida albicans is one of the agents of invasive candidiasis, a life-threatening disease strongly associated with hospitalization, particularly among patients in intensive care units with central venous catheters. This study aimed to eval…
View article: Toxicity and Teratogenic Potential of Piplartine from Piper tuberculatum Jacq. during Embryonic Development in Mice (Mus musculus)
Toxicity and Teratogenic Potential of Piplartine from Piper tuberculatum Jacq. during Embryonic Development in Mice (Mus musculus) Open
Piplartine, also known as piperlongumine, is a natural and biologically active amide alkaloid found in various Piper species within the Piperaceae family. It possesses numerous beneficial properties that can be leveraged in the development…
View article: Exploring Bodily Sensation Maps of Emotions for Physiological Correlates A Narrative Review
Exploring Bodily Sensation Maps of Emotions for Physiological Correlates A Narrative Review Open
Research on the subjective perception of emotions, based on bodily sensation maps (BSMs) indicating increased or decreased perceived physiological activity through interoception, has found distinctive bodily topographies for each emotion. …
View article: Antiviral Action against SARS-CoV-2 of a Synthetic Peptide Based on a Novel Defensin Present in the Transcriptome of the Fire Salamander (Salamandra salamandra)
Antiviral Action against SARS-CoV-2 of a Synthetic Peptide Based on a Novel Defensin Present in the Transcriptome of the Fire Salamander (Salamandra salamandra) Open
The potential emergence of zoonotic diseases has raised significant concerns, particularly in light of the recent pandemic, emphasizing the urgent need for scientific preparedness. The bioprospection and characterization of new molecules a…
View article: The Peptide Salamandrin-I Modulates Components Involved in Pyroptosis and Induces Cell Death in Human Leukemia Cell Line HL-60
The Peptide Salamandrin-I Modulates Components Involved in Pyroptosis and Induces Cell Death in Human Leukemia Cell Line HL-60 Open
Amphibian secretions have been extensively investigated for the production of bioactive molecules. Salamandrin-I is an antioxidant peptide, isolated from the skin secretion of the fire salamander, that has induced no toxicity in microglia …
View article: Lycopene from Red Guava (Psidium guajava L.): From Hepatoprotective Effect to Its Use as Promising Self-Emulsifying Drug Delivery System for Anti-Inflammatory and Antioxidant Applications
Lycopene from Red Guava (Psidium guajava L.): From Hepatoprotective Effect to Its Use as Promising Self-Emulsifying Drug Delivery System for Anti-Inflammatory and Antioxidant Applications Open
Lycopene is a carotenoid with potential use in the treatment of chronic illnesses. Here, different formulations of lycopene were studied: lycopene-rich extract from red guava (LEG), purified lycopene from red guava (LPG) and a self-emulsif…
View article: Prospecting Plant Extracts and Bioactive Molecules with Antimicrobial Activity in Brazilian Biomes: A Review
Prospecting Plant Extracts and Bioactive Molecules with Antimicrobial Activity in Brazilian Biomes: A Review Open
Antimicrobial resistance is currently one of the greatest threats to global health, food security, and development. In this aspect, medicinal plants have been studied to support the development of viable alternatives to prevent and treat i…
View article: Novel Scaffold Based on Chitosan Hydrogels/Phthalated Cashew Gum for Supporting Human Dental Pulp Stem Cells
Novel Scaffold Based on Chitosan Hydrogels/Phthalated Cashew Gum for Supporting Human Dental Pulp Stem Cells Open
Hydrogels are structures that have value for application in the area of tissue engineering because they mimic the extracellular matrix. Naturally obtained polysaccharides, such as chitosan (CH) and cashew gum, are materials with the abilit…
View article: Influence of Plant Age on Chemical Composition, Antimicrobial Activity and Cytotoxicity of Varronia curassavica Jacq. Essential Oil Produced on an Industrial Scale
Influence of Plant Age on Chemical Composition, Antimicrobial Activity and Cytotoxicity of Varronia curassavica Jacq. Essential Oil Produced on an Industrial Scale Open
Considering the therapeutic potential of Varronia curassavica Jacq. essential oil and the great value in the pharmaceutical market, this study aims to evaluate the influence of plant age on the chemical composition and biological activitie…
View article: Potential Biological Properties of Lycopene in a Self-Emulsifying Drug Delivery System
Potential Biological Properties of Lycopene in a Self-Emulsifying Drug Delivery System Open
In recent years, lycopene has been highlighted due to its antioxidant and anti-inflammatory properties, associated with a beneficial effect on human health. The aim of this study was to advance the studies of antioxidant and anti-inflammat…
View article: Perspectives on the Therapeutic Effects of Pelvic Floor Electrical Stimulation: A Systematic Review
Perspectives on the Therapeutic Effects of Pelvic Floor Electrical Stimulation: A Systematic Review Open
Pelvic, perineal, and nervous lesions, which derive principally from pregnancy and childbirth, may lead to pelvic floor dysfunctions, such as organ prolapses and lesions in the nerves and muscles due to muscle expansion and physiology. It …
View article: Neuroprotective effects on microglia and insights into the structure–activity relationship of an antioxidant peptide isolated from <i>Pelophylax perezi</i>
Neuroprotective effects on microglia and insights into the structure–activity relationship of an antioxidant peptide isolated from <i>Pelophylax perezi</i> Open
Tryptophyllins constitute a heterogeneous group of peptides that are one of the first classes of peptides identified from amphibian’s skin secretions. Here, we report the structural characterization and antioxidant properties of a novel tr…
View article: Bio-Availability, Anticancer Potential, and Chemical Data of Lycopene: An Overview and Technological Prospecting
Bio-Availability, Anticancer Potential, and Chemical Data of Lycopene: An Overview and Technological Prospecting Open
The purpose of this review was to collect relevant chemical data about lycopene and its isomers, which can be extracted using different non-polar or polar aprotic solvents by SC-CO2 or biosynthesis as a friendly technique. Lycopene and oth…
View article: Phenolic Lipids Derived from Cashew Nut Shell Liquid to Treat Metabolic Diseases
Phenolic Lipids Derived from Cashew Nut Shell Liquid to Treat Metabolic Diseases Open
Metabolic diseases are increasing at staggering rates globally. The peroxisome proliferator-activated receptors (PPARα/γ/δ) are fatty acid sensors that help mitigate imbalances between energy uptake and utilization. Herein, we report compo…
View article: Effects of ω-3 PUFA-Rich Oil Supplementation on Cardiovascular Morphology and Aortic Vascular Reactivity of Adult Male Rats Submitted to an Hypercholesterolemic Diet
Effects of ω-3 PUFA-Rich Oil Supplementation on Cardiovascular Morphology and Aortic Vascular Reactivity of Adult Male Rats Submitted to an Hypercholesterolemic Diet Open
Atherosclerosis is a cardiovascular disease associated with abnormalities of vascular functions. The consumption of mono- and polyunsaturated fatty acids can be considered a strategy to reduce clinical events related to atherosclerosis. In…
View article: Effects of Fish Oil Supplementation on Oxidative Stress Biomarkers and Liver Damage in Hypercholesterolemic Rats
Effects of Fish Oil Supplementation on Oxidative Stress Biomarkers and Liver Damage in Hypercholesterolemic Rats Open
Metabolic syndrome, especially its component related to dyslipidemia, is related to the development of nonalcoholic fatty liver disease (NAFLD), which is a disease with a significant global prevalence. Supplementation with omega-3 polyunsa…
View article: The Arsenal of Bioactive Molecules in the Skin Secretion of Urodele Amphibians
The Arsenal of Bioactive Molecules in the Skin Secretion of Urodele Amphibians Open
Urodele amphibians (∼768 spp.), salamanders and newts, are a rich source of molecules with bioactive properties, especially those isolated from their skin secretions. These include pharmacological attributes, such as antimicrobial, antioxi…
View article: The Temporal Aspect of Bodily Experiences of Emotions: Where do You Feel The First Sensation?
The Temporal Aspect of Bodily Experiences of Emotions: Where do You Feel The First Sensation? Open
Recently, body maps have increasingly been used to identify patterns in respect of the location of the physical sensations elicited by emotions. However, in addition to understanding how emotions are topographically manifest in the body, i…
View article: The Temporal Aspect of Bodily Experiences of Emotions: Where do You Feel The First Sensation?
The Temporal Aspect of Bodily Experiences of Emotions: Where do You Feel The First Sensation? Open
Recently, body maps have increasingly been used to identify patterns in respect of the location of the physical sensations elicited by emotions. However, in addition to understanding how emotions are topographically manifest in the body, i…
View article: Cationic Hylin Bioactive Peptides from Boana pulchella (Anura: Hylidae): Activity, Structure, and Interaction with Lipid Membranes
Cationic Hylin Bioactive Peptides from Boana pulchella (Anura: Hylidae): Activity, Structure, and Interaction with Lipid Membranes Open
View article: Cationic Hylin Bioactive Peptides from Boana pulchella (Anura: Hylidae): Activity, Structure, and Interaction with Lipid Membranes
Cationic Hylin Bioactive Peptides from Boana pulchella (Anura: Hylidae): Activity, Structure, and Interaction with Lipid Membranes Open
View article: Structure and Function of Cationic Hylin Bioactive Peptides from the Tree Frog Boana Pulchella in Interaction with Lipid Membranes
Structure and Function of Cationic Hylin Bioactive Peptides from the Tree Frog Boana Pulchella in Interaction with Lipid Membranes Open