Jesper Skovhus Thomsen
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View article: High doses of methylprednisolone causes substantial muscle loss with minimal impact on bone mass and architecture in C57BL/6JRj and RjOrl:SWISS mice
High doses of methylprednisolone causes substantial muscle loss with minimal impact on bone mass and architecture in C57BL/6JRj and RjOrl:SWISS mice Open
Glucocorticoids are widely used to treat chronic autoimmune and inflammatory disorders. Unfortunately, glucocorticoid treatment frequently results in severe adverse effects, such as skeletal muscle atrophy and glucocorticoid-induced osteop…
View article: Genetic rescue of pathogenic O-GlcNAc dyshomeostasis associated with microcephaly and motor deficits
Genetic rescue of pathogenic O-GlcNAc dyshomeostasis associated with microcephaly and motor deficits Open
Missense variants in O-GlcNAc transferase (OGT) result in OGT congenital disorder of glycosylation (OGT-CDG), an intellectual disability syndrome associated with O-GlcNAc dyshomeostasis and a range of neurodevelopmental defects. Inhibition…
View article: Severe Osteoporosis in Larsen Syndrome—A Case Report of Bone Morphology and A Novel Filamin B (FLNB) Variant
Severe Osteoporosis in Larsen Syndrome—A Case Report of Bone Morphology and A Novel Filamin B (FLNB) Variant Open
Larsen syndrome is a rare genetic condition characterized by facial dysmorphism and skeletal deformities. It is caused by heterozygous pathogenic variants in the Filamin B encoding gene ( FLNB ). FLNB is a cytoskeletal protein that plays a…
View article: High-fat diet induced obesity and anti-activin receptor antibody: Effects on bone properties in mice
High-fat diet induced obesity and anti-activin receptor antibody: Effects on bone properties in mice Open
View article: Pathogenic O-GlcNAc dyshomeostasis associated with cortical malformations and hyperactivity
Pathogenic O-GlcNAc dyshomeostasis associated with cortical malformations and hyperactivity Open
Missense variants in the O-GlcNAc transferase (OGT) gene have recently been shown to segregate with a syndromic form of intellectual disability (OGT-ID), underscoring the importance of protein O-GlcNAcylation in brain function. However, th…
View article: Author response: Pathogenic O-GlcNAc dyshomeostasis associated with cortical malformations and hyperactivity
Author response: Pathogenic O-GlcNAc dyshomeostasis associated with cortical malformations and hyperactivity Open
View article: Pathogenic O-GlcNAc dyshomeostasis associated with cortical malformations and hyperactivity
Pathogenic O-GlcNAc dyshomeostasis associated with cortical malformations and hyperactivity Open
Missense variants in the O-GlcNAc transferase (OGT) gene have recently been shown to segregate with a syndromic form of intellectual disability (OGT-ID), underscoring the importance of protein O-GlcNAcylation in brain function. However, th…
View article: Pathogenic O-GlcNAc dyshomeostasis associated with cortical malformations and hyperactivity
Pathogenic O-GlcNAc dyshomeostasis associated with cortical malformations and hyperactivity Open
Missense variants in the O-GlcNAc transferase ( OGT) gene have recently been shown to segregate with a syndromic form of intellectual disability (OGT-ID), underscoring the importance of protein O-GlcNAcylation in brain function. However, t…
View article: Complex Treatment of a Coronary Bifurcation Perforation With a Dual-Covered Stent Strategy
Complex Treatment of a Coronary Bifurcation Perforation With a Dual-Covered Stent Strategy Open
View article: The Effect of Anti‐Activin Receptor Type IIA and Type IIB Antibody on Muscle, Bone and Blood in Healthy and Osteosarcopenic Mice
The Effect of Anti‐Activin Receptor Type IIA and Type IIB Antibody on Muscle, Bone and Blood in Healthy and Osteosarcopenic Mice Open
Background Anti‐Activin Receptor Type IIA and Type IIB antibody (αActRIIA/IIB ab) is a recently developed drug class that targets the activin receptor signalling pathway. Inhibition of receptor ligands (activins, myostatin, growth differen…
View article: Chronotherapy with Cinacalcet has a striking effect on inhibition of parathyroid gland proliferation in rats with secondary hyperparathyroidism
Chronotherapy with Cinacalcet has a striking effect on inhibition of parathyroid gland proliferation in rats with secondary hyperparathyroidism Open
Secondary hyperparathyroidism (sHPT) is a significant clinical complication of CKD leading to bone abnormalities and cardiovascular disease. Current treatment based on activating the parathyroid calcium-sensing receptor (CaSR) using calcim…
View article: Detecting new erosions in rheumatoid arthritis over one year – Radiography and high-resolution computed tomography of finger joints
Detecting new erosions in rheumatoid arthritis over one year – Radiography and high-resolution computed tomography of finger joints Open
View article: Trabecular bone structural units and their cement lines change with age, bone volume fraction, structure, and strength in female human vertebrae
Trabecular bone structural units and their cement lines change with age, bone volume fraction, structure, and strength in female human vertebrae Open
A lifetime of successive bone remodeling events leads to trabeculae which are composed of a patchwork of bone structural units (BSUs) called hemi-osteons or trabecular packets. Traditionally, only intact surface BSUs have been studied, whi…
View article: Mapping RANKL- and OPG-expressing cells in bone tissue: the bone surface cells as activators of osteoclastogenesis and promoters of the denosumab rebound effect
Mapping RANKL- and OPG-expressing cells in bone tissue: the bone surface cells as activators of osteoclastogenesis and promoters of the denosumab rebound effect Open
View article: Short arm splints for wrist stabilization: A mechanical material test and cadaveric radiography study
Short arm splints for wrist stabilization: A mechanical material test and cadaveric radiography study Open
Purpose Documentation of the wrist stabilizing effect and mechanical properties of common splinting materials is warranted to support evidence‐based condition‐specific recommendations for wrist immobilization. The objectives of this study …
View article: The metalloproteinase PAPP-A is required for IGF-dependent chondrocyte differentiation and organization
The metalloproteinase PAPP-A is required for IGF-dependent chondrocyte differentiation and organization Open
Insulin-like growth factor (IGF) signaling is required for proper growth and skeletal development in vertebrates. Consequently, its dysregulation may lead to abnormalities of growth or skeletal structures. IGF is involved in the regulation…
View article: Identification of countercurrent tubule-vessel arrangements in the early development of mouse kidney based on immunohistochemistry and computer-assisted 3D visualization
Identification of countercurrent tubule-vessel arrangements in the early development of mouse kidney based on immunohistochemistry and computer-assisted 3D visualization Open
Nephron loop-vessel countercurrent arrangement in the medulla provides the structural basis for the formation of concentrated urine. To date, the morphogenesis of it and relevant water and solutes transportation has not been fully elucidat…
View article: High incidence of imperforate vagina in ADGRA3-deficient mice
High incidence of imperforate vagina in ADGRA3-deficient mice Open
Background Ten percent of the female population suffers from congenital abnormalities of the vagina, uterus, or oviducts, with severe consequences for reproductive and psychological health. Yet, the underlying causes of most of these malfo…
View article: The ectopic mandibular canines can start tooth formation in three different locations: a case series study based on single orthopantomograms from 47 individuals
The ectopic mandibular canines can start tooth formation in three different locations: a case series study based on single orthopantomograms from 47 individuals Open
Introduction A former study on orthopantomograms from young children with abnormal dental development (not canine ectopia) demonstrated that the tooth bud of the mandibular canine, compared to a stable longitudinal canine axis, could be lo…
View article: Protocols for preparation of biomineralized samples for computed tomography
Protocols for preparation of biomineralized samples for computed tomography Open
View article: Preoperative proximal tibial bone density, bone microarchitecture, and bone turnover are not associated with postoperative tibial component migration in cemented and cementless medial unicompartmental knee replacements: secondary analyses from a randomized controlled trial
Preoperative proximal tibial bone density, bone microarchitecture, and bone turnover are not associated with postoperative tibial component migration in cemented and cementless medial unicompartmental knee replacements: secondary analyses from a randomized controlled trial Open
Background and purpose: Cementless arthroplasty fixation relies on early bone ingrowth and may be poor in patients with low proximal tibial bone density or abnormal bone turnover. We aimed first to describe the baseline bone properties in …
View article: Transitory Activation and Improved Transition from Erosion to Formation within Intracortical Bone Remodeling in Hypoparathyroid Patients Treated with <scp>rhPTH</scp> (1–84)
Transitory Activation and Improved Transition from Erosion to Formation within Intracortical Bone Remodeling in Hypoparathyroid Patients Treated with <span>rhPTH</span> (1–84) Open
In hypoparathyroidism, lack of parathyroid hormone (PTH) leads to low calcium levels and decreased bone remodeling. Treatment with recombinant human PTH (rhPTH) may normalize bone turnover. This study aimed to investigate whether rhPTH(1–8…
View article: Trabecular bone deterioration in a postmenopausal female suffering multiple spontaneous vertebral fractures due to a delayed denosumab injection – A post-treatment re-initiation bone biopsy-based case study
Trabecular bone deterioration in a postmenopausal female suffering multiple spontaneous vertebral fractures due to a delayed denosumab injection – A post-treatment re-initiation bone biopsy-based case study Open
View article: Correlative study of liquid in human bone by 3D neutron microscopy and lab-based X-ray μCT
Correlative study of liquid in human bone by 3D neutron microscopy and lab-based X-ray μCT Open
Liquid plays an important role in bone that has a complex 3D hierarchical pore structure. However, liquid (water) is difficult to discern from e.g. an organic matrix by X-ray imaging. Therefore, we use a correlative approach using both hig…
View article: Local coordination between intracortical bone remodeling and vascular development in human juvenile bone
Local coordination between intracortical bone remodeling and vascular development in human juvenile bone Open
View article: Polychromatic neutron phase-contrast imaging of weakly absorbing samples enabled by phase retrieval
Polychromatic neutron phase-contrast imaging of weakly absorbing samples enabled by phase retrieval Open
The use of a phase-retrieval technique for propagation-based phase-contrast neutron imaging with a polychromatic beam is demonstrated. This enables imaging of samples with low absorption contrast and/or improving the signal-to-noise ratio …
View article: Correlative study of liquid in human bone by 3D neutron microscopy and lab-based X-ray µCT
Correlative study of liquid in human bone by 3D neutron microscopy and lab-based X-ray µCT Open
X-ray (xray_data.tiff) and neutron microscopy (neutron_data.tiff) of the same piece of human cortical bone. Neutron data were collected at the neutron microscope at SINQ, PSI, Switzerland while the x-ray data were collected in house at an …
View article: Correlative study of liquid in human bone by 3D neutron microscopy and lab-based X-ray µCT
Correlative study of liquid in human bone by 3D neutron microscopy and lab-based X-ray µCT Open
X-ray (xray_data.tiff) and neutron microscopy (neutron_data.tiff) of the same piece of human cortical bone. Neutron data were collected at the neutron microscope at SINQ, PSI, Switzerland while the x-ray data were collected in house at an …
View article: Flexible design in the stomatopod dactyl club
Flexible design in the stomatopod dactyl club Open
The stomatopod is a fascinating animal that uses its weaponized appendage dactyl clubs for breaking mollusc shells. Dactyl clubs are a well studied example of biomineralized hierarchical structures. Most research has focused on the regions…
View article: Loss of <i>Adgra3</i> causes obstructive azoospermia with high penetrance in male mice
Loss of <i>Adgra3</i> causes obstructive azoospermia with high penetrance in male mice Open
The adhesion receptor ADGRA3 (GPR125) is a known spermatogonial stem cell marker, but its impact on male reproduction and fertility has not been examined. Using a mouse model lacking Adgra3 ( Adgra3 −/− ), we show that 55% of the male mice…