Mark Waer
YOU?
Author Swipe
View article: Surgery in recurrent brain glioma, does it improve clinical outcome?
Surgery in recurrent brain glioma, does it improve clinical outcome? Open
Introduction Gliomas account for 24% of all primary brain and CNS tumors. Histologically, gliomas were categorized into subtypes and grades (I through IV). Low-grade gliomas are grade I and grade II, while high-grade gliomas are grade III …
View article: 3-nitropyridine analogues as novel microtubule-targeting agents
3-nitropyridine analogues as novel microtubule-targeting agents Open
Microtubule-targeting agents are an important class of anti-cancer drugs; their full potential is however not realized because of significant myelotoxicity and neurotoxicity. We here report 3-nitropyridine analogues as a novel group of mic…
View article: Data from Donor Lymphocyte–Derived Natural Killer Cells Control MHC Class I–Negative Melanoma
Data from Donor Lymphocyte–Derived Natural Killer Cells Control MHC Class I–Negative Melanoma Open
Natural killer (NK) cells provide a natural defense against MHC-I–negative tumors, such as melanoma. Donor lymphocyte infusion (DLI) containing NK cells, a form of adoptive immunotherapy used after allogenic bone marrow transplantation (al…
View article: Supplementary Figures 1-7 from Donor Lymphocyte–Derived Natural Killer Cells Control MHC Class I–Negative Melanoma
Supplementary Figures 1-7 from Donor Lymphocyte–Derived Natural Killer Cells Control MHC Class I–Negative Melanoma Open
Figure S1. Evaluation of immune cells in host mice. Figure S2. Evaluation of donor T and NK cells reconstitution. Figure S3. Melanoma-bearing host mice are protected from lethal GVHD after DLI. Figure S4. Evaluation of MHC-I expression on …
View article: Supplementary Figures 1-7 from Donor Lymphocyte–Derived Natural Killer Cells Control MHC Class I–Negative Melanoma
Supplementary Figures 1-7 from Donor Lymphocyte–Derived Natural Killer Cells Control MHC Class I–Negative Melanoma Open
Figure S1. Evaluation of immune cells in host mice. Figure S2. Evaluation of donor T and NK cells reconstitution. Figure S3. Melanoma-bearing host mice are protected from lethal GVHD after DLI. Figure S4. Evaluation of MHC-I expression on …
View article: Data from Donor Lymphocyte–Derived Natural Killer Cells Control MHC Class I–Negative Melanoma
Data from Donor Lymphocyte–Derived Natural Killer Cells Control MHC Class I–Negative Melanoma Open
Natural killer (NK) cells provide a natural defense against MHC-I–negative tumors, such as melanoma. Donor lymphocyte infusion (DLI) containing NK cells, a form of adoptive immunotherapy used after allogenic bone marrow transplantation (al…
View article: Data from Solid Tumor–Induced Immune Regulation Alters the GvHD/GvT Paradigm after Allogenic Bone Marrow Transplantation
Data from Solid Tumor–Induced Immune Regulation Alters the GvHD/GvT Paradigm after Allogenic Bone Marrow Transplantation Open
Growth of solid tumors is often associated with the development of an immunosuppressive tumor microenvironment (TME). It has been suggested that the influence of the TME may extend beyond the local tumor and results in systemic immunosuppr…
View article: Data from Solid Tumor–Induced Immune Regulation Alters the GvHD/GvT Paradigm after Allogenic Bone Marrow Transplantation
Data from Solid Tumor–Induced Immune Regulation Alters the GvHD/GvT Paradigm after Allogenic Bone Marrow Transplantation Open
Growth of solid tumors is often associated with the development of an immunosuppressive tumor microenvironment (TME). It has been suggested that the influence of the TME may extend beyond the local tumor and results in systemic immunosuppr…
View article: Supplementary Data from Solid Tumor–Induced Immune Regulation Alters the GvHD/GvT Paradigm after Allogenic Bone Marrow Transplantation
Supplementary Data from Solid Tumor–Induced Immune Regulation Alters the GvHD/GvT Paradigm after Allogenic Bone Marrow Transplantation Open
Figure S1. Treg cells accumulate at multiple organs in tumor-bearing mice. Figure S2. allo-BMT leads to aGVHD. Figure S3. Treg cells accumulate at multiple organs post-BMT. Figure S4. Efficiency of Treg depletion. Figure S5. Efficiency of …
View article: Supplementary Data from Solid Tumor–Induced Immune Regulation Alters the GvHD/GvT Paradigm after Allogenic Bone Marrow Transplantation
Supplementary Data from Solid Tumor–Induced Immune Regulation Alters the GvHD/GvT Paradigm after Allogenic Bone Marrow Transplantation Open
Figure S1. Treg cells accumulate at multiple organs in tumor-bearing mice. Figure S2. allo-BMT leads to aGVHD. Figure S3. Treg cells accumulate at multiple organs post-BMT. Figure S4. Efficiency of Treg depletion. Figure S5. Efficiency of …
View article: Small Molecule Cyclotriazadisulfonamide Abrogates the Upregulation of the Human Receptors CD4 and 4-1BB and Suppresses In Vitro Activation and Proliferation of T Lymphocytes
Small Molecule Cyclotriazadisulfonamide Abrogates the Upregulation of the Human Receptors CD4 and 4-1BB and Suppresses In Vitro Activation and Proliferation of T Lymphocytes Open
The small molecule cyclotriazadisulfonamide (CADA) down-modulates the human CD4 receptor, an important factor in T cell activation. Here, we addressed the immunosuppressive potential of CADA using different activation models. CADA inhibite…
View article: Simultaneous inhibition of human CD4 and 4-1BB biogenesis suppresses cytotoxic T lymphocyte proliferation
Simultaneous inhibition of human CD4 and 4-1BB biogenesis suppresses cytotoxic T lymphocyte proliferation Open
The small molecule cyclotriazadisulfonamide (CADA) down-modulates the human CD4 receptor, an important factor in T cell activation. Here, we addressed the immunosuppressive potential of CADA using in vitro activation models. CADA inhibited…
View article: Donor Lymphocyte–Derived Natural Killer Cells Control MHC Class I–Negative Melanoma
Donor Lymphocyte–Derived Natural Killer Cells Control MHC Class I–Negative Melanoma Open
Natural killer (NK) cells provide a natural defense against MHC-I–negative tumors, such as melanoma. Donor lymphocyte infusion (DLI) containing NK cells, a form of adoptive immunotherapy used after allogenic bone marrow transplantation (al…
View article: Improved Anti-Tumour Adaptive Immunity Can Overcome the Melanoma Immunosuppressive Tumour Microenvironment
Improved Anti-Tumour Adaptive Immunity Can Overcome the Melanoma Immunosuppressive Tumour Microenvironment Open
Clinical benefits obtained from checkpoint blockade regimens demonstrate the importance of overcoming the immunosuppressive tumour microenvironment (TME) in cancer immunotherapy. Intravenous (i.v.) injection of B16 melanoma cells (H-2Kb) l…
View article: Solid Tumor–Induced Immune Regulation Alters the GvHD/GvT Paradigm after Allogenic Bone Marrow Transplantation
Solid Tumor–Induced Immune Regulation Alters the GvHD/GvT Paradigm after Allogenic Bone Marrow Transplantation Open
Growth of solid tumors is often associated with the development of an immunosuppressive tumor microenvironment (TME). It has been suggested that the influence of the TME may extend beyond the local tumor and results in systemic immunosuppr…
View article: OSU-T315 as an Interesting Lead Molecule for Novel B Cell-Specific Therapeutics
OSU-T315 as an Interesting Lead Molecule for Novel B Cell-Specific Therapeutics Open
B cells are pathogenic in various disease processes and therefore represent an interesting target for the development of novel immunosuppressants. In the search for new therapeutic molecules, we utilized an in vitro B cell activation assay…
View article: Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment <i>in Vivo</i>
Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment <i>in Vivo</i> Open
The primary target of a novel series of immunosuppressive 7-piperazin-1-ylthiazolo[5,4- d]pyrimidin-5-amines was identified as the lipid kinase, PI4KIIIβ. Evaluation of the series highlighted their poor solubility and unwanted off-target a…
View article: Inflammatory Gene Expression Profile and Defective Interferon‐γ and Granzyme K in Natural Killer Cells From Systemic Juvenile Idiopathic Arthritis Patients
Inflammatory Gene Expression Profile and Defective Interferon‐γ and Granzyme K in Natural Killer Cells From Systemic Juvenile Idiopathic Arthritis Patients Open
Objective Systemic juvenile idiopathic arthritis (JIA) is an immunoinflammatory disease characterized by arthritis and systemic manifestations. The role of natural killer (NK) cells in the pathogenesis of systemic JIA remains unclear. The …
View article: Mouse Cytomegalovirus Infection in BALB/c Mice Resembles Virus-Associated Secondary Hemophagocytic Lymphohistiocytosis and Shows a Pathogenesis Distinct from Primary Hemophagocytic Lymphohistiocytosis
Mouse Cytomegalovirus Infection in BALB/c Mice Resembles Virus-Associated Secondary Hemophagocytic Lymphohistiocytosis and Shows a Pathogenesis Distinct from Primary Hemophagocytic Lymphohistiocytosis Open
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening immunological disorder that is characterized by systemic inflammation, widespread organ damage, and hypercytokinemia. Primary HLH is caused by mutations in granule-mediated cyt…
View article: Comparative In Vitro Immune Stimulation Analysis of Primary Human B Cells and B Cell Lines
Comparative In Vitro Immune Stimulation Analysis of Primary Human B Cells and B Cell Lines Open
B cell specific immunomodulatory drugs still remain an unmet medical need. Utilisation of validated simplified in vitro models would allow readily obtaining new insights in the complexity of B cell regulation. For this purpose we investiga…