Roy L. Silverstein
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View article: RETRACTED: Bartlett et al. Uremic Toxins Activates Na/K-ATPase Oxidant Amplification Loop Causing Phenotypic Changes in Adipocytes in In Vitro Models. Int. J. Mol. Sci. 2018, 19, 2685
RETRACTED: Bartlett et al. Uremic Toxins Activates Na/K-ATPase Oxidant Amplification Loop Causing Phenotypic Changes in Adipocytes in In Vitro Models. Int. J. Mol. Sci. 2018, 19, 2685 Open
The journal retracts the article titled “Uremic Toxins Activates Na/K-ATPase Oxidant Amplification Loop Causing Phenotypic Changes in Adipocytes in In Vitro Models” [...]
View article: Na/K-ATPase Signaling in Adipocytes Promotes Atherosclerosis
Na/K-ATPase Signaling in Adipocytes Promotes Atherosclerosis Open
BACKGROUND Adipocyte dysfunction is closely associated with oxidative stress and chronic inflammation, which contribute to systemic metabolic disturbances and atherosclerosis. We previously identified Na/K-ATPase (NKA) α1 as a signal trans…
View article: CD36 restricts lipid-associated macrophages accumulation in white adipose tissues during atherogenesis
CD36 restricts lipid-associated macrophages accumulation in white adipose tissues during atherogenesis Open
Visceral white adipose tissues (WAT) regulate systemic lipid metabolism and inflammation. Dysfunctional WAT drive chronic inflammation and facilitate atherosclerosis. Adipose tissue-associated macrophages (ATM) are the predominant immune c…
View article: Dysregulation of HO-1-SIRT1 Axis is Associated with AngII-Induced Adipocyte Dysfunction.
Dysregulation of HO-1-SIRT1 Axis is Associated with AngII-Induced Adipocyte Dysfunction. Open
Angiotensin II (AngII), a component of the Renin-Angiotensin-Aldosterone System (RAAS), has been implicated in the dysregulation of adipose tissue function. Inhibition of AngII has been shown to improve adipose tissue function in mice with…
View article: Role of adipocyte Na,K-ATPase oxidant amplification loop in cognitive decline and neurodegeneration
Role of adipocyte Na,K-ATPase oxidant amplification loop in cognitive decline and neurodegeneration Open
[This corrects the article DOI: 10.1016/j.isci.2021.103262.].
View article: Adipocyte Na, K-ATPase signaling attenuates experimental uremic cardiomyopathy
Adipocyte Na, K-ATPase signaling attenuates experimental uremic cardiomyopathy Open
Oxidative stress has been shown to cause an alteration of intracellular signaling in adipocytes that may lead to various comorbidities of obesity and cardiovascular complications. Evidence suggests that dysregulation of Na, K-ATPase signal…
View article: Contribution of adipocyte Na/K-ATPase α1/CD36 signaling induced exosome secretion in response to oxidized LDL
Contribution of adipocyte Na/K-ATPase α1/CD36 signaling induced exosome secretion in response to oxidized LDL Open
Introduction Adipose tissue constantly secretes adipokines and extracellular vesicles including exosomes to crosstalk with distinct tissues and organs for whole-body homeostasis. However, dysfunctional adipose tissue under chronic inflamma…
View article: Na/ <scp>K‐ATPase</scp> signaling tonically inhibits sodium reabsorption in the renal proximal tubule
Na/ <span>K‐ATPase</span> signaling tonically inhibits sodium reabsorption in the renal proximal tubule Open
Through its classic ATP‐dependent ion‐pumping function, basolateral Na/K‐ATPase (NKA) generates the Na + gradient that drives apical Na + reabsorption in the renal proximal tubule (RPT), primarily through the Na + /H + exchanger (NHE3). Ac…
View article: Inhibition of Na/K-ATPase signaling attenuates steatohepatitis and atherosclerosis in mice fed a western diet
Inhibition of Na/K-ATPase signaling attenuates steatohepatitis and atherosclerosis in mice fed a western diet Open
We have previously reported that the α1 subunit of sodium-potassium adenosine triphosphatase (Na/K-ATPase), acts as a receptor and an amplifier for reactive oxygen species, in addition to its distinct pumping function. On this background, …
View article: Hypertonic Saline Infusion for Hyponatremia: Limitations of the Adrogué-Madias and Other Formulas
Hypertonic Saline Infusion for Hyponatremia: Limitations of the Adrogué-Madias and Other Formulas Open
Hypertonic saline infusion is used to correct hyponatremia with severe symptoms. The selection of the volume of infused hypertonic saline ( V Inf ) should address prevention of overcorrection or undercorrection. Several formulas computing …
View article: pNaKtide Inhibits Na/K-ATPase Signaling and Attenuates Obesity.
pNaKtide Inhibits Na/K-ATPase Signaling and Attenuates Obesity. Open
Obesity is a growing public health crisis across the world and has been recognized as an underlying risk factor for metabolic syndrome. Growing evidence demonstrates the critical role of oxidative stress in the pathophysiological mechanism…
View article: Na/K-ATPase suppresses LPS-induced pro-inflammatory signaling through Lyn
Na/K-ATPase suppresses LPS-induced pro-inflammatory signaling through Lyn Open
Summary: Na/K-ATPase (NKA), besides its ion transporter function, is a signal transducer by regulating Src family kinases (SFK). The signaling NKA contributes to oxidized LDL-induced macrophage foam cell formation and interacts with TLR4. …
View article: Gene module regulation in dilated cardiomyopathy and the role of Na/K-ATPase
Gene module regulation in dilated cardiomyopathy and the role of Na/K-ATPase Open
Dilated cardiomyopathy (DCM) is a major cause of cardiac death and heart transplantation. It has been known that black people have a higher incidence of heart failure and related diseases compared to white people. To identify the relations…
View article: Tumor-Suppressor Role of the α1-Na/K-ATPase Signalosome in NASH Related Hepatocellular Carcinoma
Tumor-Suppressor Role of the α1-Na/K-ATPase Signalosome in NASH Related Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality worldwide, with an estimate of 0.84 million cases every year. In Western countries, because of the obesity epidemic, non-alcoholic steatohepatitis (NASH…
View article: Retraction Note: The Na/K-ATPase oxidant amplification loop regulates aging
Retraction Note: The Na/K-ATPase oxidant amplification loop regulates aging Open
After publication, concerns were raised regarding high similarity among the following: • multiple lanes within each of the Coomassie blue staining images in Figs.3h, 6c, S1a and S2a; • DNP blot images in Figs.3h (H2O2 + pNaKtide group), S1…
View article: Retraction Note: The Adipocyte Na/K-ATPase Oxidant Amplification Loop is the Central Regulator of Western Diet-Induced Obesity and Associated Comorbidities
Retraction Note: The Adipocyte Na/K-ATPase Oxidant Amplification Loop is the Central Regulator of Western Diet-Induced Obesity and Associated Comorbidities Open
After publication, concerns were raised regarding high similarity among different lanes in the Coomassie blue staining image in Fig. 4d.Further investigation has found that there are inconsistencies in the blot backgrounds in Figs.S5d, g a…
View article: Normalization of the α1-Na/K-ATPase/Src Signalosome Restored Microbiota Communities and Rescinded NASH Progression in the Mouse
Normalization of the α1-Na/K-ATPase/Src Signalosome Restored Microbiota Communities and Rescinded NASH Progression in the Mouse Open
BACKGROUND. Two sequelae of non-alcoholic steatohepatitis (NASH), ESLD and HCC, have become the leading causes for liver transplantation in the Western. The present study aims to approach the cellular metabolic disturbances involved in NAS…
View article: Blockage of the Na-K-ATPase signaling-mediated oxidant amplification loop elongates red blood cell half-life and ameliorates uremic anemia induced by 5/6th PNx in C57BL/6 mice
Blockage of the Na-K-ATPase signaling-mediated oxidant amplification loop elongates red blood cell half-life and ameliorates uremic anemia induced by 5/6th PNx in C57BL/6 mice Open
The anemia of CKD is multifactorial, and the current treatment based primarily on stimulating bone marrow production of RBCs with erythropoietin of erythropoietin analogs is unsatisfactory. In a murine model of CKD that is complicated by a…
View article: Gut microbiome and diet in populations with obesity: Role of the Na+/K+‐ATPase transporter signaling in severe COVID‐19
Gut microbiome and diet in populations with obesity: Role of the Na+/K+‐ATPase transporter signaling in severe COVID‐19 Open
Objective The triad of obesity, a high‐protein diet from animal sources, and disturbed gut microbiota have been linked to poor clinical outcomes in patients with COVID‐19. In this report, the effect of oxidative stress resulting from the N…
View article: Normalization of the α1-Na/K-ATPase/Src Signalosome Restored Microbiota Communities and Rescinded NASH Progression in the Mouse
Normalization of the α1-Na/K-ATPase/Src Signalosome Restored Microbiota Communities and Rescinded NASH Progression in the Mouse Open
BACKGROUND. Two sequelae of non-alcoholic steatohepatitis (NASH), ESLD and HCC, have become the leading causes for liver transplantation in the Western. The present study aims to approach the cellular metabolic disturbances involved in NAS…
View article: Acute and Chronic Hyponatremia
Acute and Chronic Hyponatremia Open
Hyponatremia is the most common electrolyte disorder in clinical practice. Catastrophic complications can occur from severe acute hyponatremia and from inappropriate management of acute and chronic hyponatremia. It is essential to define t…