J. Sidney Ang
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View article: Plasma cell-free RNA signatures of inflammatory syndromes in children
Plasma cell-free RNA signatures of inflammatory syndromes in children Open
Inflammatory syndromes, including those caused by infection, are a major cause of hospital admissions among children and are often misdiagnosed because of a lack of advanced molecular diagnostic tools. In this study, we explored the utilit…
View article: Introducing pharmacogenetic testing with clinical decision support into primary care: a feasibility study
Introducing pharmacogenetic testing with clinical decision support into primary care: a feasibility study Open
Physicians and pharmacists can collect saliva samples of sufficient quantity and quality for DNA extraction, purification and genotyping. A clinical decision support system with integrated data from pharmacogenetic tests may enable persona…
View article: Dosage Mutator Genes in <i>Saccharomyces cerevisiae</i>: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase
Dosage Mutator Genes in <i>Saccharomyces cerevisiae</i>: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase Open
Mutations that cause genome instability are considered important predisposing events that contribute to initiation and progression of cancer. Genome instability arises either due to defects in genes that cause an increased mutation rate (m…
View article: Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer
Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer Open
Significance Chromosome instability (CIN) is well established as an enabling characteristic of cancer that contributes to cancer initiation and progression. Here, we identify 245 genes whose individual overexpression causes CIN in yeast, a…
View article: Mutagen Synergy: Hypermutability Generated by Specific Pairs of Base Analogs
Mutagen Synergy: Hypermutability Generated by Specific Pairs of Base Analogs Open
We tested pairwise combinations of classical base analog mutagens in Escherichia coli to study possible mutagen synergies. We examined the cytidine analogs zebularine (ZEB) and 5-azacytidine (5AZ), the adenine analog 2-aminopurine (2AP), a…
View article: Systematic over-expression screens for chromosome instability identify conserved dosage chromosome instability genes in yeast and human tumors
Systematic over-expression screens for chromosome instability identify conserved dosage chromosome instability genes in yeast and human tumors Open
Somatic copy number amplifications (SCNAs) and gene over-expression are common features of many cancers. To determine the role of gene over-expression on genome stability, we performed functional genomic screens in the budding yeast for ch…