Sherman J. Silber
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View article: P-398 Robust and Simple In Vitro Maturation of Ovarian Tissue Oocytes
P-398 Robust and Simple In Vitro Maturation of Ovarian Tissue Oocytes Open
Study question Using in-vitro gametogenesis results in mice, can we perform simple, robust in-vitro maturation (IVM) of oocytes from human ovarian tissue? Summary answer In vitro oogenesis in mice reveals 3 phases of oocyte maturation. In …
View article: Derivation of human primordial germ cell-like cells in an embryonic-like culture
Derivation of human primordial germ cell-like cells in an embryonic-like culture Open
Primordial germ cells (PGCs) are the embryonic precursors of sperm and eggs. They transmit genetic and epigenetic information across generations. Given the prominent role of germline defects in diseases such as infertility, detailed unders…
View article: In Vitro Maturation, In Vitro Oogenesis, and Ovarian Longevity
In Vitro Maturation, In Vitro Oogenesis, and Ovarian Longevity Open
This paper will review a remarkable new approach to in vitro maturation “IVM” of oocytes from ovarian tissue, based on our results with in vitro oogenesis from somatic cells. As an aside benefit we also have derived a better understanding …
View article: Cryobiology and fertility preservation: A perspective on past, current and future studies
Cryobiology and fertility preservation: A perspective on past, current and future studies Open
Cryopreservation has been used over many decades for the maintenance of viable biological specimens. Its expansion into the area of fertility preservation has been a natural outcome of the increased risks to human fertility from diseases, …
View article: In vitro germ cell induction from fertile and infertile monozygotic twin research participants
In vitro germ cell induction from fertile and infertile monozygotic twin research participants Open
Human induced pluripotent stem cells (hiPSCs) enable reproductive diseases to be studied when the reproductive health of the participant is known. In this study, monozygotic (MZ) monoamniotic (MA) twins discordant for primary ovarian insuf…
View article: Genetic characterization of a missense mutation in the X-linked <i>TAF7L</i> gene identified in an oligozoospermic man
Genetic characterization of a missense mutation in the X-linked <i>TAF7L</i> gene identified in an oligozoospermic man Open
Although hundreds of knockout mice show infertility as a major phenotype, the causative genic mutations of male infertility in humans remain rather limited. Here, we report the identification of a missense mutation (D136G) in the X-linked …
View article: Correction to: Fresh and cryopreserved ovarian tissue transplantation for preserving reproductive and endocrine function: a systematic review and individual patient data meta-analysis
Correction to: Fresh and cryopreserved ovarian tissue transplantation for preserving reproductive and endocrine function: a systematic review and individual patient data meta-analysis Open
Oxford University Press would like to apologies for errors in the annotation of authors' affiliations in the above article. The errors occurred during revision of the article proofs. The error does not affect any results, conclusions or ot…
View article: Fresh and cryopreserved ovarian tissue transplantation for preserving reproductive and endocrine function: a systematic review and individual patient data meta-analysis
Fresh and cryopreserved ovarian tissue transplantation for preserving reproductive and endocrine function: a systematic review and individual patient data meta-analysis Open
BACKGROUND Ovarian tissue cryopreservation involves freezing and storing of surgically retrieved ovarian tissue in liquid or vapour nitrogen below –190°C. The tissue can be thawed and transplanted back with the aim of restoring fertility o…
View article: Generation of three human induced pluripotent stem cell sublines (UCLAi004-A, UCLAi004-B, and UCLAi004-C) for reproductive science research
Generation of three human induced pluripotent stem cell sublines (UCLAi004-A, UCLAi004-B, and UCLAi004-C) for reproductive science research Open
Three induced pluripotent stem cell sublines (hiPSCs) were generated from human dermal human dermal fibroblasts (HDFs) derived from a human skin punch biopsy. The biopsy was donated from a woman with known infertility due to ovarian failur…
View article: Fresh and cryopreserved ovarian tissue from deceased young donors yields viable follicles
Fresh and cryopreserved ovarian tissue from deceased young donors yields viable follicles Open
Our results indicate the ovarian tissue from deceased donors maintain high quality after long time extracorporeal circulation and transportation from the hospital to the laboratory. High survival rate of follicles at different developmenta…
View article: Generation of three human induced pluripotent stem cell sublines (UCLAi005-A, UCLAi005-B and UCLAi005-C) for reproductive science research
Generation of three human induced pluripotent stem cell sublines (UCLAi005-A, UCLAi005-B and UCLAi005-C) for reproductive science research Open
We generated three human induced pluripotent stem cell (hiPSC) sublines from human dermal fibroblasts (HDF) (MZT05) generated from a skin biopsy donated from a previously fertile woman. The skin biopsy was broadly consented for generating …
View article: The varicocele argument resurfaces
The varicocele argument resurfaces Open
A recent series of articles and reviews published in Fertility and Sterility have rekindled the more than half century debate on varicocelectomy. Every one of these articles favored strongly the repair of varicocele for male infertility. S…
View article: Structure of the Seminiferous Tubules
Structure of the Seminiferous Tubules Open
The testis is made up of the seminiferous tubules, where the spermatozoa develop, and interstitial cells (Leydig cells), where testosterone is produced. The seminiferous tubules are long U-shaped tubules which form their U-turn at the peri…
View article: Unraveling transcriptome dynamics in human spermatogenesis
Unraveling transcriptome dynamics in human spermatogenesis Open
Spermatogenesis is a dynamic developmental process that includes stem cell proliferation and differentiation, meiotic cell divisions and extreme chromatin condensation. Although studied in mice, the molecular control of human spermatogenes…