J. Simon C. Arthur
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View article: Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation
Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation Open
Naïve B cells exit quiescence and enter a proliferative state upon activation, ultimately differentiating into antibody-secreting or memory B cells. Toll-like receptor (TLR) ligands, such as lipopolysaccharide (LPS), can serve as physiolog…
View article: Author response: Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation
Author response: Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation Open
View article: Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation
Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation Open
Naïve B cells exit quiescence and enter a proliferative state upon activation, ultimately differentiating into antibody-secreting or memory B cells. Toll-like receptor (TLR) ligands, such as lipopolysaccharide (LPS), can serve as physiolog…
View article: PTP1B deficiency in myeloid cells increases susceptibility to <i>Candida albicans</i> systemic infection by modulating antifungal immunity
PTP1B deficiency in myeloid cells increases susceptibility to <i>Candida albicans</i> systemic infection by modulating antifungal immunity Open
Invasive candidiasis, primarily caused by Candida albicans , poses a significant threat to immunocompromised patients, with high mortality rates. Understanding how immune responses to Candida albicans are mounted and controlled is fundamen…
View article: <i>Candida albicans</i> infection suppresses Lipopolysaccharide or <i>Pseudomonas aeruginosa</i> stimulated murine bone marrow derived macrophage (BMDM) responses
<i>Candida albicans</i> infection suppresses Lipopolysaccharide or <i>Pseudomonas aeruginosa</i> stimulated murine bone marrow derived macrophage (BMDM) responses Open
Candida albicans is a commensal fungus which populates most healthy individuals’ microbiota but can turn opportunistic in immunocompromised individuals and cause severe disease linked with high rates of mortality. With limited therapeutic …
View article: Adipocyte MKK3 Increases in Human Obesity protecting against Insulin Resistance by p38β activation
Adipocyte MKK3 Increases in Human Obesity protecting against Insulin Resistance by p38β activation Open
Summary Obesity is a major global health concern, and a key predisposing factor for insulin resistance and type 2 diabetes mellitus. Adipocytes play a critical role in the development of obesity-induced insulin resistance, with several sig…
View article: Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation
Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation Open
Summary Naïve B cells exit quiescence and enter a proliferative state upon activation, ultimately differentiating into antibody-secreting or memory B cells. Toll-like receptor (TLR) ligands, such as lipopolysaccharide (LPS), can serve as p…
View article: Nuclear lamin A/C phosphorylation by loss of androgen receptor leads to cancer-associated fibroblast activation
Nuclear lamin A/C phosphorylation by loss of androgen receptor leads to cancer-associated fibroblast activation Open
View article: MSK1 is required for the experience- and ampakine-dependent enhancement of spatial reference memory and reversal learning and for the induction of Arc and BDNF
MSK1 is required for the experience- and ampakine-dependent enhancement of spatial reference memory and reversal learning and for the induction of Arc and BDNF Open
View article: Optimizing Spectronaut Search Parameters to Improve Data Quality with Minimal Proteome Coverage Reductions in DIA Analyses of Heterogeneous Samples
Optimizing Spectronaut Search Parameters to Improve Data Quality with Minimal Proteome Coverage Reductions in DIA Analyses of Heterogeneous Samples Open
Data-independent acquisition has seen breakthroughs that enable comprehensive proteome profiling using short gradients. As the proteome coverage continues to increase, the quality of the data generated becomes much more relevant. Using Spe…
View article: Quantitative proteomics reveals tissue-specific, infection-induced and species-specific neutrophil protein signatures
Quantitative proteomics reveals tissue-specific, infection-induced and species-specific neutrophil protein signatures Open
View article: Dexamethasone impairs the expression of antimicrobial mediators in lipopolysaccharide-activated primary macrophages by inhibiting both expression and function of interferon β
Dexamethasone impairs the expression of antimicrobial mediators in lipopolysaccharide-activated primary macrophages by inhibiting both expression and function of interferon β Open
Glucocorticoids potently inhibit expression of many inflammatory mediators, and have been widely used to treat both acute and chronic inflammatory diseases for more than seventy years. However, they can have several unwanted effects, among…
View article: Optimising Spectronaut search parameters to improve data quality with minimal proteome coverage reductions in DIA analyses of heterogeneous samples
Optimising Spectronaut search parameters to improve data quality with minimal proteome coverage reductions in DIA analyses of heterogeneous samples Open
Data independent acquisition has seen breakthroughs that enable comprehensive proteome profiling using short gradients. As the proteome coverage continues to increase, the quality of the data generated becomes much more relevant. Using Spe…
View article: Quantitative proteomics reveals tissue-specific, infection-induced and species-specific neutrophil protein signatures
Quantitative proteomics reveals tissue-specific, infection-induced and species-specific neutrophil protein signatures Open
Summary Neutrophils are one of the first responders to infection and are a key component of the innate immune system through their ability to phagocytose and kill invading pathogens, secrete antimicrobial molecules and produce extracellula…
View article: MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan
MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan Open
Positive experiences, such as social interaction, cognitive training and physical exercise, have been shown to ameliorate some of the harms to cognition associated with ageing. Animal models of positive interventions, commonly known as env…
View article: Inflammation as a therapeutic target in heart failure with preserved ejection fraction
Inflammation as a therapeutic target in heart failure with preserved ejection fraction Open
Heart failure with preserved ejection fraction (HFpEF) accounts for around half of all cases of heart failure and may become the dominant type of heart failure in the near future. Unlike HF with reduced ejection fraction there are few evid…
View article: The glucocorticoid dexamethasone impairs the expression of anti-viral mediators in activated macrophages by inhibiting both expression and function of interferon β
The glucocorticoid dexamethasone impairs the expression of anti-viral mediators in activated macrophages by inhibiting both expression and function of interferon β Open
Glucocorticoids potently inhibit expression of many inflammatory mediators, and have been very widely used to treat both acute and chronic inflammatory diseases for more than seventy years. However, they can have several unwanted effects, …
View article: Supplementary Figure 2 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice
Supplementary Figure 2 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice Open
Supplementary Figure 2 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice
View article: Supplementary Figure 1 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice
Supplementary Figure 1 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice Open
Supplementary Figure 1 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice
View article: Supplementary Figure 2 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice
Supplementary Figure 2 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice Open
Supplementary Figure 2 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice
View article: Supplementary Figure 3 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice
Supplementary Figure 3 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice Open
Supplementary Figure 3 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice
View article: Supplementary Methods, Figure Legends 1-3 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice
Supplementary Methods, Figure Legends 1-3 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice Open
Supplementary Methods, Figure Legends 1-3 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice
View article: Supplementary Methods, Figure Legends 1-3 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice
Supplementary Methods, Figure Legends 1-3 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice Open
Supplementary Methods, Figure Legends 1-3 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice
View article: Data from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice
Data from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice Open
Activating Ras mutations occur in a large portion of human tumors. Yet, the signaling pathways involved in Ras-induced tumor formation remain incompletely understood. The mitogen-activated protein kinase pathways are among the best studied…
View article: Data from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice
Data from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice Open
Activating Ras mutations occur in a large portion of human tumors. Yet, the signaling pathways involved in Ras-induced tumor formation remain incompletely understood. The mitogen-activated protein kinase pathways are among the best studied…
View article: Supplementary Figure 3 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice
Supplementary Figure 3 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice Open
Supplementary Figure 3 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice
View article: Supplementary Figure 1 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice
Supplementary Figure 1 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice Open
Supplementary Figure 1 from p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice
View article: IL-33 induces granzyme C expression in murine mast cells via an MSK1/2-CREB-dependent pathway
IL-33 induces granzyme C expression in murine mast cells via an MSK1/2-CREB-dependent pathway Open
Granzymes comprise a group of proteases involved in the killing of infected or cancerous cells by the immune system. Although best studied in T cells and natural killer (NK) cells, they are also expressed in some innate immune cells. Granz…
View article: Salt-inducible kinase 2 regulates fibrosis during bleomycin-induced lung injury
Salt-inducible kinase 2 regulates fibrosis during bleomycin-induced lung injury Open
View article: DIA label-free proteomic analysis of murine bone-marrow-derived macrophages
DIA label-free proteomic analysis of murine bone-marrow-derived macrophages Open