J. Spaun
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View article: Replacement of the international standard for tetanus antitoxin and the use of the standard in the flocculation test.
Replacement of the international standard for tetanus antitoxin and the use of the standard in the flocculation test. Open
Since 1935 the International Unit for Tetanus Antitoxin has been defined as the activity contained in a certain weight of the first International Standard for Tetanus Antitoxin. As stocks of this standard had become depleted, 11 laboratori…
View article: Laboratory toxicity test of field trial typhoid vaccines.
Laboratory toxicity test of field trial typhoid vaccines. Open
It is important for the control of vaccines to develop methods for testing their toxicity in the laboratory. Two typhoid vaccines that had given different rates of reactions among vaccinated persons in extensive field trials provided a uni…
View article: INTERNATIONAL REFERENCE PREPARATIONS OF TYPHOID VACCINE. A REPORT ON INTERNATIONAL COLLABORATIVE LABORATORY STUDIES.
INTERNATIONAL REFERENCE PREPARATIONS OF TYPHOID VACCINE. A REPORT ON INTERNATIONAL COLLABORATIVE LABORATORY STUDIES. Open
Before their establishment as International Reference Preparations of Typhoid Vaccine, an acetone-inactivated vaccine (vaccine K) and a heat-phenol-inactivated vaccine (vaccine L) were tested on man in large-scale controlled field trials a…
View article: STUDIES ON THE INFLUENCE OF THE ROUTE OF IMMUNIZATION IN THE ACTIVE MOUSE PROTECTION TEST WITH INTRAPERITONEAL CHALLENGE FOR POTENCY ASSAY OF TYPHOID VACCINES.
STUDIES ON THE INFLUENCE OF THE ROUTE OF IMMUNIZATION IN THE ACTIVE MOUSE PROTECTION TEST WITH INTRAPERITONEAL CHALLENGE FOR POTENCY ASSAY OF TYPHOID VACCINES. Open
In order to determine the reasons for the differences found in the potencies of typhoid vaccines in the course of active mouse protection tests when immunization was done subcutaneously or intraperitoneally and followed by intraperitoneal …
View article: Problems in standardization of turbidity determinations on bacterial suspensions.
Problems in standardization of turbidity determinations on bacterial suspensions. Open
The concentration of bacterial suspensions can be rapidly and conveniently determined by measuring the turbidity. Although turbidimetry offers advantages over the more laborious methods of weighing or counting, it is necessary to be aware …
View article: Studies on reproduction of the International Opacity Reference Preparation.
Studies on reproduction of the International Opacity Reference Preparation. Open
The International Opacity Reference Preparation is a polydisperse suspension of glass particles, the size distribution of which it is hardly possible to reproduce. However, by mixing glass particles of different size distributions it seems…
View article: An international collaborative study of the assay of the potency of poliomyelitis sera.
An international collaborative study of the assay of the potency of poliomyelitis sera. Open
As a first step towards the standardization of poliomyelitis vaccine, the neutralizing antibody titres of ten test antipoliomyelitis sera were measured in nine laboratories in different countries in comparison with a reference preparation.…
View article: International Standard for Antistreptolysin-O.
International Standard for Antistreptolysin-O. Open
A pool of highly potent freeze-dried sera from three patients with streptococcal infection has been examined by twelve laboratories in eleven countries and has now been established as the International Standard for Antistreptolysin-O by th…