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View article: DOP40 Inflammatory Bowel Disease single cell atlas construction to enable cell type-specific target identification
DOP40 Inflammatory Bowel Disease single cell atlas construction to enable cell type-specific target identification Open
Background Advances in single-cell technologies enable the unbiased study of cellular heterogeneity. Recently, single-cell RNA sequencing (scRNA-seq) has been utilised on intestinal and blood samples from patients with inflammatory bowel d…
View article: Quality Matters: Biocuration Experts on the Impact of Duplication and Other Data Quality Issues in Biological Databases
Quality Matters: Biocuration Experts on the Impact of Duplication and Other Data Quality Issues in Biological Databases Open
Biological databases represent an extraordinary collective volume of work. Diligently built up over decades and comprising many millions of contributions from the biomedical research community, biological databases provide worldwide access…
View article: Quality Matters: Biocuration Experts on the Impact of Duplication and Other Data Quality Issues in Biological Databases
Quality Matters: Biocuration Experts on the Impact of Duplication and Other Data Quality Issues in Biological Databases Open
The volume of biological database records is growing rapidly, populated by complex records drawn from heterogeneous sources. A specific challenge is duplication, that is, the presence of redundancy (records with high similarity) or inconsi…
View article: The transcription factor FOXM1 regulates the balance between proliferation and aberrant differentiation in head and neck squamous cell carcinoma
The transcription factor FOXM1 regulates the balance between proliferation and aberrant differentiation in head and neck squamous cell carcinoma Open
Sustained expression of FOXM1 is a hallmark of nearly all human cancers including squamous cell carcinomas of the head and neck (HNSCC). HNSCCs partially preserve the epithelial differentiation program, which recapitulates fetal and adult …
View article: Mouse model of postsurgical primary tumor recurrence and regional lymph node metastasis progression in <scp>HPV</scp>‐related head and neck cancer
Mouse model of postsurgical primary tumor recurrence and regional lymph node metastasis progression in <span>HPV</span>‐related head and neck cancer Open
HPV‐positive head and neck squamous cell carcinoma (HNSCC) is increasingly frequent. Management is particularly debated in the case of postsurgical high‐risk features, that is, positive surgical margins and extracapsular spread (ECS). In t…
View article: Developing controlled vocabularies for optimal use in data analysis and visualization
Developing controlled vocabularies for optimal use in data analysis and visualization Open