J. Steven Alexander
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View article: Calcification in Vascular Smooth Muscle Cells Is Associated with Elevated GCLm and Impaired Contraction: Insights into Osteogenic Transdifferentiation and Therapeutic Approaches
Calcification in Vascular Smooth Muscle Cells Is Associated with Elevated GCLm and Impaired Contraction: Insights into Osteogenic Transdifferentiation and Therapeutic Approaches Open
Background: Vascular calcification is a strong predictor of cardiovascular morbidity and mortality. Oxidative stress plays a key role in promoting vascular calcification. Glutathione (GSH), as a major cellular antioxidant, is produced in r…
View article: Enteric Elongation Induced by a Novel Sleeve Device in a Live Roux-en-Y Configuration
Enteric Elongation Induced by a Novel Sleeve Device in a Live Roux-en-Y Configuration Open
Short bowel syndrome (SBS) is characterized by insufficient intestinal length to support absorption causing malnutrition. The bowel adapts to SBS via intestinal dilation and delayed gastric emptying but still often requires long-term paren…
View article: Pathophysiology and Prevention of Manual-Ventilation-Induced Lung Injury (MVILI)
Pathophysiology and Prevention of Manual-Ventilation-Induced Lung Injury (MVILI) Open
Manual ventilation, most commonly with a bag-valve mask, is a form of short-term ventilation used during resuscitative efforts in emergent and out-of-hospital scenarios. However, compared to mechanical ventilation, manual ventilation is an…
View article: Impaired Peripheral Vascular Function Following Ischemic Stroke in Mice: Potential Insights into Blood Pressure Variations in the Post-Stroke Patient
Impaired Peripheral Vascular Function Following Ischemic Stroke in Mice: Potential Insights into Blood Pressure Variations in the Post-Stroke Patient Open
High systolic blood pressure and increased blood pressure variability after the onset of ischemic stroke are associated with poor clinical outcomes. One of the key determinants of blood pressure is arteriolar size, determined by vascular s…
View article: STABILITY (Symptomatic Review during Biologic Therapy) of Inflammatory Bowel Disease Patients Receiving Infusion Therapy Improves Clinical Outcomes
STABILITY (Symptomatic Review during Biologic Therapy) of Inflammatory Bowel Disease Patients Receiving Infusion Therapy Improves Clinical Outcomes Open
Several studies have correlate improved patient outcomes with increased physician–patient contacts, particularly in chronic diseases. Extending this approach to inflammatory bowel disease (IBD) care presents a promising means of improving …
View article: Distraction Enterogenesis in Rats: A Novel Approach for the Treatment of Short Bowel Syndrome
Distraction Enterogenesis in Rats: A Novel Approach for the Treatment of Short Bowel Syndrome Open
Background: Surgeons often encounter patients with intestinal failure due to inadequate intestinal length (“short bowel syndrome”/SBS). Treatment in these patients remains challenging and the process of physiologic adaptation may take year…
View article: Impaired Peripheral Vascular Function Following Ischemic Stroke: Implications for Blood Pressure Variations in the Post-stroke Patient
Impaired Peripheral Vascular Function Following Ischemic Stroke: Implications for Blood Pressure Variations in the Post-stroke Patient Open
High systolic blood pressure and increased blood pressure variability after the onset of ischemic stroke are associated with poor clinical outcomes. One of the key determinants of blood pressure is arteriolar size, determined by vascular s…
View article: Histologic Analysis of ‘Distraction Vaginogenesis’ in a Rat Model
Histologic Analysis of ‘Distraction Vaginogenesis’ in a Rat Model Open
Vaginal agenesis (VA) is frequently associated with mullerian agenesis. VA treatments include mechanical dilation and surgical vaginoplasty. We created a vaginal expansion sleeve (VES) as a novel device to progressively lengthen the vagina…
View article: Preliminary in silico study of a novel paratransgenic weapon against malaria
Preliminary in silico study of a novel paratransgenic weapon against malaria Open
Malaria is an infectious disease caused by Plasmodium spp., a protist whose infection is spread by Anopheles mosquito as a vector. A potential method to counter the infection is through paratransgenesis, a promising genetic control approac…
View article: Reply to Singh, G.D. Comment on “Dao et al. Retrospective Analysis of Real-World Data for the Treatment of Obstructive Sleep Apnea with Slow Maxillary Expansion Using a Unique Expansion Dental Appliance (DNA). Pathophysiology 2023, 30, 199–208”
Reply to Singh, G.D. Comment on “Dao et al. Retrospective Analysis of Real-World Data for the Treatment of Obstructive Sleep Apnea with Slow Maxillary Expansion Using a Unique Expansion Dental Appliance (DNA). Pathophysiology 2023, 30, 199–208” Open
In response to the commentary “Response to ‘Retrospective analysis of real-world data for the treatment of obstructive sleep apnea with slow maxillary expansion’” [...]
View article: Pathophysiology, Management, and Therapeutics in Subarachnoid Hemorrhage and Delayed Cerebral Ischemia: An Overview
Pathophysiology, Management, and Therapeutics in Subarachnoid Hemorrhage and Delayed Cerebral Ischemia: An Overview Open
Subarachnoid hemorrhage (SAH) is a type of hemorrhagic stroke resulting from the rupture of an arterial vessel within the brain. Unlike other stroke types, SAH affects both young adults (mid-40s) and the geriatric population. Patients with…
View article: Retrospective Analysis of Real-World Data for the Treatment of Obstructive Sleep Apnea with Slow Maxillary Expansion Using a Unique Expansion Dental Appliance (DNA)
Retrospective Analysis of Real-World Data for the Treatment of Obstructive Sleep Apnea with Slow Maxillary Expansion Using a Unique Expansion Dental Appliance (DNA) Open
In addition to mandibular advancement devices, dental expansion appliances are an important clinical approach for achieving an increased intra-oral space that promotes airflow and lessens the frequency or severity of apneic events in patie…
View article: Methamphetamine and Designer Stimulants Modulate Tonic Human Cerebrovascular Smooth Muscle Contractility: Relevance to Drug-Induced Neurovascular Stress
Methamphetamine and Designer Stimulants Modulate Tonic Human Cerebrovascular Smooth Muscle Contractility: Relevance to Drug-Induced Neurovascular Stress Open
To avoid criminal prosecution, clandestine chemists produce designer stimulants that mimic the pharmacological and psychoactive effects of conventional stimulants, such as methamphetamine. Following persistent or high-dose exposure, both a…
View article: ‘Distraction Vaginogenesis’: Preliminary Results Using a Novel Method for Vaginal Canal Expansion in Rats
‘Distraction Vaginogenesis’: Preliminary Results Using a Novel Method for Vaginal Canal Expansion in Rats Open
Vaginal atresia is seen in genetic disorders such as Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome, which can cause significant sexual dysfunction. Current treatments include surgical reconstruction or mechanical dilation of the vaginal c…
View article: 50. Histologic Effects of a Novel Vaginal Expansion Device on Vaginal Tissue in a Rat Model
50. Histologic Effects of a Novel Vaginal Expansion Device on Vaginal Tissue in a Rat Model Open
View article: Dysregulated Sulfide Metabolism in Multiple Sclerosis: Serum and Vascular Endothelial Inflammatory Responses
Dysregulated Sulfide Metabolism in Multiple Sclerosis: Serum and Vascular Endothelial Inflammatory Responses Open
Multiple sclerosis (MS) is a leading cause of neurodegenerative disability in younger individuals. When diagnosed early, MS can be managed more effectively, stabilizing clinical symptoms and delaying disease progression. The identification…
View article: SLAMF1 is expressed and secreted by hepatocytes and the liver in nonalcoholic fatty liver disease
SLAMF1 is expressed and secreted by hepatocytes and the liver in nonalcoholic fatty liver disease Open
This study identified for the first time SLAMF1 as a mediator of hepatocyte death in nonalcoholic fatty liver disease (NASH) and as a marker of NASH in humans. There are no pharmacological treatments available for NASH, and diagnostic tool…
View article: Improved Healthcare Access Reduces Requirements for Surgery in Indigent IBD Patients Using Biologic Therapy: A ‘Safety-Net’ Hospital Experience
Improved Healthcare Access Reduces Requirements for Surgery in Indigent IBD Patients Using Biologic Therapy: A ‘Safety-Net’ Hospital Experience Open
Low socioeconomic status (SES) is associated with greater morbidity and increased healthcare resource utilization (HRU) in IBD. We examined whether a financial assistance program (FAP) to improve healthcare access affected outcomes and HRU…
View article: Chronic Cannabis Intoxication and Propofol-Induced Salivation: Causes and Considerations
Chronic Cannabis Intoxication and Propofol-Induced Salivation: Causes and Considerations Open
Legalization/decriminalization of cannabis will increase the numbers of patients who have had recent exposure to recreational or medical cannabis. Currently, little has been reported about potential interactions between cannabis use and Pr…
View article: Bryostatin-1 Attenuates Ischemia-Elicited Neutrophil Transmigration and Ameliorates Graft Injury after Kidney Transplantation
Bryostatin-1 Attenuates Ischemia-Elicited Neutrophil Transmigration and Ameliorates Graft Injury after Kidney Transplantation Open
Ischemia reperfusion injury (IRI) is a form of sterile inflammation whose severity determines short- and long-term graft fates in kidney transplantation. Neutrophils are now recognized as a key cell type mediating early graft injury, which…
View article: Additional file 6 of Efficacy and safety testing of a COVID-19 era emergency ventilator in a healthy rabbit lung model
Additional file 6 of Efficacy and safety testing of a COVID-19 era emergency ventilator in a healthy rabbit lung model Open
Additional file 6. Rabbit MV3 FALCON Flow Waveforms. Flow waveforms for rabbit MV3 during FALCON ventilation.
View article: Additional file 10 of Efficacy and safety testing of a COVID-19 era emergency ventilator in a healthy rabbit lung model
Additional file 10 of Efficacy and safety testing of a COVID-19 era emergency ventilator in a healthy rabbit lung model Open
Additional file 10. Rabbit MV5 FALCON Flow Waveforms. Flow waveforms for rabbit MV5 during FALCON ventilation.
View article: Additional file 4 of Efficacy and safety testing of a COVID-19 era emergency ventilator in a healthy rabbit lung model
Additional file 4 of Efficacy and safety testing of a COVID-19 era emergency ventilator in a healthy rabbit lung model Open
Additional file 4. Rabbit MV2 FALCON Flow Waveforms. Flow waveforms for rabbit MV2 during FALCON ventilation.
View article: Additional file 1 of Efficacy and safety testing of a COVID-19 era emergency ventilator in a healthy rabbit lung model
Additional file 1 of Efficacy and safety testing of a COVID-19 era emergency ventilator in a healthy rabbit lung model Open
Additional file 1. Rabbit MV1 Carestation Flow Waveforms. Flow waveforms for rabbit MV1 during Carestation ventilation.
View article: Additional file 9 of Efficacy and safety testing of a COVID-19 era emergency ventilator in a healthy rabbit lung model
Additional file 9 of Efficacy and safety testing of a COVID-19 era emergency ventilator in a healthy rabbit lung model Open
Additional file 9. Rabbit MV5 Carestation Flow Waveforms. Flow waveforms for rabbit MV5 during Carestation ventilation.
View article: Additional file 2 of Efficacy and safety testing of a COVID-19 era emergency ventilator in a healthy rabbit lung model
Additional file 2 of Efficacy and safety testing of a COVID-19 era emergency ventilator in a healthy rabbit lung model Open
Additional file 2. Rabbit MV1 FALCON Flow Waveforms. Flow waveforms for rabbit MV1 during FALCON ventilation.
View article: Additional file 11 of Efficacy and safety testing of a COVID-19 era emergency ventilator in a healthy rabbit lung model
Additional file 11 of Efficacy and safety testing of a COVID-19 era emergency ventilator in a healthy rabbit lung model Open
Additional file 11. Rabbit Pressure Waveforms. Pressure waveforms for rabbits MV1 to MV5 during Carestation and FALCON ventilation.
View article: Additional file 3 of Efficacy and safety testing of a COVID-19 era emergency ventilator in a healthy rabbit lung model
Additional file 3 of Efficacy and safety testing of a COVID-19 era emergency ventilator in a healthy rabbit lung model Open
Additional file 3. Rabbit MV2 Carestation Flow Waveforms. Flow waveforms for rabbit MV2 during Carestation ventilation.
View article: Additional file 5 of Efficacy and safety testing of a COVID-19 era emergency ventilator in a healthy rabbit lung model
Additional file 5 of Efficacy and safety testing of a COVID-19 era emergency ventilator in a healthy rabbit lung model Open
Additional file 5. Rabbit MV3 Carestation Flow Waveforms. Flow waveforms for rabbit MV3 during Carestation ventilation.
View article: Additional file 8 of Efficacy and safety testing of a COVID-19 era emergency ventilator in a healthy rabbit lung model
Additional file 8 of Efficacy and safety testing of a COVID-19 era emergency ventilator in a healthy rabbit lung model Open
Additional file 8. Rabbit MV4 FALCON Flow Waveforms. Flow waveforms for rabbit MV4 during FALCON ventilation.