Jonathan G. Stine
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View article: Aerobic Exercise Training Leads to MASH Resolution as Defined by the MASH Resolution Index
Aerobic Exercise Training Leads to MASH Resolution as Defined by the MASH Resolution Index Open
Purpose Exercise training is recommended for all patients with metabolic dysfunction-associated steatotic liver disease. Whether exercise training improves liver histology independent of body weight loss remains controversial. Given the in…
View article: Co-designing Approaches to Sustainable Exercise Care for People with Metabolic Dysfunction-associated Steatotic Liver Disease
Co-designing Approaches to Sustainable Exercise Care for People with Metabolic Dysfunction-associated Steatotic Liver Disease Open
This co-design methodology highlights unique consumer-informed research questions. Exercise interventions and their associated implementation trials will benefit from being co-designed with both people with MASLD and care stakeholders.
View article: Skeletal muscle and MASLD: Mechanistic and clinical insights
Skeletal muscle and MASLD: Mechanistic and clinical insights Open
Metabolic dysfunction–associated steatotic liver disease (MASLD) is intrinsically linked with widespread metabolic perturbations, including within skeletal muscle. Indeed, MASLD is associated with a range of skeletal muscle abnormalities, …
View article: The Role of Exercise in Steatotic Liver Diseases: An Updated Perspective
The Role of Exercise in Steatotic Liver Diseases: An Updated Perspective Open
Background The increasing prevalence of metabolic dysfunction‐associated steatotic liver disease (MASLD), formerly known as non‐alcoholic fatty liver disease (NAFLD), parallels the rise in sedentary lifestyles. MASLD is the most common for…
View article: Advanced Liver Fibrosis Impairs Cardiorespiratory Fitness in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease
Advanced Liver Fibrosis Impairs Cardiorespiratory Fitness in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease Open
Background MASLD is a leading reason for liver transplant waitlisting. The relationship between cardiorespiratory fitness (CRF) and liver fibrosis in patients with MASLD remains unclear. This study aims to provide further evidence supporti…
View article: Digital therapeutics lead to clinically significant body weight loss in patients with metabolic dysfunction–associated steatotic liver disease: A systematic review and meta-analysis
Digital therapeutics lead to clinically significant body weight loss in patients with metabolic dysfunction–associated steatotic liver disease: A systematic review and meta-analysis Open
Background: Most patients with metabolic dysfunction–associated steatotic liver disease are unable to achieve clinically significant body weight loss with traditional in-person approaches. Digital therapeutic (DTx)-delivered interventions …
View article: Frailty in liver transplantation: Exploring prescribing exercise as medicine to improve patient outcomes
Frailty in liver transplantation: Exploring prescribing exercise as medicine to improve patient outcomes Open
Liver transplantation (LT) represents a curative avenue for individuals with advanced chronic liver disease. Given the inherent illness severity of LT candidates, identifying patients at greater risk for adverse outcomes before and after t…
View article: AMPED study: Protocol for a randomized controlled trial of different doses of aerobic exercise training
AMPED study: Protocol for a randomized controlled trial of different doses of aerobic exercise training Open
Recently renamed, metabolic dysfunction–associated steatotic liver disease remains a leading cause of chronic liver disease worldwide. Regular physical activity is recommended as a treatment for all with this condition because it is highly…
View article: Exercise improves surrogate measures of liver histological response in metabolic dysfunction‐associated steatotic liver disease
Exercise improves surrogate measures of liver histological response in metabolic dysfunction‐associated steatotic liver disease Open
Background and Aims Exercise is recommended for the management of metabolic dysfunction‐associated steatotic liver disease (MASLD), yet effects on liver histology remain unknown, especially without significant weight loss. We aimed to exam…
View article: The health care experience of adults with metabolic dysfunction–associated steatohepatitis and influence of PNPLA3: A qualitative study
The health care experience of adults with metabolic dysfunction–associated steatohepatitis and influence of PNPLA3: A qualitative study Open
Background: Metabolic dysfunction–associated steatohepatitis (MASH) is a progressive form of metabolic dysfunction–associated steatotic liver disease, for which there is limited information about patient experience, including the patient j…
View article: Comparing preferences to evaluations of barrier self-efficacy for two strength training programs in US older adults
Comparing preferences to evaluations of barrier self-efficacy for two strength training programs in US older adults Open
Background/Objectives Engagement in regular physical activity is one of the best strategies for older adults to remain healthy. Unfortunately, only 35% of older adults meet guidelines for muscle strengthening activities. Eliciting particip…
View article: Editorial: Enhancing frailty assessment in liver transplantation candidates—The role of the Duke Activity Status Index in predicting mortality and guiding prehabilitation
Editorial: Enhancing frailty assessment in liver transplantation candidates—The role of the Duke Activity Status Index in predicting mortality and guiding prehabilitation Open
LINKED CONTENT This article is linked to Williams et al papers. To view these articles, visit https://doi.org/10.1111/apt.17834 and https://doi.org/10.1111/apt.17874
View article: IMPACT OF A 4-MINUTE STRENGTH TRAINING PROGRAM ON LOWER BODY FUNCTION IN OLDER ADULTS WITH MOBILITY DISABILITY
IMPACT OF A 4-MINUTE STRENGTH TRAINING PROGRAM ON LOWER BODY FUNCTION IN OLDER ADULTS WITH MOBILITY DISABILITY Open
One in four older adults experience mobility disability, often resulting in financial strain and declines in quality of life. Though resistance training (RT) can improve physical function, too few older adults do RT. This study specificall…
View article: Exercise training improves serum biomarkers of liver fibroinflammation in patients with metabolic dysfunction‐associated steatohepatitis
Exercise training improves serum biomarkers of liver fibroinflammation in patients with metabolic dysfunction‐associated steatohepatitis Open
Background and Aims Exercise training is recommended for all patients with metabolic dysfunction‐associated steatotic liver disease and may reverse liver fibrosis. Whether exercise training improves liver fibrosis without body weight loss …
View article: Unlocking metabolic flexibility: Is this the key to preventing weight gain in liver transplant recipients?
Unlocking metabolic flexibility: Is this the key to preventing weight gain in liver transplant recipients? Open
1Division of Gastroenterology and Hepatology, Department of Medicine, PennState Health Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA 2Fatty Liver Program, PennState Health Milton S. Hershey Medical Center, Hershey, Pennsylva…
View article: Use of a Mobile-Assisted Telehealth Regimen to Increase Exercise in Transplant Candidates: A Home-Based Prehabilitation Pilot and Feasibility Trial
Use of a Mobile-Assisted Telehealth Regimen to Increase Exercise in Transplant Candidates: A Home-Based Prehabilitation Pilot and Feasibility Trial Open
INTRODUCTION: Physical fitness assessed by the Liver Frailty Index (LFI) and 6-minute walk test (6MWT) informs the prognosis of liver transplant candidates, although there are limited data on its reversibility after prehabilitation. On a h…
View article: Sweating it out: How physical activity can combat high genetic risk for nonalcoholic fatty liver disease
Sweating it out: How physical activity can combat high genetic risk for nonalcoholic fatty liver disease Open
Nonalcoholic fatty liver disease (NAFLD) continues to be a leading cause of chronic liver disease worldwide of great public health interest.1 Because physical inactivity and sedentary behaviour contribute heavily to disease pathogenesis, l…
View article: Exercise Is Medicine for Nonalcoholic Fatty Liver Disease: Exploration of Putative Mechanisms
Exercise Is Medicine for Nonalcoholic Fatty Liver Disease: Exploration of Putative Mechanisms Open
Exercise remains a key component of nonalcoholic fatty liver disease (NAFLD) treatment. The mechanisms that underpin improvements in NAFLD remain the focus of much exploration in our attempt to better understand how exercise benefits patie…