James T. Rutka
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View article: Preclinical Assessment of Checkpoint blockade Combined with DNA Methyltransferase Inhibition in High-Risk Pediatric Brain Tumors Reveals Limited Therapeutic Synergy
Preclinical Assessment of Checkpoint blockade Combined with DNA Methyltransferase Inhibition in High-Risk Pediatric Brain Tumors Reveals Limited Therapeutic Synergy Open
Background Despite intensive therapies, outcomes for high-risk pediatric brain tumors (PBTs) remain dismal, prompting the search for novel treatments. DNA methyltransferase inhibitors (DNMTi) have been shown to prime tumors to improve resp…
View article: CNSC-39. USE OF MAGNETIC RESONANCE-GUIDED FOCUSED ULTRASOUND IN THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA
CNSC-39. USE OF MAGNETIC RESONANCE-GUIDED FOCUSED ULTRASOUND IN THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA Open
Diffuse intrinsic pontine glioma (DIPG) is the leading cause of brain tumour-related deaths in childhood. Current treatment is radiation with or without chemotherapy, as surgical resection is impossible due to its location within the brain…
View article: A comprehensive review on the current applications and future perspectives of radioembolization in endovascular neurosurgery
A comprehensive review on the current applications and future perspectives of radioembolization in endovascular neurosurgery Open
In recent years, there has been advancement in the management of primary and secondary brain tumors within a multidisciplinary framework. However, substantial challenges persist in optimizing treatment strategies, enhancing survival rates,…
View article: Late Effects in Survivors of Pediatric Medulloblastoma: A Comprehensive Review
Late Effects in Survivors of Pediatric Medulloblastoma: A Comprehensive Review Open
Medulloblastoma (MB) treatment has advanced significantly with the integration of molecular subgrouping, enabling more precise risk stratification and tailored therapies. While survival outcomes have improved, long‐term treatment‐related m…
View article: 8 ADVANCES IN THE MANAGEMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA: CURRENT EXPERIMENTAL APPROACHES AND FUTURE CLINICAL DIRECTIONS
8 ADVANCES IN THE MANAGEMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA: CURRENT EXPERIMENTAL APPROACHES AND FUTURE CLINICAL DIRECTIONS Open
Diffuse intrinsic pontine glioma (DIPG) arises within the pons of the brainstem in children ages 5 – 7 years with a median survival of one year. DIPGs are surgically inaccessible and radiation therapy (XRT) provides only transient benefit,…
View article: Auger electron-emitting EGFR-targeted and non-targeted [197Hg]Hg-gold nanoparticles for treatment of glioblastoma multiforme (GBM)
Auger electron-emitting EGFR-targeted and non-targeted [197Hg]Hg-gold nanoparticles for treatment of glioblastoma multiforme (GBM) Open
Background We describe here radiation nanomedicines for glioblastoma multiforme (GBM) composed of gold nanoparticles (AuNPs) that integrate the Auger electron-emitter, 197 Hg. [ 197 Hg]Hg-AuNPs were conjugated to anti-epidermal growth fact…
View article: In vitro suppression of glioblastoma cell functions by TG100-115, a transient receptor potential melastatin 7 kinase inhibitor
In vitro suppression of glioblastoma cell functions by TG100-115, a transient receptor potential melastatin 7 kinase inhibitor Open
Glioblastomas (GBMs) are highly aggressive and lethal primary brain tumors, known for their rapid proliferation, diffuse infiltration, and resistance to conventional therapies. Recent studies have highlighted the involvement of transient r…
View article: Safe and Effective: Words Carry Power and Responsibility
Safe and Effective: Words Carry Power and Responsibility Open
View article: What defines response to vagus nerve stimulation in children with drug‐resistant epilepsy? A prospective cohort study from the <scp>CONNECTiVOS</scp> collaboration
What defines response to vagus nerve stimulation in children with drug‐resistant epilepsy? A prospective cohort study from the <span>CONNECTiVOS</span> collaboration Open
Objectives Responsiveness to vagus nerve stimulation (VNS) in children with drug‐resistant epilepsy (DRE) is often defined based on reduction in seizure frequency, typically at the 50% threshold, with limited consideration to the effects o…
View article: Efficacy of DNA Methyltransferase Inhibitor Immune Priming Therapy in Combination with PD-1 Inhibitors to Treat High-Risk Pediatric Brain Tumors
Efficacy of DNA Methyltransferase Inhibitor Immune Priming Therapy in Combination with PD-1 Inhibitors to Treat High-Risk Pediatric Brain Tumors Open
Background Despite intensive therapies, outcomes for high-risk pediatric brain tumors (PBTs) remain dismal, prompting the search for novel treatments. DNA methyltransferase inhibitors (DNMTi) have been shown to prime tumors to improve resp…
View article: History of tumor, spine, and trauma neurosurgery in Ukraine: growth and resilience
History of tumor, spine, and trauma neurosurgery in Ukraine: growth and resilience Open
View article: Long-term outcomes of vagus nerve stimulation in children with drug resistant epilepsy are driven by early benefit
Long-term outcomes of vagus nerve stimulation in children with drug resistant epilepsy are driven by early benefit Open
View article: Training the Neurosurgeon-Scientist: A Comparative Analysis of the Canadian Surgeon Scientist Training Program and the Scandinavian Model
Training the Neurosurgeon-Scientist: A Comparative Analysis of the Canadian Surgeon Scientist Training Program and the Scandinavian Model Open
View article: Birth characteristics and the risk of childhood brain tumors: A case–control study in Ontario, Canada
Birth characteristics and the risk of childhood brain tumors: A case–control study in Ontario, Canada Open
Various birth characteristics may influence healthy childhood development, including the risk of developing childhood brain tumors (CBTs). In this study, we aimed to investigate the association between delivery methods, obstetric history, …
View article: Convection-enhanced delivery of [177Lu]Lu-labeled gold nanoparticles combined with anti-PD1 checkpoint immunotherapy improves the survival of immunocompetent C57BL/6J mice with orthotopic GL261 murine glioma tumors
Convection-enhanced delivery of [177Lu]Lu-labeled gold nanoparticles combined with anti-PD1 checkpoint immunotherapy improves the survival of immunocompetent C57BL/6J mice with orthotopic GL261 murine glioma tumors Open
This study demonstrates that combining a locally-infused radiation nanomedicine, [177Lu]Lu-MCP-AuNP and anti-PD1 checkpoint immunotherapy improved the survival of mice with glioma tumors in the brain. In the future, this treatme…
View article: <i>CASCADES</i>, a novel <i>SOX2</i> super‐enhancer‐associated long noncoding <scp>RNA</scp>, regulates cancer stem cell specification and differentiation in glioblastoma
<i>CASCADES</i>, a novel <i>SOX2</i> super‐enhancer‐associated long noncoding <span>RNA</span>, regulates cancer stem cell specification and differentiation in glioblastoma Open
Glioblastoma is the most common primary malignant brain tumor in adults, with a median survival of just over 1 year. The failure of available treatments to achieve remission in patients with glioblastoma (GBM) has been attributed to the pr…
View article: Toward standardized brain tumor tissue processing protocols in neuro-oncology: a perspective for gliomas and beyond
Toward standardized brain tumor tissue processing protocols in neuro-oncology: a perspective for gliomas and beyond Open
Implementation of standardized protocols in neurooncology during the surgical resection of brain tumors is needed to advance the clinical treatment paradigms that use tissue for diagnosis, prognosis, bio-banking, and treatment. Currently r…
View article: Add‐On Deep Brain Stimulation versus Continued Vagus Nerve Stimulation for Childhood Epilepsy (<scp>ADVANCE</scp>): A Partially Randomized Patient Preference Trial
Add‐On Deep Brain Stimulation versus Continued Vagus Nerve Stimulation for Childhood Epilepsy (<span>ADVANCE</span>): A Partially Randomized Patient Preference Trial Open
Outcomes following vagus nerve stimulation (VNS) improve over years after implantation in children with drug‐resistant epilepsy. The added value of deep brain stimulation (DBS) instead of continued VNS optimization is unknown. In a prospec…
View article: Current immunotherapeutic approaches to diffuse intrinsic pontine glioma
Current immunotherapeutic approaches to diffuse intrinsic pontine glioma Open
Diffuse intrinsic pontine glioma (DIPG) is an aggressive brain tumour that occurs in the pons of the brainstem and accounts for over 80% of all brainstem gliomas. The median age at diagnosis is 6–7 years old, with less than 10% overall sur…
View article: Editorial. AtlasGPT: dawn of a new era in neurosurgery for intelligent care augmentation, operative planning, and performance
Editorial. AtlasGPT: dawn of a new era in neurosurgery for intelligent care augmentation, operative planning, and performance Open
"Editorial. AtlasGPT: dawn of a new era in neurosurgery for intelligent care augmentation, operative planning, and performance" published on 27 Feb 2024 by American Association of Neurological Surgeons.
View article: Lipidomic-Based Approach to 10 s Classification of Major Pediatric Brain Cancer Types with Picosecond Infrared Laser Mass Spectrometry
Lipidomic-Based Approach to 10 s Classification of Major Pediatric Brain Cancer Types with Picosecond Infrared Laser Mass Spectrometry Open
Picosecond infrared laser mass spectrometry (PIRL-MS) is shown, through a retrospective patient tissue study, to differentiate medulloblastoma cancers from pilocytic astrocytoma and two molecular subtypes of ependymoma (PF-EPN-A, ST-EPN-RE…
View article: Declaration of Computational Neurosurgery
Declaration of Computational Neurosurgery Open
View article: P133: CNS hemangioblastoma in pediatric patients with von Hippel–Lindau disease: When to start surveillance*
P133: CNS hemangioblastoma in pediatric patients with von Hippel–Lindau disease: When to start surveillance* Open
Central nervous system (CNS) hemangioblastoma (HB) occurs in 60–80% of patients with von Hippel-Lindau disease (VHL). Thus, regular surveillance for the early detection of CNS HB is recommended. However, expert recommendations for the age …
View article: Intraoperative changes in large-scale thalamic circuitry following laser ablation of hypothalamic hamartomas
Intraoperative changes in large-scale thalamic circuitry following laser ablation of hypothalamic hamartomas Open
Successful disconnection of HH is associated with intraoperative, large-scale changes in thalamocortical connectivity. These changes provide novel insights into the large-scale basis of gelastic seizures and may represent intraoperative bi…
View article: Postoperative cerebellar mutism syndrome is an acquired autism-like network disturbance
Postoperative cerebellar mutism syndrome is an acquired autism-like network disturbance Open
Background Cerebellar mutism syndrome (CMS) is a common and debilitating complication of posterior fossa tumor surgery in children. Affected children exhibit communication and social impairments that overlap phenomenologically with subsets…
View article: Preclinical pediatric brain tumor models for immunotherapy: Hurdles and a way forward
Preclinical pediatric brain tumor models for immunotherapy: Hurdles and a way forward Open
Brain tumors are the most common solid tumor in children and the leading cause of cancer-related deaths. Over the last few years, improvements have been made in the diagnosis and treatment of children with Central Nervous System tumors. Un…
View article: Correction: Maternal and childhood medical history and the risk of childhood brain tumours: a case–control study in Ontario, Canada
Correction: Maternal and childhood medical history and the risk of childhood brain tumours: a case–control study in Ontario, Canada Open
View article: Correction: Use of monopolar cautery in patient with a vagal nerve stimulator during neuromuscular scoliosis surgery
Correction: Use of monopolar cautery in patient with a vagal nerve stimulator during neuromuscular scoliosis surgery Open
View article: Transient receptor potential melastatin 7 signaling in U251 cell migration and invasion involves calcineurin
Transient receptor potential melastatin 7 signaling in U251 cell migration and invasion involves calcineurin Open
Transient receptor potential melastatin 7 (TRPM7) is a divalent cation channel that has crucial functions in glioblastoma (GBM), which remains the most prevalent and lethal primary brain tumor in adults. Altering TRPM7 activity has previou…
View article: Expression of Concern
Expression of Concern Open
In accordance with industry best practices, Journal of Neurosurgery Publishing Group (JNSPG) is issuing this Expression of Concern to alert the readership to potential issues raised with the following articles.