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View article: Sparse Bayesian learning for label efficiency in cardiac real-time MRI
Sparse Bayesian learning for label efficiency in cardiac real-time MRI Open
Cardiac real-time magnetic resonance imaging (MRI) is an emerging technology that images the heart at up to 50 frames per second, offering insight into the respiratory effects on the heartbeat. However, this method significantly increases …
View article: Long-duration human spaceflight induces atrophy in the left ventricular papillary muscles
Long-duration human spaceflight induces atrophy in the left ventricular papillary muscles Open
Microgravity exposure induces cardiac deconditioning, primarily due to hypovolemia and inactivity. Animal models suggest microgravity may cause left ventricular (LV) papillary muscle atrophy, but this has not been studied in humans. This s…
View article: Evidence of effective cardiovascular countermeasures during spaceflights: insights from wearable monitoring
Evidence of effective cardiovascular countermeasures during spaceflights: insights from wearable monitoring Open
Microgravity induces profound cardiovascular changes, prompting space agencies to develop countermeasures to preserve their crewmembers’ health. This study aimed to use a portable device based on electro-, impedance- and seismo-cardiograph…
View article: Stable Cytokine Network during Hypoxia and Exercise in Patients with Fontan Circulation
Stable Cytokine Network during Hypoxia and Exercise in Patients with Fontan Circulation Open
Moderate normobaric hypoxia combined with submaximal exercise did not elicit systemic immune activation in stable patients with Fontan circulation. These data challenge assumptions of latent immune vulnerability and support the safety of c…
View article: Daily use of countermeasures to prevent headward fluid shifts throughout 30 days of strict head-down tilt bed rest
Daily use of countermeasures to prevent headward fluid shifts throughout 30 days of strict head-down tilt bed rest Open
We demonstrate that daily use of lower body negative pressure or venoconstrictive thigh cuffs following aerobic exercise is well tolerated throughout 30 days of exposure to the spaceflight analog strict head-down tilt bed rest. Both counte…
View article: Alterations in CNS-derived blood biomarkers during 30 days simulated microgravity
Alterations in CNS-derived blood biomarkers during 30 days simulated microgravity Open
Introduction Spaceflight induces physiological adaptations, including headward fluid shifts that may impact the central nervous system (CNS). Ground-based analogs such as 6° head-down tilt bed rest (HDTBR) provide a controlled setting to s…
View article: Continuous wavelet based transfer function analysis of cerebral autoregulation dynamics for neuromonitoring using near-infrared spectroscopy
Continuous wavelet based transfer function analysis of cerebral autoregulation dynamics for neuromonitoring using near-infrared spectroscopy Open
Introduction Near-infrared spectroscopy is now a popular method in neuromonitoring. Derived parameters like cerebral oxygenation index or Fast Fourier Transform based coherence estimates between blood pressure and cerebral blood flow have …
View article: Evidence of Effective Cardiovascular Countermeasures During Spaceflights: Insights from Wearable Monitoring
Evidence of Effective Cardiovascular Countermeasures During Spaceflights: Insights from Wearable Monitoring Open
Microgravity induces profound cardiovascular changes, prompting space agencies to develop countermeasures to preserve their crewmembers’ health. This study aimed to use a portable device based on electro-, impedance- and seismo-cardiograph…
View article: Warming Increases Environmental <scp>DNA</scp> (<scp>eDNA</scp>) Removal Rates in Flowing Waters
Warming Increases Environmental <span>DNA</span> (<span>eDNA</span>) Removal Rates in Flowing Waters Open
The use of environmental DNA (eDNA) for aquatic conservation is emerging, but its value is limited by our understanding of how environmental factors like temperature impact eDNA persistence. Although elevated temperatures are known to incr…
View article: Sparse Bayesian Learning for Label Efficiency in Cardiac Real-Time MRI
Sparse Bayesian Learning for Label Efficiency in Cardiac Real-Time MRI Open
Cardiac real-time magnetic resonance imaging (MRI) is an emerging technology that images the heart at up to 50 frames per second, offering insight into the respiratory effects on the heartbeat. However, this method significantly increases …
View article: Mechanical countermeasures for spaceflight-associated neuro-ocular syndrome during 30-days of head down tilt bed rest: design, implementation, and tolerability
Mechanical countermeasures for spaceflight-associated neuro-ocular syndrome during 30-days of head down tilt bed rest: design, implementation, and tolerability Open
After longer duration space missions, some astronauts experience structural and functional changes in the eye and structural changes in the brain, termed Spaceflight-Associated Neuro-Ocular Syndrome (SANS). Countermeasures against SANS are…
View article: Influence of Simulated Altitude Exposure (2500 m) on Patients with Fontan Palliation Based on Circulating Hypoxia-Associated Factors
Influence of Simulated Altitude Exposure (2500 m) on Patients with Fontan Palliation Based on Circulating Hypoxia-Associated Factors Open
Patients with a univentricular heart live with chronic hypoxia (75–85%) in their first years of life, which could affect adaptation to altitude or other hypoxic insults later in life. To test this hypothesis, we exposed 18 patients with Fo…
View article: A SWAT model depicts the impact of land use change on hydrology, nutrient, and sediment loads in a Lake Michigan watershed
A SWAT model depicts the impact of land use change on hydrology, nutrient, and sediment loads in a Lake Michigan watershed Open
High levels of nutrient loads in a catchment indicate the presence of pollution sources that must be identified and quantified. These loads in surface and groundwater have been a major concern that impacts water quality in the Midwestern U…
View article: Effect of Acute Hypoxia Exposure on the Availability of A<sub>1</sub>Adenosine Receptors and Perfusion in the Human Brain
Effect of Acute Hypoxia Exposure on the Availability of A<sub>1</sub>Adenosine Receptors and Perfusion in the Human Brain Open
In animal studies it has been observed that the inhibitory neuromodulator adenosine is released into the cerebral interstitial space during hypoxic challenges. Adenosine's actions on the A1 adenosine receptor (A1AR) protect the brain from …
View article: Baroreflex activation therapy through electrical carotid sinus stimulation
Baroreflex activation therapy through electrical carotid sinus stimulation Open
An imbalance between cardiovascular parasympathetic and sympathetic activity towards sympathetic predominance has been implicated in the pathogenesis of treatment-resistant arterial hypertension and heart failure. Arterial baroreceptors co…
View article: Impact of Daily Lower‐Body Negative Pressure or Cycling Followed by Venous Constrictive Thigh Cuffs on Bedrest‐Induced Orthostatic Intolerance
Impact of Daily Lower‐Body Negative Pressure or Cycling Followed by Venous Constrictive Thigh Cuffs on Bedrest‐Induced Orthostatic Intolerance Open
Background Orthostatic intolerance occurs following immobilization in patients on Earth and in astronauts after spaceflight. Head‐down tilt bedrest is a terrestrial model for weightlessness and induces orthostatic intolerance. We hypothesi…
View article: Long-duration Spaceflight Induces Atrophy in the Left Ventricular Papillary Muscles.
Long-duration Spaceflight Induces Atrophy in the Left Ventricular Papillary Muscles. Open
Microgravity exposure induces cardiac deconditioning, primarily due to hypovolemia and inactivity. Animal models suggest microgravity may cause left ventricular (LV) papillary muscle atrophy, but this has not been studied in humans. This s…
View article: Cardiopulmonary deconditioning and plasma volume loss are not sufficient to provoke orthostatic hypertension
Cardiopulmonary deconditioning and plasma volume loss are not sufficient to provoke orthostatic hypertension Open
Orthostatic hypertension, defined by an increase of systolic blood pressure (SBP) of ≥20 mmHg upon standing, harbors an increased cardiovascular risk. We pooled data from two rigorously conducted head-down tilt bedrest studies to test the …
View article: Glucose-sensitive hypothalamic nuclei traced through functional magnetic resonance imaging
Glucose-sensitive hypothalamic nuclei traced through functional magnetic resonance imaging Open
Introduction Hypothalamic glucose-sensitive neural circuits, which regulate energy metabolism and can contribute to diseases such as obesity and type 2 diabetes, have been difficult to study in humans. We developed an approach to assess hy…
View article: Impact of daily artificial gravity on autonomic cardiovascular control following 60-day head-down tilt bed rest
Impact of daily artificial gravity on autonomic cardiovascular control following 60-day head-down tilt bed rest Open
Impaired cardiovascular autonomic control following space flight or immobilization may limit the ability to cope with additional hemodynamic stimuli. Head-down tilt bedrest is an established terrestrial analog for space flight and offers t…
View article: Electrocardiographic changes during sustained normobaric hypoxia in patients after myocardial infarction
Electrocardiographic changes during sustained normobaric hypoxia in patients after myocardial infarction Open
The safety of prolonged high-altitude stays and exercise for physically fit post-myocardial infarction (MI) patients is unclear. Myocardial tissue hypoxia and pulmonary hypertension can affect cardiac function and electrophysiology, possib…
View article: Randomized Trial Comparing SGLT2 Inhibition and Hydrochlorothiazide on Sympathetic Traffic in Type 2 Diabetes
Randomized Trial Comparing SGLT2 Inhibition and Hydrochlorothiazide on Sympathetic Traffic in Type 2 Diabetes Open
Increased renal sodium excretion eliciting body weight loss may promote sympathetic activation. However, sympathetic excitation in the face of increased sodium loss may be attenuated by SGLT2 inhibitor-specific actions.
View article: Effects of daily artificial gravity training on orthostatic tolerance following 60-day strict head-down tilt bedrest
Effects of daily artificial gravity training on orthostatic tolerance following 60-day strict head-down tilt bedrest Open
Purpose Orthostatic intolerance commonly occurs following immobilization or space flight. We hypothesized that daily artificial gravity training through short-arm centrifugation could help to maintain orthostatic tolerance following head-d…
View article: Cerebral blood flow autoregulation assessment by correlation analysis between mean arterial blood pressure and transcranial doppler sonography or near infrared spectroscopy is different: A pilot study
Cerebral blood flow autoregulation assessment by correlation analysis between mean arterial blood pressure and transcranial doppler sonography or near infrared spectroscopy is different: A pilot study Open
Purpose Recently, cerebral autoregulation indices based on moving correlation indices between mean arterial pressure (MAP) and cerebral oximetry (NIRS, ORx) or transcranial Doppler (TCD)-derived middle cerebral artery flow velocity (Mx) ha…
View article: Electrocardiographic Changes During Sustained Normobaric Hypoxia in Patients After Myocardial Infarction
Electrocardiographic Changes During Sustained Normobaric Hypoxia in Patients After Myocardial Infarction Open
Background Whether physically fit patients who have recovered from myocardial infarction can safely stay and exercise at high altitude is unclear. Myocardial tissue hypoxia and pulmonary hypertension could affect cardiac function, electrop…
View article: Impaired Physical Performance in X-linked Hypophosphatemia Is not Caused by Depleted Muscular Phosphate Stores
Impaired Physical Performance in X-linked Hypophosphatemia Is not Caused by Depleted Muscular Phosphate Stores Open
Context X-linked hypophosphatemia (XLH) is a rare genetic disease, characterized by renal phosphate wasting and complex musculoskeletal manifestations including decreased physical performance. Objective To characterize muscular deficits in…
View article: Hypoxia and Cardiac Function in Patients With Prior Myocardial Infarction
Hypoxia and Cardiac Function in Patients With Prior Myocardial Infarction Open
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